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| 1 | Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis显示文摘Dear Editor,Plants utilize K^+ions to maintain hydrostatic pressure,drive irreversible cell expansion for growth,and facilitate reversible changes in guard cell volume that cause stomatal opening or closing.KAT1 is a voltage-dependent potassium channel from Arabidopsis thaliana that is mainly expressed in guard cells.KAT1 allows the influx of K+,leading to the swelling and opening of the stoma,and therefore plays a key role in regulating the aperture of stomatal pores on the surface of plant leaves. | Siyu Li Fan Yang Demeng Sun Yong Zhang Mengge Zhang Sanling Liu Peng Zhou Chaowei Shi Longhua Zhang Changlin Tian | 2020 | Cell Research2020，30，11： | 2 |
| 2 | Amine-functionalized mesoporous UiO-66 aerogel for CO_(2) adsorption显示文摘A mesoporous UiO-66-NH_(2) aerogel is prepared via a straightforward sol-gel method without using any binders or mechanical pressures, in which the amine groups are directly introduced into the matrix by using 2-aminoterephthalic acid. The novel UiO-66-NH_(2) aerogel also exhibits high specific surface area and mesopore-dominated structure, implying its highly potential use in CO_(2) adsorption. For ulteriorly investigating the effect of amine loading on the CO_(2) adsorption ability, a series of UiO-66-NH_(2) aerogel with different amino content is fabricated by changing the ligand/metal molar ratio. When the molar ratio is 1.45, the CO_(2) adsorption capacity reaches the optimum value of 2.13 mmol·g^(-1) at 25 ℃ and 0.1 MPa, which is 12.2% higher than that of pure UiO-66 aerogel. Additionally, UiO-66-NH_(2)-1.45 aerogel also has noticeable CO_(2) selectivity against N_(2) and CH_(4) as well as good regeneration stability. Such results imply that it has good application prospect in the field of CO_(2) adsorption, and also contains the potential to be applied in catalysis, separation and other fields. | Mengge Shang Jing Zhang Jinqiang Sun Shimo Yu Feng Hua Xiaoxu Xuan Xun Sun Serguei Filatov Xibin Yi | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 0 |
| 3 | Muscle-inspired soft robots based on bilateral dielectric elastomer actuators显示文摘Muscle groups perform their functions in the human body via bilateral muscle actuation,which brings bionic inspiration to artificial robot design.Building soft robotic systems with artificial muscles and multiple control dimensions could be an effective means to develop highly controllable soft robots.Here,we report a bilateral actuator with a bilateral deformation function similar to that of a muscle group that can be used for soft robots.To construct this bilateral actuator,a low-cost VHB 4910 dielectric elastomer was selected as the artificial muscle,and polymer films manufactured with specific shapes served as the actuator frame.By end-to-end connecting these bilateral actuators,a gear-shaped 3D soft robot with diverse motion capabilities could be developed,benefiting from adjustable actuation combinations.Lying on the ground with all feet on the ground,a crawling soft robot with dexterous movement along multiple directions was realized.Moreover,the directional steering was instantaneous and efficient.With two feet standing on the ground,it also acted as a rolling soft robot that can achieve bidirectional rolling motion and climbing motion on a 2°slope.Finally,inspired by the orbicularis oris muscle in the mouth,a mouthlike soft robot that could bite and grab objects 5.3 times of its body weight was demonstrated.The bidirectional function of a single actuator and the various combination modes among multiple actuators together allow the soft robots to exhibit diverse functionalities and flexibility,which provides a very valuable reference for the design of highly controllable soft robots. | Yale Yang Dengfeng Li Yanhua Sun Mengge Wu Jingyou Su Ying Li Xinge Yu Lu Li Junsheng Yu | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 4 | Differential immune responses in pregnant patients recovered from COYID-19显示文摘Pregnant women are generally more susceptible to viral infection.Although the impact of SARS-CoV-2 in pregnancy remains to be determined,evidence indicates that the risk factors for severe COVID-19 are similar in pregnancy to the general population.Here we systemically analyzed the clinical characteristics of pregnant and non-pregnant female COVID-19 patients who were hospitalized during the same period and found that pregnant patients developed marked lymphopenia and higher inflammation evident by higher C-reactive protein and IL-6.To elucidate the pathways that might contribute to immunopathology or protective immunity against COVID-19 during pregnancy,we applied single-cell mRNA sequencing to profile peripheral blood mononuclear cells from four pregnant and six non-pregnant female patients after recovery along with four pregnant and three non-pregnant healthy donors.We found normal clonal expansion of T cells in the pregnant patients,heightened activation and chemotaxis in NK,NKT,and MAIT cells,and differential interferon responses in the monocyte compartment.Our data present a unique feature in both innate and adaptive immune responses in pregnant patients recovered from COVID-19. | Ge Chen Yiming Zhang Yaoyao Zhang Jihui Ai Bin Yang Mengge Cui Qiuyue Liao Hanxiao Chen Hualin Bai Dashing Shang Jing Chen ChaoYang Sun Haiyi Liu Fengyuan Liu Bin Mao Guoqiang Sun Lu Chen Jing-wen Lin Kezhen Li | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 5 | Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma显示文摘Glioblastoma(GBM)is the most common and aggressive malignant brain tumor in adults and is poorly controlled.Previous studies have shown that both macrophages and angiogenesis play significant roles in GBM progression,and co-targeting of CSF1R and VEGFR is likely to be an effective strategy for GBM treatment.Therefore,this study developed a novel and selective inhibitor of CSFIR and VEGFR,SYHA1813,possessing potent antitumor activity against GBM.SYHA1813 inhibited VEGFR and CSFIR kinase activities with high potency and selectivity and thus blocked the cell viability of HUVECs and macrophages and exhibited anti-angiogenetic effects both in vitro and in vivo.SYHA1813 also displayed potent in vivo antitumor activity against GBM in immune-competent and immune-deficient mouse models,including temozolomide(TMZ)insensitive tumors.Notably,SYHA1813 could penetrate the blood-brain barrier(BBB)and prolong the survival time of mice bearing intracranial GBM xenografts.Moreover,SYHA1813 treatment resulted in a synergistic antitumor efficacy in combination with the PD-1 antibody.As a clinical proof of concept,SYHA1813 achieved confirmed responses in patients with recurrent GBM in an ongoing first-in-human phase I trial.The data of this study support the rationale for an ongoing phase I clinical study(ChiCTR2100045380). | Yingqiang Liu Zhengsheng Zhan Zhuang Kang Mengyuan Li Yongcong Lv Shenglan Li Linjiang Tong Fang Feng Yan Li Mengge Zhang Yaping Xue Yi Chen Tao Zhang Peiran Song Yi Su Yanyan Shen Yiming Sun Xinying Yang Yi Chen Shanyan Yao Hanyu Yang Caixia Wang Meiyu Geng Wenbin Li Wenhu Duan Hua Xie Jian Ding | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 6 | Structural basis of humanα7 nicotinic acetylcholine receptor activation显示文摘Dear Editor,Nicotinic acetylcholine receptors(nAChRs)are a class of pentameric ligand-gated ion channels(pLGICs)widely expressed in nervous system.nAChRs function as neurotransmitter receptors that respond to endogenous acetylcholine and choline,modulating neuronal excitability and synaptic communication.The homomericα7 nAChR is among the most abundant subtypes of nAChR in the brain.Dysfunction ofα7 is found to be associated with several neuropsychiatric and neurologic disorders,including schizophrenia and Alzheimer’s disease.1,2 Stimulation ofα7 has been reported to improve attention,cognitive performance,and neuronal resistance to injury.Therefore,agonists and positive allosteric modulators(PAMs)ofα7 have become hot candidates in the drug development for the treatment ofα7-related diseases.3,4 EVP-6124(abbreviated as EVP)is a high-affinityα7-selective agonist.5 PNU-120596(abbreviated as PNU)is the first reportedα7-selective PAM that could increase the peak current of the receptor evoked by agonists and delay channel desensitization.6 Both EVP and PNU are in clinical trials for the treatment of Alzheimer’s disease,schizophrenia,and cognitive impairment.Despite the significance ofα7 in physiology and pharmacology,the mechanisms underlying the activation ofα7 upon agonist and/or PAM binding remain elusive.Little is known about the structural basis of the higher selectivity of EVP and PNU forα7,which would be highly valuable for rational drug development targeting the receptor.Herein,we report the structures of full-length humanα7 in apo,EVP-bound and EVP/PNU-bound states at 3.18,2.85 and 3.02Å,respectively(Fig.1a–c;Supplementary information,Figs.S1–S4 and Table S1). | Yue Zhao Sanling Liu Yingxin Zhou Mengge Zhang Haopeng Chen HEric Xu Demeng Sun Lei Liu Changlin Tian | 2021 | Cell Research2021，31，6： | 0 |
| 7 | Origami-inspired folding assembly of dielectric elastomers for programmable soft robots显示文摘Origami has become an optimal methodological choice for creating complex three-dimensional(3D)structures and soft robots.The simple and low-cost origami-inspired folding assembly provides a new method for developing 3D soft robots,which is ideal for future intelligent robotic systems.Here,we present a series of materials,structural designs,and fabrication methods for developing independent,electrically controlled origami 3D soft robots for walking and soft manipulators.The 3D soft robots are based on soft actuators,which are multilayer structures with a dielectric elastomer(DE)film as the deformation layer and a laser-cut PET film as the supporting flexible frame.The triangular and rectangular design of the soft actuators allows them to be easily assembled into crawling soft robots and pyramidal-and square-shaped 3D structures.The crawling robot exhibits very stable crawling behaviors and can carry loads while walking.Inspired by origami folding,the pyramidal and square-shaped 3D soft robots exhibit programmable out-of-plane deformations and easy switching between two-dimensional(2D)and 3D structures.The electrically controllable origami deformation allows the 3D soft robots to be used as soft manipulators for grasping and precisely locking 3D objects.This work proves that origami-inspired fold-based assembly of DE actuators is a good reference for the development of soft actuators and future intelligent multifunctional soft robots. | Yanhua Sun Dengfeng Li Mengge Wu Yale Yang Jingyou Su Tszhung Wong Kangming Xu Ying Li Lu Li Xinge Yu Junsheng Yu | 2022 | Microsystems & Nanoengineering2022，8，2： | 0 |
| 8 | BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period显示文摘The seat of human intelligence is the human cerebral cortex,which is responsible for our exceptional cognitive abilities.Identifying principles that lead to the development of the large-sized human cerebral cortex will shed light on what makes the human brain and species so special.The remarkable increase in the number of human cortical pyramidal neurons and the size of the human cerebral cortex is mainly because human cortical radial glial cells,primary neural stem cells in the cortex,generate cortical pyramidal neurons for more than 130 days,whereas the same process takes only about 7 days in mice.The molecular mechanisms underlying this difference are largely unknown.Here,we found that bone morphogenic protein 7(BMP7)is expressed by increasing the number of corti-cal radial glial cells during mammalian evolution(mouse,ferret,monkey,and human).BMP7 expression in cortical radial glial cells promotes neurogenesis,inhibits gliogenesis,and thereby increases the length of the neurogenic period,whereas Sonic Hedgehog(SHH)signaling promotes cortical gliogenesis.We demonstrate that BMP7 sign-aling and SHH signaling mutually inhibit each other through regulation of GLI3 repressor formation.We propose that BMP7 drives the evolutionary expansion of the mammalian cortex by increasing the length of the neurogenic period. | Zhenmeiyu Li Guoping Liu Lin Yang Mengge Sun Zhuangzhi Zhang Zhejun Xu Yanjing Gao Xin Jiang Zihao Su Xiaosu Li Zhengang Yang | 2024 | Protein & Cell2024，15，1： | 0 |
| 9 | Fabricating a hollow cuboctahedral structure for N-doped carbon coated p-n heterojunctions towards high-performance photocatalytic organic transformation显示文摘The application of semiconductors-based photocatalysts in organic transformation has been limited by the low light utilization efficiency and the rapid recombination of photo-induced charge carriers.In this paper,we have successfully fabricated a hollow cuboctahedral nanostructure(CNNCH),which is composed of N-doped carbon layer and CuO/NiO p-n heterojunctions.The hollow structure in CNNCH can effectively favor the light utilization through the multiple light reflection and scattering.The separation of photo-induced charge carriers can be highly improved by the exitence of charge transfer pathways between the p-n heterojunctions and semiconductor/N-doped carbon layer interfaces.Due to the above advantages,hollow cuboctahedral CNNCH as the photocatalyst has behaved high performance towards the photocatalytic cross-dehydrogenative coupling reaction. | Hao Gao Liming Sun Mengge Li Wenwen Zhan Xiaojun Wang Xiguang Han | 2022 | Nano Research2022，15，5： | 0 |
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