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| 1 | Microstructure and properties of Ti-6Al-4V fabricated by low-power pulsed laser directed energy deposition显示文摘Thin-wall structures of Ti-6A1-4V were fabricated by low-power pulsed laser directed energy deposition. During deposition, consistent with prior reports, columnar grains were observed which grew from the bottom toward the top of melt pool tail. This resulted in a microstructure mainly composed of long and thin prior epitaxial β columnar grains (average width ^200μm). A periodic pattern in epitaxial growth of grains was observed, which was shown to depend upon laser traverse direction. Utilizing this, a novel means was proposed to determine accurately the fusion boundary of each deposited layer by inspection of the periodic wave patterns. As a result it was applied to investigate the influence of thermal cycling on microstructure evolution. Results showed that acicular martensite,α' phase, and a small amount of Widmanstatten, a laths, gradually converted to elongated acicular a and a large fraction of Widmanstatten a laths under layer-wise thermal cycling. Tensile tests showed that the yield strength, ultimate tensile strength and elongation of Ti-6Al-4V thin wall in the build direction were 9.1 %, 17.3% and 42% higher respectively than those typically observed in forged solids of the same alloy. It also showed the yield strength and ultimate tensile strength of the transverse tensile samples both were 13.3% higher than those from the build direction due to the strengthening effect of a large number of vertical β grain boundaries, but the elongation was 69.7% lower than that of the build direction due to the uneven grain deformation of β grains. | Hua Tan Mengle Guo Adam T. Clare Xin Lin Jing Chen Weidong Huang | 2019 | Journal of Materials Science & Technology2019，35，9： | 5 |
| 2 | Advances in Studies on Interaction between Selenium and Heavy Metal Cadmium显示文摘Selenium is an essential functional element of the human body,and the issue of selenium accompanying heavy metals is receiving much concern.This paper expounded the form of existence of selenium and cadmium in soil and influencing factors of their bioavailability,and further elaborated the interaction between selenium and cadmium.On the basis,it provided references for further studies on the interaction between selenium and cadmium,and provided basis for establishing selenium-enriched barrier technology for crops. | Liping PAN Yongxian LIU Yanfei HUANG Mengling NONG Shiyang LU Jinping CHEN Yuying ZHAO Liumei XIONG Xiu LAN Kebing LI | 2017 | Asian Agricultural Research2017，9，8： | 3 |
| 3 | The Pumilio RNA-binding protein APUM24 regulates seed maturation by fine-tuning the BPM-WRI1 module in Arabidopsis显示文摘Pumilio RNAbindingproteinsparticipateinmes-senger RNA(mRNA)degradation and t ranslational repression,but their roles in plant development are largely unclear.Here,we show that Arabidopsis PUMILIO PROTEIN24(APUM24),an atypical Pumiliohomology domaincontaining protein,plays an im-portant part in regulating seed maturation,a major stage of plant development.APUM24 is strongly expressed in maturing seeds.Reducing APUM24 expression resulted in abnormal seed maturation,wrinkled seeds,and lower seed oil contents,and APUM24 knockdown resulted in lower levels of WRINKLED 1(WRI1),a key transcription factor con-trolling seed oil accumulation,and lower expression of WRI1 target genes.APUM24 reduces the mRNA stability of BTB/POZMATH(BPM)family genes,thus decreasing BPM protein levels.BPM is responsible for the 26S proteasomemediated degradation of WRI1 and has important functions in plant growth and development.The 3′untranslated regions of BPM family genes contain putative Pumilio response elements(PREs),which are bound by APUM24.Re-duced BPM or increased WRI1 expression rescued the decient seed maturation of apum242 knock-down mutants,and APUM24 overexpression re-sulted in increased seed size and weight.Therefore,APUM24 is crucial to seed maturation through its action as a positive regulatornetuning the BPMWRI1 module,making APUM24 apromising target for breeding strategies to increase crop yields. | Ruihua Huang Mengling Liu Guanping Gong Pingzhi Wu Barunava Patra Ling Yuan Hongting Qin Xiaoxu Wang Guohe Wang Huimei Liao Lu Gao Chengwei Yang Hongqing Li Shengchun Zhang | 2021 | Journal of Integrative Plant Biology2021，63，7： | 2 |
| 4 | Intrahepatic cholestasis of pregnancy: detection with urinary bile acid assays显示文摘 | William M. Huang David E. Seubert James G. Donnelly Mengling Liu Norman B. Javitt | 2007 | Journal of Perinatal Medicine2007，，： | 1 |
| 5 | Electrolytic boronizing of titanium in Naz B4 07 -20 % Kz C03 显示文摘 | Huang Youguo Chen Iiarong Zhang Mengling | 2013 | Mater Manuf Processes2013，28，： | 1 |
| 6 | Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects显示文摘 | Ruocco Maria Grazia Pilones Karsten A Kawashima Noriko Cammer Michael Huang Julie Babb James S Liu Mengling Formenti Silvia C Dustin Michael L Demaria Sandra | 2012 | EN2012，，10： | 1 |
| 7 | AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma显示文摘Osteosarcoma(OS)is the most common primary malignant bone tumor in children and adolescents.Although activator of HSP90 ATPase activity 1(AHA1)is reported to be a potential oncogene,its role in osteosarcoma progression remains largely unclear.Since metabolism reprogramming is involved in tumorigenesis and cancer metastasis,the relationship between AHA1 and cancer metabolism is unknown.In this study,we found that AHA1 is significantly overexpressed in osteosarcoma and related to the prognosis of osteosarcoma patients.AHA1 promotes the growth and metastasis of osteosarcoma both in vitro and in vivo.Mechanistically,AHA1 upregulates the metabolic activity to meet cellular bioenergetic needs in osteosarcoma.Notably,we identifed that isocitrate dehydrogenase 1(IDH1)is a novel client protein of Hsp90 AHA1.Furthermore,the IDH1 protein level was positively correlated with AHA1 in osteosarcoma.And IDH1 overexpression could partially reverse the effect of AHA1 knockdown on cell growth and migration of osteosarcoma.Moreover,high IDH1 level was also associated with poor prognosis of osteosarcoma patients.This study demonstrates that AHA1 positively regulates IDH1 and metabolic activity to promote osteosarcoma growth and metastasis,which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients. | Diwei Zheng Weihai Liu Wenlin Xie Guanyu Huang Qiwei Jiang Yang Yang Jiarong Huang Zihao Xing Mengling Yuan Mengning Wei Yao Li Junqiang Yin Jingnan Shen Zhi Shi | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 8 | Effects of Several Passivating Agents on Improvement of Cd Polluted Soil显示文摘Clay minerals,phosphates,alkaline materials,organic materials are common improvers in the management of Cd polluted soil. This paper systematically summarized types of common soil improvers and their passivation mechanism of Cd in soil. It reviewed advances in researches of soil improvers. Besides,it introduced major problems in four common passivating agents for management of Cd polluted soil. Finally,according to different mechanism characteristics of passivating agents,it came up with some recommendations. | Yuying ZHAO Yongxian LIU Zhilian FAN Yanfei HUANG Liping PAN Mengling NONG Shiyang LU Jinping CHEN Xiu LAN | 2017 | Asian Agricultural Research2017，9，10： | 0 |
| 9 | KDM4C与ATF4协同作用转录调控氨基酸代谢显示文摘组蛋白赖氨酸甲基转移酶(KNITs)和去甲基化酶(KDMs)通过控制组蛋白赖氨酸的甲基化状态,在转录调控中起着重要的作用。 | Erhu Zhao Jane Ding Yingfeng Xia Mengling Liu Bingwei Ye Jeong-Hyeon Choi Chunhong Yan Zheng Dong Shuang Huang Yunhong Zha Liqun Yang 崔红娟 Han-Fei Ding | 2017 | 科学新闻2017，19，4： | 0 |
| 10 | Active DNA demethylation regulates MAMP-triggered immune priming in Arabidopsis显示文摘Plants recognize microbe-associated molecular patterns(MAMPs)to activate immune responses and defense priming to defend against pathogen infections.Transcriptional regulation of gene expression is crucial for plant immunity and is mediated by multiple factors,including DNA methylation.However,it remains unknown whether and how DNA demethylation contributes to immune responses in MAMPtriggered immunity.Here,we report that active DNA demethylation is required for MAMP-triggered immunity to bacterial pathogens.The rdd-2 triple mutant carrying mutations in ROS1,DML2,and DML3 that encode DNA glycosylases,which are key DNA demethylation enzymes,exhibits compromised immune responses triggered by the MAMPs fig22 and elf18.Genome-wide methylome analysis reveals that fig22 induces rapid and specific DNA demethylation in an RDD-dependent manner.The expression levels of salicylic acid signaling-related and phytoalexin biosynthesis-related genes are tightly associated with the fig22-induced promoter demethylation.The compromised accumulation of priming compounds and antimicrobial metabolites ultimately leads to a defense priming defect in the rdd-2 mutant.Our results reveal the critical role of active DNA demethylation in the MAMP-triggered immune response and provide unique insight into the molecular mechanism of fig22-modulated DNA demethylation. | Mengling Huang Ying Zhang Ying Wang Jiatao Xie Jiasen Cheng Yanping Fu Daohong Jiang Xiao Yu Bo Li | 2022 | Journal of Genetics and Genomics2022，49，8： | 0 |
| 11 | 转录分析显示高危险的人类神经母细胞瘤和小鼠神经母细胞瘤的球形细胞中有共同的代谢调节显示文摘高危险性的神经母细胞瘤(neuroblastoma)仍然是一种最致命的幼童癌症之一,而识别驱动或维持高危险性的神经母细胞瘤的代谢途径则可能开辟新的治疗方针。 | Mengling Liu Yingfeng Xia Jane Ding Bingwei Ye Erhu Zhao Jeong-Hyeon Choi Ahmet Alptekin Chunhong Yan Zheng Dong Shuang Huang Liqun Yang Hongjuan Cui 查运红 Han-Fei Ding | 2017 | 科学新闻2017，19，4： | 0 |
| 12 | The application of artificial intelligence in the management of sepsis显示文摘Sepsis is a complex and heterogeneous syndrome that remains a serious challenge to healthcare worldwide.Patients afflicted by severe sepsis or septic shock are customarily placed under intensive care unit(ICU)supervision,where a multitude of apparatus is poised to produce high-granularity data.This reservoir of high-quality data forms the cornerstone for the integration of AI into clinical practice.However,existing reviews currently lack the inclusion of the latest advancements.This review examines the evolving integration of artificial intelligence(AI)in sepsis management.Applications of artificial intelligence include early detection,subtyping analysis,precise treatment and prognosis assessment.AI-driven early warning systems provide enhanced recognition and intervention capabilities,while profiling analyzes elucidate distinct sepsis manifestations for targeted therapy.Precision medicine harnesses the potential of artificial intelligence for pathogen identification,antibiotic selection,and fluid optimization.In conclusion,the seamless amalgamation of artificial intelligence into the domain of sepsis management heralds a transformative shift,ushering in novel prospects to elevate diagnostic precision,therapeutic efficacy,and prognostic acumen.As AI technologies develop,their impact on shaping the future of sepsis care warrants ongoing research and thoughtful implementation. | Jie Yang Sicheng Hao Jiajie Huang Tianqi Chen Ruoqi Liu Ping Zhang Mengling Feng Yang He Wei Xiao Yucai Hong Zhongheng Zhang | 2023 | Medical Review2023，3，5： | 0 |
| 13 | Chiral carbon dots from glucose by room temperature alkaliassisted synthesis for electrocatalytic oxidation of tryptophan enantiomers显示文摘Chiral catalysis is one of the most direct and effective approach to obtain pure optical enantiomers.Chiral carbon dots(CDs)as carbon-based chiral catalysts show great potential in chiral catalysis.Herein,we report a facile one step base-catalyzed aldol condensation to fabricate the chiral CDs from glucose at ambient temperature and pressure.The formation of chiral CDs involves the processes of isomerization and aldol condensation.These chiral CDs have been demonstrated that they have selective capacity for electrocatalytic oxidization of tryptophan enantiomers.L type of CDs(LCDs)is more likely to catalyze L-tryptophan(Trp)than D-Trp with the selective factor(I_(L)/I_(D))of 1.60,whereas the D type of CDs(DCDs)tends to catalyze D-Trp(I_(L)/I_(D):0.63).Theoretical calculations combined with various contrast experiments(temperature and pH)demonstrate that the selectively electrocatalytic capacity of chiral CDs toward Trp isomers is due to the different hydrogen-bond interactions between chiral CDs and Trp. | Mengling Zhang Xing Fan Xin Du Yurong Ma Xiting Wang Hui Huang Yang Liu Youyong Li Zhenhui Kang | 2023 | Nano Research2023，16，7： | 0 |
| 14 | Ultralow-adhesion icephobic surfaces:Combining superhydrophobic and liquid-like properties in the same surface显示文摘As a ubiquitous natural phenomenon,ice/frost formation on solid surfaces have adverse effects on many commercial and residential activities.Icephobic surfaces feature low ice adhesion strengths(<100 kPa)can passively retard ice formation and ease ice removal.Superhydrophobic surfaces and liquid-lubricating surfaces are two prevailing categories of icephobic surfaces.However,their long-term stability is relatively poor,and the ice adhesion strengths are not low enough for passive removal of small ice crystals(e.g.,frosts)from the surfaces.Herein,we combine the superhydrophobic and liquid-like properties in one surface to obtain durable icephobic surfaces with extremely low ice adhesion strengths(about 0.035 kPa).Ices and frosts can be removed from the surface under the action of gravity or gas purge.These surfaces are prepared based on surface nanoconical structure and covalently-grafted liquid-like perfluorinated polyether(PFPE)coating,which show synergy effects on suppressing icing and frosting by promoting expulsion of subcooled condensate droplets from the nanotexture and decreasing ice adhesion strengths.The icephobic surfaces show significantly better durability compared to lubricant-impregnated textured surfaces.Our results provide a new avenue to design passive anti-icing/anti-frosting surfaces for a wide range of applications where surfaces are exposed to humid and low-temperature environments. | Mengling Ouyang Ruisheng Guo Yue Fan Yi Zhou Chengjiao Wu Liwei Chen Shilin Huang Xuelin Tian | 2023 | Nano Research2023，16，1： | 0 |
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