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| 1 | Biting force and tongue muscle strength as useful indicators for eating and swallowing capability assessment among elderly patients显示文摘Weakened capability of eating and swallowing is common among elderly population,affecting negatively on their health and well-being.This work measured occlusal force and tongue muscle strength of elderly patients and then assessed whether correlations existed between oral physiological properties and the eating and swallowing capability.A total of 26 elderly patients with potential swallow disorder were recruited in this work.Participants’denture status and daily diet texture were determined by a pre-questionnaire analysis.Their swallowing capability was assessed and rated by water drinking test.Maximum tongue pressure,incisor occlusal force and hand gripping force were measured for each subject.It was observed that participating subjects have on average a significantly lower biting force and maximum tongue pressure than that of normal adults.The swallowing grades assessed by water drinking test showed significant correlations with both the biting force(r=−0.498,P<0.05)and the tongue muscle strength(r=−0.544,P<0.05).The biting force of dysphagia participants correlates significantly with dental conditions(P<0.05).The observed correlation between tongue pressure and diet texture indicates that tongue muscle strength could be used as a reliable indicator of the eating and swallowing capability for elderly people. | Xinmiao Wang Gangying Zheng Mingsong Su Yanqiu Chen Hua Xie Weijia Han Qing Yang Jianqin Sun Jianshe Chen | 2019 | Food Science and Human Wellness2019，8，2： | 4 |
| 2 | A novel requirement analysis approach for periodic control systems显示文摘 | Zheng WANG Geguang PU Jiangwen LI Yuxiang CHEN Yongxin ZHAO Mingsong CHEN Bin GU Mengfei YANG Jifeng HE | 2013 | Frontiers of Computer Science2013，7，2： | 3 |
| 3 | The staphylococcal nuclease prevents biofilm formation in Staphylococcus aureus and other biofilm-forming bacteria显示文摘The staphylococcal nuclease, encoded by the nuc1 gene, is an important virulence factor of Staphylococcus aureus. However, the physiological role of the nuclease has not been fully characterized. The current study observed that biofilm development could be prevented in staphylococcal nuclease-producing strains of S. aureus; however, when the nuc1 gene was knocked out, the ability to form a biofilm significantly increased. Scanning electron and confocal scanning laser microscopy were used to evaluate the role of the nuc1 gene in biofilm formation. Moreover, the nuc1 gene product, staphylococcal nuclease, and recombinant NUC1 protein were found to have a visible effect on other biofilm-forming bacteria, such as Pseudomonas aeruginosa, Actinobacillus pleuropneumoniae, and Haemophilus parasuis. The current study showed a direct relationship between staphylococcal nuclease production and the prevention of biofilm development. The findings from this study underscore the important role of staphylococcal nuclease activity to prevent biofilm formation in S. aureus. They also provided evidence for the biological role of staphylococcal nucleases in other organisms. | TANG JunNi KANG MingSong CHEN HuanChun SHI XianMing ZHOU Rui CHEN Juan DU YiWu | 2011 | Science China(Life Sciences)2011，54，9： | 2 |
| 4 | The CRL3^(BTBD9) E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration显示文摘Tumor necrosis factor alpha-induced protein 1(TNFAIP1)modulates a plethora of important biological processes,including tumorigenesis and cancer cell migration.However,the regulatory mechanism of TNFAIP1 degradation remains largely elusive.In the present study,with a label-free quantitative proteomic approach,TNFAIP1 was identified as a novel ubiquitin target of the Cullin-RING E3 ubiquitin ligase(CRL)complex.More importantly,Cul3-ROC1(CRL3),a subfamily of CRLs,was identified to specifically interact with TNFAIP1 and promote its polyubiquitination and degradation.Mechanistically,BTBD9,a specific adaptor component of CRL3 complex,was further defined to bind and promote the ubiquitination and degradation of TNFAIP1 in cells.As such,downregulation of BTBD9 promoted lung cancer cell migration by upregulating the expression of TNFAIP1,whereas TNFAIP1 deletion abrogated this effect.Finally,bioinformatics and clinical sample analyses revealed that BTBD9 was downregulated while TNFAIP1 was overexpressed in human lung cancer,which was associated with poor overall survival of patients.Taken together,these findings reveal a previously unrecognized mechanism by which the CRL3^(BTBD9) ubiquitin ligase controls TNFAIP1 degradation to regulate cancer cell migration. | Lihui Li Wenjuan Zhang Yue Liu Xiaojun Liu Lili Cai Jihui Kang Yunjing Zhang Wenlian Chen Changsheng Dong Yanmei Zhang Mingsong Wang Wenyi Wei Lijun Jia | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 5 | Constitutive modeling for elevated temperature flow behavior of 42CrMo steel显示文摘 | LIN Yongcheng CHEN Mingsong ZHONG Jue | 2008 | Computational Materials Science2008，42，： | 1 |
| 6 | Constitutive modeling for elevated temperature flow behavior of 42CrMo steel 显示文摘 | Lin Y C Chen Mingsong Zhong Jue | 2008 | Computational Materials Science2008，42，： | 1 |
| 7 | Recrystallization nucleation under close-setδphase in a nickel-based superalloy during annealing显示文摘Annealing is one of the most efficient heat treatment to refine the grain microstructure in metal alloys.Prior to the annealing,an aging treatment can be implemented to precipitate the second phases for more nucleation sites in deformed mixed grains during subsequent recrystallization.However,the underlying mechanism behind the second phases and recrystallization has not yet been fully understood.Taking a typical deformed nickel(Ni)-based(GH4169)superalloy as an exapmle,this research aims to clairfy the connections between the recrystallization and delta(δ)phase(Ni_(3)Nb) during annealing.All deformed samples were also treated by aging and then annealing.The results show that the microstructure and component ofδphase dominated the recrystallization nucleation in the Ni-based alloy.Moreover,there was the presence of theδphase interval limiting nucleation(PILN)andδphase protecting nucleation(PPN),when a high content of close-set phase was precipitated from the matrix.The PILN determined the primary condition for the recrystallization nucleation that happended at the interval ofδphase larger than the critical nucleation size.The peak nucleation occurred in the PPN,where the recrystallization nucleus were free of the penetration by the adjacent grains,before the nucleation incubation time was reached.Thus,a new feasible JNtheory was proposed to determine the maximum domain of recrystallization nucleation under close-set precipitated phases.All the possible nucleation sites were assumed under PPN in the JNtheory.As such,the original microstructure can be expected to design for the annealing via the aging process.A quantitative evaluation of recrystallization nucleation can also achieved in the Ni-based alloys during aging. | Guanqiang Wang Mingsong Chen Yongcheng Lin Hongbin Li Yuqiang Jiang Yanyong Ma Chengxu Peng Jinliang Cai Quan Chen | 2022 | Journal of Materials Science & Technology2022，，20： | 1 |
| 8 | Numerical simulation and experimental verifcation of microstructure evolution in a three- dimensional hot upsetting process 显示文摘 | Lin Yongcheng Chen Mingsong | 2009 | Materials Science and Technology2009，209，9： | 1 |
| 9 | Effect of temperature and strain rate on the compressive deformation behavior of 42CrMo steel 显示文摘 | Lin Yongcheng Chen Mingsong Zhong Jue | 2008 | Journal of Materials Processing Technology2008，205，13： | 1 |
| 10 | Numerical simulation and ex-perimental verification of microstructure evolution in a three - di-mensional hot upsetting process 显示文摘 | LIN Yongcheng CHEN Mingsong | 2009 | Journal of Materials Pro-cessing Technology2009，209，9： | 1 |
| 11 | Numerical Simula- tion for Stress/Strain Distribution and Microstructural E- volution in 42CrMo Steel During Hot Upsetting Process显示文摘 | LIN Y C CHEN Mingsong JUE Zhong | 2008 | Computational Materials Science2008，43，4： | 1 |
| 12 | A Soy Protein-Based Composite Film with a Hierarchical Structure Inspired by Nacre显示文摘Soy protein-based composite film is a potential replacement for petroleum-based film with multipurpose applica-tions and cleaner production.It is difficult to improve both the tensile strength and toughness of a protein-based film without sacrificing its elongation.In this study,inspired by the hierarchical structure of nacre,a facile yet delicate strategy was developed to fabricate a novel bio-based film with excellent toughness and high strength.Triglycidylamine(TGA)crosslinked soy protein(SPI)as hard phase and thermoplastic polyurethane elastomer(TPU)as soft phase comprise an alternative lay-up hierarchical structure.The interface of these two phases is enhanced using triglycidylamine(TGA)surface-modified TPU(MTPU).The tensile strength of SPI/MTPU/TGA films increases by 392%to 7.78 MPa and their toughness increases by 391%to 8.50 MJ/m^(3) compared to soy protein/glycerol film.The proposed hierarchical structure can also be extended to other high-performance materials and polymers. | Yecheng Xu Chaojie Xu Mingsong Chen Jianzhang Li Ling Zeng Jing Luo Qiang Gao Sheldon Q.Shi | 2022 | Journal of Renewable Materials2022，10，3： | 1 |
| 13 | Mod-eling of flow stress of 42CrMo steel under hot com- pression显示文摘 | Lin Yongcheng Chen Mingsong Zhang Jun | 2009 | Materials Science and Engineering A2009，499，12： | 1 |
| 14 | Prediction of 42CrMo steel flow stress at high temperature and strain rate显示文摘 | LIN Y C CHEN Mingsong ZHONG Jue | 2008 | Mechanics Research Communications2008，35，： | 1 |
| 15 | Biofilm formation by field isolates and reference strains of Haemophilus parasuis显示文摘 | Hui Jin Rui Zhou Mingsong Kang Rui Luo Xuwang Cai Huanchun Chen | 2006 | Veterinary Microbiology2006，，1： | 1 |
| 16 | Modeling of flow stress of 42CrMo steel under hot compression 显示文摘 | Lin Yongcheng Chen Mingsong Zhang Jun | 2009 | Materials Science and Engineering2009，499，： | 1 |
| 17 | Effect of temperature and strain rate on the compres-sive deformation behavior of42CrMo steel显示文摘 | LIN Yongcheng CHEN Mingsong ZHONG Jue | 2008 | Journal of Materials Processing Technology2008，205，13： | 1 |
| 18 | Preparation, characte- rization and activity evaluation of Ag2 Mo4 O13 photocatalyst 显示文摘 | Liu Wei Ji Mingsong Chen Shifu | 2011 | J Hazardous Mater2011，186，： | 1 |
| 19 | A novel annealing method to uniformly refine deformed mixed grain microstructure of a solution-treated Ni-based superalloy显示文摘Increasing static recrystallization(SRX)nucleation rate and decreasing grain growth rate are the main ways to obtain uniform and fine grain microstructure by annealing treatment.However,it is contradictory to raise the SRX nucleation rate and reduce grain growth rate during isothermal annealing treatment.This is because the increase of the SRX nucleation rate needs to raise annealing temperature,while the decline of grain growth rate needs to reduce the annealing temperature.To solve the contradiction,a novel method named cooling recrystallization annealing treatment(CRT)is designed and verified.For the CRT,the relatively high annealing temperature in the primary stage can promote SRX nucleation,and the gradually decreased annealing temperature can reduce the growth rate of SRX grains.Besides,an aged treatment is first carried out to precipitate high content of theδphase before the CRT.Enoughδphases not only provide large numbers of sites for SRX nucleation but also limit the grain growth due to the pinning effect,especially in the primary high-temperature stage.The results show that the novel method can refine deformed mixed grain microstructure well when the suitable cooling rate,start and final recrystallization annealing temperatures are employed.The deformed mixed grain can be uniformly refined to an average size of 8.26μm with the route of 900℃×12 h+1020℃→970℃×20 min. | WANG GuanQiang CHEN MingSong LIN YongCheng LI HongBin ZENG WeiDong MA YanYong CAI JinLiang PENG ChengXu ZOU FenYang | 2021 | Science China(Technological Sciences)2021，64，8： | 1 |
| 20 | Constitutive modeling for elevated temperature flow behavior of42CrMo steel显示文摘 | Lin Y C Chen Mingsong Zhong Jue | 2008 | Computational Materials Science2008，42，3： | 1 |
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