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| 1 | Advanced inorganic/polymer hybrid electrolytes for all-solid-state lithium batteries显示文摘Solid-state batteries have become a frontrunner in humankind’s pursuit of safe and stable energy storage systems with high energy and power density.Electrolyte materials,currently,seem to be the Achilles’heel of solid-state batteries due to the slow kinetics and poor interfacial wetting.Combining the merits of solid inorganic electrolytes(SIEs)and solid polymer electrolytes(SPEs),inorganic/polymer hybrid electrolytes(IPHEs)integrate improved ionic conductivity,great interfacial compatibility,wide electrochemical stability window,and high mechanical toughness and flexibility in one material,having become a sought-after pathway to high-performance all-solid-state lithium batteries.Herein,we present a comprehensive overview of recent progress in IPHEs,including the awareness of ion migration fundamentals,advanced architectural design for better electrochemical performance,and a perspective on unconquered challenges and potential research directions.This review is expected to provide a guidance for designing IPHEs for next-generation lithium batteries,with special emphasis on developing high-voltage-tolerance polymer electrolytes to enable higher energy density and three-dimensional(3D)continuous ion transport highways to achieve faster charging and discharging. | Xiaoyu JI Yiruo ZHANG Mengxue CAO Quanchao GU Honglei WANG Jinshan YU Zi-Hao GUO Xingui ZHOU | 2022 | Journal of Advanced Ceramics2022，11，6： | 2 |
| 2 | Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma显示文摘Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1). | Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu | 2020 | Protein & Cell2020，11，4： | 2 |
| 3 | Assessment of the three factors affecting Myanmar’s forest cover change using Landsat and MODIS vegetation continuous fields data显示文摘Long-term observation of the earth is essential for studying the factors affecting global environmental changes.Digital earth technology can facilitate the monitoring of global environmental change with its ability to process vast amounts of information.In this study,we map the forest cover change of Myanmar from 2000 to 2005 using a training data automation procedure and support vector machines algorithm.Our results show that Myanmar’s forests have declined 0.68%annually over this six-year period.We validated our derived change results and found the overall accuracy to be greater than 88%.We also assessed forest loss from protected areas,areas close to roads,and areas subject to fire,which were most likely to lose forested area.The results revealed the main reasons for forest losses in some hotspots to be increased agricultural conversion,fire,and the construction of highways.This information is useful for identifying the driving forces behind forest changes and to support environmental policy development in Myanmar. | Fu-Jiang Liu Chengquan Huang Yong Pang Mengxue Li Dan-Xia Song Xiao-Peng Song Saurabh Channan Joseph O.Sexton Die Jiang Ping Zhang Yan Guo Yao-Feng Li John R.Townshend | 2016 | International Journal of Digital Earth2016，9，6： | 1 |
| 4 | Anatomical traits associated with absorption and mycorrhizal colonization are linked to root branch order in twenty-three Chinese temperate tree species显示文摘 | Guo Dali Xia Mengxue Wei Xing | 2008 | New Phytologist2008，180，： | 1 |
| 5 | Anatomic',d traits associated with absorption and mycorrhizal colonization are linked to root branch order in twenty-three Chinese temperate tree species 显示文摘 | Guo Dali Xia Mengxue Wei Xing | 2008 | New Phytologist2008，180，： | 1 |
| 6 | Anatomical traits asso- ciated with absorption and mycorrhizal colonization are linked to root branch order in twenty-three Chinese temperate tree species 显示文摘 | Guo Dali Xia Mengxue Wei Xing | 2008 | New Phytologist2008，180，3： | 1 |
| 7 | Anatomical traits asso- ciated with absorption and mycorrhizal colonization are linked to root branch order in twenty-three Chinese temperate tree species 显示文摘 | Guo Dali Xia Mengxue Wei Xing | 2008 | New Phytologist2008，180，3： | 1 |
| 8 | A stretchable and adhesive ionic conductor based on polyacrylic acid and deep eutectic solvents显示文摘Hydrogels are a widely used ionic conductor in on-skin electronic and iontronic devices.However,hydrogels dehydrate in the open air and freeze at low temperatures,limiting their real applications when they are attached on skin or exposed to low temperatures.Polymer-ionic liquid gels can overcome these two obstacles,but synthetic ionic liquids are expensive and toxic.In this work,we present an ionic conductor based on polyacrylic acid(PAAc)and deep eutectic solvents(DESs)that well addresses the aforementioned challenges.We polymerize acrylic acid in DESs to get the PAAc–DES gel,which exhibits excellent stretchability(>1000%),high electrical conductivity(1.26 mS cm^(−1)),high adhesion to the skin(~100 Nm^(−1)),as well as good anti-drying and anti-freezing properties.We also demonstrate that the PAAc-DES gel can be used as an on-skin electrode to record the surface electromyographic signal with high signal quality,or as a transparent stretchable electrode in iontronic devices that can work at–20℃.We believe that the PAAc–DES gels are an ideal candidate as epidermal electrodes or transparent stretchable electrodes. | Gang Li Zhihao Deng Minkun Cai Kaixi Huang Mengxue Guo Ping Zhang Xingyu Hou Yuan Zhang Yueji Wang Yan Wang Xiang Wu Chuan Fei Guo | 2021 | npj Flexible Electronics2021，5，1： | 1 |
| 9 | Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge显示文摘Coronavirus disease 2019(COviD-19)was first reported three years ago,when a group of individuals were infected with the original SARS-CoV-2 strain,based on which vaccines were developed.Here,we develop six human monoclonal antibodies(mAbs)from two elite convalescents in Wuhan and show that these mAbs recognize diverse epitopes on the receptor binding domain(RBD)and can inhibit the infection of SARS-CoV-2 original strain and variants of concern(VOCs)to varying degrees,including Omicron strains XBB and XBB. | Qianyun Liu Haiyan Zhao Zhiqiang Li Zhen Zhang Rui Huang Mengxue Gu Ke Zhuang Qing Xiong Xianying Chen Weiyi Yu Shengnan Qian Yuzhen Zhang Xue Tan Muyi Zhang Feiyang Yu Ming Guo Zhixiang Huang Xin Wang Wenjie Xiang Bihao Wu Fanghua Mei Kun Cai Limin Zhou Li Zhou Ying Wu Huan Yan heng Cao Ke Lan Yu Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 10 | Generation of CRISPR/Cas9-mediated lactoferrin-targeted mice by pronuclear injection of plasmid pX330显示文摘Lactoferrin is a member of the transferrin family of multifunctional iron binding glycoproteins.While numerous physiological functions have been described for lactoferrin,the mechanisms underlying these functions are not clear.To further study the functions and mechanisms of lactoferrin,we modified the lactoferrin promoter of mice using the CRISPR/Cas9 system to reduce or eliminate lactoferrin expression.Seven mice with lactoferrin promoter mutations were obtained with an efficiency of 24%(7/29)by injecting the plasmid pX330,expressing a small guide RNA and human codonoptimized SpCas9,into fertilized eggs of mice.Plasmid integration and off-targeting of pX330 were not detected.These results confirmed that pronuclear injection of a circular plasmid is a feasible and efficient method for targeted mutagenesis in mice. | Mengxu GE Fei LIU Fei CHANG Zhaolin SUN Jing FEI Ying GUO Yunping DAI Zhengquan YU Yaofeng ZHAO Ning LI Qingyong MENG | 2015 | Frontiers of Agricultural Science and Engineering2015，2，3： | 0 |
| 11 | Rapid screening of SARS-CoV-2 inhibitors via ratiometric fluorescence of RBD–ACE2 complexes in living cells by competitive binding显示文摘To the Editor:The current coronavirus disease-19(COVID-19)pandemic spurs the development of antiviral drugs for SARS-CoV-2,as the number of patients with viral infections continues to rise globally in the context of widespread vaccination.Targeting the interaction between the receptor binding domain(RBD)of SARS-CoV-2 spike protein and the host cell ACE2 is a promising therapeutic strategy to effectively inhibit viral entry. | Lu Miao Wei Zhou Chunyu Yan Yuebin Zhang Qinglong Qiao Xuelian Zhou Yingzhu Chen Guangying Wang Zhendong Guo Jun Liu Hailong Piao Xia Pan Mengxue Yan Weijie Zhao Guohui Li Yueqing Li Zhaochao Xu | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 0 |
| 12 | Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms显示文摘Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon rupture.Currently,there is no approved drug therapy for AAA.Surgical repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed cases.It is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA progression.We contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery methods.There is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and progression.In this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic target.Indeed,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in vivo.In parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug delivery.This NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of AAA.In summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA. | Nisakorn Yodsanit Takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric William Kent Yuyuan Wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi Huang Nicholas Hoyt Mengxue Zhang John A.Hossack Morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong Bowen Wang | 2023 | Bioactive Materials2023，，8： | 0 |
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