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| 1 | Long-term outcome of percutaneous ethanol injection therapy for minimum-sized hepatocellular carcinoma显示文摘AIM: To evaluate long-term follow-up of minimum-sized hepatocellular carcinoma (HCC) treated with percutaneous ethanol injection (PEI). METHODS: PEI was applied to 42 lesions in 31 patients (23 male and eight female) with HCC < 15 mm in diameter, over the past 15 years. RESULTS: Overall survival rate was 74.1% at 3 years, 49.9% at 5 years, 27.2% at 7 years and 14.5% at 10 years. These results are superior to, or at least the same as those for hepatic resection and radiofrequency ablation. Survival was affected only by liver function, but not by sex, age, etiology of Hepatitis B virus or Hepatitis C virus, α-fetoprotein levels, arterial and portal blood flow, histological characteristics, and tumor multiplicity or size. Patients in Child-Pugh class A and B had 5-, 7- and 10-years survival rates of 76.0%, 42.2% and 15.8%, and 17.1%, 8.6% and 0%, respectively (P = 0.025). CONCLUSION: Treatment with PEI is best indicated for patients with HCC < 15 mm in Child-Pugh class A. | Miyuki Taniguchi Soo Ryang Kim Susumu Imoto Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Noriko Sasase Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2008 | World Journal of Gastroenterology2008，14，13： | 16 |
| 2 | Small-for-size syndrome in liver transplantation:Definition,pathophysiology and management显示文摘Background:Since the first success in an adult patient,living donor liver transplantation(LDLT)has become an universally used procedure.Small-for-size syndrome(SFSS)is a well-known complication after partial LT,especially in cases of adult-to-adult LDLT.The definition of SFSS slightly varies among transplant physicians.The use of a partial liver graft has risks of SFSS development.Persistent portal vein(PV)hypertension and PV hyper-perfusion after LT were identified as the main factors.Hence,various approaches were explored to modulate PV flow and decrease PV pressure in order to alleviate this syndrome.Herein,the definition,clinical symptoms,pathophysiology,basic research,as well as preventive and treatment strategies for SFSS are reviewed based on an extensive review of the literature and on our own experiences.Data sources:The articles were collected through PubMed using search terms“liver transplantation”,“living donor liver transplantation”,“living liver donation”,“partial graft”,“small-for-size graft”,“small-forsize syndrome”,“graft volume”,“remnant liver”,“standard liver volume”,“graft to recipient body weight ratio”,“sarcopenia”,“porcine”,“swine”,and“rat”.English publications published before March 31,2020 were included in this review.Results:Many transplant surgeons performed PV flow modulation,including portocaval shunt,splenic artery ligation and splenectomy.With these techniques,patient outcome has been improved even when using a'small'graft.Other factors,such as preoperative recipients’nutritional and skeletal muscle status,graft congestion,and donor factors,were also identified as risk factors which all have been addressed using various strategies.Conclusions:The surgical approach controlling PV flow and pressure could help to prevent SFSS especially in severely ill recipients.In the absence of efficacious medications to resolve SFSS,conservative treatments,including aggressive fluid balance correction for massive ascites,anti-microbiological therapy to prevent or control sepsis and intensive nutritional therapy,are all required if SFSS could not be prevented. | Yuichi Masuda Kazuki Yoshizawa Yasunari Ohno Atsuyoshi Mita Akira Shimizu Yuji Soejima | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，4： | 13 |
| 3 | Clinical development of reovirus for cancer therapy:An oncolytic virus with immune-mediated antitumor activity显示文摘 | Jun Gong Esha Sachdev Alain C Mita Monica M Mita | 2016 | World Journal of Methodology2016，6，1： | 8 |
| 4 | Diagnostic sensitivity of imaging modalities for hepatocellular carcinoma smaller than 2 cm显示文摘AIM:To compare the imaging results with histology and to evaluate the diagnostic sensitivity of imaging modalities for hepatocellular carcinoma(HCC)smaller than 2 cm.METHODS:Nodules smaller than 2 cm(n=34)revealed by ultrasonography(US)in 29 patients with liver cirrhosis were analyzed.Histological diagnosis of HCC was performed by ultrasonographic guidance:moderately-differentiated HCC(n=24);well-differentiated HCC(n=10).The patterns disclosed by the four imaging modalities defined the conclusive diagnosis of HCC:(1)contrast-enhanced computed tomography(CECT),hypervascularity in the arterial phase and washout in the equilibrium phase;(2)Sonazoid contrast-enhanced US(CEUS),hypervascularity in the early vascular phase and defect in the Kupffer phase;(3)gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid(Gd-EOBDTPA)-enhanced magnetic resonance imaging(MRI),hypervascularity in the arterial phase and/or defect in the hepatobiliary phase;and(4)CT arterioportal angiography:hypervascularity by CT during arteriography and/ or perfusion defect by CT during arterial portography.RESULTS:Overall,the sensitivity of diagnosing HCC smaller than 2 cm was 52.9%(18/34)(95%CI:35.170.2)by CECT;67.6%(23/34)(95%CI:49.5-82.6)by Sonazoid CEUS;76.5%(26/34)(95%CI:58.8-89.3) by Gd-EOB-DTPA MRI;and 88.2%(30/34)(95%CI: 72.5-96.7)by CT arterioportal angiography.The diagnostic sensitivity of detecting moderately-differentiated HCC by CECT,Sonazoid CEUS,Gd-EOB-DTPA MRI and CT arterioportal angiography was 62.5%(15/24)(95%CI: 40.6-81.2),79.2%(19/24)(95%CI:57.8-92.9),75.0% (18/24)(95%CI:53.3-90.2)and 95.8%(23/24)(95% CI:78.9-99.9),respectively.A significant difference(P< 0.05)was observed between CECT and CT arterioportal angiography in all nodules.There was no difference between Sonazoid CEUS,Gd-EOB-DTPA MRI,and CT arterioportal angiography.The combined sensitivity of Sonazoid CEUS and Gd-EOB-DTPA MRI was 94.1%(32/34).CONCLUSION:Changing the main diagnostic modality for HCC smaller than 2 cm from CT arterioportal angiography to Sonazoid CEUS and Gd-EOB-DTPA MRI is recommended. | Keiji Mita Soo Ryang Kim Masatoshi Kudo Susumu Imoto Taisuke Nakajima Kenji Ando Katsumi Fukuda Toshiyuki Matsuoka Yoko Maekawa Yoshitake Hayashi | 2010 | World Journal of Gastroenterology2010，16，33： | 7 |
| 5 | Scirrhous hepatocellular carcinoma displaying atypical findings on imaging studies显示文摘We describe a 15-mm scirrhous hepatocellular carcinoma(HCC) in a 60-year-old man with B-type cirrhosis.Ultrasound disclosed a 15-mm hypoechoic nodule in segment 7.Contrast-enhanced US revealed heterogeneous,not diffuse,hypervascularity in the early phase and a defect in the Kupffer phase.Contrast-enhanced computed tomography(CT) revealed a heterogeneous hypervascular nodule in the early phase and a low-density area in the late phase.Magnetic resonance imaging(MRI) revealed iso-to hypointensity at T1 and high intensity at T2-weighted sequences.Contrast-enhanced MRI also revealed a heterogeneous hypervascular nodule in the early phase and washout in the late phase.Super-paramagnetic iron oxide-MRI revealed a hyperintense nodule.CT during hepatic arteriography and CT during arterial portography revealed heterogeneous hyperattenuation and a perfusion defect,respectively.Based on these imaging findings the nodule was diagnosed as a mixed well-differentiated and moderately-differentiated HCC.Histologically,the nodule was moderately-differentiated HCC characterized by typical cytological and structural atypia with dense fibrosis.Immunohistochemically,the nodule was positive for heterochromatin protein 1 and alpha-smooth muscle actin,and negative for cytokeratin 19.From the above findings,the nodule was diagnosed as scirrhous HCC.Clinicians engaged in hepatology should exercise caution with suspected scirrhous HCC when imaging studies reveal atypical findings,as shown in our case on the basis of chronic liver disease. | Soo Ryang Kim Susumu Imoto Taisuke Nakajima Kenji Ando Keiji Mita Katsumi Fukuda Ryo Nishikawa Yu-ichiro Koma Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2009 | World Journal of Gastroenterology2009，15，18： | 4 |
| 6 | Multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated hepatocellular carcinoma in a patient with alcohol-related liver cirrhosis显示文摘We describe a rare case of the transformation of a dysplastic nodule into well-differentiated hepato- cellular carcinoma (HCC) in a 56-year-old man with alcoholrelated liver cirrhosis. Ultrasound (US) disclosed a 10 mm hypoechoic nodule and contrast enhanced US revealed a hypovascular nodule, both in segment seven. US-guided biopsy revealed a high-grade dysplastic nodule characterized by enhanced cellularity with a high N/C ratio, increased cytoplasmic eosinophilia, and slight cell atypia. One year later, the US pattern of the nodule changed from hypoechoic to hyperechoic without any change in size or hypovascularity. US-guided biopsy revealed well-differentiated HCC of the same features as shown in the first biopsy, but with additional pseudoglandular formation and moderate cell atypia. Moreover, immunohistochemical staining of cyclase- associated protein 2, a new molecular marker of well- differentiated HCC, turned positive. This is the first case of multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated HCC within one year in alcohol-related liver cirrhosis. | Soo Ryang Kim Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Michiie Sakamoto Yoshihiro Kanbara Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2007 | World Journal of Gastroenterology2007，13，8： | 4 |
| 7 | Aeromagnetic signatures of Precambrian shield and suture zones of Peninsular India显示文摘In many Precambrian provinces the understanding of the tectonic history is constrained by limited exposure and aeromagnetic data provide information below the surface cover of sediments,water,etc.and help build a tectonic model of the region.The advantage of using the aeromagnetic data is that the data set has uniform coverage and is independent of the accessibility of the region.In the present study,available reconnaissance scale aeromagnetic data over Peninsular India are analyzed to understand the magnetic signatures of the Precambrian shield and suture zones thereby throwing light on the tectonics of the region.Utilizing a combination of differential reduction to pole map,analytic signal,vertical and tilt derivative and upward continuation maps we are able to identify magnetic source distribution,tectonic elements,terrane boundaries,suture zones and metamorphic history of the region.The magnetic sources in the region are mainly related to charnockites,iron ore and alkaline intrusives.Our analysis suggests that the Chitradurga boundary shear and Sileru shear are terrane boundaries while we interpret the signatures of Palghat Cauvery and Achankovil shears to represent suture zones.Processes like metamorphism leave their signatures on the magnetic data:prograde granulites(charnockites)and retrograde eclogites are known to have high susceptibility.We fnd that charnockites intruded by alkali plutons have higher magnetization compared to the retrogressed charnockites.We interpret that the Dharwar craton to the north of isograd representing greenschist to amphibolite facies transition,has been subjected to metamorphism under low geothermal conditions.Some recent studies suggest a plate tectonic model of subductionecollisioneaccretion tectonics around the Palghat Cauvery shear zone(PCSZ).Our analysis is able to identify several west to east trending high amplitude magnetic anomalies with deep sources in the region from Palghat Cauvery shear to Achankovil shear.The magnetic high associated with PCSZ may represent the extruded high pressureeultra high temperature metamorphic belt(granulites at shallow levels and retrogressed eclogites at deeper levels)formed as a result of subduction process.The EW highs within the Madurai block can be related to the metamorphosed clastic sediments,BIF and mafc/ultramafc bodies resulting from the process of accretion. | Mita Rajaram S.P.Anand | 2014 | Geoscience Frontiers2014，5，1： | 3 |
| 8 | Determinants of Innovation显示文摘 | Mita Bhattacharya Harry Bloch | | Small Business Economics0，，： | 2 |
| 9 | Nonsurgical policy for treatment of bilioenteric anastomotic stricture after living donor liver transplantation显示文摘 | Atsuyoshi Mita Yasuhiko Hashikura Yuichi Masuda Yasunari Ohno Koichi Urata Yuichi Nakazawa Toshihiko Ikegami Masaru Terada Hironori Yamamoto Shin‐ichi Miyagawa | 2007 | Transplant International2007，，4： | 2 |
| 10 | Hepatic portal venous gas in pancreatic solitary metastasis from an esophageal squamous cell carcinoma显示文摘BACKGROUND:Hepatic portal venous gas(HPVG) is a rare entity commonly associated with intestinal necrosis and fatal outcome,and various underlying diseases have been reported.Pancreatic solitary metastasis without local extension is also rare in esophageal squamous cell carcinoma.METHODS:This report describes an interesting and unusual case of HPVG arising from pancreatic tumor.Autopsy revealed pathogenesis of HPVG and synchronous tumors of the esophagus and pancreas.RESULTS:A 73-year-old man developed synchronous double tumor in the esophagus and pancreas several months before acute abdomen and his death,which were generated by HPVG.Autopsy revealed that HPVG was caused by gastric wall infarction owing to expansion of an isolated pancreatic metastasis from esophageal squamous cell carcinoma.CONCLUSIONS:This is the first case of HPVG that was derived from pancreatic tumor infiltration.If he had been diagnosed with solitary pancreatic metastasis from esophageal squamous cell carcinoma in the first time,he might have an option for chemotherapy,which could let him live longer. | Takeshi Sawada Yasushi Adachi Manabu Noda Kimishige Akino Takefumi Kikuchi Hiroaki Mita Yoshifumi Ishii Takao Endo | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，1： | 2 |
| 11 | Vibration Control of Tall Buildings Using Mega SubConfiguration显示文摘 | Maria Q. Feng Akira Mita | 1995 | Journal of Engineering Mechanics1995，，10： | 2 |
| 12 | Effects of transforming growth factor beta on corneal epithelial and stromal cell function in a rat wound healing model after excimer laser keratectomy显示文摘 | Mita T Yamashita H Kaji Y | 1998 | Graefes Arch Clin Exp Ophthalmol1998，236，： | 2 |
| 13 | Gene expression analysis in the larval silk gland of the eri silkworm Samia ricini显示文摘昆虫为目的一个范围生产丝绸。在鳞翅目,丝绸为茧生产作为材料被利用并且服务保护幼虫免受不利环境条件或食肉动物的伤害。在 Saturniidae 家庭的种类例如,生产茧的一个特别宽的变化有许多小洞的大、金色的有颜色的茧和那些。尽管在国内蚕(Bombyx mori L.) 的丝绸腺的基因表示广泛地被学习了,更加,更少调查集中了于天蚕蛾家庭的成员。这里,我们从 eri 蚕(Samia ricini ) 的丝绸腺建立了表示顺序标签,天蚕蛾种,并且使用这些分析基因表示。尽管我们识别了丝心蛋白在确定的图书馆的重链基因,为另外的主要丝绸蛋白质的基因例如丝心蛋白光链和 fibrohexamerin,是不在的。这发现与这些后者蛋白质缺乏天蚕蛾丝绸的以前的报告一致。最近,一系列象 fibrohexamerin 一样基因在 Bombyx 染色体被识别。我们使用了这个信息进行这里建立的图书馆的详细分析。这分析识别了这些基因的通常认为的相当或相同事物。我们也发现几编码也是在另外的鳞翅目的丝绸的现在的小丝绸蛋白质分子的基因。基因表示模式在 eri 和国内蚕之间被比较,并且保存并且 nonconserved 表示模式为测试基因被识别。如此的微分基因表示可能是在在这些之间的丝绸性质的差别的主要原因之一种类。我们相信我们的学习能作为为丝绸腺基因表示的一个基本目录具有值,它将让步到丝绸进化的进一步的理解。 | Takuya Tsubota Kimiko Yamamoto Kazuei Mita Hideki Sezutsu | 2016 | Insect Science2016，23，6： | 2 |
| 14 | Quantification of leukotriene B4 glucuronide in human urine 显示文摘 | Mita H Turikisawa N Yamada T Taniguchi M | 2007 | Prostaglandins Other Lipid Mediators2007，83，1： | 1 |
| 15 | Segmentation of Bright Targets Using Wavelets and Adaptive Thresholding显示文摘 | Mita D Desai | 2001 | IEEE Transactions on Image Processing2001，10，7： | 1 |
| 16 | Changes in microtubules in onion leaf sheath cells during bulb development显示文摘 | Mita T Shibaoka H | 1983 | Plant Cell Physiol1983，24，： | 1 |
| 17 | Phase I, pharmacokinetic (PK), and pharmacodynamic (PD) study of AP23573, an mTOR inhibitor, administered Ⅳ daily X 5 every other week in patients (pts) with refractory or advanced malignanciSs显示文摘 | Mita MM Rowinsky EK Goldston ML | 2004 | Clin Oncol2004，30，3： | 1 |
| 18 | Phase Ⅰ and pharmcokinetic study of pemetrexed administered every 3 weeks to advanced cancer patients with normal and impaired renal function 显示文摘 | Mita AC Sweeney C J Baker SD | 2006 | J Clin Oncol2006，24，18： | 1 |
| 19 | PhaseI pharma- cokinetie and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand recep- tor显示文摘 | Tolcher AW Mita M Meropol NJ etal | 2007 | J Clin Oncol2007，25，： | 1 |
| 20 | survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics 显示文摘 | Mita A C Mita M M Nawrocki S T | 2008 | Clin Cancer Res2008，14，16： | 1 |
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