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| 1 | Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2. | 杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH | 2004 | Journal of Microbiology and Immunology2004，2，4： | 5 |
| 2 | Uterine biology in pigs and sheep显示文摘There is a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling, implantation, regulation of gene expression by uterine epithelial and stromal cells, placentation and exchange of nutrients and gases. The uterus provide a microenvironment in which molecules secreted by uterine epithelia or transported into the uterine lumen represent histotroph required for growth and development of the conceptus and receptivity of the uterus to implantation. Pregnancy recognition signaling mechanisms sustain the functional lifespan of the corpora lutea (CL) which produce progesterone, the hormone of pregnancy essential for uterine functions that support implantation and placentation required for a successful outcome of pregnancy. It is within the peri-implantation period that most embryonic deaths occur due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. With proper placentation, the fetal fluids and fetal membranes each have unique functions to ensure hematotrophic and histotrophic nutrition in support of growth and development of the fetus. The endocrine status of the pregnant female and her nutritional status are critical for successful establishment and maintenance of pregnancy. This review addresses the complexity of key mechanisms that are characteristic of successful reproduction in sheep and pigs and gaps in knowledge that must be the subject of research in order to enhance fertility and reproductive health of livestock species. | Fuller W Bazer Gwonhwa Song Jinyoung Kim Kathrin A Dunlap Michael Carey Satterfield Gregory A Johnson Robert C Burghardt Guoyao Wu | 2012 | Journal of Animal Science and Biotechnology2012，3，3： | 3 |
| 3 | In vivo anti-tumor activity of murine hematopoietic stem cells expressing a p185HER2-specific chimeric T-cell receptor gene显示文摘We have confirmed efficient anti-tumor activities of the peripheral lymphocytes transduced with a p185HER2-specific chimeric T-cell receptor gene both in murine and in human in our previous studies. To further test the feasibility of chimeric T-cell receptor in a bone marrow transplantation model, we first, made two murine tumor cell lines: MT901 and MCA-205, to express human p185HER2 by retroviral gene transduction. Murine bone marrow cells were retrovirally transduced to express the chimeric T-cell receptor and gene-modified bone marrow cells were transplanted into lethally irradiated mouse. Six months post transplantation, p185HER2-positive tumor cells:MT-901/HER2 or MCA-205/ HER2 was subcutaneously or intravenously injected to make mouse models simulating primary breast cancer or pulmonary metastasis. The in vivo anti-tumor effects were monitored by the size of the subcutaneous tumor or counting the tumor nodules in the lungs after India ink staining. The size of the subcutaneous tumor was significantly inhibited and the number of pulmonary nodules were significantly decreased in mouse recipients transplanted with chimeric T-cell receptor modified bone marrow cells compared with the control group. Our results suggest the efficient in vivo anti-tumor activities of chimeric T-cell receptor gene modified bone marrow cells. | JIAN MIN YANG MICHAEL S FRIEDMAN MARIANNE T HUBEN JENNIFER FULLER QIAO LI ALFRED E CHANG JAMES J MULE KEVIN T MCDONAGH | 2006 | Journal of Microbiology and Immunology2006，4，2： | 3 |
| 4 | Using clustering and classification approaches in interactive retrieval显示文摘 | Ming Fang Wu Michael Fuller Ross Wilkinson | | Infor mation Processing Management0，37，3： | 1 |
| 5 | Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial显示文摘 | Helen M Colhoun D John Betteridge Paul N Durrington Graham A Hitman H Andrew W Neil Shona J Livingstone Margaret J Thomason Michael I Mackness Valentine Charlton-Menys John H Fuller | 2004 | The Lancet . 2004 (9435)2004，，9435： | 1 |
| 6 | Stem Cells and Cancer: Two Faces of Eve显示文摘 | Michael F. Clarke Margaret Fuller | 2006 | Cell2006，，6： | 1 |
| 7 | Functional expression of olfactory-adrenergic receptor chimeras and intracellular retention of heterologously expressed olfactory receptors显示文摘 | Timothy S McClintock Teresa M Landers Alexander A Gimelbrant Lynn Z Fuller Brian A Jackson Channa K Jayawickreme Michael R Lerner | 1997 | Molecular Brain Research1997，，2： | 1 |
| 8 | The radial artery in coronary surgery: a 5-year experience—clinical and angiographic results显示文摘 | James Tatoulis Alistair G Royse Brian F Buxton John A Fuller Peter D Skillington John C Goldblatt Robin P Brown Michael A Rowland | 2002 | The Annals of Thoracic Surgery2002，，： | 1 |
| 9 | An improved method for the in vitro evolution of aptamers and applications in protein detection and purification显示文摘 | Murphy Michael B Fuller Shirin T Richardson Paul M | 2005 | Nucleic Acids Res2005，31，18： | 1 |
| 10 | Stimulation of ‘stress-regulated'mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses显示文摘 | Clerk A Stephen J Fuller Ashour Michael | 1998 | J Biol Chem1998，273，13： | 1 |
| 11 | Using Clustering and Classification Approaches in Interactive Retrieval 显示文摘 | MingFang Wu Michael Fuller Ross Wilkinson | 2001 | Information Processing & Management2001，37，3： | 1 |
| 12 | Stimulation of ' stress - regulated' mitogen - activated protein kinases ( stress - activated protein kinases/c - Jun N - terminal kinases and p38 - mitogen - activated protein kinases) in perfused rat hearts by oxidative and other stresses显示文摘 | Clerk A Fuller SJ Michael A | 1998 | J Biol Chem1998，273，13： | 1 |
| 13 | A longitudinal study evaluating the effects of interferon-alpha therapy on cognitive and psychiatric function in adults with chronic hepatitis C显示文摘 | Marilyn Huckans Bret Fuller Viva Wheaton Sarah Jaehnert Carilyn Ellis Michael Kolessar Daniel Kriz Jeanne Renee Anderson Kristin Berggren Hannah Olavarria Anna W. Sasaki Michael Chang Kenneth D. Flora Jennifer M. Loftis | 2014 | Journal of Psychosomatic Research2014，，： | 1 |
| 14 | The radial artery in coronary surgery: a 5-year experience—clinical and angiographic results显示文摘 | James Tatoulis Alistair G Royse Brian F Buxton John A Fuller Peter D Skillington John C Goldblatt Robin P Brown Michael A Rowland | 2002 | The Annals of Thoracic Surgery2002，，1： | 1 |
| 15 | Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial显示文摘 | Helen M Colhoun D John Betteridge Paul N Durrington Graham A Hitman H Andrew W Neil Shona J Livingstone Margaret J Thomason Michael I Mackness Valentine Charlton-Menys John H Fuller | 2004 | The Lancet2004，，9435： | 1 |
| 16 | Stimulation of 'stress-regulated' mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and P38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses 显示文摘 | Fuller SJ Michael A | 1998 | J Biol Chem1998，273，13： | 1 |
| 17 | Stimulation of ' stress - regulated' mitogen - activated protein kinase ( stress - activated protein kinases/c -Jun N -terminal kinases and p38 - mitogen - activated protein kinases) in perfused rat hearts by oxidative and other stresses 显示文摘 | CLERK A FULLER S J MICHAEL A | 1998 | J Biol Chem1998，273，： | 1 |
| 18 | DNA vaccines : protective immunizations by parenteral, mucosal and gcne - gun inoculations 显示文摘 | Michael WC Webster RG Fuller | 1993 | Proc Natl Sei USA1993，90，11： | 1 |
| 19 | Using Clustering and Classification Approaches in Interactive Retrieval显示文摘 | MingFang Wu Michael Fuller Ross Wilkinson | 2001 | Information Processing & Management(S0306-4573)2001，37，3： | 1 |
| 20 | An improved method for the in vitro evolution of aptamers and applications in protein detection and purification 显示文摘 | Murphy Michael B Fuller Shirin T Richardson PaulM | 2005 | Nucleic Acids Res2005，31，18： | 1 |
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