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| 1 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 2 | Growth patterns and metastatic behavior of human tumors growing in athymic mice显示文摘 | Kyriazis AP Di PL Michael GJ | 1978 | Cancer Research1978，38，10： | 1 |
| 3 | Caveolin-1, TGF-β receptor internalization, and the pathogenesis ofsystemic sclerosis 显示文摘 | Francesco DG Michael PL Sergio AJ | 2008 | Curr Opin Rheumatol2008，20，6： | 1 |
| 4 | Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases显示文摘 | Cates CA Michael PL Stayrook KR | 1996 | Cancer Lett1996，110，12： | 1 |
| 5 | A further assessment of predictors of the child behavior in dental treatment 显示文摘 | Klorman R Michael R Hilpert PL | 1979 | J Dent Res1979，58，： | 1 |
| 6 | MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype显示文摘 | Frangogiannis NG Mendoza LH Ren G Akrivakis S Jackson PL Michael LH | 2003 | Am J Physiol Heart Circ Physiol2003，285，2： | 1 |
| 7 | Characterization of Endothelial Progenitor Cell Interactions with Human Tropoelastin 显示文摘 | Yu Y Wise SG Michael PL | 2015 | PLoS One2015，10，01： | 1 |
| 8 | Burnout as a crisis in self-efficacy:Conceptual and practical implications显示文摘 | Michael PL | 1992 | Work Stress1992，6，2： | 1 |
| 9 | Reboxitine: a review of efficacy and tolerability显示文摘 | Delgado PL Michaels T | 1999 | Drugs Today1999，35，9： | 1 |
| 10 | CAPRIE trial 显示文摘 | Andrew PD Michael PL | 1997 | Lancet1997，349，2： | 1 |
| 11 | Addition of gabapentin to a modified FOLFOX regimen does not reduce oxaliplatin-induced neurotoxicity显示文摘 | Mitchell PL Goldstein D Michael M | 2006 | Clin Colorectal Cancer2006，6，2： | 1 |
| 12 | Elevated depressive af- fect is associated with adverse cardiovascular outcomes among African Americans with chronic kidney disease 显示文摘 | Michael J Fischer PL Kimmel | 2011 | Kidney Int2011，80，6： | 1 |
| 13 | Mussel inspired protein-mediated surface modification to electrospun fibers and their potential biomedical applications 显示文摘 | Xie J Michael PL Zhong S | 2012 | Journal of Biomedical Materials Research Part A2012，，100： | 1 |
| 14 | Job burnout 显示文摘 | MASLAEH C WILMAR BS MICHAEL PL | 2001 | Annual Review of Psychology2001，52，1： | 1 |
| 15 | Prognostic relevance of CA 19-9, CEA, CLIP, and LDH kinetics in patients treated with palliative second-line therapy for advanced pancreatic cancer显示文摘 | Michael H Rudiger PL Petra S | 2010 | Tumor Biol2010，31，4： | 1 |
| 16 | Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorbtion 显示文摘 | Michael H Harkonen PL Vaananen HK | 2005 | J Bone Miner Res2005，20，12： | 1 |
| 17 | In vitro studies of the combination of imatiniv mesylate and arsenic trioxide in chronic myelogenous leukemia显示文摘 | Rosee PL Johnson K Michael E | 2002 | Exp Hematol2002，30，： | 1 |
| 18 | Alcoholic hepatitis显示文摘 | Michael R Mathurin PL | 2009 | NEJM2009，360，10： | 1 |
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