|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Screening and verification of ssDNA aptamers targeting human hepatocellular carcinoma显示文摘Hepatocellular 癌(HCC ) 是在世界上的最恶意的癌症之一。能认出为 HCC 特定的 biomarkers 的分子的探针着急地被需要改进早诊断的敏感和特性。最近的研究由指数的丰富使用了 ligands 的系统的进化的方法并且生产了能明确地绑在老鼠肝癌症房间和纸巾的几 aptamers。然而,与人的肝癌症的有约束力的亲密关系充分没被识别。用导出人的 hepatoma,房间线 HepG2 同样积极的目标房间线和正常 hepatocyte 房间作为否定的衬里 HL-7702,我们获得了能明确地在 nanomolar 范围与 Kd 绑在人的肝癌症房间并且认出嵌入石蜡的人的 HCC 纸巾的 aptamer HA09。这 aptamer 可以便于新奇 biomarkers 的发现并且与诊断、治疗学的含意为细胞内部的交货用作一根理想的分子的探针。 | Bin Lu Jiucun Wang Jun Zhang Xiaojiao Zhang Dongqin Yang Lijun Wu Zhongguang Luo Yanyun Ma Qi Zhang Yunfang Ma Xiaoyu Pei Hua Yu Jie Liu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 3 |
| 3 | CPT1C-mediated fatty acid oxidation facilitates colorectal cancer cell proliferation and metastasis显示文摘Fatty acid oxidation(FAO)has been proven to be an accomplice in tumor progression.Carnitine palmitoyltransferase 1C(CPT1C),a rate-limiting enzyme in FAO,mainly functions to catalyze fatty acid carnitinylation and guarantee subsequent entry into the mitochondria for FAO in colorectal cancer(CRC).Gene expression data and clinical information extracted from The Cancer Genome Atlas(TCGA)database show significantly higher expression of CPT1C in patients with metastatic CRC(P=0.005).Moreover,overexpression of CPT1C is correlated with worse relapse-free survival in CRC(HR 2.1,P=0.0006),while no statistical significance is indicated for CPT1A and CPT1B.Further experiments demonstrate that downregulation of CPT1C expression leads to a decrease in the FAO rate,suppression of cell proliferation,cell cycle arrest and repression of cell migration in CRC,whereas opposite results are obtained when CPT1C is overexpressed.Furthermore,an FAO inhibitor almost completely reverses the enhanced cell proliferation and migration induced by CPT1C overexpression.In addition,analysis of TCGA data illustrates a positive association between CPT1C expression and HIF1αlevel,suggesting that CPT1C is a transcriptional target of HIF1α.In conclusion,CPT1C overexpression indicates poor relapse-free survival of patients with CRC,and CPT1C is transcriptionally activated by HIF1α,thereby promoting the proliferation and migration of CRC cells. | Jing Li Wanwei Zheng Jie Wu Jun Zhang Bin Lv Wenshuai Li Jie Liu Xin Zhang Tiansheng Huang Zhongguang Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 1 |
| 4 | Identification and construction of a novel biomimetic delivery system of paclitaxel and its targeting therapy for cancer显示文摘Dear Editor,Paclitaxel(PTX)is among the frst-line therapeutic agents against diverse malignancies.However,problems still exist concerning its poor water-solubility,multidrug resistance,lack of specific targeting ability and severe toxic effects,and these issues are far from fully resolved despite the various PTX formulations available on.the market,e.g.the gold standard,PTX albumin nanoparticles Abraxane I and PTX liposomes Lipusu.Some studies that try to solve the multiple problems faced by chemotherapy drug delivery,however,fell into the prevailing trap of overcomplicated formulation design which sacrifices the druggability.To better reconcile this paradox,a novel glycosylated liposomal PTX was designed,inspired by the cytomembrane glycosyls with important roles in.maintaining both membrane structure and physiological functions,3 such as enhan-cing membrane stability,evading immunological clearance,and recognizing corresponding receptors.Ginsenosides,as natural amphiphilic molecules,are structurally similar to cholesterol,contain glycosyl moieties,and are easily obtainable. | Xue Wang Wanwei Zheng Qing Shen Yahua Wang Yujen Tseng Zhongguang Luo Xiaoyou Wang Lei Shi Chong Li Jie Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 5 | Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘In the initial published version of this article, there was a mistake in the P value for the correlation between gene-expression changes and 5 hmC changes in tumors. The correct P value should be same as the P value shown in Fig. S6A: 9.8?×?10?6 (mistakenly shown as “9.8?×?106” in the main text). This correction does not affect the description of results or the conclusions of this study, since the range of P value is between 0 and 1. | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2019 | Cell Research2019，29，7： | 1 |
| 6 | SIRT6 promotes autophagy through direct interaction with ULK1 and competitive binding to PUMA显示文摘Akt aberrant activation accelerated tumor development and metastasis,and our previous study identified silent information regulator 6(SIRT6)as a novel and critical tumor suppressor in colorectal cancer(CRC)downstream of Akt.1 However,the function of SIRT6 in cancer progression has not been fully elucidated.In the present study,we found that except for inducing apoptosis,SIRT6 could serve as a crucial regulator to initiate autophagy by directly interacting with and activating ULK1.More importantly,we also reported autophagy regulation in a SIRT6-dependent indirect manner,namely,SIRT6 competitively bound to PUMA,which led to the release of ULK1.Of note,autophagy inhibition enhanced the pro-apoptotic effect of Midostaurin both in vitro and in vivo.Summarily,SIRT6 induced apoptosis accompanied by protective autophagy,and SIRT6 promoted autophagy by directly interacting with ULK1 and competitive binding to PUMA.This new insight identified the dual function of SIRT6 on apoptosis and autophagy,which has attractive clinical applications in cancer therapy. | Zhongguang Wu Lanhui Hong Guang Luo Siyao Lu Yanqiu Li Jiangang Wang Yingjie Zhang Lingling Zhang | 2023 | Genes & Diseases2023，10，5： | 0 |
| 7 | Forecasting the development of the COVID-19 epidemic by nowcasting: when did things start to get better?显示文摘Background:Now the coronavirus disease 2019(COVID-19)epidemic becomes a global phenomenon and its development concerns billions of peoples1 lives.The development of the COVID-19 epidemic in China could be used as a reference for the other countries,control strategy.Methods:We used a classical susceptible-infected-recovered(SIR)model to forecast the development of the COVID-19 epidemic in China by nowcasring.The linear regression analyses were employed to predict the COVID-19 epidemic’s inflexion point.Finally,we used a susceptible-exposed-infected-recovered(SEIR)model to simulate the development of the COVID-19 epidemic in China throughout 2020.Results:Our nowcasts show that the COVID-19 transmission rate started to slow down on January 30.The linear regression analyses further show that the inflexion point of this epidemic would arrive between February 17 and 18.The final SEIR model simulation forecasted that the COVID-19 epidemic would probably infect about 82,000 people and last throughout 2020 in China.We also applied our method to USA's and global COVID-19 data and the nowcasts show that the development of COVID-19 pandemic is not optimistic in the rest of 2020.Conclusion:The COVID-19 epidemic's scale in China is much smaller than the previous estimations.After implemented strict control and prevention measures,such as city lockdown,it took a week to slow down the COVID-19 transmission and about four weeks to really mitigate the COVID-19 prevalence in China. | Yuehui Zhang Lin Chen Qili Shi Zhongguang Luo Libing Shen | 2021 | Quantitative Biology2021，9，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员