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| 1 | Freeform OST-HMD system with large exit pupil diameter and vision correction capability显示文摘Compactness and light weight,large exit pupil diameter and distance,small distortion for virtual image,and see-through light paths are pivotal factors to achieve a better,wearable experience of optical see-through headmounted displays(OST-HMDs).In addition,light efficiency of the virtual image light path is an important factor for heat dissipation in HMD devices.This paper presents a new type of OST-HMD optical system that includes three wedge-shaped freeform prisms and two symmetric lenses.Based on a 0.71 in.microdisplay,an OST-HMD prototype with a diagonal field of view(FOV)of 45.3°,an F-number(F/#)of 1.8,an exit pupil size of 12 mm×8 mm,and an eye relief of 18 mm is demonstrated.The maximum value of distortion of the final system is 0.6%and 0.4%for virtual image and see-through light path,respectively.The overall dimension of the optical system per eye is no larger than 30 mm(width)×40 mm(height)×14 mm(thickness),and the weight of the optical module including lenses,holder,and microdisplay is 12.8 g.The light efficiency of the virtual image light path is up to 50%higher than those of other OST-HMD optical solutions. | DEWEN CHENG JIAXI DUAN HAILONG CHEN HE WANG DANYANG LI QIWEI WANG QICHAO HOU TONG YANG WEIHONG HOU DONGHUA WANG XIAOYU CHI BIN JIANG YONGTIAN WANG | 2022 | Photonics Research2022，10，1： | 5 |
| 2 | Power transmission risk assessment considering component condition显示文摘This paper proposes a new method for power transmission risk assessment considering historical failure statistics of transmission systems and operation failure risks of system components.Component failure risks are integrated into the new method based on operational condition assessment of components using the support vector data description(SVDD)approach.The traditional outage probability model of transmission lines has been modified to build a new framework for power transmission system risk assessment.The proposed SVDD approach can provide a suitable mechanism to map component assessment grades to failure risks based on probabilistic behaviors of power system failures.Under the new method,both up-todate component failure risks and traditional system risk indices can be processed with the proposed outage model.As a result,component failure probabilities are not only related to historical statistic data but also operational data of components,and derived risk indices can reflect current operational conditions of components.In simulation studies,the SVDD approach is employed to evaluate component conditions and link such conditions to failure rates using up-to-date component operational data,including both on-line and off-line data of components.The IEEE 24-bus RTS-1979 system is used to demonstrate that component operational conditions can greatly affect the overall transmission system failure risks. | Lei GUO Qiwei QIU Jian LIU Yu ZHOU Linglei JIANG | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，1： | 4 |
| 3 | Desmoglein 2(DSG2) Is A Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia显示文摘Human adenovirus type 55(HAdV-B55) is a re-emergent acute respiratory disease pathogen that causes adult communityacquired pneumonia(CAP). Previous studies have shown that the receptor of HAdV-B14, which genome is highly similar with HAdV-B55, is human Desmoglein 2(DSG2). However, whether the receptor of HAdV-B55 is DSG2 is undetermined because there are three amino acid mutations in the fiber gene between HAdV-B14 and HAdV-B55. Here, firstly we found the 3T3 cells, a mouse embryo fibroblast rodent cell line which does not express human DSG2, were able to be infected by HAdV-B55 after transfected with pcDNA3.1-DSG2, while normal 3T3 cells were still unsusceptible to HAdV-B55 infection. Next, A549 cells with h DSG2 knock-down by siRNA were hard to be infected by HAdV-B3/-B14/-B55, while the control siRNA group was still able to be infected by all these types of HAdVs. Finally, immunofluorescence confocal microscopy indicated visually that Cy3-conjugated HAdV-B55 viruses entered A549 cells by binding to DSG2 protein.Therefore, DSG2 is a major receptor of HAdV-B55 causing adult CAP. Our finding is important for better understanding of interactions between adenoviruses and host cells and may shed light on the development of new drugs that can interfere with these processes as well as for the development of potent prophylactic vaccines. | Jing Zhang Kui Ma Xiangyu Wang Yinbo Jiang Shan Zhao Junxian Ou Wendong Lan Wenyi Guan Xiaowei Wu Heping Zheng Bin Yang Chengsong Wan Wei Zhao Jianguo Wu Qiwei Zhang | 2021 | Virologica Sinica2021，36，6： | 4 |
| 4 | Pervasive intelligent endogenous 6G wireless systems:Prospects,theories and key technologies显示文摘The worldwide large-scale commercial deployment of 5G has commenced in 2020 for supporting enhanced Mobile BroadBand(eMBB),ultra-Reliable and Low-Latency Communications(uRLLC),and massive Machine-Type Communications(mMTC)services.Nevertheless,the upsurge of Artificial Intelligence(AI)-powered applications,the developmental law of one-decade-one-generation of wireless communications and the inherent limitations of 5G have also been spurring the industry and academia to dedicate their efforts to the research of future 6G wireless systems.6G will be a disruptive,pervasive,intelligent,and endogenous wireless system,which will revolutionize all walks of life and accelerate the transformation and innovation of the global society.In this paper,we present a forward-looking,comprehensive and in-depth analysis and technical identification of 6G.Specifically,we firstly introduce the fundamental theories of 6G in terms of potential requirements.Then,we focus our attention on the discussion of promising key technologies in terms of spectrum,air interface,delay,access,energy consumption,coverage,AI,electromagnetism,interaction,etc. | Yun Chen Wenfeng Liu Zhiang Niu Zhongxiu Feng Qiwei Hu Tao Jiang | 2020 | Digital Communications and Networks2020，6，3： | 3 |
| 5 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 6 | Three-dimensional ATUM-SEM reconstruction and analysis of hepatic endoplasmic reticulum-organelle interactions显示文摘The endoplasmic reticulum(ER)is a contiguous and complicated membrane network in eukaryotic cells,and membrane contact sites(MCSs)between the ER and other organelles perform vital cellular functions,including lipid homeostasis,metabolite exchange,calcium level regulation,and organelle division.Here,we establish a whole pipeline to reconstruct all ER,mitochondria,lipid droplets,lysosomes,peroxisomes,and nuclei by automated tape-collecting ultramicrotome scanning electron microscopy and deep learning techniques,which generates an unprecedented 3D model for mapping liver samples.Furthermore,the morphology of various organelles and the MCSs between the ER and other organelles are systematically analyzed.We found that the ER presents with predominantly flat cisternae and is knitted tightly all throughout the intracellular space and around other organelles.In addition,the ER has a smaller volume-to-membrane surface area ratio than other organelles,which suggests that the ER could be more suited for functions that require a large membrane surface area.Our data also indicate that ER-mitochondria contacts are particularly abundant,especially for branched mitochondria.Our study provides 3D reconstructions of various organelles in liver samples together with important fundamental information for biochemical and functional studies in the liver. | Yi Jiang Linlin Li Xi Chen Jiazheng Liu Jingbin Yuan Qiwei Xie Hua Han | 2021 | Journal of Molecular Cell Biology2021，13，9： | 2 |
| 7 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 8 | Arabinose substitution degree in xylan positively affects lignocellulose enzymatic digestibility after various NaOH/H 2 SO 4 pretreatments in Miscanthus显示文摘 | Fengcheng Li Shuangfeng Ren Wei Zhang Zhengdan Xu Guosheng Xie Yan Chen Yuanyuan Tu Qing Li Shiguang Zhou Yu Li Fen Tu Lin Liu Yanting Wang Jianxiong Jiang Jingping Qin Shizhong Li Qiwei Li Hai-Chun Jing Fasong Zhou Neal Gutterson Liangcai Peng | 2012 | Bioresource Technology2012，，： | 1 |
| 9 | Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria显示文摘Phenylketonuria(PKU),a disease resulting in the disability to degrade phenylalanine(Phe)is an inborn error with a 1 in 10,000 morbidity rate on average around the world which leads to neurotoxicity.As an potential alternative to a protein-restricted diet,oral intake of engineered probiotics degrading Phe inside the body is a promising treatment,currently at clinical stage II(Isabella,et al.,2018).However,limited transmembrane transport of Phe is a bottleneck to further improvement of the probiotic’s activity.Here,we achieved simultaneous degradation of Phe both intracellularly and extracellularly by expressing genes encoding the Phe-metabolizing enzyme phenylalanine ammonia lyase(PAL)as an intracellularly free and a cell surface-immobilized enzyme in Escherichia coli Nissle 1917(EcN)which overcomes the transportation problem.The metabolic engineering strategy was also combined with strengthening of Phe transportation,transportation of PAL-catalyzed trans-cinnamic acid and fixation of released ammonia.Administration of our final synthetic strain TYS8500 with PAL both displayed on the cell surface and expressed inside the cell to the Pah^(F263S)PKU mouse model reduced blood Phe concentration by 44.4%compared to the control Ec N,independent of dietary protein intake.TYS8500 shows great potential in future applications for PKU therapy. | Yu Jiang Bingbing Sun Fenghui Qian Feng Dong Chongmao Xu Wuling Zhong Rui Huang Qiwei Zhai Yu Jiang Sheng Yang | 2023 | Science China(Life Sciences)2023，66，1： | 1 |
| 10 | Control of Fusarium wilt disease of cucumber plants with the application of a bioorganic fertilizer显示文摘 | Shusheng Zhang Waseem Raza Xingming Yang Jiang Hu Qiwei Huang Yangchun Xu Xinghai Liu Wei Ran Qirong Shen | 2008 | Biology and Fertility of Soils2008，，8： | 1 |
| 11 | The potent roles of salt-inducible kinases(SIKs)in metabolic homeostasis and tumorigenesis显示文摘Salt-inducible kinases(SIKs)belong to AMP-activated protein kinase(AMPK)family,and functions mainly involve in regulating energy response-related physiological processes,such as gluconeogenesis and lipid metabolism.However,compared with another well-established energy-response kinase AMPK,SIK roles in human diseases,especially in diabetes and tumorigenesis,are rarely investigated.Recently,the pilot roles of SIKs in tumorigenesis have begun to attract more attention due to the finding that the tumor suppressor role of LKB1 in non-small-cell lung cancers(NSCLCs)is unexpectedly mediated by the SIK but not AMPK kinases.Thus,here we tend to comprehensively summarize the emerging upstream regulators,downstream substrates,mouse models,clinical relevance,and candidate inhibitors for SIKs,and shed light on SIKs as the potential therapeutic targets for cancer therapies. | Zicheng Sun Qiwei Jiang Jie Li Jianping Guo | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 12 | A robust ethane-trapping metal-organic framework for efficient purification of ethylene显示文摘Owing to the similar physicochemical properties between ethane(C_(2)H_(6))and ethylene(C_(2)H_(4)),obtaining polymerization-grade C_(2)H_(4)(≥99.95%pure)is still a tricky problem in the petrochemical industry.Here,we report a robust scandium-based metalorganic framework(Sc BPDC),which is connected by oxygen-rich phenyl ligand with exceptionally high thermal stability(up to873 K)and capacity of C_(2)H_(6)(4.94 mmol/g at 100 k Pa and 283 K),exhibiting superior separation performance of C_(2)H_(6)/C_(2)H_(4) mixture(the IAST selectivity is up to 1.7 at 283 K).Importantly,Sc BPDC can produce 8.96 L/kg C_(2)H_(4) with≥99.99%purity while the C_(2)H_(4)/C_(2)H_(6)(50:50,v/v)as the mixture injection and the low isosteric heat of Sc BPDC(16.4 k J/mol for C_(2)H_(6))validates the facility of adsorbent regeneration.Furthermore,theoretical calculations demonstrate the C_(2)H_(6) molecules are trapped in the nonpolar pore surface via C–H···πand C–H···O interactions between multiple hydrogen atoms of C_(2)H_(6) and the host framework. | Sisi Jiang Liangying Li Lidong Guo Changhua Song Qiwei Yang Zhiguo Zhang Yiwen Yang Qilong Ren Zongbi Bao | 2021 | Science China Chemistry2021，64，4： | 1 |
| 13 | AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma显示文摘Osteosarcoma(OS)is the most common primary malignant bone tumor in children and adolescents.Although activator of HSP90 ATPase activity 1(AHA1)is reported to be a potential oncogene,its role in osteosarcoma progression remains largely unclear.Since metabolism reprogramming is involved in tumorigenesis and cancer metastasis,the relationship between AHA1 and cancer metabolism is unknown.In this study,we found that AHA1 is significantly overexpressed in osteosarcoma and related to the prognosis of osteosarcoma patients.AHA1 promotes the growth and metastasis of osteosarcoma both in vitro and in vivo.Mechanistically,AHA1 upregulates the metabolic activity to meet cellular bioenergetic needs in osteosarcoma.Notably,we identifed that isocitrate dehydrogenase 1(IDH1)is a novel client protein of Hsp90 AHA1.Furthermore,the IDH1 protein level was positively correlated with AHA1 in osteosarcoma.And IDH1 overexpression could partially reverse the effect of AHA1 knockdown on cell growth and migration of osteosarcoma.Moreover,high IDH1 level was also associated with poor prognosis of osteosarcoma patients.This study demonstrates that AHA1 positively regulates IDH1 and metabolic activity to promote osteosarcoma growth and metastasis,which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients. | Diwei Zheng Weihai Liu Wenlin Xie Guanyu Huang Qiwei Jiang Yang Yang Jiarong Huang Zihao Xing Mengling Yuan Mengning Wei Yao Li Junqiang Yin Jingnan Shen Zhi Shi | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 14 | Control of Fusarium wilt disease of cucumber plants with the application of a bioorganic fertilizer显示文摘 | Shusheng Zhang Waseem Raza Xingming Yang Jiang Hu Qiwei Huang Yangchun Xu Xinghai Liu Wei Ran Qirong Shen | 2008 | Biology and Fertility of Soils2008，，8： | 1 |
| 15 | Refex seizures induced by micturition: a case report显示文摘Background Refex seizures(RS)induced by micturition are extremely rare,and the clinical and electroencephalogram features of RS are not widely known among clinicians.In particular,the origin of the epileptic area is still unclear.Case presentation An 8-year-old girl who had generalized tonic-clonic seizures was diagnosed with RS induced by micturition based on the clinical manifestation and EEG recordings.We also reviewed the clinical and EEG characteristics of RS induced by micturition in literature by searching the databases of PubMed and MEDLINE using keywords“micturition refex seizure”,“refex seizure induced by micturition”,and“micturition induced seizure”by January 2022.We speculate that the mechanism of micturition-induced RS may involve excessive neuronal excitation in regions that participate in micturition.Conclusions The RS in this patient was considered to be induced by micturition.Awareness should be raised to this rare form of RS among practitioners. | Zhiyun Zhang Qiwei Li Tiejia Jiang Jiajia Fang | 2023 | Acta Epileptologica2023，6，1： | 0 |
| 16 | Detector development at the Back-n white neutron source显示文摘Purpose Back-n is a white neutron beamline at China spallation neutron source,which was established in the year of 2018.It is a powerful facility for nuclear data measurement,neutron detector calibration,and radiation effect research.Method A series of detectors were built for different experiments,including beam monitoring,beam profile measurement,neutron induced secondaries(fission fragments,light charged particles and gamma)cross section measurement,and neutron resonance radiography,etc.A common digitization electronics and a cluster-based DAQ were developed for these detector systems.Most detectors have been employed at Back-n and serviced for experiments from the beginning of the beamline running.Results and conclusion As an overview of detectors of Back-n,the details of the detector design and the experiment performing are described in this paper.Some developing systems,e.g.,MTPC and B-MCP,are also included. | Fan Ruirui Li Qiang Bao Jie Li Yang Liu Rong Jiang Wei Ren Jie Zhang Qiwei Cao Ping Gu Minhao Ren Zhizhou Yi Han Tang Jingyu An Qi Bai Haofan Bai Jiangbo Chen Qiping Chen Yonghao Chen Zhen Cui Zengqi Fan Anchuan Feng Changqing Feng Fanzhen Gao Keqing Han Changcai Han Zijie He Guozhu He Yongcheng Hong Yang Hu Yiwei Huang Hanxiong Jia Weihua Jiang Haoyu Jiang Zhijie Jin Zhengyao Kang Ling Li Bo Li Chao Li Gong Li Jiawen Li Xiao Liu Jie Liu Shubin Luan Guangyuan Ning Changjun Qi Binbin Ruan Xichao Song Zhaohui Sun Kang Tan Zhixin Tang Shengda Wang Pengcheng Wang Zhaohui Wen Zhongwei Wu Xiaoguang Wu Xuan Xie Likun Yang Yiwei Yu Yongji Zhang Guohui Zhang Linhao Zhang Mohan Zhang Xianpeng Zhang Yuliang Zhang Yue Zhang Zhiyong Zhao Maoyuan Zhou Luping Zhou Zhihao Zhu Kejun The CSNS Back-n Collaboration | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 17 | Dipyridyl Azo Compound 4,4'-Azopyridine as a Potential Coating Material for Toilet Sanitizer显示文摘Good toilet hygiene can reduce the risk of pathogenic transmission.During flushing,pathogenic bacteria can be spread by the water droplets,especially in the toilet seat.Escherichia coli(E.coli)is one of the frequently occurring Gram-negative bacterial pathogens found in the toilet seats.In this study,we investigated the potential anti-E.coli activity of some azobenzene compounds.Among them,compound 2,with the heterocyclic nitrogen in both phenyl rings,showed the strongest antibacterial effect on E.coli,with the minimum inhibitory concentration of 80μg/mL and the minimum bactericidal concentration of 320μg/mL.Compound 2 displayed a comparative zone of clearance[(14.50±2.29)mm]to that of ampicillin[(13.17±1.76)mm].The reactive oxygen species(ROS)assay suggested that compound 2 might induce the loss of bacteria via the oxidative stress by eliciting the generation of intracellular ROS.We further examined the potential cytotoxicity of compound 2 to the human skin HaCaT cells.Compound 2-treated skin cells showed a good maintenance of cellular morphology and a clear definition of cell nuclei,with a satisfactory cell viability(ca.90%)at 80μg/mL.Overall,compound 2 would be a possible antibacterial coating agent for the surface sanitizer of the toilet seats to inhibit the growth of E.coli. | WANG Qiwei JIANG Lu LAM Pik-Ling CHUI Chung-Hin WONG Wai-Yeung | 2023 | Chemical Research in Chinese Universities2023，39，6： | 0 |
| 18 | Green photochemical synthesis of fluorescent carbon spheres in-situ enwrapped around Ag nanoparticles显示文摘Biocompatible carbon-spheres-based nanocomposites exhibit great potential in biomedical and clinical applications. In this contribution we report the first green photochemical synthesis of carbon spheres through in-situ enwrapping around silver nanoparticles(CS–Ag NPs). Since mesoporous carbon spheres can provide the location for combining Ag NPs and other agents, one-step synthesis of glutathione-stabilized CS–Ag NPs could be readily realized by photoreduction. TEM characterization of CS–Ag NPs nanocomposites illustrates that Ag NPs were superbly wrapped inside the carbon spheres and also adhered to the surfaces of the carbon spheres. These porous CS–Ag NPs show excellent fluorescence and effective antibacterial efficiency, exhibiting ideal lengthened activities against Escherichia coli and Staphylococcus aureus compared with bare Ag NPs. The relevant rationale behind it could be attributed to the fact that CS–Ag NPs nanocomposites can provide some excellent niches for the durable and slow release of silver ions. This raises the possibility of promising applications of CS–Ag NPs nanocomposites as excellent antibacterial agents for the efficient monitoring of some disease-related bacteria. | Wei Ge Xiaoli Liu Jing Ye Qiwei Li Hui Jiang Xuemei Wang | 2015 | Science China Chemistry2015，58，4： | 0 |
| 19 | GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer显示文摘Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer. | Qiwei Jiang Yong Li Songwang Cai Xingyuan Shi Yang Yang Zihao Xing Zhenjie He Shengte Wang Yubin Su Meiwan Chen Zhesheng Chen Zhi Shi | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 20 | Petrogenesis and Tectonic Implications of the Tertiary Choke Shield Basalt and Continental Flood Basalt from the Central Ethiopian Plateau显示文摘The voluminous Choke Shield basalts and flood basalts are distributed in the central Ethiopian Plateau.They are tholeiitic in composition and have OIB-like geochemical features.The ca.23 Ma Choke Shield basalts have SiO_(2)(47.1 wt.%-59.6 wt.%),MgO(1.01 wt.%-7.8 wt.%),Na_(2)O+K_(2)O(2.7 wt.%-8.4 wt.%),and display right inclined REE patterns((La/Yb)N=21.4-24.2) with enrichment of Nb,Ta,Zr,Hf and Pb in the primitive mantle-normalized trace element diagrams.They show low initial ^(87)Sr/^(86)Sr ratios(0.703 47-0.703 77) and high ε_(Nd)(t) values(+4.4 to+5.0).In comparison,the 24Ma high-Ti(HT1) flood basalts have SiO_(2)(38.9 wt.%-50.8 wt.%),MgO(3.9 wt.%-11.4 wt.%),Na_(2)O+K_(2)O(1.6 wt.%-5.8 wt.%), and display right inclined REE patterns((La/Yb)N=24-130.3) with enrichment of Nb,Ta,Zr,Hf,and Pb.They also show low initial ^(87)Sr/^(86)Sr ratios(0.703 30-0.704 44) and highε_(Nd)(t) values(+2.2 to+5.3).Both types of basalts were contaminated by minor crustal materials and underwent fractional crystallization of clinopyroxene,plagioclase,olivine,and minor Fe-Ti oxide.The Choke Shield basalts were generated by 1%-5% melting of garnet-spinel to phlogopite-bearing spinel lherzolite in a shallow zone of the mantle plume,while the flood basalts were formed by <20% melting of amphibole-bearing garnet to garnet-spinel lherzolite in a deeper zone of the same mantle plume.The mantle source beneath the central Ethiopian Plateau was significantly heterogeneous during the Tertiary.It was characterized by EMI and EMII end-members that were formed by the metasomatism of the different components. | Junaid Khan Huazhou Yao Junhong Zhao Qiwei Li Wenshuai Xiang Junsheng Jiang Asma Tahir | 2023 | Journal of Earth Science2023，34，1： | 0 |
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