|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively delineate the PDAC intra-tumoral heterogeneity and the underlying mechanism for PDAC progression, we employed single-cell RNA-seq (scRNA-seq) to acquire the transcriptomic atlas of 57,530 individual pancreatic cells from primary PDAC tumors and control pancreases, and identified diverse malignant and stromal cell types, including two ductal subtypes with abnormal and malignant gene expression profiles respectively, in PDAC. We found that the heterogenous malignant subtype was composed of several subpopulations with differential proliferative and migratory potentials. Cell trajectory analysis revealed that components of multiple tumor-related pathways and transcription factors (TFs) were differentially expressed along PDAC progression. Furthermore, we found a subset of ductal cells with unique proliferative features were associated with an inactivation state in tumor-infiltrating T cells, providing novel markers for the prediction of antitumor immune response. Together, our findings provide a valuable resource for deciphering the intra-tumoral heterogeneity in PDAC and uncover a connection between tumor intrinsic transcriptional state and T cell activation, suggesting potential biomarkers for anticancer treatment such as targeted therapy and immunotherapy. | Junya Peng Bao-Fa Sun Chuan-Yuan Chen Jia-Yi Zhou Yu-Sheng Chen Hao Chen Lulu Liu Dan Huang Jialin Jiang Guan-Shen Cui Ying Yang Wenze Wang Dan Guo Menghua Dai Junchao Guo Taiping Zhang Quan Liao Yi Liu Yong-Liang Zhao Da-Li Han Yupei Zhao Yun-Gui Yang Wenming Wu | 2019 | Cell Research2019，29，9： | 24 |
| 3 | Application of in vitro and in vivo models in the study of food allergy显示文摘Food allergy is one of the most important food safety problems that has attracted increasing attention.The food allergy experimental models provide not only the accurate allergen detection and evaluation methods but also the powerful approaches for mechanism investigations.In this paper,we reviewed the common food allergy cell models including mast cell,basophil granulocyte and basophil,as well as the animal models of BALB/c mouse,C3H/HeJ mouse,and BN rat.We also introduced zebrafish,a promising model organism for investigating immunity though lacking direct applications in food allergy to date,and focused on traumatic inflammation,bacterial infection and viral infection models.In addition,we also summarized the clinical diagnostic research methods for food allergy.The elucidation of these topics will help researchers to understand the characteristics and mechanisms of various models and thus select the proper models for particular study,so as to support further investigations of food allergy. | Jianjian Huang Changjun Liu Yanbo Wang Chong Wang Menghua Xie Yi Qian Linglin Fu | 2018 | Food Science and Human Wellness2018，7，4： | 7 |
| 4 | 中风病始发态证候影响因素的研究显示文摘调查分析性别、年龄、职业、伴发疾病、既往史对1663例中风病始发态患者证候得分均值和发生概率的影响。结果显示:男性疾湿证显著高于女性;年龄对证候有显著影响,并与气虚证、痰湿证、血瘀证呈显著正相关关系;职业对证候无规律性影响;伴发疾病评分与风证、火热证、痰湿证、气虚证、阴虚阳亢证里显著正相关关系。提示临床辨证、证候研究、新药研制中要重视和考虑上述因素的影响。 | Wang Shundao Ren Zhanli Du Menghua et, al.(Xingtai Municipal people’s Hospital, Hebei 054031)(Beijing University of TCM, Beijing 100029) | 1996 | 北京中医药大学学报1996，19，4： | 6 |
| 5 | Quantitative study of protein coronas on gold nano- particles with different surface modifications显示文摘 | Menghua Cui Renxiao Liu Zhaoyi Deng Guanglu Ge Ying Liu Liming Xie | 2014 | Nano Research2014，7，3： | 6 |
| 6 | The Biological Property of Synthetic Evolved Digital Circuits with ESD Immunity - Redundancy or Degeneracy?显示文摘 | Menghua Man Shanghe Liu Xiaolong Chang Mai Lu | 2013 | Journal of Bionic Engineering2013，10，3： | 6 |
| 7 | The Immunity of Evolvable Digital Circuits to ESD Interference显示文摘 | Shanghe Liu Menghua Man Zhengquan Ju Xiaolong Chang Jie Chu Liang Yuan | 2012 | Journal of Bionic Engineering2012，9，3： | 6 |
| 8 | 中国东部沿海杨树人工林养分重吸收和化学计量对氮添加的响应显示文摘叶片养分重吸收对土壤养分的变化很敏感。然而,我们尚不清楚氮沉降如何影响植物大量元素重吸收率。杨树(Populus deltoids)是世界上栽培最广泛的阔叶树种之一。本文研究了在氮添加条件下,杨树重吸收率及其化学计量比的规律和主要驱动因素。通过一个4年的氮添加实验,我们探究中国东部沿海两个林分(8和12年)杨树人工林重吸收率及其化学计量比对氮添加的响应。我们测定了在一系列氮添加浓度水平(0、50、100、150、300 kg N ha^(−1) yr^(−1))下,土壤和叶片(包括绿叶和落叶)中氮、磷、钾、钙、镁的浓度。研究结果表明,除钙元素重吸收率和钙、镁元素重吸收率化学计量比外,氮添加对两个林分大量元素重吸收率及其化学计量比都没有显著影响。氮、磷重吸收率尺度斜率在不同氮添加水平下均小于1,表明氮添加条件下,氮、磷元素重吸收率解耦。养分重吸收率与绿叶中养分含量显著正相关,表明重吸收主要受到绿叶养分调控。我们的研究结果为中国东部沿海地区12年生杨树人工林的生长受氮限制提供了直接证据。 | Dalong Jiang Qian Li Qinghong Geng Menghua Zhang Chonghua Xu Guoqing Hu Caiqin Shen Honghua Ruan Xia Xu | 2021 | Journal of Plant Ecology2021，14，4： | 5 |
| 9 | Adaptive Proportional-Derivative Sliding Mode Control Law With Improved Transient Performance for Underactuated Overhead Crane Systems显示文摘In this paper, an adaptive proportional-derivative sliding mode control(APD-SMC) law, is proposed for 2D underactuated overhead crane systems. The proposed controller has the advantages of simple structure, easy to implement of PD control, strong robustness of SMC with respect to external disturbances and uncertain system parameters, and adaptation for unknown system dynamics associated with the feedforward parts. In the proposed APD-SMC law, the PD control part is used to stabilize the controlled system, the SMC part is used to compensate the external disturbances and system uncertainties,and the adaptive control part is utilized to estimate the unknown system parameters. The coupling behavior between the trolley movement and the payload swing is enhanced and, therefore, the transient performance of the proposed controller is improved.The Lyapunov techniques and the La Salle's invariance theorem are employed in to support the theoretical derivations. Experimental results are provided to validate the superior performance of the proposed control law. | Menghua Zhang Xin Ma Rui Song Xuewen Rong Guohui Tian Xincheng Tian Yibin Li | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，3： | 5 |
| 10 | Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation显示文摘Pancreatic ductal adenocarcinoma(PDAC)has poor prognosis due to limited therapeutic options.This study examines the roles of genome-wide association study identified PDAC-associated genes as therapeutic targets.We have identified HNF4G gene whose silencing most effectively repressed PDAC cell invasiveness.HNF4G overexpression is induced by the deficiency of transcriptional factor and tumor suppressor SMAD4.Increased HNF4G are correlated with SMAD4 deficiency in PDAC tumor samples and associated with metastasis and poor survival time in xenograft animal model and in patients with PDAC(log-rank P=0.036;HR=1.60,95%CI=1.03–2.47).We have found that Metformin suppresses HNF4G activity via AMPK-mediated phosphorylation-coupled ubiquitination degradation and inhibits in vitro invasion and in vivo metastasis of PDAC cells with SMAD4 deficiency.Furthermore,Metformin treatment significantly improve clinical outcomes and survival in patients with SMAD4-deficient PDAC(log-rank P=0.022;HR=0.31,95%CI=0.14–0.68)but not in patients with SMAD4-normal PDAC.Pathway analysis shows that HNF4G may act in PDAC through the cell-cell junction pathway.These results indicate that SMAD4 deficiency-induced overexpression of HNF4G plays a critical oncogenic role in PDAC progression and metastasis but may form a druggable target for Metformin treatment. | Chengcheng Wang Taiping Zhang Quan Liao Menghua Dai Junchao Guo Xinyu Yang Wen Tan Dongxin Lin Chen Wu Yupei Zhao | 2021 | Protein & Cell2021，12，2： | 5 |
| 11 | Optimal Coordination Control Strategy of Hybrid Energy Storage Systems for Tie-line Smoothing Services in Integrated Community Energy Systems显示文摘Increasing renewable energy penetration into integrated community energy systems(ICESs)requires more efficient methods to prevent power fluctuations of the tie–line(connection of the ICESs to the main grid).In this paper,centrally-controlled air conditioners are considered as a virtual energy storage system(VESS).The optimal thermostat regulation is used to manage the charging/discharging power of the VESS within the customer comfort level range and the virtual state of charge(VSOC)is used to describe the charging/discharging power of the VESS.On this basis,the model of the hybrid energy storage system is built with a VESS and a battery storage system(BSS).Then,an optimal coordination control strategy(OCCS)for a hybrid energy storage system is developed considering the state-space equation to describe the OCCS,the constraints of the OCCS,and the objective function to express the optimal coordination control performance.Finally,the influence of the outdoor temperature and the deadband of air conditioners on the results of the OCCS is analyzed.Results show that the OCCS can realize optimal allocation of the storage response amount to trace the reference target accurately and guarantee both the state of charge(SOC)of the batteries in a reasonable range to prolong the battery life and ensure the level of comfort experienced by users. | Dan Wang Yunqiang Zhi Bo Yu Zhaoyu Chen Qingsong An Ling Cheng Menghua Fan | 2018 | CSEE Journal of Power and Energy Systems2018，4，4： | 5 |
| 12 | Using Imbalanced Triangle Synthetic Data for Machine Learning Anomaly Detection显示文摘The extreme imbalanced data problem is the core issue in anomaly detection.The amount of abnormal data is so small that we cannot get adequate information to analyze it.The mainstream methods focus on taking fully advantages of the normal data,of which the discrimination method is that the data not belonging to normal data distribution is the anomaly.From the view of data science,we concentrate on the abnormal data and generate artificial abnormal samples by machine learning method.In this kind of technologies,Synthetic Minority Over-sampling Technique and its improved algorithms are representative milestones,which generate synthetic examples randomly in selected line segments.In our work,we break the limitation of line segment and propose an Imbalanced Triangle Synthetic Data method.In theory,our method covers a wider range.In experiment with real world data,our method performs better than the SMOTE and its meliorations. | Menghua Luo Ke Wang Zhiping Cai Anfeng Liu Yangyang Li Chak Fong Cheang | 2019 | Computers, Materials & Continua2019，，1： | 4 |
| 13 | Bio-Inspired Electromagnetic Protection Based on Neural Information Processing显示文摘 | Xiaolong Chang Shanghe Liu Menghua Man Weihua Han Jie Chu Liang Yuan | 2014 | Journal of Bionic Engineering2014，11，1： | 4 |
| 14 | Application of Lignin and Its Derivatives as Slow/Controlled Release Materials in Agricultural Fields显示文摘Lignin is the main by-product of pulp and papermaking and is not effectively utilized. Conversion of industrial lignins into value-added materials is beneficial for the effective utilization of resources as well as for environmental protection. Because of their adsorptivity, slow-release property,biocompatibility, and biodegradability, lignin and its derivatives find potential applications as eco-friendly slow/controlled release materials in agricultural fields. This report reviews the recent research advances in lignin-based slow/controlled release fertilizers and pesticides. | YingJuan Fu MengHua Qin ZhaoJiang Wang ZongQuan Li | 2018 | Paper And Biomaterials2018，3，1： | 3 |
| 15 | A Hybrid CNN for Image Denoising显示文摘Deep convolutional neural networks(CNNs)with strong learning abilities have been used in the field of image denoising.However,some CNNs depend on a single deep network to train an image denoising model,which will have poor performance in complex screens.To address this problem,we propose a hybrid denoising CNN(HDCNN).HDCNN is composed of a dilated block(DB),RepVGG block(RVB),feature refinement block(FB),and a single convolution.DB combines a dilated convolution,batch normalization(BN),common convolutions,and activation function of ReLU to obtain more context information.RVB uses parallel combination of convolution,BN,and ReLU to extract complementary width features.FB is used to obtain more accurate information via refining obtained feature from the RVB.A single convolution collaborates a residual learning operation to construct a clean image.These key components make the HDCNN have good performance in image denoising.Experiment shows that the proposed HDCNN enjoys good denoising effect in public data sets. | Menghua Zheng Keyan Zhi Jiawen Zeng Chunwei Tian Lei You | 2022 | Journal of Artificial Intelligence and Technology2022，2，3： | 2 |
| 16 | Prunus sunhangii: A new species of Prunus from central China显示文摘A new species of Rosaceae from Central China, Prunus sunhangii D. G. Zhang & T. Deng, sp. nov., is described and illustrated. The new species is placed in Prunus subgenus Cerasus by flower and fruit characteristics. It is most similar to Prunus cerasoides, but differs by having longitudinally 2-lobed apical petals, an acuminate leaf apex, 17—25 stamens, white petals, dark black drupes, brown hypanthium, and different phenology. The phylogenetic placement of this species was assessed based on morphological and molecular data. Molecular analysis(cp DNA + ITS) corroborated its placement in subgenus Cerasus,specifically Prunus section Serrula. | Xiaoshuang Zhang Zhilin Jiang Ziyoviddin Yusupov Menghua Zhang Daigui Zhang Komiljon Tojibaev Ying Meng Tao Deng | 2019 | Plant Diversity2019，41，1： | 2 |
| 17 | Quantitative deconvolution of autocorrelations and cross correlations from two-dimensional lifetime decay maps in fluorescence lifetime correlation spectroscopy显示文摘Fluorescence correlation spectroscopy(FCS) is a widely used method for measuring molecular diffusion and chemical kinetics. However, when a mixture of fluorescent species is taken into account, the conventional FCS method has limitations in extracting autocorrelations for different species and cross correlations between different species. Recently developed fluorescence lifetime correlation spectroscopy(FLCS) based on time-tagged time-resolved(TTTR) photon recording, which can record the global and micro arrival time for each individual photon, has been used to discriminate different species according to fluorescence lifetime. Here, based on two-dimensional lifetime decay maps constructed from TTTR photon stream, we have developed a quantitative lifetime-deconvolution FCS model(LDFCS) to extract precise chemical rates for chemical conversions in multi-species systems. The key point of LDFCS model is separation of different species according to the global distribution of fluorescence lifetime and then deconvolution of autocorrelations and cross-correlations from the two-dimensional lifetime decay maps constructed by the micro arrival times of photon pairs at each delay time. | Shanshan Gao Menghua Cui Ruiru Li Ling Liang Ying Liu Liming Xie | 2017 | Science Bulletin2017，62，1： | 2 |
| 18 | Probabilistic total transfer capability analysis based on static voltage stability region integrated with a modified distributed-level nodal-loading model显示文摘In this paper, a new evaluation method of probabilistic TTC based on SVSR calculation is developed through a hierarchical simulation. A smooth technology based on the non-parametric kernel estimator is adapted to obtain the time-dependent probabilistic density function of the feeder-head load data. In order to describe possible operating change directions of the operating point, the original hyper-cone-like(HCL) model is constructed to consider the probabilistic distribution function(PDF) extracted from feeder-head load data to replace the simple Normal Distribution model and the uncertain generator outputs. To realize the fast TTC calculation of the current operating point in random conditions, a sub-hyper-cone-like(SHCL) model in full power injections space is proposed, which is a similarity transformation of the original one. | WANG Dan ZHOU Yue JIA HongJie WANG ChengShan LU Ning FAN MengHua | 2015 | Science China(Technological Sciences)2015，58，12： | 2 |
| 19 | Principles of electromagnetic protection bionics and research of fault self-recovery mechanism显示文摘As we have borrowed the wisdom from biological neural network, the characteristic of interference- proof in information transferring process has been carefully studied. Our study includes the response of electrical-interference-proof circuit in electromagnetic environment, by means of bionics redesign. In this way, new principles, new technics and new ways are adopted to solve the unavoidable situations in traditional electro- magnet protection design. Based on the Boolean model, the complex bionic topological networks were firstly built and the charactoristics of degeneracy were analyzed, then the bidirectional actions between degeneracy in networks and the robustness of functions were proved in order to fill up the gap to deal with the need of interference-proof. Based on the creation of the neuron networks and the electrical synapses ' charac- teristic of plasticity, the impact of the distribution in the weight of synapse on the character of network self- recovery was studied afterwards so that the corresponding mechanism could be defined. | Yuan Liang Man Menghua Chang Xiaolong | 2014 | Engineering Sciences2014，12，3： | 2 |
| 20 | Fusion of visible and thermal images for facial expression recognition显示文摘 | Shangfei WANG Shan HE Yue WU Menghua HE Qiang JI | 2014 | Frontiers of Computer Science2014，8，2： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员