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| 1 | Surface and intrinsic contributions to extinction properties of ZnSe quantum dots显示文摘This work studies extinction properties of ZnSe quantum dots terminated with either Se-surface or Zn-surface(Se-ZnSe or Zn-ZnSe QDs).In addition to commonly observed photoluminescence quenching by anionic surface sites,Se-ZnSe QDs are found to show drastic signatures of Se-surface states in their UV-visible(Vis)absorption spectra.Similar to most QDs reported in literature,monodisperse Zn-ZnSe QDs show sharp absorption features and blue-shifted yet steep absorption edge respect to the bulk bandgap.However,for monodisperse Se-ZnSe QDs,all absorption features are smeared and a low-energy tail is identified to extend to an energy window below the bulk ZnSe bandgap.Along increasing their size,a cyclic growth of ZnSe QDs switches their surface from Zn-terminated to Se-terminated ones,which confirms that the specific absorption signatures are reproducibly repeated between those of two types of the QDs.Though the extinction coefficients per unit of Se-ZnSe QDs are always larger than those of Zn-ZnSe QDs with the same size,both of them approach the same bulk limit.In addition to contribution of the lattice,extinction coefficients per nanocrystal of Zn-ZnSe QDs show an exponential term against their sizes,which is expected for quantum-confinement enhancement of electron-hole wavefunction overlapping.For Se-ZnSe QDs,there is the third term identified for their extinction coefficients per nanocrystal,which is proportional to the square of size of the QDs and consistent with surface contribution. | Shangxin Lin Jiongzhao Li Chaodan Pu Hairui Lei Meiyi Zhu Haiyan Qin Xiaogang Peng | 2020 | Nano Research2020，13，3： | 5 |
| 2 | Tenant-based access control model for multi-tenancy and sub-tenancy architecture in Software-as-a-Service显示文摘 | Qiong zuo Meiyi XIE Guanqiu QI Hong ZHU | 2017 | Frontiers of Computer Science2017，11，3： | 3 |
| 3 | Differences in vascular endothelial function and serum proteome between obese people with phlegm-dampness constitution and balanced constitution显示文摘OBJECTIVE:To evaluate the extent of vascular endothelial dysfunction and preliminary identify serum protein biomarkers associated with obese individuals at risk for cardiovascular disease(CVD).METHODS:Fifteen obese volunteers with the phlegmdampness constitution or balanced constitution were recruited for this study respectively.The clinical baseline data was collected,and the vascular endothelial function was evaluated using the EndoPAT?.Blood samples were collected for the serum proteome analysis.The differences in the serum protein expression levels between the two groups were detected and the protein interaction network analysis,correlation analysis,receiver operating characteristic(ROC)curve analysis,and random forest model investigation were conducted.RESULTS:There were no statistical differences found in the baseline data.For vascular endothelial function,the reactive hyperemia index(RHI)of the phlegm-dampness constitution obese group was significantly lower than that of the balanced constitution obese group(1.46±0.30 vs 2.82±0.78,P<0.0001),indicating vascular endothelial dysfunction.There are 66 differentially expressed serum proteins between the two groups.apolipoprotein A2(Apo A2),angiotensin-converting enzyme 2(ACE-2),interleukin-33(IL-33),and forkhead box P3(FoxP3)showed significant differences and area under curve values of their ROC curves were greater than 0.7 and correlated significantly with RHI.CONCLUSION:Vascular endothelial dysfunction was present in the phlegm-dampness constitution obese group.Thus,alterations in the expression levels of key serum proteins,including Apo A2,ACE-2,IL-33,and Fox P3 could serve as potential biomarkers in the obese population at risk of CVD. | ZHU Linghui SUN Ziwei GUAN Yuanyuan LIU Meiyi ZHENG Yi YU Ruoxi WANG Qi LI Lingru | 2024 | Journal of Traditional Chinese Medicine2024，44，1： | 0 |
| 4 | Neuritin affects the activity of neuralized-like 1 by promoting degradation and weakening its affinity for substrate显示文摘Neuritin plays a key role in neural development and regeneration by promoting neurite outgrowth and synapse maturation.Our previous research revealed the mechanism by which neuritin inhibits Notch signaling through interaction with neuralized-like 1(Neurl1)to promote neurite growth.However,how neuritin regulates Notch signaling through Neurl1 has not been elucidated.Here,we first confirm that neuritin is an upstream regulator of Neurl1 and inhibits Notch signaling through Neurl1.Neurl1 is an E3 ubiquitin ligase that can promote ubiquitination and endocytosis of the Notch1 ligand Jagged1.Therefore,we observe the effect of neuritin on the ligase activity of Neurl1.The results indicate that neuritin inhibits Neurl1 activity by reducing the ubiquitination level and endocytosis of the target protein Jagged1.Moreover,we find that decreased activity of Neurl1 results in reduced expression of Notch receptor Notch intracellular domain(NICD)and downstream target gene hairy and enhancer of split-1(HES1).Furthermore,we investigate how neuritin affects Neurl1 enzyme activity.The results show that neuritin not only weakens the affinity between Neurl1 and Jagged1 but also promotes the degradation of Neurl1 by the 26S proteasome pathway.Taken together,our results suggest that neuritin negatively regulates Notch signaling by inhibiting the activity of Neurl1,promoting the degradation of Neurl1 and weakening the affinity of Neurl1 for Jagged1.Our study clarifies the molecular mechanisms of neuritin in regulating the Notch signaling pathway and provides new clues about how neuritin mediates neural regeneration and plasticity. | Jingling Zhu Yu Li Chen Zhong Meiyi Zhu Yan Zheng Anying Xiong Pingping Meng Liya Shan Yang Li Jin Huang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，10： | 0 |
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