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| 1 | Large eddy simulation of a planar jet flow with nanoparticle coagulation显示文摘易于在一口平面喷气的大协调结构的 nanoparticles 的凝结和生长被使用大旋涡模拟探索了。粒子地被一片刻采用方法接近获得 nanoparticle 将军动态方程。在直径包含 1 nm 的粒子的不可压缩的液体被投射进一没有粒子周围。当喷气发展,结果证明协调结构统治 nanoparticle 数字紧张直径和多分散性分布的进化。另外,当配对的旋涡引起粒子分布成为制服时,增加粒子的散开的协调结构行为,和旋涡滚动起来做更不规则地散布的粒子。当喷气下游地旅行,平均时间的粒子数字集中在郊区在喷气核心并且更高变得更低,而在全部流动地上的平均时间的粒子团维持未改变,,并且他们的最大值在喷气区域的接口上并且周围。 | Mingzhou Yu Jianzhong Lin Lihua Chen Tatleung Chan | 2006 | Acta Mechanica Sinica2006，22，4： | 25 |
| 2 | Building a sequence map of the pig pan-genome from multiple de novo assemblies and Hi-C data显示文摘Pigs were domesticated independently in the Near East and China,indicating that a single reference genome from one individual is unable to represent the full spectrum of divergent sequences in pigs worldwide.Therefore,12 de novo pig assemblies from Eurasia were compared in this study to identify the missing sequences from the reference genome.As a result,72.5 Mb of nonredundant sequences(~3% of the genome)were found to be absent from the reference genome(Sscrofa11.1)and were defined as pan-sequences.Of the pan-sequences,9.0 Mb were dominant in Chinese pigs,in contrast with their low frequency in European pigs.One sequence dominant in Chinese pigs contained the complete genic region of the tazarotene-induced gene 3(TIG3)gene which is involved in fatty acid metabolism.Using flanking sequences and Hi-C based methods,27.7% of the sequences could be anchored to the reference genome.The supplementation of these sequences could contribute to the accurate interpretation of the 3D chromatin structure.A web-based pan-genome database was further provided to serve as a primary resource for exploration of genetic diversity and promote pig breeding and biomedical research. | Xiaomeng Tian Ran Li Weiwei Fu Yan Li Xihong Wang Ming Li Duo Du Qianzi Tang Yudong Cai Yiming Long Yue Zhao Mingzhou Li Yu Jiang | 2020 | Science China(Life Sciences)2020，63，5： | 7 |
| 3 | Characterization particulate matter from several Chinese cooking dishes and implications in health effects显示文摘Cooking fume produced by oil and food at a high temperature releases large amount of fine particulate matter(PM) which have a potential hazard to human health. This chamber study investigated particle emission characteristics originated from using four types of oil(soybean oil, olive oil, peanut oil and lard) and different kinds of food materials(meat and vegetable). The corresponding emission factors(EFs) of number, mass, surface area and volume for particles were discussed. Temporal variation of size-fractionated particle concentration showed that olive oil produced the highest number PM concentration for the entire cooking process. Multiple path particle dosimetry(MPPD) model was performed to predict deposition in the human respiratory tract. Results showed that the pulmonary airway deposition fraction was the largest. It was also found that particles produced from olive oil led to the highest deposition. We strongly recommend minimizing the moisture content of ingredients before cooking and giving priority to the use of peanut oil instead of olive oil to reduce human exposure to PM. | Lina Wang Xinran Zheng Svetlana Stevanovic Xin Wu Zhiyuan Xiang Mingzhou Yu Jing Liu | 2018 | Journal of Environmental Sciences2018，30，10： | 6 |
| 4 | An analytical solution for the population balance equation using a moment method显示文摘Brownian coagulation is the most important inter-particle mechanism affecting the size distribution of aerosols.Analytical solutions to the governing population balance equation(PBE) remain a challenging issue.In this work,we develop an analytical model to solve the PBE under Brownian coagulation based on the Taylor-expansion method of moments.The proposed model has a clear advantage over conventional asymptotic models in both precision and efficiency.We first analyze the geometric standard deviation(GSD) of aerosol size distribution.The new model is then implemented to determine two analytic solutions,one with a varying GSD and the other with a constant GSD.The varying solution traces the evolution of the size distribution,whereas the constant case admits a decoupled solution for the zero and second moments.Both solutions are confirmed to have the same precision as the highly reliable numerical model,implemented by the fourth-order Runge-Kutta algorithm,and the analytic model requires significantly less computational time than the numerical approach.Our results suggest that the proposed model has great potential to replace the existing numerical model,and is thus recommended for the study of physical aerosol characteristics,especially for rapid predictions of haze formation and evolution. | Mingzhou Yu Jianzhong Lin Junji Cao Martin Seipenbusch | 2015 | Particuology2015，13，1： | 4 |
| 5 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 6 | Asymptotic behavior of the Taylor-expansion method of moments for solving a coagulation equation for Brownian particles显示文摘The evolution equations of moments for the Brownian coagulation of nanoparticles in both continuum and free molecule regimes are analytically studied.These equations are derived using a Taylor-expansion technique.The self-preserving size distribution is investigated using a newly defined dimensionless parameter,and the asymptotic values for this parameter are theoretically determined.The dimensionless time required for an initial size distribution to achieve self-preservation is also derived in both regimes.Once the size distribution becomes self-preserving,the time evolution of the zeroth and second moments can be theoretically obtained,and it is found that the second moment varies linearly with time in the continuum regime.Equivalent equations,rather than the original ones from which they are derived,can be employed to improve the accuracy of the results and reduce the computational cost for Brownian coagulation in the continuum regime as well as the free molecule regime. | Zhongli Chen Jianzhong Lin Mingzhou Yu | 2014 | Particuology2014，12，3： | 2 |
| 7 | Rice FLOURY ENDOSPERM 18 encodes a pentatricopeptide repeat protein required for 5′ processing of mitochondrial nad5 messenger RNA and endosperm development显示文摘Pentatricopeptide repeat(PPR) proteins, composing one of the largest protein families in plants,are involved in RNA binding and regulation of organelle RNA metabolism at the posttranscriptional level. Although several PPR proteins have been implicated in endosperm development in rice(Oryza sativa), the molecular functions of many PPRs remain obscure. Here, we identified a rice endosperm mutant named floury endosperm 18(flo18) with pleiotropic defects in both reproductive and vegetative development.Map-based cloning and complementation tests showed that FLO18 encodes a mitochondriontargeted P-type PPR protein with 15 PPR motifs.Mitochondrial function was disrupted in the flo18 mutant, as evidenced by decreased assembly of Complex I in the mitochondrial electron transport chain and altered mitochondrial morphology. Loss of FLO18 function resulted in defective 5′-end processing of mitochondrial nad5 transcripts encoding subunit 5 of nicotinamide adenine dinucleotide hydrogenase. These results suggested that FLO18 is involved in 5′-end processing of nad5 messenger RNA and plays an important role in mitochondrial function and endosperm development. | Mingzhou Yu Mingming Wu Yulong Ren Yihua Wang Jingfang Li Cailin Lei Yinglun Sun Xiuhao Bao Hongming Wu Hang Yang Tian Pan Yongfei Wang Ruonan Jing Mengyuan Yan Houda Zhang Lei Zhao Zhichao Zhao Xin Zhang Xiuping Guo Zhijun Cheng Bing Yang Ling Jiang Jianmin Wan | 2021 | Journal of Integrative Plant Biology2021，63，5： | 2 |
| 8 | Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China显示文摘Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been reported.However,the clinical outcome and pathogenesis remain unclear.In this study,we recruited 43 laboratory-confirmed COVID-19 patients.We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom onset.However,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies appeared.Furthermore,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease damage.Prolonged viral RNA shedding is associated with viral mutations and host factors. | Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
| 9 | A study on the heat and mass transfer properties of multiple pulsating impinging jets显示文摘 | Peng Xu Shuxia Qiu MingZhou Yu Xianwu Qiao Arun S. Mujumdar | 2012 | International Communications in Heat and Mass Transfer2012，，3： | 1 |
| 10 | A new moment method for solving the coagulation equation for particles in Brownian motion显示文摘 | YU Mingzhou LIN Jianzhong CHANT | 2008 | Aerosol Science and Technology2008，42，9： | 1 |
| 11 | Taylor-expansion moment method for agglomerate coagulation due to Brownian motion in the entire size regime显示文摘 | YU Mingzhou LIN Jianzhong | 2009 | Journal of Aerosol Science2009，40，6： | 1 |
| 12 | Solution of the agglomerate Brownian coagulation using Taylor-expansion moment method显示文摘 | YU Mingzhou LIN Jianzhong | 2009 | Journal of Colloid and Interface Science2009，336，1： | 1 |
| 13 | Methylation of TFPI-2 is an early event of esophageal carcinogenesis显示文摘 | Yan Jia Yunsheng Yang Malcolm V Brock Baoping Cao Qimin Zhan Yazhuo Li Yuanzi Yu James G Herman Mingzhou Guo | 2012 | Epigenomics2012，，2： | 1 |
| 14 | A new moment method for solving the coagulation equa- tion for particles in brownian motion 显示文摘 | Yu Mingzhou Lin Jiangzhong Chan Tatleung | 2008 | Aerosol Science and Technology2008，42，9： | 1 |
| 15 | Size Dependence of the Ratio of Aerosol Coagulation to Deposition Rates for Indoor Aerosols显示文摘 | Mingzhou Yu AnttiJoonas Koivisto Kaarle H?meri Martin Seipenbusch | 2013 | Aerosol Science and Technology2013，，4： | 1 |
| 16 | Size resolved particle emission rates from an evolving indoor aerosol system显示文摘 | Antti J. Koivisto Mingzhou Yu Kaarle H?meri Martin Seipenbusch | 2011 | Journal of Aerosol Science2011，，： | 1 |
| 17 | Alteration of the respiratory microbiome in COVID-19 patients with different severities显示文摘Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,898 deaths as of March 14, 2021, although300,002,228 vaccines have been administered globally. COVID-19patients have different clinical phenotypes and can be divided into asymptomatic, normal, mild, severe, and critical patients. | Zhengtu Li Yinhu Li Linghua Li Xiaoneng Mo Shaoqiang Li Mingzhou Xie Yangqing Zhan Ye Lin Zhun Li Min Xie Zhaoming Chen Airu Zhu Ruosu Ying Le Yu Jin cun Zhao Shuai Cheng Li Weiping Cai Feng Ye | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
| 18 | Large Eddy Simulation of the Particle Coagulation in High Concentration Particle-Laden Planar Jet Flow显示文摘Particle coagulation by Brownian motion is an important but difficult research topic.When particle volume concentration is larger than 0.1%,the classic SMOLUCHOWSKI equation is not applicative anymore.The high concentration coagulation,with HEINE's correction,source terms for the Taylor-series expansion method of moments(TEMOM) are firstly driven in this paper.Ultra-fine particle(d0?100 mm) with initial volume fraction f?1% coagulation in a planar jet turbulence flow is simulated via the large eddy simulation(LES).The instantaneous and time-averaged particle distributions and the high concentration enhancement are given out.The particle number concentration distribution results show that the coagulation is more intense comparing to dilute case in previous research,especially near the nozzle exit.After jet flow is fully developed,the effect is much more obvious at the region between vortexes.The time-averaged γ(the high concentration enhance factor) distributes sharply and symmetrically about the jet centerline at the upstream,but becomes broad and flat at downstream where the cross-stream averaged γ fluctuates drastically.As a new attempt,this paper shows Brownian coagulation with high concentration also can be calculated via TEMOM appropriately,and the coagulation at the region between vortexes is about 1.38 times intensive of the dilute result calculated by the classic Smoluchowski theory. | LIN Peifeng WU Dichong YU Mingzhou WANG Chao ZHANG Lite ZHU Zefei | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 0 |
| 19 | Interannual variability and climatic sensitivity of global wildfire activity显示文摘Understanding historical wildfire variations and their environmental driving mechanisms is key to predicting and mitigating wildfires. However, current knowledge of climatic responses and regional contributions to the interannual variability (IAV) of global burned area remains limited. Using recent satellite-derived wildfire products and simulations from version v1.0 of the land component of the U.S. Department of Energy's Energy Exascale Earth System Model (E3SM land model [ELM] v1) driven by three different climate forcings, we investigated the burned area IAV and its climatic sensitivity globally and across nine biomes from 1997 to 2018. We found that 1) the ELM simulations generally agreed with the satellite observations in terms of the burned area IAV magnitudes, regional contributions, and covariations with climate factors, confirming the robustness of the ELM to the usage of different climate forcing sources;2) tropical savannas, tropical forests, and semi-arid grasslands near deserts were primary contributors to the global burned area IAV, collectively accounting for 71.7%–99.7% of the global wildfire IAV estimated by both the satellite observations and ELM simulations;3) precipitation was a major fire suppressing factor and dominated the global and regional burned area IAVs, and temperature and shortwave solar radiation were mostly positively related with burned area IAVs;and 4) noticeable local discrepancies between the ELM and remote-sensing results occurred in semi-arid grasslands, croplands, boreal forests, and wetlands, likely caused by uncertainties in the current ELM fire scheme and the imperfectly derived satellite observations. Our findings revealed the spatiotemporal diversity of wildfire variations, regional contributions and climatic responses, and provided new metrics for wildfire modeling, facilitating the wildfire prediction and management. | Rongyun TANG Jiafu MAO Mingzhou JIN Anping CHEN Yan YU Xiaoying SHI Yulong ZHANG Forrest M.HOFFMAN Min XU Yaoping WANG | 2021 | Advances in Climate Change Research2021，12，5： | 0 |
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