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| 1 | The DTH8-Hd1 Module Mediates Day-Length-Dependent Regulation of Rice Flowering显示文摘Photoperiodic flowering 是最重要的小径之一在米饭(Oryza sativa ) 管理 flowering,在哪个标题日期 1 (Hd1 ) , Arabidopsis CONSTANS 基因的 ortholog,编码一个枢轴的管理者。Hd1 在短天的条件(SD ) 下面支持 flowering,但是镇压在由调整领导日期 3a (Hd3a ) 的表示的长天的条件(LD ) 下面的 flowering,在米饭的 FLOWERING 地点 T (英尺) ortholog。然而, Hd1 怎么响应天长度改变它的规章的活动的分子的机制仍然保持大部分未知。在这研究,我们证明在由 Hd1 的 LD 的 flowering 的压抑依赖于到领导 8 的抄写因素天(DTH8 ) 。DTH8 功能的损失由 Hd1 导致 Hd3a 的激活,导致早 flowering。我们发现 Hd1 直接与 DTH8 交往并且 DTH8-Hd1 建筑群的形成为由在 LD 的 Hd1 的 Hd3a 的 transcriptional 压抑是必要的,含有 Hd1 功能的开关被 DTH8 在 LD 而非在 SD 调停。而且,我们表明 DTH8 与 Hd3a 倡导者联系在 Hd3a 地点调制 H3K27 trimethylation (H3K27me3 ) 的水平。面对 DTH8-Hd1 建筑群, H3K27me3 水平在 Hd3a 被增加,而 DTH8 功能的损失在 Hd3a 导致了减少的 H3K27me3 水平。一起拿,我们的调查结果显示响应天长度, DTH8 在调停起一个关键作用 ? 由通过到在 photoperiodic flowering 的形状 epigenetic 修正的 DTH8-Hd1 模块的 Hd1 的 Hd3a 的 transcriptional 规定。 | Anping Dul Wei Tian Menghao Wei Wei Yan Hang He Da Zhou Xi Huang Shigui Li Xinhao Ouyang | 2017 | Molecular Plant2017，10，7： | 21 |
| 2 | Single-phase multiferroics: new materials, phenomena,and physics显示文摘Multiferroics,where multiple ferroic orders coexist and are intimately coupled,promise novel applications in conceptually new devices on one hand,and on the other hand provide fascinating physics that is distinctly different from the physics of high-Tc superconductors and colossal magnetoresistance manganites.In this mini-review;we highlight the recent progress of single-phase multiferroics in the exploration of new materials,efficient roadmaps for functionality enhancement,new phenomena beyond magnetoelectric coupling,and underlying novel physics.In the meantime;a slightly more detailed description is given of several multiferroics with ferrimagnetic orders and double-layered perovskite structure and also of recently emerging 2D multiferroics.Some emergent phenomena such as topological vortex domain structure,non-reciprocal response,and hybrid mechanisms for multiferroicity engineering and magnetoelectric coupling in various types of multiferroics will be briefly reviewed. | Chengliang Lu Menghao Wu Lin Lin Jun-Ming Liu | 2019 | National Science Review2019，6，4： | 9 |
| 3 | Effects of adding bulking agents on the biodrying of kitchen waste and the odor emissions produced显示文摘The effects of adding a bulking agent on the performance and odor emissions(ammonia and eight sulfur-containing odorous compounds) when biodrying kitchen waste were investigated. Three treatments were considered: the addition of either cornstalks(CS) or wood peat(WP) to kitchen waste as a bulking agent before biodrying, and a control treatment(CK). The water-removal rates for CK, CS, and WP treatments were 0.35, 0.56, and0.43 kg/kg, respectively. Addition of bulking agents to kitchen waste produced less leachate,higher moisture-removal rates, and lower consumption of volatile solids. The CS treatment had the highest biodrying index(4.07), and those for the WP and CK treatments were 3.67 and 1.97, respectively. Adding cornstalks or wood peat decreased NH3 emissions by 55.8%and 71.7%, respectively. Total sulfur losses were 3.6%–21.6% after 21 days biodrying, and H2 S and Me2 SS were the main(> 95%) sulfur compounds released. The smallest amounts of sulfur-containing odorous compounds were emitted when cornstalks were added, and adding cornstalks and wood peat decreased total sulfur losses by 50.6%–64.8%. | Jing Yuan Yun Li Hongyu Zhang Difang Zhang David Chadwick Guoxue Li Guoying Wang Menghao Chi Fan Yang | 2018 | Journal of Environmental Sciences2018，30，5： | 7 |
| 4 | Effects of Bionic Volute Tongue on Aerodynamic Performance and Noise Characteristics of Centrifugal Fan Used in the Air-conditioner显示文摘The aerodynamic noise generated by the centrifugal fan used in the air conditioner is related to the comfort of human living and working,which can be controlled by using the bionic design and optimization of key components of centrifugal fan.Inspired by the non-smooth leading edge of long-eared owl wing,eight kinds of volute tongues are proposed to reduce the aerodynamic noise of a centrifugal fan.The flow and sound characteristics are numerically investigated by incorporating computational fluid dynamics and computational aero-acoustics.The optimal result exhibits a noise reduction of up to 1.5 dB with a slight increase in mass flow rate.The acoustic characteristics,with respect to the sound pressure level,power spectral density,and sound directivity are discussed.The time-domain,frequency-domain,and root mean square values of pressure fluctuation are monitored and analyzed to assess the unsteady flow interaction between the volute tongue and impeller.The intensity and scale of vortices in the centrifugal fan are suppressed in the upstream and downstream of the bionic volute tongue,and the turbulence effect on the surface of the volute tongue becomes even and weak. | Liming Wu Xiaomin Liu Menghao Wang | 2020 | Journal of Bionic Engineering2020，17，4： | 7 |
| 5 | β-Glucosidase treatment and infestation by the rice brown planthopper Nilaparvata lugens elicit similar signaling pathways in rice plants显示文摘β-Glucosidase has been reported to induce the production of herbivore-induced plant volatiles. How-ever, how it works remains unclear. Here, we investigated the levels of salicylic acid (SA), jasmonic acid (JA), ethylene, and H2O2, all of which are known signaling molecules that play important roles in in-duced plant defense in rice plants treated with β-glucosidase, and compared these to levels in plants infested by the rice brown planthopper Nilaparvata lugens (Stl). Results showed that wounding and treatment by β-glucosidase increased the levels of SA, ethylene, and H2O2, but not JA, in all plants compared to control plants. The signaling pathways activated by β-glucosidase treatment are similar to those activated by an infestation by N. lugens, although the magnitude and timing of the signals elicited by the two treatments are different. This may explain why both treatments have similar volatile profiles and are equally attractive to the parasitoid Anagrus nilaparvatae Pang et Wang. | WANG Xia ZHOU GuoXin XIANG CaiYu DU MengHao CHENG JiaAn LIU ShuSheng LOU YongGen | 2008 | Chinese Science Bulletin2008，53，1： | 5 |
| 6 | Development of a procedure for estimating the parameters of mechanistic VOC emission source models from chamber testing data显示文摘In order to evaluate the impacts of volatile organic compounds(VOCs)emissions from building materials on the indoor air quality beyond the standard chamber test conditions and test period,mechanistic emission source models have been developed in the past.However,very limited data are available for the required model parameters including the initial concentration(C_(m0)),in-material diffusion coefficient(D_(m)),partition coefficient(Kma),and convective mass transfer coefficient(k_(m)).In this study,a procedure was developed for estimating the model parameters by using VOC emission data from standard small chamber tests.In the procedure,initial values of the model parameters were refined by multivariate regression analysis of the measured emission data.To verify the procedure and estimate its uncertainty,simulated chamber test data were generated by adding 10% experimental uncertainties on the theoretical curve from the analytical solution to a mechanistic emission model.Then the procedure was applied to the generated data to estimate the model parameters.Results indicated that estimates converged to the original parameter values used for the data generation and the error of estimated parameters D_(m1)C_(m0) and K_(ma) were within±10%,±23%,and±25%of the true values,respectively.The procedure was further demonstrated by applying it to estimate the model parameters from real chamber test data.Wide application of the procedure would result in a database of mechanistic source model parameters for assessing the impact of VOC emissions on indoor pollution load,which are essential input data for evaluating the effectiveness of various indoor air quality(IAQ)design and control strategies as well as the energy required for meeting given IAQ requirements. | Zhenlei Liu Andreas Nicolai Marc Abadie Menghao Qin John Grunewald Jianshun Zhang | 2021 | Building Simulation2021，14，2： | 4 |
| 7 | Recent advances in the anti-HCV mechanisms of interferon显示文摘Interferon(IFN)in combination with ribavirin has been the standard of care(SOC)for chronic hepatitis C for the past few decades.Although the current SOC lacks the desired efficacy,and 4 new direct-acting antiviral agents have been recently approved,interferons are still likely to remain the cornerstone of therapy for some time.Moreover,as an important cytokine system of innate immunity,host interferon signaling provides a powerful antiviral response.Nevertheless,the mechanisms by which HCV infection controls interferon production,and how interferons,in turn,trigger anti-HCV activities as well as control the outcome of HCV infection remain to be clarified.In this report,we review current progress in understanding the mechanisms of IFN against HCV,and also summarize the knowledge of induction of interferon signaling by HCV infection. | Menghao Huang Jian-Dong Jiang Zonggen Peng | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 4 |
| 8 | SRSF1 plays a critical role in invariant natural killer T cell development and function显示文摘Invariant natural killer T(iNKT)cells are highly conserved innate-like T lymphocytes that originate from CD4^(+)CD8^(+)double-positive(DP)thymocytes.Here,we report that serine/arginine splicing factor 1(SRSF1)intrinsically regulates iNKT cell development by directly targeting Myb and balancing the abundance of short and long isoforms.Conditional ablation of SRSF1 in DP cells led to a substantially diminished iNKT cell pool due to defects in proliferation,survival,and TCRαrearrangement.The transition from stage 0 to stage 1 of iNKT cells was substantially blocked,and the iNKT2 subset was notably diminished in SRSF1-deficient mice.SRSF1 deficiency resulted in aberrant expression of a series of regulators that are tightly correlated with iNKT cell development and iNKT2 differentiation,including Myb,PLZF,Gata3,ICOS,and CD5.In particular,we found that SRSF1 directly binds and regulates pre-mRNA alternative splicing of Myb and that the expression of the short isoform of Myb is substantially reduced in SRSF1-deficient DP and iNKT cells.Strikingly,ectopic expression of the Myb short isoform partially rectified the defects caused by ablation of SRSF1.Furthermore,we confirmed that the SRSF1-deficient mice exhibited resistance to acute liver injury uponα-GalCer and Con A induction.Our findings thus uncovered a previously unknown role of SRSF1 as an essential post-transcriptional regulator in iNKT cell development and functional differentiation,providing new clinical insights into iNKT-correlated disease. | Jingjing Liu Menghao You Yingpeng Yao Ce Ji Zhao Wang Fang Wang Di Wang Zhihong Qi Guotao Yu Zhen Sun Wenhui Guo Juanjuan Liu Shumin Li Yipeng Jin Tianyan Zhao Hai-Hui Xue Yuanchao Xue Shuyang Yu | 2021 | Cellular & Molecular Immunology2021，18，11： | 3 |
| 9 | Combining immune checkpoint blockade with ATP-based immunogenic cell death amplifier for cancer chemo-immunotherapy显示文摘Amplifying“eat me signal”during tumor immunogenic cell death(ICD)cascade is crucial for tumor immunotherapy.Inspired by the indispensable role of adenosine triphosphate(ATP,a necessary“eat me signal”for ICD),a versatile ICD amplifier was developed for chemotherapy-sensitized immunotherapy.Doxorubicin(DOX),ATP and ferrous ions(Fe^(2+))were co-assembled into nanosized amplifier(ADO-Fe)throughπ‒πstacking and coordination effect.Meanwhile,phenylboric acid-polyethylene glycol-phenylboric acid(PBA-PEG-PBA)was modified on the surface of ADO-Fe(denoted as PADO-Fe)by the virtue of d-ribose unit of ATP.PADO-Fe could display active targetability against tumor cells via sialic acid/PBA interaction.In acidic microenvironment,PBA-PEG-PBA would dissociate from amplifier.Moreover,high H_(2)O_(2)concentration would induce hydroxyl radical(·OH)and oxygen(O_(2))generation through Fenton reaction by Fe^(2+).DOX and ATP would be released from the amplifier,which could induce ICD effect and“ICD adjuvant”to amplify this process.Together with programmed death ligands 1(PD-L1)checkpoint blockade immunotherapy,PADO-Fe could not only activate immune response against primary tumor,but also strong abscopal effect against distant tumor.Our simple and multifunctional ICD amplifier opens a new window for enhancing ICD effect and immune checkpoint blockade therapy. | Jiulong Zhang Xiaoyan Sun Xiufeng Zhao Chunrong Yang Menghao Shi Benzhuo Zhang Haiyang Hu Mingxi Qiao Dawei Chen Xiuli Zhao | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 10 | Effect of cathodic potential on stress corrosion cracking behavior of 21Cr2NiMo steel in simulated seawater显示文摘This study aims at providing systematically insights to clarify the impact of cathodic polarization on the stress corrosion cracking(SCC)behavior of 21 Cr2 NiMo steel.Slow-strain-rate tensile tests demonstrated that 21 Cr2 NiMo steel is highly sensitive to hydrogen embrittlement at strong cathodic polarization.The lowest SCC susceptibility occurred at-775 mV vs.SCE,whereas the SCC susceptibility was remarkably higher at potentials below-950 mV vs.SCE.Scanning electron microscopy(SEM)and electron backscattered diffraction(EBSD)revealed that the cathodic potential decline caused a transition from transgranular to intergranular mode in the fracture path.The intergranular mode transformed from bainite boundaries separation to prior austenitic grain boundaries separation under stronger cathodic polarization.Furthermore,corrosion pits promoted the nucleation of SCC cracks.In conclusion,with the decrease in the applied potential,the SCC mechanism transformed from the combination of hydrogen embrittlement and anodic dissolution to typical hydrogen embrittlement. | Menghao Liu Zhiyong Liu Cuiwei Du Xiaoqin Zhan Chunduo Dai Yue Pan Xiaogang Li | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，2： | 2 |
| 11 | Room-temperature multiferroicity and diversified magnetoelectric couplings in 2D materials显示文摘Multiferroics are rare in nature due to the mutual exclusive origins of magnetism and ferroelectricity. The simultaneous coexistence of robust magnetism/ferroelectricity and strong magnetoelectric coupling in single multiferroics is hitherto unreported, which may also be attributed to their potential conflictions. In this paper, we show the first-principles evidence of such desired coexistence in ultrathin-layer CuCrS2 and CuCrSe2. The vertical ferroelectricity is neither induced by an empty d shell nor spin-driven, giving rise to an alternative possibility of resolving those intrinsic exclusions and contradictions. Compared with their bulk phases, the ferromagnetism in the thin-layer structures(two–six layers) can be greatly stabilized due to the enhanced carrier density and orbital shifting by vertical polarization, and the Curie temperatures of both ferromagnetism and ferroelectricity can be above room temperature. Moreover, a considerable net magnetization can be reversed upon ferroelectric switching, where the change in spin-resolved band structure also renders efficient ‘magnetic reading + electrical writing’. The thickness-different layers may even exhibit diversified types of magnetoelectric coupling, which both enriches the physics of multiferroics and facilitates their practical applications. | Tingting Zhong Xiaoyong Li Menghao Wu Jun-Ming Liu | 2020 | National Science Review2020，7，2： | 2 |
| 12 | The variations of the Martian exobase altitude显示文摘The exobase is defined as the interface between the strongly collisional and the collisionless parts of an atmosphere. Although in reality the exobase is a transition region of finite depth, it is conventionally defined as the boundary above which an upwardly ejected neutral particle makes one collision at higher altitudes. Such an idealized definition is of practical use and serves as a good tracer of the overall size of an atmosphere as it expands and contracts under the influences of both external and internal sources. Knowledge of the atmospheric properties near the exobase is crucial to first-order estimates of atmospheric escape rates on terrestrial planets. Since its arrival at Mars on 21 September 2014, the Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft has provided comprehensive maps of the Martian upper atmosphere under a variety of conditions. This allows, for the first time, a thorough investigation of the variations of the exobase altitude on this red planet. In this study, we use the N2 density measurements accumulated by MAVEN’s Neutral Gas and Ion Mass Spectrometer from October 2014 to November 2018 to determine the exobase altitudes for a large number of MAVEN orbits. Our analysis reveals clearly the variations of exobase altitude with local time and solar extreme ultraviolet (EUV) flux, as well as tentative evidence for the impact of global dust storms. These observations are indicative of thermal expansion of the Martian upper atmosphere, driven either externally by solar EUV energy deposition or internally by global dust storms. | MengHao Fu Jun Cui XiaoShu Wu ZhaoPeng Wu Jing Li | 2020 | Earth and Planetary Physics2020，4，1： | 2 |
| 13 | An enhanced method for nucleic acid detection with CRISPR-Cas12a using phosphorothioate modified primers and optimized gold-nanopaticle strip显示文摘CRISPR-Cas12a system has been shown promising for nucleic acid diagnostics due to its rapid,portable and accurate features.However,cleavage of the amplicons and primers by the cis-and trans-activity of Cas12a hinders the attempts to integrate the amplification and detection into a single reaction.Through phosphorothioate modification of primers,we realized onepot detection with high sensitivity using plasmids of SARS-CoV-2,HPV16 and HPV18.We also identified the activated Cas12a has a much higher affinity to C nucleotide-rich reporter than others.By applying such reporters,the reaction time required for a lateral-flow readout was significantly reduced.Furthermore,to improve the specificity of the strip-based assay,we created a novel reporter and,when combined with a customized gold-nanopaticle strip,the readout was greatly enhanced owing to the elimination of the nonspecific signal.This established system,termed Targeting DNA by Cas12a-based Eye Sight Testing in an Onepot Reaction(TESTOR),was validated using clinical cervical scrape samples for human papillomaviruses(HPVs)detection.Our system represents a general approach to integrating the nucleic acid amplification and detection into a single reaction in CRISPR-Cas systems,highlighting its potential as a rapid,portable and accurate detection platform of nucleic acids. | Jiaojiao Gong Lijuan Kan Xiuming Zhang Ying He Jiaqiang Pan Liping Zhao Qianyun Li Menghao Liu Jie Tian Sili Lin Zhouyu Lu Liang Xue Chaojun Wang Guanghui Tang | 2021 | Bioactive Materials2021，6，12： | 1 |
| 14 | An improved bearing fault detection strategy based on artificial bee colony algorithm显示文摘The operating state of bearing affects the performance of rotating machinery;thus,how to accurately extract features from the original vibration signals and recognise the faulty parts as early as possible is very critical.In this study,the one‐dimensional ternary model which has been proved to be an effective statistical method in feature selection is introduced and shapelet transformation is proposed to calculate the parameter of one‐dimensional ternary model that is usually selected by trial and error.Then XGBoost is used to recognise the faults from the obtained features,and artificial bee colony algorithm(ABC)is introduced to optimise the parameters of XGBoost.Moreover,for improving the performance of intelligent algorithm,an improved strategy where the evolution is guided by the probability that the optimal solution appears in certain solution space is proposed.The experimental results based on the failure vibration signal samples show that the average accuracy of fault signal recognition can reach 97%,which is much higher than the ones corresponding to traditional extraction strategies.And with the help of improved ABC algorithm,the performance of XGBoost classifier could be optimised;the accuracy could be improved from 97.02%to 98.60%compared with the traditional classification strategy. | Haiquan Wang Wenxuan Yue Shengjun Wen Xiaobin Xu Hans-Dietrich Haasis Menghao Su Ping liu Shanshan Zhang Panpan Du | 2022 | CAAI Transactions on Intelligence Technology2022，7，4： | 1 |
| 15 | Simulation of Coupled Heat and Moisture Transfer in Air- Conditioned Buildings显示文摘 | Qin Menghao Belarbi Rafik Ait-Mokhtar Abdelkarim | 2009 | Automation in Construction2009，18，5： | 1 |
| 16 | Biosynthesis of aspergiolide A, a novel antitumor compound by a marine-derived fungus Aspergillus glaucus via the polyketide pathway显示文摘 | Kejing Tao Lin Du Xueqian Sun Menghao Cai Tianjiao Zhu Xiangshan Zhou Qianqun Gu Yuanxing Zhang | 2008 | Tetrahedron Letters2008，，9： | 1 |
| 17 | Coupled heat and moisture transfer in multi-layerbuilding materia!s显示文摘 | Menghao Qin Rafik Belarbi | 2009 | Construction and Building Materials2009，，23： | 1 |
| 18 | Nonisothermal moisture transport in hygro- scopic building materials: modeling for the determination of moisture transport coefficients 显示文摘 | QIN Menghao | 2008 | Transp Porous Med2008，72，2： | 1 |
| 19 | Experimental and theoretical investigation of non-isothermal transfer in hygroscopic building materials 显示文摘 | QIN Menghao | 2007 | Building and Environment2007，43，12： | 1 |
| 20 | Simulation of coupled heat and moisture transfer in air-conditioned buildings 显示文摘 | QIN Menghao | 2009 | Automation in Construction2009，18，5： | 1 |
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