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| 1 | Preparation and characterization of quaternized chitosan/ poly(acrylontrile) composite nanofiltration membrane from anhydride mixture cross-linking显示文摘 | Ruihua Huang Guohua Chen Mingkun Sun | 2008 | Sep Purif Technol2008，58，3： | 1 |
| 2 | Studies on nanofiltration membrane formed by diisocyanate cross linking of quaternized chitosan on poly (acrylonitrile) (PAN) support 显示文摘 | Huang Ruihua Chen Guohua Sun Mingkun | 2006 | Journal of Membrane Science2006，286，12： | 1 |
| 3 | Preparation and characterization of quaterinized chitosan/poly (acrylonitrile) composite nanofiltration membrane from anhydride mixture crossdinking显示文摘 | Huang Ruihua Chen Guohua Sun Mingkun | 2008 | Separation and Purification Technology2008，58，3： | 1 |
| 4 | Preparation and characteristics of quaternized chitosan/poly(acrylonitrile) composite nanofiltration membrane from epichlorohydrin cross-linking显示文摘 | Huang Ruihua Chen Guohua Sun Mingkun | 2007 | Carbohydrate Polymers2007，70，： | 1 |
| 5 | Preparation and characterization of quaternized chitosan/poly (acrylonitrile) composite nanofiltration membrane from anhydride mixture cross-linking显示文摘 | Huang Ruihua Chen Guohua Sun Mingkun | 2008 | Separation and Purification Technology2008，58，： | 1 |
| 6 | Studies on Nanofiltration Membrane Formed by Diisocyanate Cross-Linking of Quaternized Chitosan on Poly (Acrylonitrile) (PAN) Support 显示文摘 | Huang Ruihua Chen Guohua Sun Mingkun | 2006 | J membr Sci2006，286，12： | 1 |
| 7 | Preparation and characterization of quaternized chitosan/poly(acrylontrile) composite nanofiltration membrane from anhydride mixture cross-linking显示文摘 | Ruihua Huang Guohua Chen Mingkun Sun | | 0，，3： | 1 |
| 8 | Stu-dies on nanofiltration membrane formed by diisocyanate cross-lin king of quaternized chitosan on poly (acrylonitrile) (PAN)support显示文摘 | Huang Ruihua Chen Guohua Sun Mingkun | 2006 | J Membrane Sci2006，286，12： | 1 |
| 9 | Studies on nanofiltration membrane formed by diisocyanate crosslinkingof quaternized chitosan on poly (aerylonltrile) (PAN) support 显示文摘 | Huang Ruihua Chen Guohua Sun Mingkun | 2006 | Journal of membrane Science2006，286，2： | 1 |
| 10 | Orlistat induces ferroptosis-like cell death of lung cancer cells显示文摘Aberrant de novo lipid synthesis is involved in the progression and treatment resistance of many types of cancers,including lung cancer;however,targeting the lipogenetic pathways for cancer therapy remains an unmet clinical need.In this study,we tested the anticancer activity of orlistat,an FDA-approved anti-obesity drug,in human and mouse cancer cells in vitro and in vivo,and we found that orlistat,as a single agent,inhibited the proliferation and viabilities of lung cancer cells and induced ferroptosis-like cell death in vitro.Mechanistically,we found that orlistat reduced the expression of GPX4,a central ferroptosis regulator,and induced lipid peroxidation.In addition,we systemically analyzed the genome-wide gene expression changes affected by orlistat treatment using RNA-seq and identified FAF2,a molecule regulating the lipid droplet homeostasis,as a novel target of orlistat.Moreover,in a mouse xenograft model,orlistat significantly inhibited tumor growth and reduced the tumor volumes compared with vehicle control(P<0.05).Our study showed a novel mechanism of the anticancer activity of orlistat and provided the rationale for repurposing this drug for the treatment of lung cancer and other types of cancer. | Wenjing Zhou Jing Zhang Mingkun Yan Jin Wu Shuo Lian Kang Sun Baiqing Li Jia Ma Jun Xia Chaoqun Lian | 2021 | Frontiers of Medicine2021，15，6： | 1 |
| 11 | Lysine acetylation regulates the activity of Escherichia coil pyridoxine 5'-phosphate oxidase显示文摘N 离氨酸 acetylation 是在优核质和初核质的最丰富的 translational 以后修正之一。Escherichia coli 的蛋白质 acetylome 用集体 spectrometry (MS ) 被屏蔽了技术,和许多 acetylated 蛋白质被识别了,包括维生素 5 磷酸盐 oxidase (EcPNPOx ) ,但是生物角色在 EcPNPOx 由离氨酸 acetylation 玩了仍然保持未知。在这研究, EcPNPOx 是第一 overexpressed 并且净化,并且二 acetylated 离氨酸残余被随后的液体层析双人脚踏车团 spectrometry 分析识别。指导地点的 mutagenesis 分析证明 acetylated 离氨酸残余在酶的活动和蛋白质的酶的性质起重要作用。EcPNPOx 能是 non-enzymatically 由乙酰磷酸盐的 acetylated 和由在 vitro 的 CobB 的 deacetylated。而且, acetylated 的酶的活动和 deacetylated EcPNPOx 在 vitro 被比较,并且结果证明 acetylation 导致了它的酶的活动的减少,它能被 CobB deacetylation 救。一起拿,我们的数据建议 CobB 在 vitro 调制 EcPNPOx 的酶的活动。 | Jing Gu Yuanyuan Chen Hongsen Guo Manluan Sun Mingkun Yang Xude Wang Xian'en Zhang Jiaoyu Deng | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 0 |
| 12 | Genomic Epidemiology of SARS-CoV-2 in Pakistan显示文摘COVID-19 has swept globally and Pakistan is no exception.To investigate the initial introductions and transmissions of the SARS-CoV-2 in Pakistan,we performed the largest genomic epidemiology study of COVID-19 in Pakistan and generated 150 complete SARS-CoV-2 genome sequences from samples collected from March 16 to June 1,2020.We identified a total of 347 mutated positions,31 of which were over-represented in Pakistan.Meanwhile,we found over 1000 intra-host single-nucleotide variants(iSNVs).Several of them occurred concurrently,indicating possible interactions among them or coevolution.Some of the high-frequency iSNVs in Pakistan were not observed in the global population,suggesting strong purifying selections.The genomic epidemiology revealed five distinctive spreading clusters.The largest cluster consisted of 74 viruses which were derived from different geographic locations of Pakistan and formed a deep hierarchical structure,indicating an extensive and persistent nation-wide transmission of the virus that was probably attributed to a signature mutation(G8371T in ORF1ab)of this cluster.Furthermore,28 putative international introductions were identified,several of which are consistent with the epidemiological investigations.In all,this study has inferred the possible pathways of introductions and transmissions of SARS-CoV-2 in Pakistan,which could aid ongoing and future viral surveillance and COVID-19 control. | Shuhui Song Cuiping Li Lu Kang Dongmei Tian Nazish Badar Wentai Ma Shilei Zhao Xuan Jiang Chun Wang Yongqiao Sun Wenjie Li Meng Lei Shuangli Li Qiuhui Qi Aamer Ikram Muhammad Salman Massab Umair Huma Shireen Fatima Batool Bing Zhang Hua Chen Yun-Gui Yang Amir Ali Abbasi Mingkun Li Yongbiao Xue Yiming Bao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 0 |
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