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| 1 | GSA:Genome Sequence Archive显示文摘With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive(GSA; http://bigd.big.ac.cn/gsa or http://gsa.big.ac.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration(INSDC), GSA adopts four data objects(Bio Project, Bio Sample,Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world,and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world. | Yanqing Wang Fuhai Song Junwei Zhu Sisi Zhang Yadong Yang Tingting Chen Bixia Tang Lili Dong Nan Ding Qian Zhang Zhouxian Bai Xunong Dong Huanxin Chen Mingyuan Sun Shuang Zhai Yubin Sun Lei Yu Li Lan Jingfa Xiao Xiangdong Fang Hongxing Lei Zhang Zhang Wenming Zhao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 13 |
| 2 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 3 | Light absorption properties and potential sources of brown carbon in Fenwei Plain during winter 2018–2019显示文摘A distinctive kind of organic carbon aerosol that could absorb ultraviolet-visible radiation is called brown carbon(Br C),which has an important positive influence on radiative budget and climate change.In this work,we reported the absorption properties and potential source of Br C based on a seven-wavelength aethalometer in the winter of 2018–2019 at an urban site of Sanmenxia in Fenwei Plain in central China.Specifically,the mean value of Br C absorption coefficient was 59.6±36.0 Mm^(-1) at 370 nm and contributed 37.7%to total absorption,which made a significant impact on visibility and regional environment.Absorption coefficients of Br C showed double-peak pattern,and Br C had shown small fluctuations under haze days compared with clean days.As for the sources of Br C,Br C absorption coefficients expressed strong correlations with element carbon aerosols and primary organic carbon aerosols,indicating that most of Br C originated from primary emissions.The linear correlations between trace metal elements(K,As,Fe,Mn,Zn,and Pb)and Br C absorption coefficients further referred that the major sources of Br C were primary emissions,like coal burning,biomass burning,and vehicle emissions.The moderate relationship between Br C absorption coefficients and secondary organic aerosols suggested that secondary production of Br C also played an important role.The 120 hr backward air mass trajectories analysis and concentration-weighted trajectories analysis were also used to investigate potential sources of Br C in and around this area,which inferred most parts of Br C were derived from local emissions. | Wenyu Zhang Weigang Wang Jie Li Shuangliang Ma Chaofan Lian Kun Li Bo Shi Mingyuan Liu Yanyu Li QingQing Wang Yele Sun Shengrui Tong Maofa Ge | 2021 | Journal of Environmental Sciences2021，33，4： | 6 |
| 4 | Ultrasensitive and stable all graphene field-effect transistor-based Hg^(2+)sensor constructed by using different covalently bonded RGO films assembled by different conjugate linking molecules显示文摘As'molecular bridge,'coupling agents can not only realize the covalent connection of composites,but also affect their properties,thus affecting the properties of devices based on them.Herein,leveraging differences in charge conduction properties of the(3-aminopropyl)trimethoxysilane and 5,10,15,20-tetrakis(4-aminophenyl)-21H,23H-porphine caused by conjugacy structural differences,two kinds of layerby-layer assembled smart carbon materials with different electrical properties are obtained at the same reduction temperature.The two graphene ultrathin films are then“planted”on Si/SiO2 substrates,respectively,as semiconductor layer and source/drain electrodes to fabricate an ultra-stable all-graphene field effect transistor(AG-FET).Enabled by the covalent functionalized configuration and the functionally diverse of coupling agents,the AG-FET obtained by this simple method won the high electrical characteristics,the hole,electron mobility,and the shelflife could reach 3.79 cm2/(V·s),3.78 cm2/(V·s),and 18months,respectively.In addition,good material stability and excellent device structure endow the device exceptional stability,electrical stability,and solvent resistance,improving its application prospect in solution phase sensing/detection.Such characteristics could be used to sense,transduce,and respond to external stimuli,especially in solution phase to monitor the important analytes,such as Hg^(2+)in a flowing sewage environment.We believe that such easy-to-manufacture AG-FETs with ultrahigh performance and ultrahigh stability could also show great application prospects in other significant fields. | Mingyuan Sun Congcong Zhang Duo Chen Jian Wang Yanchen Ji Na Liang Haoyang Gao Shanshan Cheng Hong Liu | 2021 | SmartMat2021，2，2： | 2 |
| 5 | Rapidly developable therapeutic-grade equine immunoglobulin against the SARS-CoV-2 infection in rhesus macaques显示文摘Dear Editor,The unprecedented COVID-19 pandemic caused by SARS-CoV-2 remains ongoing,but there is a lack of fully effective treatments.Convalescent plasma-derived hyperimmune globulins have been a safe and effective treatment but restricted by the difficulties in obtaining sufficient plasma with high antibody titers from a large number of recovered patients.Heterologous antibodies,particularly equine antibodies,have been widely used for decades as the therapeutics against some viral infections or as antivenoms.1 Equine antibodies could be rapidly developed and manufactured into therapeutic antibodies in large quantities under WHO standardized guidelines.Here we explored the development of equine antibody-derived F(ab′)2 as an option to treat COVID-19 by targeting the receptor-binding domain(RBD)of the viral spike protein that is essential for the viral entry into the host cells.2 We observed excellent neutralization titers of the F(ab′)2 in vitro and high potency against SARS-CoV-2 infection in the nonhuman primate rhesus macaques. | Xiaolei Liu Yi Liu Xuemin Jin Zhanlong He Zhen Huang Shumin Sun Yuwei Gao Jingyu Li Qin Ning Zhongping Xie Ningyi Jin Mingyuan Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 2 |
| 6 | Effect of alloying degree in PtSn catalyst on the catalytic behavior for ethanol electro-oxidation显示文摘 | Mingyuan Zhu Gongquan Sun Qin Xin | 2008 | Electrochimica Acta2008，，5： | 1 |
| 7 | Comparative study on in vitro transformation of paralytic shellfish poisoning (PSP) toxins in different shellfish tissues显示文摘Dissected tissues of three shellfish species,the Chinese scallop,Chlamys farreri,Manila clam,Ruditapes philippinarum,and Razor shell,Solen strictu were evaluated for in vitro transformation of paralytic shellfish poisoning(PSP) toxins. Tissue homogenates were incubated with extraction from toxic algae Alexandrium minutum to determine toxin conversion. The effects of heating and addition of a natural reductant(glutathione) on toxin conversion were also assessed. The toxin profile was investigated through high performance liquid chromatography with fluorescence detection(HPLC-FLD) . The evident variations in the toxin content were observed only in Chinese scallop viscera homogenates. The concentration of GTX4 was reduced by 45%(approximately 0.8 μmol/dm 3 ) and 25%(approximately 1 μmol/dm 3 ) for GTX1,while GTX2 and GTX3 increased by six times(approximately 1 μmol/dm 3 ) and 3 times(approximately 0.3 μmol/dm 3 ) respectively. Simultaneously,the total toxicity decreased by 38% during the 48 h incubation period,the final toxicity was 20.4 nmol STXeq/g. Furthermore,heated Chinese scallop viscera homogenates samples were compared with non-heated samples. The concentration of the GTX4 and GTX1 was clearly 28%(approximately 0.53 μmol/dm 3 ) and 17%(approximately 0.69 μmol/dm 3 ) higher in heated samples,GTX2 and GTX3 were four times(0.66 μmol/dm 3 ) and two times(0.187 μmol/dm 3 ) lower respectively. GSH(+) Chinese scallop viscera homogenates samples were compared with GSH(-) samples,the concentration in the GTX4 and GTX1 was 9%(approximately 0.12 μmol/dm 3 ) and 11%(approximately 0.36 μmol/dm 3 ) lower respectively,GTX2 and GTX3 was 17%(approximately 0.14 μmol/dm 3 ) and 19%(approximately 0.006 μmol/dm 3 ) higher respectively. In contrast,there was a little change in the concentration of PSP toxins of Manila clam and Razor shell tissue homogenates. These observations on three shellfish tissues confirmed that there were species-specific differences in PSP toxins transformation. PSP toxins transformation was more pronounced in viscera tissue than in muscle tissue. PSP toxins was possibly interfered by some carbamoylase enzyme,and the activity in Chinese scallop viscera tissue is more remarkable than in the other two species. | TIAN Hua GAO Chunlei WANG Zongling SUN Ping FAN Shiliang ZHU Mingyuan | 2010 | Acta Oceanologica Sinica2010，29，1： | 1 |
| 8 | Effect of pretreatment on rheological properties of silicon carbide aqueous suspension 显示文摘 | Huang Qiang Gu Mingyuan Sun Kang | 2002 | Ceramics International2002，28，7： | 1 |
| 9 | Thermodynamic Optimization of The CeCl3 - AECl2 (AE = Mg, Ca, Sr, Ba) Phase Diagrams 显示文摘 | Zhang Jing Sun Yimin Guan Mingyuan | 2003 | CALPHAD2003，27，： | 1 |
| 10 | One-pot synthesis of CNT-SAPO-34 composite supported copper and cerium catalysts with excellent surface resistance to SO_(2) and H_(2)O in NH_(3)-SCR显示文摘CuCe/CNT_(x)-SAPO-34(x=0,0.5,1,2) with various CNT doping quantities were synthesized through the one-pot hydrothermal synthesis method using CNT and SAPO-34 as composite supporters.The selected CuCe/CNT_1-SAPO-34 catalyst exhibits remarkable SCR activity and high H_(2)O/SO_(2) resistance in a wide temperature range of 200-450℃.X-ray diffraction(XRD),N_(2) adsorption-desorption,scanning electron microscopy(SEM),X-ray photoelectro n spectroscopy(XPS),H_(2)-temperature programmed reduction(H2-TPR),and NH3-temperature programmed desorption(NH_(3)-TPD) were used to characterize the physiochemical structure,surface state of active sites reducibility,and surface acidity of the catalysts.The characterization results reveal that CuCe/CNT_1-SAPO-34 possesses a hierarchical structure,small particle size,high levels of surface Cu^(2+),Ce^(3+) and chemisorbed oxygen,enhanced reducibility,and suitable surface acidity.For comparison,CuCe/CNT_1-SAPO-34(P) mixed mechanically with CuCe/CNT_0-SAPO-34and CNT was investigated through the NH3-SCR with and without H_(2)O/SO_(2),it also displays lower resistance of H_(2)O and SO_(2) than CuCe/CNT_1-SAPO-34.The catalytic performance made CuCe/CNT_1-SAPO-34 a promising catalyst for the NO_(x) emission control from diesel vehicles. | Yuanyuan Ma Zhifang Li Nan Zhao Mingyuan Shi Yuhang Sun Zheng Nan Liying Wang | 2023 | Journal of Rare Earths2023，41，9： | 1 |
| 11 | Dispersion properties of a water-soluble phenol-formaldehyde resin显示文摘 | Sun Limei Li Mingyuan Lin Meiqin | 2009 | Journal of Dispersion Science and Technology2009，30，5： | 1 |
| 12 | Local measurement of gas-liquid bubbly flow with a double-sensor probe显示文摘 | Sun Kexia Zhang Mingyuan Chen Xuejun | 2000 | J Chinese Chem Engr2000，，： | 1 |
| 13 | Understanding the dynamical-microphysical-electrical processes associated with severe thunderstorms over the Beijing metropolitan region显示文摘The Dynamical-microphysical-electrical Processes in Severe Thunderstorms and Lightning Hazards(STORM973)project conducted coordinated comprehensive field observations of thunderstorms in the Beijing metropolitan region(BMR)during the warm season from 2014 to 2018.The aim of the project was to understand how dynamical,microphysical and electrical processes interact in severe thunderstorms in the BMR,and how to assimilate lightning data in numerical weather prediction models to improve severe thunderstorm forecasts.The platforms used in the field campaign included the Beijing Lightning Network(BLNET,consisting of 16 stations),2 X-band dual linear polarimetric Doppler radars,and 4 laser raindrop spectrometers.The collaboration also made use of the China Meteorological Administration’s mesoscale meteorological observation network in the Beijing-Tianjin-Hebei region.Although diverse thunderstorm types were documented,it was found that squall lines and multicell storms were the two major categories of severe thunderstorms with frequent lightning activity and extreme rainfall or unexpected local short-duration heavy rainfall resulting in inundations in the central urban area,influenced by the terrain and environmental conditions.The flash density maximums were found in eastern Changping District,central and eastern Shunyi District,and the central urban area of Beijing,suggesting that the urban heat island effect has a crucial role in the intensification of thunderstorms over Beijing.In addition,the flash rate associated with super thunderstorms can reach hundreds of flashes per minute in the central city regions.The super(5%of the total),strong(35%),and weak(60%)thunderstorms contributed about 37%,56%,and 7%to the total flashes in the BMR,respectively.Owing to the close connection between lightning activity and the thermodynamic and microphysical characteristics of the thunderstorms,the lightning flash rate can be used as an indicator of severe weather events,such as hail and short-duration heavy rainfall.Lightning data can also be assimilated into numerical weather prediction models to help improve the forecasting of severe convection and precipitation at the cloud-resolved scale,through adjusting or correcting the thermodynamic and microphysical parameters of the model. | Xiushu QIE Shanfeng YUAN Zhixiong CHEN Dongfeng WANG Dongxia LIU Mengyu SUN Zhuling SUN Abhay SRIVASTAVA Hongbo ZHANG Jingyu LU Hui XIAO Yongheng BI Liang FENG Ye TIAN Yan XU Rubin JIANG Mingyuan LIU Xian XIAO Shu DUAN Debin SU Chengyun SUN Wenjing XU Yijun ZHANG Gaopeng LU Da-Lin ZHANG Yan YIN Ye YU | 2021 | Science China Earth Sciences2021，64，1： | 1 |
| 14 | Effect of Pretreatment on Rheological Properties of Silicon Carbide Aqueous Suspension显示文摘 | Huang Qiang Gu Mingyuan Sun kang | 2002 | Ceramics International2002，28，7： | 1 |
| 15 | Green carbon science:fundamental aspects显示文摘Carbon energy has contributed to the creation of human civilization,and it can be considered that the configuration of the carbon energy system is one of the important laws that govern the operation of everything in the universe.The core of the carbon energy system is the opposition and unity of two aspects:oxidation and reduction.The operation of oxidation and reduction is based on the ternary elemental system composed of the three elements of carbon,hydrogen and oxygen.Its operation produces numerous reactions and reaction products.Ancient Chinese philosophy helps us to understand in depth the essence of green carbon science,to explore its scientific basis,and to identify the related platforms for technology development. | Mingyuan He Kun Zhang Yejun Guan Yuhan Sun Buxing Han | 2023 | National Science Review2023，10，9： | 1 |
| 16 | Effect of pretreatment on rheological properties of silicon carbide aqueous suspension显示文摘 | HUAGN Qiang GU Mingyuan SUN Kang | | 0，，07： | 1 |
| 17 | A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection显示文摘Dear Editor,Identifying the host factors that are utilized for virus infection and mapping their cell-type expression profile can help to understand the viral tissue/organ tropism and pathogenesis.Much effort has been devoted to the identification of SARS-CoV-2 infection-dependent host factors.CRISPR-based activation(Konermann et al.,2015). | Fei Feng Yunkai Zhu Yanlong Ma Yuyan Wang Yin Yu Xinran Sun Yuanlin Song Zhugui Shao Xinxin Huang Ying Liao Jingyun Ma Yuping He Mingyuan Wang Longhai Tang Yaowei Huang Jincun Zhao Qiang Ding Youhua Xie Qiliang Cai Hui Xiao Chun Li Zhenghong Yuan Rong Zhang | 2023 | Protein & Cell2023，14，1： | 0 |
| 18 | Trend of global carbon dioxide capture,utilization and storage industry and challenges and countermeasures in China显示文摘This paper systematically reviews the trend of carbon dioxide capture,utilization and storage(CCUS)industry in the world and China,presents the CCUS projects,clusters,technologies and strategies/policies,and analyzes the CCUS challenges and countermeasures in China based on the comparison of CCUS industrial development at home and abroad.The global CCUS development has experienced three stages:exploration stage,policy driven stage,and dual-drive stage.Currently,the active large-scale CCUS projects around the world focus on enhanced oil recovery(EOR)and are expanding into storage in saline aquifers.The CCUS industry of China has evolved in three stages:exploration,pilot test,and industrialization.In the current critical period of transition from field test to industrialization,China’s CCUS projects are EOR-dominated.By comparing the industrial development of CCUS in China and abroad,it is found that the scale-up and industrialization of CCUS in China face challenges in technology,facilities and policies.Finally,future solutions to CCUS development in China are proposed as follows:strengthening the top-level design and planning of CCUS;developing high-efficiency and low-cost CCUS technologies throughout the whole industrial chain;deploying CCUS oil and gas+new energy clusters;improving the policy support system of CCUS;and strengthening discipline construction and personnel training,etc. | DOU Lirong SUN Longde LYU Weifeng WANG Mingyuan GAO Feng GAO Ming JIANG Hang | 2023 | Petroleum Exploration and Development2023，50，5： | 0 |
| 19 | The mechanism of Callistephus chinensis flavonoid compounds in the treatment of diabetes using network pharmacology and molecular docking显示文摘The purpose of this project is used for exploring the mechanism of Callistephus chinensis in the treatment of diabetes by network pharmacology and molecular docking methods.The target of Callistephus chinensis was obtained from SwissTargetPrediction database,while the target related to diabetes was obtained from GeneCards and OMIM databases.The target was added in String database to build the protein interaction network.GO biological process enrichment analysis and KEGG pathway enrichment analysis were carried out by Metascape software,then the target-pathway network was constructed.Molecular docking was carried out in Discovery Studio 2016 Client software to verify the binding force of Callistephus chinensis flavonoid compounds with key targets.In this study,10 potential active components were selected from the flavonoid monomer compounds of Callistephus chinensis.1847 biological processes(BP),126 cell compositions(CC)and 256 molecular functions(MF)were obtained by GO enrichment analysis;a total of 194 pathways were involved in KEGG enrichment analysis of 192 cross targets.Network analysis showed that quercetin was the main active component of flavonoids in the treatment of diabetes,AKT1,TNF,VEGFA,EGFR,SRC and other related signals were in relation to the treatment of diabetes.This study showed that Callistephus chinensis flavonoid compounds play a role in the treatment of diabetes by regulating multi-target and multi-pathway. | Mingyuan Yuan Xiaoli Wang Ziqi Sun Xiaoshu Zhang | 2024 | Journal of Polyphenols2024，6，1： | 0 |
| 20 | Unlocking single-atom catalysts via amorphous substrates显示文摘Single-atom catalysts(SACs)reveal great potential for application in catalysis due to their fully exposed active sites.In general,single atoms(SAs)and the coordination substrates need to have strong interactions or charge transfer to ensure the atomic dispersion,which requires the selection of a suitable substrate to stabilize the target atoms.Recent studies have demonstrated that amorphous materials with abundant defects and coordinatively unsaturated sites can be used as substrates for more efficient capturing SAs,further enhancing the catalytic performance.In this review,we discuss recent research progress of SAs loaded on amorphous substrates for enhanced catalytic activity.Firstly,we summarize the commonly used amorphous substrates for stabilizing SAs.Subsequently,we present several advanced applications of amorphous SACs in the field of catalysis,including electrocatalysis and photocatalysis.And then,we also clarify the synergistic mechanism between SAs and amorphous substrate on catalytic process.Finally,we summarize the challenges with our personal views and provide a critical outlook on how amorphous SACs continue to evolve. | Bohua Sun Mingyuan Xu Xiaoxia Li Baohong Zhang Rui Hao Xiaoyu Fan Binbin Jia Dingshun She | 2024 | Nano Research2024，17，5： | 0 |
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