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| 1 | Polyaniline-coated selenium/carbon composites encapsulated in graphene as efficient cathodes for Li-Se batteries显示文摘 | Biwu Wang Jingjing Zhang Zhigang Xia Meiqiang Fan Chunju Lv Guanglei Tian Xiaona Li | 2018 | Nano Research2018，11，5： | 5 |
| 2 | Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis显示文摘在蛋白质周转(蛋白质 degradome ) 的全球变化组成对内在或外来的刺激的细胞的回答的中央部分。然而,介绍蛋白质 degradome 仍然保持技术上挑战性。最近, proteasome 的抑制,例如由使用 bortezomib (BTZ ) ,为对待多重骨髓瘤和其它人恶意,但是药行动和肿瘤药抵抗还有待于被完成的为 BTZ 的机制的系统的理解作为主要化学疗法的策略出现了。这里,我们开发了并且适用 dual-fluorescence-based 蛋白质周转试金(ProTA ) 到份量上在导致 BTZ 的 proteasomal 抑制之上在人的蛋白质 degradome 介绍全球变化。ProTA 和随后的网络分析描出在 BTZ 化疗的 BTZ 行动和肿瘤药抵抗的潜在的分子的基础。最后,把 BTZ 的使用与指向识别 ProTA 的关键基因的药相结合或在 BTZ 行动的小径在多重骨髓瘤房间减少了 BTZ 抵抗。显著地, BTZ 稳定 proteasome 子单元 PSMC1 和 proteasome 集会因素 PSMD10,建议为调整 proteasome 动态平衡的以前下面欣赏的机制。因此, ProTA 是为介绍人的蛋白质 degradome 阐明的一个新奇工具药行动和抵抗的潜在的机制,它可能便于指向 proteostasis 对待人的混乱的治疗学的开发。 | Tao Yu Yonghui Tao Meiqiang Yang Peng Chen Xiaobo Gao Yanbo Zhang Tao Zhang Zi Chen Jian Hou Yan Zhang Kangcheng Ruan Hongyan Wang Ronggui Hu | 2014 | Cell Research2014，24，10： | 2 |
| 3 | MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3显示文摘Central precocious puberty(CPP)refers to a human syndrome of early puberty initiation with characteristic increase in hypothalamic production and release of gonadotropin-releasing hormone(GnRH).Previously,loss-of-function mutations in human MKRN3,encoding a putative E3 ubiquitin ligase,were found to contribute to about 30%of cases of familial CPP.MKRN3 was thereby suggested to serve as a‘brake’of mammalian puberty onset,but the underlying mechanisms remain as yet unknown.Here,we report that genetic ablation of Mkrn3 did accelerate mouse puberty onset with increased production of hypothalamic GnRH1.MKRN3 interacts with and ubiquitinates MBD3,which epigenetically silences GNRH1 through disrupting the MBD3 binding to the GNRH1 promoter and recruitment of DNA demethylase TET2.Our findings have thus delineated a molecular mechanism through which the MKRN3-MBD3 axis controls the epigenetic switch in the onset of mammalian puberty. | Chuanyin Li Wenli Lu Liguang Yang Zhengwei Li Xiaoyi Zhou Rong Guo Junqi Wang Zhebao Wu Zhiya Dong Guang Ning Yujiang Shi Yinmin Gu Peng Chen Zijian Hao Tianting Han Meiqiang Yang Wei Wang Xuehui Huang Yixue Li Shan Gao Ronggui Hu | 2020 | National Science Review2020，7，3： | 2 |
| 4 | New existence results for higher-order nonlinear fractional differential equa- tion with integral boundary conditions 显示文摘 | FENG Meiqiang ZHANG Xuemei GE Weigao | 2011 | Boundary Value Problems2011，2011，： | 1 |
| 5 | A class of three -point boundary value problem for second-order impulsive Integro-diiTerential equations in Banach spaces显示文摘 | Meiqiang Feng Huihui Pang | 2009 | Nonlinear analysis2009，，7： | 1 |
| 6 | Positive Solutions for a Class of Boundary-value Problem with Integral Boundary Con-ditions in Banach Spaces显示文摘 | FENG Meiqiang JI Dehong GE Weigao | 2008 | J Comput Appl Math2008，222，： | 1 |
| 7 | Positive solutions for a class of 2n-order singular boundary value problems显示文摘 | Zhang Xuemei Feng Meiqiang | 2008 | Nonlinear Analysis2008，69，： | 1 |
| 8 | Positive solutions for a class of boundary value problem with integral boundary condi- tions in Banach spaces显示文摘 | Feng Meiqiang Ji Dehong Ge Weigao | 2008 | J Comput Appl Math2008，222，2： | 1 |
| 9 | Hydrolysis of A1Li/NaBH4 system promoted by Co powder with different par- ticle size and amount as synergistic hydrogen generation for portable fuel cell显示文摘 | Fan Meiqiang Wang Yu Tian Guanglei | 2013 | International Journal of Hydrogen Ener- gy2013，38，10： | 1 |
| 10 | Transformation techniques and fixed point theories to establish the posi- tive solutions of second-order impulsive differential e- quations 显示文摘 | ZHANG Xuemei FENG Meiqiang | 2014 | Journal of Computational and Applied Mathematics2014，271，： | 1 |
| 11 | Exact number of solutions for a class of two-point boundary value problems with one-dimensional p-Laplacian显示文摘 | FENG MEIQIANG ZHANG XUEMEI GE WEIGAO | 2008 | Journal of Mathematical Analysis and Applications2008，338，： | 1 |
| 12 | Hydrogen production for micro-fuel-cell from activated A1-Sn-Zn-X(X: hydride or halide)mixture in water显示文摘 | Pan Meiqiang Sun Lixian Xu Fen | 2011 | Renewable Energy2011，36，： | 1 |
| 13 | Exist- ence of solutions of boundary value problems with inte- gral boundary conditions for second-order impulsive in- tegro-differential equations in Banach spaces 显示文摘 | ZHANG Xuemei FENG Meiqiang GE Weigao | 2010 | Jour- nal of Computational and Applied Mathematics2010，233，8： | 1 |
| 14 | Multiple positive solu- tions of multi-point boundary value problem for second- order impulsive differential equations 显示文摘 | FENG Meiqiang XIE Dongxiu | 2009 | Journal of Computational and Applied Mathematics2009，223，1： | 1 |
| 15 | Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression显示文摘 | Zhengzhao Liu Peng Chen Hong Gao Yu Gu Jiao Yang Hong Peng Xingxing Xu Haifeng Wang Meiqiang Yang Xiaoying Liu Libin Fan Shiyao Chen Jian Zhou Yihong Sun Kangchen Ruan Shuqun Cheng Masaaki Komatsu Eileen White Lin Li Hongbin Ji Daniel Finley Ronggui Hu | 2014 | Cancer Cell2014，，： | 1 |
| 16 | Existence of symmetric positive solu- tions for a boundary value problem with integral bound- ary conditions 显示文摘 | FENG Meiqiang | 2011 | Applied Mathematics Letters2011，24，8： | 1 |
| 17 | Ion chromatography in combination with ESI ion trap MS for the analysis of diphacinone in animal livers 显示文摘 | CAI Meiqiang CHEN Xiaohong YAN Yongqing | 2009 | Chromatographia2009，69，12： | 1 |
| 18 | Simultaneous measurement of indandione-type rodentieides in human serum by liquid chromatography-electrospray ionization tandem mass spectrometry显示文摘 | JIN Micong CAI Meiqiang CHEN Xiaohong | 2009 | J Anal Toxicol2009，33，5： | 1 |
| 19 | Existence of positive solutions for singular eigenvalue problems显示文摘 | Meiqiang Feng Weigao Ge | 2006 | Electron J Diff Eqns2006，2006，105： | 1 |
| 20 | Existence and monotone iteration of positive solutions for a three - point boundary value problem显示文摘 | PANG Huihui FENG Meiqiang GE Weigao | 2008 | Appl Math Lett2008，21，7： | 1 |
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