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| 1 | Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis显示文摘AIM:To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis(NASH).METHODS:In total 26 patients,23 NASHs and 3 normal controls were enrolled in this study.NASH was staged based on Brunt criterion.At a region of interest(ROI),a shear wave was evoked by implementing an acoustic radiation force impulse(ARFI),and the propagation velocity was quantif ied.RESULTS:Shear wave velocity(SWV) could be reproducibly quantified at all ROIs in all subjects except for 4 NASH cases,in which a reliable SWV value was not calculated at several ROIs.An average SWV of 1.34 ± 0.26 m/s in fibrous stage 0-1 was significantly slower than 2.20 ± 0.74 m/s and 2.90 ± 1.01 m/s in stages 3 and 4,respectively,but was not significantly different from 1.79 ± 0.78 m/s in stage 2.When a cutoff value was set at 1.47 m/s,receiver operating characteristic analysis showed significance to dissociate stages 3 and 4 from stage 0-1(P=0.0092) with sensitivity,specificity and area under curve of 100%,75% and 94.2%,respectively.In addition,the correlation between SWV and hyaluronic acid was significant(P<0.0001),while a tendency toward negative correlation was observed with serum albumin(P=0.053).CONCLUSION:The clinical implementation of ARFI provides noninvasive repeated evaluations of liver stiffness at an arbitrary position,which has the potential to shed new light on NASH management. | Akihiko Osaki Tomoyuki Kubota Takeshi Suda Masato Igarashi Keisuke Nagasaki Atsunori Tsuchiya Masahiko Yano Yasushi Tamura Masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa Toru Kikuchi Minoru Nomoto Yutaka Aoyagi | 2010 | World Journal of Gastroenterology2010，16，23： | 30 |
| 2 | Airglow observation by Fabry-Perot Interferometer显示文摘An all-sky and a scanning Fabry-Perot interferometers (FPI)have been developed for observations of vertical winds and two-dimensional atmospheric motions in the low-thermosphere and the mesosphereregion by the measurement of Doppler shift and broadening of airglow, emission lines. The system 0f FPI isdescribed and the method of data analysis is propsoed,an example of observation is also given. | Ai Yong Mamoru Ishii Minoru Kubota Shoichi Okano Zhang Xunjie Lu Shu | 1998 | Wuhan University Journal of Natural Sciences1998，3，2： | 5 |
| 3 | Ureteroscopy assisted retrograde nephrostomy: a new technique for percutaneous nephrolithotomy (PCNL)显示文摘 | Takashi Kawahara Hiroki Ito Hideyuki Terao Minoru Yoshida Takehiko Ogawa Hiroji Uemura Yoshinobu Kubota Junichi Matsuzaki | 2011 | BJU International2011，，4： | 1 |
| 4 | Interferon induces insulin resistance in patients with chronic active hepatitis C显示文摘 | Eiichi Imano Tsutomu Kanda Yoshitaka Ishigami Minoru Kubota Masahiko Ikeda Munehide Matsuhisa Ryuzo Kawamori Yoshimitsu Yamasaki | 1998 | Journal of Hepatology1998，，2： | 1 |
| 5 | Regulation of serotonin transporter gene expression in human glial cells by growth factors显示文摘 | Nobuo Kubota Yuji Kiuchi Mariko Nemoto Hideto Oyamada Minoru Ohno Hisayuki Funahashi Seiji Shioda Katsuji Oguchi | 2001 | European Journal of Pharmacology2001，，1： | 1 |
| 6 | Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice显示文摘 | Kodama Takahiro Takehara Tetsuo Hikita Hayato Shimizu Satoshi Shigekawa Minoru Tsunematsu Hinako Li Wei Miyagi Takuya Hosui Atsushi Tatsumi Tomohide Ishida Hisashi Kanto Tatsuya Hiramatsu Naoki Kubota Satoshi Takigawa Masaharu Tomimaru Yos | 2011 | Journal of Clinical Investigation2011，，8： | 1 |
| 7 | Successful hepatic vein reconstruction in 42 consecutive living related liver transplantations显示文摘 | Keiichi Kubota Masatoshi Makuuchi Tadatoshi Takayama Yasushi Harihara Minoru Watanabe Keiji Sano Kiyoshi Hasegawa Hideo Kawarasaki | 2000 | Surgery2000，，1： | 1 |
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