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| 1 | Melatonin enhances radiofrequency-induced NK antitumor immunity,causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development显示文摘Surgery is the comm on treatme nt for early lung cancer with multiple pulm onary no dules,but it is often accompanied by the problem of significant malignancy of other nodules in non-therapeutic areas.In this study,we found that a combined treatment of local rad iofreq ue ncy ablati on(RFA)and melatonin(MLT)greatly improved clinical outcomes for early lung cancer patie nts with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated areas.Mechanically,as demonstrated in an associated mouse lung tumor model,RFA not only effectively remove treated tumors but also stimulate antitumor immunity,which could inhibit tumor growth in non-ablated areas.MLT enhanced RFA-stimulated NK activity and exerted synergistic antitumor effects with RFA.Transcriptomics and proteomics analyses of residual tumor tissues revealed enhanced oxidative phosphorylation and reduced acidification as well as hypoxia in the tumor microenvironment,which suggests reprogrammed tumor metabolism after combined treatment with RFA and MLT.Analysis of residual tumor further revealed the depressed activity of MAPK,NF-kappa B,Wnt,and Hedgehog pathways and upregulated P53 pathway in tumors,which was in line with the inhibited tumor growth.Combined RFA and MLT treatment also reversed the Warburg effect and decreased tumor malignancy.These findings thus demonstrated that combined treatment of RFA and MLT effectively inhibited the malignancy of non-ablated nodules and provided an innovative non-invasive strategy for treating early lung tumors with multiple pulmonary nodules.Trial registration:www.chictr.org.cn,identifier ChiCTR2100042695,http://www.chictr.org.cn/showproj.aspx?proj=120931. | Ming Li Bingjie Hao Menghuan Zhang Russel J.Reiter Shumeng Lin Tiansheng Zheng Xiangyun Chen Yanbei Ren Liduo Yue Baigenzhin Abay Guojie Chen Xiao Xu Yufeng Shi Lihong Fan | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 2 | Maternal exposure to triclosan constitutes a yet unrecognized risk factor for autism spectrum disorders显示文摘Dear Editor,Autism spectrum disorders(ASD)are complex neurodevelopmental disorders characteristic of core behavioral traits like restricted,repetitive behaviors and deficiency in social interactions.1 The prevalence of ASD has rapidly increased worldwide,rising from 1/149 in 2000,1/68 in 2012,and to?1/40 in 2016 of children at the age of 3-17 in the United States.2 ASD prevalence was found to be associated with socioeconomic status(SES)as overpresented in high-income households,3 and to be significantly enriched in certain regions,e.g.,reaching up to 4.88%in Florida.2 In the last decades,advances in genetic studies have led to unprecedented understanding of the genetic factors that were associated with<50%of human ASD. | Zijian Hao Qionghui Wu Zhengwei Li Yali Li Qiu Li Xi Lai Huan Liu Menghuan Zhang Ting Yang Jie Chen Yaping Tang Jingkun Miao Huatai Xu Tingyu Li Ronggui Hu | 2019 | Cell Research2019，29，10： | 5 |
| 3 | Sulfonic acid-based metal organic framework functionalized magnetic nanocomposite combined with gas chromatography-electron capture detector for extraction and determination of organochlorine显示文摘The metal organic framework functionalized with sulfonic acid was combined with magnetic nanoparticles to fabricate a new nanocomposite(denoted as Fe3O4@PDA@Zr-SO3H).By combining with gas chromatography-electron capture detector,the resulting Fe3O4@PDA@Zr-SO3H nanocomposite was successfully used as a high-efficiency adsorbent for pre-concentrating eight organochlorine pesticides from water sample in environment.Apart from the ability of fast separation,the as-prepared Fe3O4@PDA@Zr-SO3H nanocomposite also exhibited high adsorption capacity for organochlorine pesticides.With the use of optimal experimental conditions,the linear relationship can be obtained in the range of 0.05~300μg/L,the correlation coefficient was over 0.9978,and the relative standard deviation was located in 2.5%-7.7%.Moreover,the limit of detection and quantification was between0.005-0.016μg/L and 0.017~0.050μg/L.Finally,the nanocomposite was used for the determination of organochlorine pesticides from environmental water samples,and displayed the recovery of 82%-118%. | Ying Wang Qing Ye Menghuan Yu Xijun Zhang Chunhui Deng | 2020 | Chinese Chemical Letters2020，31，7： | 3 |
| 4 | 显示文摘 | Liao Hsuehchung Wu Mingchung Jao Menghuan | 2012 | Crys- tEngComm2012，14，10： | 1 |
| 5 | Physicochemical properties and biological activities of polysaccharides from the peel of Dioscorea opposita Thunb.extracted by four different methods显示文摘Polysaccharides are the important biologically active components found in the peel of Dioscorea opposita Thunb.(DTTP).The influences of 4 extraction methods,namely hot water extraction(W),acidic extraction(HA),hot-compressed water extraction(HCW)and enzyme-assisted extraction(EAE),on the yields,physicochemical properties,hypoglycemic and antioxidant activities of polysaccharides from DTTP were studied and compared.Among these DTTP polysaccharides,DTTP-HA was outstanding in several respects.DTTP-HA was the most water soluble;it had the highest total carbohydrate content(85.08%),the highest uronic acid(13.20%)and the highest thermal stability.DTTP-HA and DTTP-W possessed a triple-helix structure.These 4 kinds of polysaccharides have the same types of monosaccharides,but in different molar percentages.Extraction method had a significant impact on the microstructures of the extracted polysaccharides.DTT-HA exhibited irregular structure with many holes.Among the 4 extracted methods,the DTTP-HA and DTTP-W initially exhibited higher hypoglycemic and antioxidant activities.The better bioactivities of DTTP-HA may be related to the above factors.The findings indicated that acid extraction is an effective method to extract polysaccharides with high biological activities from DTTP. | Zuowei Zhao Li Wang Yuan Ruan Chunnan Wen Menghuan Ge Yanyan Qian Bingji Ma | 2023 | Food Science and Human Wellness2023，12，1： | 1 |
| 6 | Critical involvement of lysyl oxidase in seizure-induced neuronal damage through ERK-Alox5-dependent ferroptosis and its therapeutic implications显示文摘Recent insights collectively suggest the important roles of lysyl oxidase(LysOX)in the pathological processes of several acute and chronic neurological diseases,but the molecular regulatory mechanisms remain elusive.Herein,we explore the regulatory role of LysOX in the seizure-induced ferroptotic cell death of neurons.Mechanistically,LysOX promotes ferroptosis-associated lipid peroxidation in neurons via activating extracellular regulated protein kinase(ERK)-dependent 5-lipoxygenase(Alox5)signaling.In addition,overexpression of LysOX via adeno-associated viral vector(AAV)-based gene transfer enhances ferroptosis sensitivity and aggravates seizure-induced hippocampal damage.Our studies show that pharmacological inhibition of LysOX withβ-aminopropionitrile(BAPN)significantly blocks seizure-induced ferroptosis and thereby alleviates neuronal damage,while the BAPN-associated cardiotoxicity and neurotoxicity could further be reduced through encapsulation with bioresponsive amorphous calcium carbonate-based nanocarriers.These findings unveil a previously unrecognized LysOX-ERK-Alox5 pathway for ferroptosis regulation during seizure-induced neuronal damage.Suppressing this pathway may yield therapeutic implications for restoring seizure-induced neuronal injury. | Xiaoyuan Mao Xuan Wang Mingzhu Jin Qin Li Jining Jia Menghuan Li Honghao Zhou Zhaoqian Liu Weilin Jin Yanli Zhao Zhong Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 7 | Constructions of ROS-responsive titanium-hydroxyapatite implant for mesenchymal stem cell recruitment in peri-implant space and bone formation in osteoporosis microenvironment显示文摘To solve the issue of unsatisfactory recruitment of mesenchymal stem cells(MSCs)around implant in osteoporotic fractures,we fabricated a ROS-responsive system on titanium surface through hydroxyapatite coating and biomolecule grafting.The porous hydroxyapatite and phosphorylated osteogenic growth peptides(p-OGP)were introduced onto titanium surface to synergistically improve osteogenic differentiation of MSCs.After the p-OGPpromoted expression of osteogenic related proteins,the calcium and phosphate ions were released through the degradation of hydroxyapatite and integrated into bone tissues to boost the mineralization of bone matrix.The ROS-triggered release of DNA aptamer(Apt)19S in the osteoporotic microenvironment guides MSC migration to implant site due to its high affinity with alkaline phosphatase on the membrane of MSCs.Once MSCs reached the implant interface,their osteogenic differentiation potential was enhanced by p-OGP and hydroxyapatite to promote bone regeneration.The study here provided a simple and novel strategy to prepare functional titanium implants for osteoporotic bone fracture repair. | Maohua Chen Yuting Sun Yanhua Hou Zhong Luo Menghuan Li Yujia Wei Maowen Chen Lu Tan Kaiyong Cai Yan Hu | 2022 | Bioactive Materials2022，7，12： | 1 |
| 8 | Recent advancements in 2D nanomaterials for cancer therapy显示文摘Since mechanical exfoliation of graphene in 2004, unprecedented scientific and technological advances have been achieved in the development of two-dimensional(2 D) nanomaterials. These 2 D nanomaterials exhibit various unique mechanical, physical and chemical properties on account of their ultrathin thickness, which are highly desirable for many applications such as catalysis, optoelectronics, energy storage/conversion, as well as disease diagnosis and therapeutics. In this review, we summarized recent progress on the design and fabrication of functional 2 D nanomaterials capable of being applied for the cancer treatment including drug delivery, photodynamic therapy, and photothermal therapy. Their anticancer mechanisms were discussed in detail, and the related safety concerns were analyzed based on current research developments. This review is expected to provide an insight in the field of 2 D nanostructured materials for anticancer applications. | Menghuan Li Zhong Luo Yanli Zhao | 2018 | Science China Chemistry2018，61，10： | 1 |
| 9 | Highly efficient deep blue organic electroluminescent device based on 1-methyl-9,10-di(1- naphthyl) anthracene 显示文摘 | Ho Menghuan Wu Yaoshan | 2006 | Applied physics letters2006，89，25： | 1 |
| 10 | Large-scale synthesis and surface plasmon resonance properties of angled silver/silver homojunction nanowires显示文摘 | Xuandi Lai Xiumei Feng Menghuan Zhang Ruijin Hong Yongxiang Chen Aiqing Li Xiulong Deng Jianqiang Hu | 2014 | Journal of Nanoparticle Research2014，，3： | 1 |
| 11 | A mitochondria-targeting lipid——small molecule hybrid nanoparticle for imaging and therapy in an orthotopic glioma model显示文摘Hybrid lipid-nanoparticle complexes have shown attractive characteristics as drug carriers due to their integrated advantages from liposomes and nanoparticles.Here we developed a kind of lipid-small molecule hybrid nanoparticles(LPHNPs) for imaging and treatment in an ortho topic glioma model.LPHNPs were prepared by engineering the co-assembly of lipids and an amphiphilic pheophorbide a-quinolinium conjugate(PQC),a mitochondria-targeting small molecule.Compared with the pure nanofiber self-assembled by PQC,LPHNPs not only preserve the comparable antiproliferative potency,but also possess a spherical nanostructure that allows the PQC molecules to be administrated through intravenous injection.Also,this co-assembly remarkably improved the drug-loading capacity and formulation stability against the physical encapsulation using conventional liposomes.By integrating the advantages from liposome and PQC molecule,LPHNPs have minimal system toxicity,enhanced potency of photodynamic therapy(PDT) and visualization capacities of drug biodistribution and tumor imaging.The hybrid nanoparticle demonstrates excellent curative effects to significantly prolong the survival of mice with the orthotopic glioma.The unique co-assembly of lipid and small molecule provides new potential for constructing new liposome-derived nanoformulations and improving cancer treatment. | Menghuan Tang Kai Lin Mythili Ramachandran Longmeng Li Hongye Zou Huzhi Zheng Zhao Ma Yuanpei Li | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 1 |
| 12 | Deep tumor-penetrating nano-delivery strategy to improve diagnosis and therapy in patient-derived xenograft(PDX)oral cancer model and patient tissue显示文摘Nanoprodrugs that are directly assembled by prodrugs attract considerable attention with high anticancer potentials.However,their stability and efficiency of tumor-targeted delivery remain a major challenge in practical biomedical applications.Here,we report a new deep tumor-penetrating nano-delivery strategy to achieve enhanced anti-cancer performance by systematic optimization of a porphyrin-doxorubicin-based nanoprodrug using various PEGylations/crosslinks and co-administration of targeting peptide iRGD.Polyethylene glycols(PEGs)with different molecular weights and grafts are employed to crosslink the nanoprodrug and optimize size,charge,tumor accumulation and penetration,and anti-cancer efficiency,etc.The tumor penetration was validated in syngeneic oral cancer mouse models,patient-derived xenograft(PDX)models,and oral cancer tissue from patients.The optimized nanoprodrug co-administrated with iRGD remarkably enhances the accumulation and penetration both in tumor vascular and PDX tumor tissue.It is effective and safe to improve in vivo therapeutic efficacy via the passive tumor targeting dependent and independent mode.Our tumor-penetrating nano-delivery strategy is promising to strengthen the nanoprodrugs in clinical implementation. | Longmeng Li Aaron R.Lindstrom Andrew C.Birkeland Menghuan Tang Tzu-Yin Lin Yikai Zhou Bai Xiang Xiangdong Xue Yuanpei Li | 2023 | Nano Research2023，16，2： | 1 |
| 13 | Optimal technology licensing contract with quality improvement innovation under Cournot competition显示文摘This paper analyzes the optimal licensing contract for the patentor with a quality improvement innovation in a Cournot duopoly market.We examine and compare three licensing contracts(fixed-fee licensing,royalty licensing,and two-part ad valorem licensing)in terms of the patent-holding firm’s profit,consumer surplus,and social welfare.We also study the impact of quality differences on the choice of licensing contract.One might expect that consumer surplus and social welfare are greater under fixed-fee licensing.However,we show that this conclusion seems to be untrue under quality improvement technology licensing.Moreover,we find that(1)there exists a threshold for the degree of quality difference above which fixed-fee licensing will be listed for the consideration of the patent-holding firm and below which it will be abandoned;(2)royalty licensing and two-part ad valorem licensing are always profitable for the patentholding firm and two-part ad valorem licensing brings the patentee the most profit. | Huaige Zhang Xianpei Hong Menghuan Zhou | 2022 | Journal of Management Analytics2022，9，4： | 0 |
| 14 | ATP Mimics pH-Dependent Dual Peroxidase-Catalase Activities Driving H_(2)O_(2) Decomposition显示文摘Adenosine triphosphate(ATP)is produced mainly in the mitochondrion,and its primary task is to function as a ubiquitous energy currency to meet the cellular metabolic demands in biological systems.Thus far,its potential role as performing enzymatic functions has not been elucidated. | Ying Shi Menghuan Tang Chaoqun Sun Yadi Pan Li Liu Yijuan Long Huzhi Zheng | 2019 | CCS Chemistry2019，1，4： | 0 |
| 15 | Role of miR-302/367 cluster in human physiology and pathophysiology显示文摘MicroRNAs(miRNAs)are small non-coding RNAs that negatively regulate target mRNAs at the post-transcriptional level.Increasing evidence shows the involvement of miRNAs in diverse biological processes.miR-302/367 cluster is highly conserved among vertebrates and made up of five members,including miR-367,miR-302a,miR-302b,miR-302c and miR-302d.miR-302/367 cluster plays an important role in cell proliferation,differentiation and reprogramming,affecting the development of tumor,cardiovascular system,nervous system and immune system.In this review,we will summarize the role of miR-302/367 cluster in embryonic stem cells and induced pluripotent stem cells and try to point out its relationship with tumors,cardiovascular system,nervous system and immune system. | Menghuan Guo Lu Gan Jing Si Jinhua Zhang Zhiyuan Liu Jin Zhao Zhong Gou Hong Zhang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 0 |
| 16 | Indoor Positioning Using Public FM and DTMB Signals Based on Compressive Sensing显示文摘Location-Based Services have become an indispensable part of our daily life, the sparsity of location finding makes it possible to estimate specific position by Compressive Sensing(CS). Using public Frequency Modulation(FM) broadcasting and Digital Television Terrestrial Multimedia Broadcasting(DTMB) signals, this paper presents an indoor positioning scheme, which is consisted of an offline stage and an online stage. In the offline stage, the Received Signal Strength(RSS) at the Reference Points(RPs) is measured, including the average and variance of public FM broadcasting and DTMB signals. In the online stage, the K-Weighted Nearest Neighbor algorithm is used to fulfill coarse positioning, which is able to narrow the selection scope of locations and choose partial RPs for accurate positioning. Then, the accurate positioning is implemented through CS. Experiment shows that the average positioning error of the proposed scheme is 1.63 m. What’s more, a CS-based method has been proposed in this paper to reduce the labor cost when collecting data. Experiment shows the average positioning error is 2.04 m, with the advantage of a 34% labor cost reduction. Experiment results indicate that the proposed system is a practical indoor positioning scheme. | Menghuan Yang Hong Wu Zhiyang Liu Shuxue Ding Hongzhao Peng | 2019 | China Communications2019，16，5： | 0 |
| 17 | PhoPepMass: A database and search tool assisting human phosphorylation peptide identification from mass spectrometry data显示文摘Protein phosphorylation, one of the most important protein post-translational modifications, is involved in various biological processes, and the identification of phosphorylation peptides(phosphopeptides)and their corresponding phosphorylation sites(phosphosites) will facilitate the understanding of the molecular mechanism and function of phosphorylation. Mass spectrometry(MS) provides a highthroughput technology that enables the identification of large numbers of phosphosites. PhoPepMass is designed to assist human phosphopeptide identification from MS data based on a specific database of phophopeptide masses and a multivariate hypergeometric matching algorithm. It contains 244,915 phosphosites from several public sources. Moreover, the accurate masses of peptides and fragments with phosphosites were calculated. It is the first database that provides a systematic resource for the query of phosphosites on peptides and their corresponding masses. This allows researchers to search certain proteins of which phosphosites have been reported, to browse detailed phosphopeptide and fragment information, to match masses from MS analyses with defined threshold to the corresponding phosphopeptide, and to compare proprietary phosphopeptide discovery results with results from previous studies. Additionally, a database search software is created and a 'two-stage search strategy' is suggested to identify phosphopeptides from tandem mass spectra of proteomics data. We expect PhoPepMass to be a useful tool and a source of reference for proteomics researchers. PhoPepMass is available at https://www.scbit.org/phopepmass/index.html. | Menghuan Zhang Hui Cui Lanming Chen Ying Yu Michael O. Glocker Lu Xie | 2018 | Journal of Genetics and Genomics2018，45，7： | 0 |
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