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| 1 | Press-pack IGBTs for HVDC and FACTS显示文摘The popularity of insulated gate bipolar transistors(IGBTs)for use in high-voltage direct current(HVDC)transmission and flexible AC transmission systems(FACTS)is increasing.Unfortunately,for these applications wire-bond IGBT technology has a number of shortcomings,such as insufficient current ratings for the most powerful schemes,and inability to fail to short-circuit.Press-pack IGBT technology,conversely,offers increased current ratings,and an inherent short-circuit failure mode,making it a more attractive choice for HVDC and FACTS.However,the design and manufacture of these devices requires a comprehensive understanding of the unique technical challenges,which differ markedly from those for wirebond modules or traditional pressure contact devices.Specific challenges include providing a high degree of mechanical protection for the IGBT chip against normal operating stresses.Furthermore,it is essential to achieve uniform contact pressure across each chip surface to ensure optimum performance.To achieve this,manufacturers have designed products that use rigid copper electrodes manufactured to tighter tolerances than for other pressure contact devices,such as thyristors,and products that use compliant electrodes,incorporating spring assemblies.Dynex is in the advanced stages of development of press-pack IGBT technology with demonstrated robust solutions for the technical challenges outlined in this paper.Design success has been achieved through the use of state-of-the-art simulations in conjunction with a long history of manufacturing expertise for bipolar and IGBT products.Finally,multiple press-pack IGBT variants are currently undergoing evaluation tests prior to product release. | Robin Simpson Ashley Plumpton Michael Varley Charles Tonner Paul Taylor Xiaoping Dai | 2017 | CSEE Journal of Power and Energy Systems2017，3，3： | 10 |
| 2 | Intratidal and neap-spring variations of suspended sediment concentrations and sediment transport processes in the North Branch of the Changjiang Estuary显示文摘Profiles of tidal current and suspended sediment concentration(SSC) were measured in the North Branch of the Changjiang Estuary from neap tide to spring tide in April 2010. The measurement data were analyzed to determine the characteristics of intratidal and neap-spring variations of SSC and suspended sediment transport. Modulated by tidal range and current speed, the tidal mean SSC increased from 0.5 kg/m3 in neap tide to 3.5 kg/m3 in spring tide. The intratidal variation of the depth-mean SSC can be summarized into three types: V-shape variation in neap tide, M-shape and mixed M-V shape variation in medium and spring tides. The occurrence of these variation types is controlled by the relative intensity and interaction of resuspension, settling and impact of water exchange from the rise and fall of tide. In neap tide the V-shape variation is mainly due to the dominant effect of the water exchange from the rise and fall of tide. During medium and spring tides, resuspension and settling processes become dominant. The interactions of these processes, together with the sustained high ebb current and shorter duration of low-tide slack, are responsible for the M-shape and M-V shape SSC variation. Weakly consolidated mud and high current speed cause significant resuspension and remarkable flood and ebb SSC peaks. Settling occurs at the slack water periods to cause SSC troughs and formation of a thin fluff layer on the bed. Fluxes of water and suspended sediment averaged over the neap-spring cycle are all seawards, but the magnitude and direction of tidal net sediment flux is highly variable. | LI Zhanhai LI Michael Z DAI Zhijun ZHAO Fangfang LI Jiufa | 2015 | Acta Oceanologica Sinica2015，34，1： | 9 |
| 3 | Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference显示文摘Mesenchymal stem cells(MSCs)are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic,chondrogenic and adipogenic lineages.We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood.Here,we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs.Using two different siRNA bioinformatic prediction programs,we design five siRNAs targeting mouse BMP9(or simB9),which are expressed under the control of the converging H1 and U6 promoters in recombinant adenovirus vectors.We demonstrate that two of the five siRNAs,simB9-4 and simB9-7,exhibit the highest efficiency on silencing exogenous mouse BMP9 in MSCs.Furthermore,simB9-4 and simB9-7 act synergistically in inhibiting BMP9-induced expression of osteogenic markers,matrix mineralization and ectopic bone formation from MSCs.Thus,our findings demonstrate the important role of BMP9 in osteogenic differentiation of MSCs.The characterized simB9 siRNAs may be used as an important tool to investigate the molecular mechanism behind BMP9 osteogenic signaling.Our results also indicate that recombinant adenovirus-mediated expression of siRNAs is efficient and sustained,and thus may be used as an effective delivery vehicle of siRNA therapeutics. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C.Haydon Michael J.Lee Russell R.Reid Jennifer Moriatis Wolf Qiong Shi Hue H.Luu Tong-Chuan He Yaguang Weng | 2018 | Genes & Diseases2018，5，2： | 8 |
| 4 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 5 | Nickel-coated silicon photocathode for water splitting in alkaline electrolytes显示文摘切开的 Photoelectrochemical (PEC ) 水是一条有希望的途径收获并且存储太阳能[1 ] 。硅广泛地由于它匹配太阳的光谱的合适的乐队差距(1.12 eV ) 为 PEC photoelectrodes 被调查了[2 ] 。这里,我们调查作为催化剂两个都采用镍并且第一次在基本电解质为 photoelectrochemical 氢进化保护 p 类型硅光阴极的层。硅光阴极被在 5 nm Ni 跟随的 p 类型硅晶片上扔 15 nm Ti 做。光阴极在碱的答案(1 M KOH ) 负担得起 0.3 V 对可逆的氢电极(RHE ) 的一个发作潜力。Ni/Ti/p-Si 光阴极的稳定性在 KOH 在 12 h 上看了 100 mV 腐烂,但是稳定性显著地被改进光阴极什么时候在钾硼酸盐缓冲区答案被操作(pH 9.5 ) 。电极表面被发现在 10 妈 / 厘米的经常的当前的密度在连续操作的 12 h 以后仍然保持未经触动 < 啜 class= “ a-plus-plus ” > 在钾硼酸盐缓冲区的 2 ,建议 Ni 负担得起 Si 的好保护在硼酸盐缓冲区基于光阴极。 | Ju Feng Ming Gong Michael J. Kenney Justin Z. Wu Bo Zhang Yanguang Li Hongjie Dai | 2015 | Nano Research2015，8，5： | 6 |
| 6 | Millisecond synthesis of CoS nanopartides for highly efficient overall water splitting显示文摘High performance and low-cost electrocatalysts for overall water splitting,i.e.,catalyzing hydrogen and oxygen evolution reactions with the same material,are of great importance for large-scale,renewable energy conversion processes.Here,we report an ultrafast(~7 ms)synthesis tech nique for tran sition metal chalcoge nide n anoparticles assisted by high temperature treatme nt.As a proof of con cept,we dem on strate that cobalt sulfide(~20 nm in diameter)@few-layer graphe ne(~2 nm in thick ness)core-shell nan oparticles embedded in RGO nano sheets exhibit remarkable bifunctional electrocatalytic activity and stability for overall water splitting,which is comparable to commercial 40 wt.%platinum/carbon(Pt/C)electrocatalysts.After 60 h of continuous operation,10 mA crrT?water splitting current density can still be achieved at a low potential of^1.77 V without any activity decay,which is among the most active for non-noble material based electrocatalysts.The presented study provides prospects in synthesizing highly efficient bifunctional electrocatalysts for large-scale energy conversion application via a simple yet efficient technique. | Yanan Chen Shaomao Xu Shuze Zhu Rohit Jiji Jacob Glenn Pastel Yanbin Wang Yiju Li Jiaqi Dai Fengjuan Chen Hua Xie Boyang Liu Yonggang Yao Lourdes G. Salamanca-Riba Michael R. Zachariah Teng Li Liangbing Hu | 2019 | Nano Research2019，12，9： | 6 |
| 7 | Executive Summary: Heart Disease and Stroke Statistics— 2010 Update: A Report From the American Heart Association显示文摘 | Donald Lloyd-Jones Robert J. Adams Todd M. Brown Mercedes Carnethon Shifan Dai Giovanni De Simone T. Bruce Ferguson Earl Ford Karen Furie Cathleen Gillespie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern P. Michael Ho Virginia Howard Brett Kissela Stev | 2010 | Circulation2010，，7： | 5 |
| 8 | An electrodeposition approach to metal/metal oxide heterostructures for active hydrogen evolution catalysts in near-neutral electrolytes显示文摘Neutral water splitting is attractive for its use of non-corrosive and environmentally friendly electrolytes.However,catalyst development for hydrogen and oxygen evolution remains a challenge under neutral conditions.Here we report a simple electrodeposition and reductive annealing procedure to produce a highly active Ni-Co-Cr metal/metal oxide heterostructured catalyst directly on Ni foam.The resulting electrocatalyst for hydrogen evolution reaction (HER) requires only 198 mV of overpotential to reach 100 mNcm2 in 1 M potassium phosphate (pH =7.4) and can operate for at least two days without significant performance decay.Scanning transmission electron microscopy coupled with electron energy loss spectroscopy (STEM-EELS) imaging reveals a Ni-Co alloy core decorated with blended oxides layers of NiO,CoO and Cr2O3.The metal/metal oxide interfaces are suggested to be responsible for the high HER activity. | Michael J.Kenney Jianan Erick Huang Yong Zhu Yongtao Meng Mingquan Xu Guanzhou Zhu Wei-Hsuan Hung Yun Kuang Mengchang Lin Xiaoming Sun Wu Zhou Hongjie Dai | 2019 | Nano Research2019，12，6： | 4 |
| 9 | Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea显示文摘AIM: To validate 4-sample lactose hydrogen breath testing(4SLHBT) compared to standard 13-sample LHBT in the clinical setting.METHODS: Irritable bowel syndrome patients with diarrhea(IBS-D) and healthy volunteers(HVs) were enrolled and received a 10 g, 20 g, or 40 g doselactose hydrogen breath test(LHBT) in a randomized, double-blinded, controlled trial. The lactase gene promoter region was sequenced. Breath samples and symptoms were acquired at baseline and every 15 min for 3 h(13 measurements). The detection rates of lactose malabsorption(LM) and lactose intolerance(LI) for a 4SLHBT that acquired four measurements at 0, 90, 120, and 180 min from the same data set were compared with the results of standard LHBT.RESULTS: Sixty IBS-D patients and 60 HVs were studied. The genotype in all participants was C/C-13910. LM and LI detection rates increased with lactose dose from 10 g, 20 g to 40 g in both groups(P < 0.001). 4SLHBT showed excellent diagnostic concordance with standard LHBT(97%-100%, Kappa 0.815-0.942) with high sensitivity(90%-100%) and specificity(100%) at all three lactose doses in both groups.CONCLUSION: Reducing the number of measurements from 13 to 4 samples did not significantly impact on the accuracy of LHBT in health and IBS-D. 4SLHBT is a valid test for assessment of LM and LI in clinical practice. | Jian-Feng Yang Mark Fox Hua Chu Xia Zheng Yan-Qin Long Daniel Pohl Michael Fried Ning Dai | 2015 | World Journal of Gastroenterology2015，21，24： | 4 |
| 10 | Prevalence and Presentation of Lactose Intolerance and Effects on Dairy Product Intake in Healthy Subjects and Patients With Irritable Bowel Syndrome显示文摘 | Jianfeng Yang Yanyong Deng Hua Chu Yanqun Cong Jianmin Zhao Daniel Pohl Benjamin Misselwitz Michael Fried Ning Dai Mark Fox | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 11 | Inquiry-Based Learning in China:Do Teachers Practice What They Preach,and Why?显示文摘China is undergoing an education reform that calls for a change from a rigid,fixed curriculum and didactic pedagogy to a more flexible,school-based curriculum and more inquiry-based pedagogy.This study investigated the extent to which Chinese middle and high school teachers(a)endorse an inquiry-based approach and underlying learning principles,(b)practice this mode of teaching,and(c)believe that the approach is practically viable in the current educational contexts in China.A structured survey was developed to solicit Chinese teachers’responses to the above three issues.A total of 582 valid responses were collected,representing middle and high schools in different geographic locations.The results show that Chinese teachers are receptive to inquiry-based pedagogy but find practical constraints in fully implementing it.Several cultural and pragmatic reasons are explored.Policy implications are discussed with respect to teacher education/development,capacity building for the new pedagogy,and teaching/evaluation alignment.Finally cultural issues are discussed regarding using inquiry-based learning to enhance critical thinking and nurture independent thinkers. | David Yun DAI Kathryn A.GERBINO Michael J.DALEY | 2011 | Frontiers of Education in China2011，6，1： | 2 |
| 12 | Implantation of trabecular micro-bypass stent using a novel “landing strip” technique显示文摘AIM:To describe a novel technique of creating a landing strip within the trabecular meshwork to guide trabecular micro-bypass stent(iStent) implantation in patients who underwent phacoemulsification.METHODS:Thirty-four eyes from 30 patients who underwent i Stent implantation after phacoemulsification from May 2014 to February 2015 were included in our retrospective study. All iStents were implanted via the 'landing strip' technique. A 25-gauge microvitreoretinal blade was used to bisect the trabecular meshwork to less than 1 clock-hour, effectively creating a landing strip. The iStent applicator was pressed along the landing strip and then the stent was released into the trabecular meshwork. RESULTS:Of the 34 eyes with iStent implantation, 27(79.4%) eyes had primary open-angle glaucoma, 6(17.6%) eyes had pseudoexfoliation glaucoma, and 1(2.9%) eye had ocular hypertension. At 6-month follow-up(n=17), the mean number of hypotensive medications decreased from 2.2±1.2 at baseline to 0.8±1.3(P=0.05) and mean intraocular pressure decreased from 19.7±4.1 mm Hg at baseline to 16.7±2.1 mm Hg(P=0.58). Two eyes(5.9%) required subsequent trabeculectomy. CONCLUSION:The 'landing strip' technique appears to be an effective way to assist with iS tent implantation. | Cindy X.Zheng Marlene R.Moster Priyanka Gogte Yang Dai Remy S.Manzi Michael Waisbourd | 2017 | International Journal of Ophthalmology(English edition)2017，10，5： | 2 |
| 13 | The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin显示文摘 | Simon R. Smukler Margot E. Arntfield Rozita Razavi George Bikopoulos Phillip Karpowicz Raewyn Seaberg Feihan Dai Simon Lee Rosemary Ahrens Paul E. Fraser Michael B. Wheeler Derek van der Kooy | 2011 | Cell Stem Cell2011，，3： | 2 |
| 14 | Cell atlas of CCl_(4)-induced progressive liver fibrosis reveals stage-specific responses显示文摘Chronic liver injury leads to progressive liver fibrosis and ultimately cirrhosis,a major cause of morbidity and mortality worldwide.However,there are currently no effective anti-fibrotic therapies available,especially for latestage patients,which is partly attributed to the major knowledge gap regarding liver cell heterogeneity and cellspecific responses in different fibrosis stages.To reveal the multicellular networks regulating mammalian liver fibrosis from mild to severe phenotypes,we generated a single-nucleus transcriptomic atlas encompassing 49919nuclei corresponding to all main liver cell types at different stages of murine carbon tetrachloride(CCl_(4))-induced progressive liver fibrosis.Integrative analysis distinguished the sequential responses to injury of hepatocytes,hepatic stellate cells and endothelial cells.Moreover,we reconstructed the cell-cell interactions and gene regulatory networks implicated in these processes.These integrative analyses uncovered previously overlooked aspects of hepatocyte proliferation exhaustion and disrupted pericentral metabolic functions,dysfunction for clearance by apoptosis of activated hepatic stellate cells,accumulation of pro-fibrotic signals,and the switch from an anti-angiogenic to a pro-angiogenic program during CCl_(4)-induced progressive liver fibrosis.Our dataset thus constitutes a useful resource for understanding the molecular basis of progressive liver fibrosis using a relevant animal model. | Peng-Cheng Guo Jing Zuo Ke-Ke Huang Guang-Yao Lai Xiao Zhang Juan An Jin-Xiu Li Li Li Liang Wu Yi-Ting Lin Dong-Ye Wang Jiang-Shan Xu Shi-Jie Hao Yang Wang Rong-Hai Li Wen Ma Yu-Mo Song Chang Liu Chuan-Yu Liu Zhen Dai Yan Xu Amar Deep Sharma Michael Ott Qing Ou-Yang Feng Huo Rong Fan Yong-Yin Li Jin-Lin Hou Giacomo Volpe Long-Qi Liu Miguel A.Esteban Yi-Wei Lai | 2023 | Zoological Research2023，44，3： | 1 |
| 15 | Heart Disease and Stroke Statistics— 2010 Update: A Report From the American Heart Association显示文摘 | Donald Lloyd-Jones Robert J. Adams Todd M. Brown Mercedes Carnethon Shifan Dai Giovanni De Simone T. Bruce Ferguson Earl Ford Karen Furie Cathleen Gillespie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern P. Michael Ho Virginia Howard Brett Kissela Stev | 2010 | Circulation2010，，7： | 1 |
| 16 | Effect of Hypercarbia and Isoflurane on Brain Cell Death and Neurocognitive Dysfunction in 7-day-old Rats显示文摘 | Greg Stratmann Laura D. V. May Jeffrey W. Sall Rehan S. Alvi Joseph S. Bell Brandi K. Ormerod Vinuta Rau Joan F. Hilton Ran Dai Michael T. Lee Kavel H. Visrodia Ban Ku Emanuel J. Zusmer Jeremy Guggenheim Atoosa Firouzian | 2009 | Anesthesiology2009，，4： | 1 |
| 17 | High-Performance Silicon Photoanodes Passivated with Ultrathin Nickel Films for Water Oxidation显示文摘 | Michael J. Kenney Ming Gong Yanguang Li Justin Z. Wu Ju Feng Mario Lanza Hongjie Dai | 2013 | Science2013，，6160： | 1 |
| 18 | The Beijing four-component density functional program package (BDF) and its application to EuO, EuS, YbO and YbS显示文摘 | Wenjian Liu Gongyi Hong Dadi Dai Lemin Li Michael Dolg | 1997 | Theoretical Chemistry Accounts1997，，2： | 1 |
| 19 | Heart Disease and Stroke Statistics— 2010 Update: A Report From the American Heart Association显示文摘 | Donald Lloyd-Jones Robert J. Adams Todd M. Brown Mercedes Carnethon Shifan Dai Giovanni De Simone T. Bruce Ferguson Earl Ford Karen Furie Cathleen Gillespie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern P. Michael Ho Virginia Howard Brett Kissela Stev | 2010 | Circulation2010，，7： | 1 |
| 20 | Oxidative Stress Measured by Urine F2-Isoprostane Level is Associated With Prostate Cancer显示文摘 | Daniel A. Barocas Saundra Motley Michael S. Cookson Sam S. Chang David F. Penson Qi Dai Ginger Milne L. Jackson Roberts Jason Morrow Raoul S. Concepcion Joseph A. Smith Jay H. Fowke | 2011 | The Journal of Urology2011，，6： | 1 |
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