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| 1 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 2 | Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer显示文摘 | Masahito Tachibana Paula Amato Michelle Sparman Nuria Marti Gutierrez Rebecca Tippner-Hedges Hong Ma Eunju Kang Alimujiang Fulati Hyo-Sang Lee Hathaitip Sritanaudomchai Keith Masterson Janine Larson Deborah Eaton Karen Sadler-Fredd David Battaglia David L | 2013 | Cell2013，，6： | 2 |
| 3 | Mesenchymal stromal cells may enhance metastasis of neuroblastoma via SDF-1/CXCR4 and SDF-1/CXCR7 signaling显示文摘 | Ming Ma Jie Yu Ye Ruixia Deng Cathleen Michelle Dee Godfrey Chi-Fung Chan | 2011 | Cancer Letters2011，，1： | 2 |
| 4 | HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells显示文摘 | Jie Ma Annamaria Altomare Michele Guarino Michele Cicala Florian Rieder Claudio Fiocchi Dan Li Weibiao Cao Jose Behar Piero Biancani Karen M. Harnett | 2012 | AJP: Gastrointestinal and Liver Physiology2012，，5： | 2 |
| 5 | Applications of entropic spanning graphs 显示文摘 | Hero A Ma B Michel O | 2002 | IEEE Signal Processing Magazine2002，19，5： | 1 |
| 6 | Antiatherosclerotic activity of inhibitors of 3-hydroxy-3methylglutaryl coenzyme A reductase in cholesterol-fed rabbits:a biochemical and morphological evaluation显示文摘 | Thomas MA Bacan Michelle J Mazur Sandra Back Mueller | 1994 | Atherosclerosis1994，111，： | 1 |
| 7 | MELD or MELD-Na as a Predictive Model for Mortality Following Transjugular Intrahepatic Portosystemic Shunt Placement显示文摘Background and Aim:The model for end-stage liver disease(MELD)was originally developed to predict survival after transjugular intrahepatic portosystemic shunt(TIPS).The MELD-sodium(MELD-Na)score has replaced MELD for organ allocation for liver transplantation.However,there are limited studies to compare the MELD with MELD-Na to predict mortality after TIPS.Methods:We performed a retrospective chart review of patients who underwent TIPS placement between 2006 and 2016 at our institution.The primary outcome was mortality,and the secondary outcomes sought to assess which variables could provide prognostic information for mortality after TIPS placement.We performed receiver operating characteristic(ROC)curve analysis to assess the performance of MELD and MELD-Na.Results:There were 186 eligible patients in the analysis.The mean pre-TIPS MELD and MELD-Na were 13 and 15,respectively.Overall,mortality after TIPS was 15%at 30 days and 16.7%at 90 days.In a comparison of the areas under the ROCs for MELD and MELD-Na,MELD was superior to MELD-Na for 30-day(0.762 vs.0.709)and 90-day(0.780 vs.0.730)mortality after TIPS.The optimal cutoff score for 30-day mortality was 15(0.676–0.848)for MELD and 17(0.610–0.808)for MELD-Na,whereas the optimal cutoff score for 90-day mortality was 16(95%CI:0.705–0.855)for MELD and 17(95%CI:0.643–0.817)for MELDNa.There were 24 patients with high MELD-Na≥17,but with low MELD<15,and 90-day mortality in this group was 8.3%.Conclusions:Although MELD-Na is a superior prognostic tool to MELD for predicting overall mortality in cirrhotic patients,MELD tended to outperform MELD-Na to predict mortality after TIPS. | Arunkumar Krishnan Tinsay A.Woreta Dhananjay Vaidya Yisi Liu James P.Hamilton Kelvin Hong Alia Dadabhai Michelle Ma | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 1 |
| 8 | Permanent cerebral hypoperfusion: breconditioning-like'effects on rat energy metabolism towards acute systemic hypotension 显示文摘 | Plaschke K Weigand MA Michel A | 2000 | Brain Res2000，858，2： | 1 |
| 9 | Three dimensional computed tomography angiography in imaging jugular foramen lesions显示文摘 | Cristobal R Metts B Michel MA | 2007 | Otol Neurotol2007，28，3： | 1 |
| 10 | The relationship be- tween meniscal tears and meniscal position显示文摘 | Deborah MA Ling L Michel DC | 2010 | Ther Adv Musculoskelet Dis2010，2，6： | 1 |
| 11 | Effect of changes in weight-bearing exercise on lumber bone mass after age fifty显示文摘 | Michel BA Lane NE Bloch MA | 1991 | Ann Med1991，23，4： | 1 |
| 12 | VSL #3<sup>?</sup> probiotic therapy does not reduce portal pressures in patients with decompensated cirrhosis显示文摘 | Saumya Jayakumar Michelle Carbonneau Naomi Hotte A. Dean Befus Chris St. Laurent Richard Owen Mairin McCarthy Karen Madsen Robert J. Bailey Mang Ma Vince Bain Kevin Rioux Puneeta Tandon | 2013 | Liver Int2013，，10： | 1 |
| 13 | Cultural social support for Canadian aborigi- nal elite athletes during their sport development显示文摘 | Schinke RJ Eys MA Michel G Danielson R Pehier D Pheasant C | 2006 | Internation- al Journal of Sport Psychology2006，，4： | 1 |
| 14 | Intraocular pressure measurement after pars plana vitrectomy 显示文摘 | Del prior LV Michels RG William MA | 1989 | Ophthalmology1989，96，9： | 1 |
| 15 | Tear film dynamics and lipid layer characteristics—Effect of age and gender显示文摘 | Cécile Ma?ssa Michel Guillon | 2010 | Contact Lens and Anterior Eye2010，，4： | 1 |
| 16 | Assembly and specific recognition of k29- and k33-1inked polyubiquitin显示文摘 | Michel MA Elliott PR Swatek KN | 2015 | Mol Cell2015，58，1： | 1 |
| 17 | Three dimensional computed tomography angiography in im ng jugular foramen lesions显示文摘 | Cristobal R Metts B Michel MA | 2007 | Otology & Nearotology(Otol Neuro-tol)2007，28，3： | 1 |
| 18 | Permanent cerebral hypoperfusion:'preconditioning-like' effects on rat energy metabolism towards acute systemic hypotension显示文摘 | Plaschke K Weigand MA Michel A | | 0，，02： | 1 |
| 19 | Type 1 diabetes 显示文摘 | Atkinson MA Eisenbarth GS Michels AW | 2014 | Lancet2014，383，9911： | 1 |
| 20 | Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome显示文摘Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation.In an effort to unravel the basic principle underlying genome folding,here we focus on the genome itself and report a fundamental role for L1(LINE1 or LINE-1)and B1/Alu retrotransposons,the most abundant subclasses of repetitive sequences,in chromatin compartmentalization.We find that homotypic clustering of L1 and B1/Alu demarcates the genome into grossly exclusive domains,and characterizes and predicts Hi-C compartments.Spatial segregation of L1-rich sequences in the nuclear and nucleolar peripheries and B1/Alu-rich sequences in the nuclear interior is conserved in mouse and human cells and occurs dynamically during the cell cycle.In addition,de novo establishment of L1 and B1 nuclear segregation is coincident with the formation of higher-order chromatin structures during early embryogenesis and appears to be critically regulated by L1 and B1 transcripts.Importantly,depletion of L1 transcripts in embryonic stem cells drastically weakens homotypic repeat contacts and compartmental strength,and disrupts the nuclear segregation of L1-or B1-rich chromosomal sequences at genome-wide and individual sites.Mechanistically,nuclear co-localization and liquid droplet formation of L1 repeat DNA and RNA with heterochromatin protein HP1αsuggest a phase-separation mechanism by which L1 promotes heterochromatin compartmentalization.Taken together,we propose a genetically encoded model in which L1 and B1/Alu repeats blueprint chromatin macrostructure.Our model explains the robustness of genome folding into a common conserved core,on which dynamic gene regulation is overlaid across cells. | J.Yuyang Lu Lei Chang Tong Li Ting Wang Yafei Yin Ge Zhan Xue Han Ke Zhang Yibing Tao Michelle Percharde Liang Wang Qi Peng Pixi Yan Hui Zhang Xianju Bi Wen Shao Yantao Hong Zhongyang Wu Runze Ma Peizhe Wang Wenzhi Li Jing Zhang Zai Chang Yingping Hou Bing Zhu Miguel Ramalho-Santos Pilong Li Wei Xie Jie Na Yujie Sun Xiaohua Shen | 2021 | Cell Research2021，31，6： | 1 |
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