|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 胎儿期恰逢1959~1961年饥荒的中国成人精神分裂症的发病率显示文摘背景:精神分裂症是一种常见的中度精神障碍。子宫内营养缺乏可增大患精神分裂症的危险。其主要依据来自1944~1945年荷兰饥饿冬天(Dutch Hunger Winter)研究,当时食品摄入在短期内极剧下降。这项有关饥荒期间受孕人群的大型队列研究显示,发生精神分裂症的危险增大两倍。
目的:确定经受1959~1961年大饥荒的中国人是否有相似的结果。
设计、地点及参试者:发生精神分裂症危险的调查于安徽省芜湖地区进行,这是当初受灾最重的地区之一。对饥荒之前、饥荒期间和饥荒以后出生的人群发病率进行比较。芜湖及其周围6个县是由一所精神病院负责的。对1971~2001年所有的精神病病历记录均进行检查。精神分裂症患者的临床和社会人口学资料由对自然灾害暴露情况不知情的研究者摘录。有关饥荒年出生人数和死亡人数的数据是有效可用的,累积死亡率根据以后的人口学调查进行估计。
主要观测指标:饥荒的证据已经核实,计算未校正的以及对死亡率进行校正后的发生精神分裂症的相对危险度。
结果:安徽省的出生率(每1000人)在饥荒期问降低了约80%,从1958年的28.28降至1959年的20.97、1960年的8.61和1961年的11.06。在饥荒期间出生的人,晚年发生精神分裂症的校正后危险明显增高,从1959年的0.84%增至1960年的2.15%和1961年的1.81%。死亡率校正相对危险在1960年出生者为2.30(95%可信区间,1.99~2.05),1961年出生者为1.93(95%可信区间,1.68~2.23)。
结论:我们的调查重复了荷兰不同种族人群的数据,结果显示,出生前遭受饥荒可增高晚年患精神分裂症的危险。 | David St Clair Mingqing Xu Peng Wang Yaqin Yu Yourong Fang Feng Zhang Xiaoying Zheng Niufan Gu Guoyin Feng Pak Sham Lin He 张继志(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 3 |
| 2 | Molecular analysis of green-tide-forming macroalgae in the Yellow Sea显示文摘 | Jinfeng Wang Peng Jiang Yulin Cui Nan Li Mingqing Wang Hanzhi Lin Peimin He Song Qin | 2010 | Aquatic Botany2010，，1： | 1 |
| 3 | Spectral conditions for the existence of specifiedpaths and cycles in graphs 显示文摘 | Zhai Mingqing Lin Huiqiu Gong Shicai | 2015 | Linear Algebra Appl2015，471，： | 1 |
| 4 | Generative artificial intelligence and its applications in materials science:Current situation and future perspectives显示文摘Generative Artificial Intelligence(GAI)is attracting the increasing attention of materials community for its excellent capability of generating required contents.With the introduction of Prompt paradigm and reinforcement learning from human feedback(RLHF),GAI shifts from the task-specific to general pattern gradually,enabling to tackle multiple complicated tasks involved in resolving the structure-activity relationships.Here,we review the development status of GAI comprehensively and analyze pros and cons of various generative models in the view of methodology.The applications of task-specific generative models involving materials inverse design and data augmentation are also dissected.Taking ChatGPT as an example,we explore the potential applications of general GAI in generating multiple materials content,solving differential equation as well as querying materials FAQs.Furthermore,we summarize six challenges encountered for the use of GAI in materials science and provide the corresponding solutions.This work paves the way for providing effective and explainable materials data generation and analysis approaches to accelerate the materials research and development. | Yue Liu Zhengwei Yang Zhenyao Yu Zitu Liu Dahui Liu Hailong Lin Mingqing Li Shuchang Ma Maxim Avdeev Siqi Shi | 2023 | Journal of Materiomics2023，9，4： | 1 |
| 5 | Surface Properties and Etherification in Microemulsion Systems of Novel Bronsted Acid Surfactants显示文摘 | YANG Mingqing WEI Zhonglin DUAN Haifeng LIN Yingjie | 2018 | Chemical Research in Chinese Universities2018，34，3： | 0 |
| 6 | Effects of Different Cultivation Patterns of Wheat on Population Structure of Puccinia striiformis West.f. sp. tritici显示文摘The paper was to study the effects of different cultivation patterns( mix cultivation and monocultivation) of wheat on population structure of Puccinia striiformis West. f. sp. tritici in the fields. Five race-specific-markers( CY32,CY31,CY29,CY23 and Shuiyuan pathotype) were used to survey 113 infected samples collected from two cultivation patterns. The results indicated that frequency of race-specific-markers under monocultivation was higher than that under mix cultivation; the dominant race-specific-markers were CY32 and CY29 under monocultivation,and the frequency of detection were 81. 5% and 78. 5%,respectively. The dominant race-specific-markers were CY29 and Shuiyuan pathotype under mix cultivation,and the frequency of detection are 41. 7% and 18. 8%,respectively.Several race-specific-markers were detected in single infected leaf,and 41. 7% of infected single leaf were detected with more than two race-specific-markers,58. 3% of infected single leaf were detected with one race-specific-marker under mix cultivation pattern,while there were 75. 0% infected leaves with more than two race-specific-markers and 25. 0% infected single leaf detected with one race-specific-marker under monocultivation pattern. The results indicated that mix cultivation pattern of wheat can reduce races on single leaf,affect the distribution of races in infected leaves,and suppress the occurrence frequency of dominant races of P. striiformis in the fields significantly,subsequently reduced severity and prevalence of the disease. | Li Jinbin Liu Lin Yang Jing Lan Mingqing Chen Mengqi Yang Jincheng Chen Xiangdong Li Yueqiu Zhu Youyong Li Chengyun | 2014 | Plant Diseases and Pests2014，5，2： | 0 |
| 7 | Fouling characteristics of cnidarians(Hydrozoa and Anthozoa)along the coast of China显示文摘Hydrozoans and anthozoans are an important component of a great variety of marine communities,particularly abundant and ubiquitous as part of the fouling assemblages around the globe.Several negative impacts have been associated to their occurrence on artificial substrata.In the coastal waters of China,a total of 76 species of fouling cnidarians were observed and classified.According to the occurrence frequency or biomass,the major species in the Bohai and Yellow Seas were Ectopleura marina,Bougainvillia sp.,and Eudendrium capillare;in the East China Sea Anthopleura nigrescens,Diadumene lineata,and Ectopleura crocea;and in the South China Sea Clytia sp.,Obelia sp.,and Actiniaria spp.The peak period of settlement of most species was mainly in summer and autumn.With the decrease of latitude,species number increased greatly and even cnidarian fouling was observed all year round in the East and South China Seas.Salinity was another factor aff ecting species distribution.Naturally,immersion time of substrata also directly aff ects the characteristics of cnidarians in fouling communities. | Tao YAN Mingqing LIN Wenhao CAO Shuaishuai HAN Xikun SONG | 2021 | Journal of Oceanology and Limnology2021，39，6： | 0 |
| 8 | Identification of Bulbocodin D and C as novel STAT3 inhibitors and their anticancer activities in lung cancer cells显示文摘Cancer stands as one of the predominant causes of mortality globally, necessitating ongoing efforts to develop innovative therapeutics. Historically, natural products have been foundational in the quest for anticancer agents. Bulbocodin D (BD) and Bulbocodin C (BC), two bibenzyls derived from Pleione bulbocodioides (Franch.) Rolfe, have demonstrated notable in vitro anticancer activity. In human lung cancer A549 cells, the IC50s for BD and BC were 11.63 and 11.71 μmol·L^(−1), respectively. BD triggered apoptosis, as evidenced by an upsurge in Annexin V-positive cells and elevated protein expression of cleaved-PARP in cancer cells. Furthermore, BD and BC markedly inhibited the migratory and invasive potentials of A549 cells. The altered genes identified through RNA-sequencing analysis were integrated into the CMap dataset, suggesting BD’s role as a potential signal transducer and activator of transcription 3 (STAT3) inhibitor. SwissDock and MOE analyses further revealed that both BD and BC exhibited a commendable binding affinity with STAT3. Additionally, a surface plasmon resonance assay confirmed the direct binding affinity between these compounds and STAT3. Notably, treatment with either BD or BC led to a significant reduction in p-STAT3 (Tyr 705) protein levels, regardless of interleukin-6 stimulation in A549 cells. In addition, the extracellular signal-regulated kinase (ERK) was activated after BD or BC treatment. An enhancement in cancer cell mortality was observed upon combined treatment of BD and U0126, the MEK1/2 inhibitor. In conclusion, BD and BC emerge as promising novel STAT3 inhibitors with potential implications in cancer therapy. | HE Xinyu FU Jiarui LYU Wenyu HUANG Muyang MO Jianshan CHENG Yaxin XU Yulian ZHENG Lijun ZHANG Xiaolei QI Lu ZHANG Lele ZHENG Ying HUANG Mingqing NI Lin LU Jinjian | 2023 | Chinese Journal of Natural Medicines2023，21，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员