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| 1 | Self-assembly nanomicelle-microneedle patches with enhanced tumor penetration for superior chemo-photothermal therapy显示文摘Nanomedicine with high specificity has been a promising tool for cancer diagnosis and therapy.However,the successful application of nanoparticle-based superficial cancer therapy is severely hindered by restricted deep tumor tissue accumulation and penetration.Herein,a self-assembly nanomicelle dissolving microneedle(DMN)patch according to the“nano in micro”strategy was conducted to co-deliver a first-line chemotherapeutic agent paclitaxel(PTX),and a photosensitizer IR780(PTX/IR780-NMs@DMNs)for chemo-photothermal synergetic melanoma therapy.Upon direct insertion into the tumor site,DMNs created a regular and multipoint three-dimensional drug depot to maximize the tumor accumulation.Accompanied by the DMN dissolution,the composition of the needle matrixes self-assembled into nanomicelles,which could efficiently penetrate deep tumor tissue.Upon laser irradiation,the nanomicelles could not only ablate tumor cells directly by photothermal conversion but also trigger PTX release to induce tumor cell apoptosis.In vivo results showed that compared with intravenous injection,IR780 delivered by PTX/IR780-NMs@DMNs was almost completely accumulated at the tumor site.The antitumor results revealed that the PTX/IR780-NMs@DMNs could effectively eliminate tumors with an 88%curable rate without any damage to normal tissues.This work provides a versatile and generalizable framework for designing self-assembly DMN-mediated combination therapy to fight against superficial cancer. | Ying Sun Minglong Chen Dan Yang Wanbing Qin Guilan Quan Chuanbin Wu Xin Pan | 2022 | Nano Research2022，15，3： | 2 |
| 2 | Multiscale analysis of the contents of palmatine in the Nature populations of Phellodendron amurense in Northeast China显示文摘Palmatine is a valuable ingredient in Chinese medicine that is produced by Phellodendron amurense Rupr.The contents of palmatine content in root bark, trunk bark,perennial branch bark, annual branches, and leaves of the trees with different ages and geographies in Northeast China were measured by high-performance liquid chromatography.The contents of palmatine in the barks of root, trunk, and perennial branch were significantly higher than those in annual branches and leaves. The contents of palmatine in trunk bark and root bark from Lesser Khingan Mountains increased with age, which is significantly opposite to other three vegetation types. The contents of palmatine in perennial branch bark, annual bark and leaves had no significant regularity. Moreover, the contents of palmatine in samples of root bark, trunk bark, perennial branch bark and annual bark varied significantly with latitude. The nature populations of P. amurense growing at low latitude contained significantly more palmatine than those growing at high latitude. These results provide a scientific basis for the reasonable cultivation and efficient utilization of P. amurense. | Minglong Sun Lijiao Xu Yingli Peng Tong Liu Yuhong Zhang Zhiqiang Zhou | 2016 | Journal of Forestry Research2016，27，2： | 2 |
| 3 | Simulations of granular flow along an inclined plane using the Savage-Hutter model显示文摘In this work a velocity-dependent friction is introduced into a depth-averaged Savage-Hutter dynamical model for shallow granular flows. The process of granular material flowing along an inclined plane and then depositing on a horizontal plane is simulated. The surface profiles and evolution of various types of energy are investigated and compared when using the standard Coulomb-type friction versus velocity-dependent friction. Interestingly, there is a small difference between the two different types of friction. | Minglong Fei Qicheng Sun Deyu Zhong Gordon G.D.Zhou | 2012 | Particuology2012，10，2： | 2 |
| 4 | Epicardial adipose tissue around the superior vena cava: A single center study of factors related to atrial fibrillation显示文摘The superior vena cava(SVC)is the main component of non-pulmonary vein(PV)ectopy in patients with atrial fibrillation(AF).Researchers have found that epicardial adipose tissue(EAT)volume is related to the AF substrate,which can be defined by the low voltage area(LVA).This study aimed to investigate the relationship between SVC-EAT and SVC-AF.Twenty-six patients with SVC-AF triggers were identified as the SVC-AF group.Other three groups were defined and included as the LVA-AF group(LVA>5%),non-LVA-AF group(LVA<5%),and physical examination(PE)group.EAT around left atrium(LA-EAT)and SVC-EAT volumes were obtained using a cardiac risk assessment module.According to the SVC/LA-EAT ratio,there are significant differences between the SVC-AF group and the three control groups(the SVC-AF group 0.092±0.041 vs.the LVA-AF group 0.054±0.026,the non-LVA-AF group 0.052±0.022,and the PE group 0.052±0.019,all P<0.001).Receiver operating characteristic curve analysis suggests the optimal cut-off point of SVC/LA-EAT ratio is 6.8%for detecting SVC-AF patients,with 81.1%sensitivity,73.1%specificity,and an area under the curve of 0.83(95%confidence interval,0.75-0.91).Those with SVC-AF have a higher SVC/LA-EAT ratio and empirical SVC isolation could be considered if the SVC/LA-EAT ratio was over 6.8%. | Xingxing Sun Jun Wang Qing Yan Weizhu Ju Fengxiang Zhang Gang Yang Kai Gu Hailei Liu Zidun wang Xiaohong Jiang Mingfang Li Di Xu Yi Xu Hongwu Chen Minglong Chen | 2022 | The Journal of Biomedical Research2022，36，6： | 0 |
| 5 | A nomogram predicting atrial fibrillation in patients with dilated cardiomyopathy显示文摘To the Editor:Dilated cardiomyopathy(DCM)is a type of primary myocardial disease with unknown etiology.[1]It is a disorder of the heart muscle mainly characterized by left ventricular dilation and systolic dysfunction,resulting from the response of the myocardium to genetic and environmental insults.The clinical manifestations arc progressive heart failure,arrhythmia,thromboembolism,and even sudden death. | Yangming Mao Yanmin Liu Jian Zhang Yeqian Zhu Xinguang Chen Ling Sun Yao Lu Hongwu Chen Weizhu Ju Gang Yang Pengcheng Zhao Minglong Chen Fengxiang Zhang | 2022 | Chinese Medical Journal2022，，8： | 0 |
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