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| 1 | Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases显示文摘Reactive oxygen species (ROS) have been known to play an important role in the pathogenesis of atherosclerosis and several other cardiovascular diseases. It is now apparent that ROS induce endothelial cell damage and vascular smooth muscle cell (VSMC) growth and cardiac remodeling, which are associated with hypertension, atherosclerosis, heart failure, and restenosis. Several lines of evidence have indicated that ROS and mitogen-activated protein (MAP) kinases were involved in vascular remodeling under various pathological conditions. Recently, it was also reported that MAP kinases were sensitive to oxidative stress. MAP kinases play an important role in cell differentiation, growth, apoptosis, and the regulation of a variety of transcription factors and gene expressions. Bioflavonoids and polyphenolic compounds are believed to be beneficial for the prevention and treatment of athero-sclerosis and cardiovascular diseases. One of the most widely distributed bioflavonoids, 3,3',4',5,7-penta-hydroxyflavone (quercetin) and its metabolite quercetin 3-O-β-D-glucuronide (Q3GA) inhibited Angiotensin Ⅱ-stimulated JNK activation and resultant hypertrophy of VSMC. Several studies have suggested that various antioxi-dants including probucol, N-acetyl-L-cysteine, diphenylene iodonium, Trolox C (vitamin E analogue), and vitamin C inhibit VSMC growth, which is associated with pathogenesis of cardiovascular diseases. Therefore, inhibition of MAP kinases by antioxidant treatment may prove to be a therapeutic strategy for cardiovascular diseases. In contrast, some clinical studies have reported that antioxidant vitamins did not show beneficial effects in coron aryartery disease or in a number of high-risk people. Thus, further studies are needed to clarify why antioxidants showed beneficial effects in vitro, whereas less satisfactory results were obtained in some clinical conditions. | Moe KYAW Masanori YOSHIZUMI Koichiro TSUCHIYA Yuki IZAWA Yasuhisa KANEMATSU Toshiaki TAMAKI | 2004 | Acta Pharmacologica Sinica2004，25，8： | 24 |
| 2 | Sequence Information on Simple Sequence Repeats and Single Nucleotide Polymorphisms through Transcriptome Analysis of Mungbean显示文摘Mungbean(Vigna radiata(L.) Wilczek) is a unique species in its ability to fix atmospheric nitrogen,with early maturity,and relatively good drought resistance.We used 454 sequencing technology for transcriptome sequencing.A total of 150 159 and 142 993 reads produced 5 254 and 6 374 large contigs(≥500 bp) with an average length of 833 and 853 for Sunhwa and Jangan,respectively.Functional annotation to known sequences yielded 41.34% and 41.74% unigenes for Jangan and Sunhwa.A higher number of simple sequence repeat(SSR) motifs was identified in Jangan(1 630) compared with that of Sunhwa(1 334).A similar SSR distribution pattern was observed in both varieties.A total of 8 249 single nucleotide polymorphisms(SNPs) and indels with 2 098 high-confidence candidates were identified in the two mungbean varieties.The average distance between individual SNPs was ~860 bp.Our report demonstrates the utility of transcriptomic data for implementing a functional annotation and development of genetic markers.We also provide large resource sequence data for mungbean improvement programs. | Kyaw Thu Moe Jong-Wook Chung Young-Il Cho Jung-Kyung Moon Ja-Hwan Ku Jin-Kyo Jung Jungran Lee Yong-Jin Park | 2011 | Journal of Integrative Plant Biology2011，53，1： | 4 |
| 3 | 显示文摘 | Moe Kyaw Ito Mitsunobu | 1999 | Chemical Engi-neering Science1999，54，： | 1 |
| 4 | Semaphorin 3A controls timing and patterning of the dental pulp innervation 显示文摘 | Kyaw Moe Angelina Sijaona Anjana Shrestha | 2012 | Differentiation2012，84，10： | 1 |
| 5 | Disease burden of intensive care unit-acquired pneumonia in China: a systematic review and meta-analysis显示文摘 | Yaowen Zhang Zhiyuan Yao Siyan Zhan Zhirong Yang Dong Wei Jing Zhang Jingyi Li Moe H. Kyaw | 2014 | International Journal of Infectious Diseases2014，，： | 1 |
| 6 | Current Trends in Diagnostic Biomarkers of Acute Coronary Syndrome显示文摘 | Kyaw Thu Moe Philip Wong | 2010 | Annals of the Academy of Medicine Singapore2010，，03： | 1 |
| 7 | Suppression of nitrous oxide production by the herbicides glyphosate and propanil in soils supplied with organic matter显示文摘 | Khin Moe Kyaw Toyota K | 2007 | Soil Science and Plant Nutrition2007，53，4： | 1 |
| 8 | Effect of Dendranthema on Cotesia plutellae Parasitism in Brassicaceous Crops: Control of Diamondback Moth (DBM), Plutella xylostella (Linnaeus)显示文摘 | Phyoe Wai Htun Weine Nway Nway Oo Moe Kyaw Thu | 2011 | Journal of Agricultural Science and Technology(A)2011，1，2X： | 0 |
| 9 | Postvaccination breakthrough SARS-CoV-2 infections among adults in Malaysia and attitudes towards future vaccination显示文摘Objective:To determine the frequency and severity of the breakthrough infections and the associated factors in Malaysia.Methods:This cross-sectional study was conducted among the adult general population in Malaysia who completed at least one dose of vaccination.The validated online questionnaires were used for data collection between December 2022 to February 2023.The participants were recruited by a convenient sampling method.The data were analysed by descriptive statistics,and logistic regression by using SPSS(Version 27).Qualitative data from open-ended questions were analysed as thematic analysis by using RQDA software.Results:A total of 524 participants'data were analyzed and 77.5%of them completed three doses of COVID-19 vaccination.Breakthrough infections after vaccination were reported in 57.3%of the participants.Age group of 18 and 30 years(aOR 2.32,95%CI 1.01-5.32)and other ethnicities(aOR 2.00,95%CI 1.02-3.93)significantly associated with the occurrence of breakthrough infections.A total of 35.5%of the participants were not willing to take another booster dose in the future because of their attitudes towards fear of long-term side effects,lack of trust to the vaccine,less susceptibility to severe infection,belief in natural immunity,and myths.Conclusions:Future public health policies and interventions should be focused on disseminating the information about safety of booster doses of vaccine,management and re-assurance of side effects,and targeted vaccination to the working(younger age group)and ethnic minorities. | Praneetha Kumar Nair Kai Ern Koh Christine Yvonne Bede Lee Ai Ren Natasha Mevuni Dinethma Mahanama Thin Mon Kyaw Htoo Htoo Kyaw Soe Soe Moe Kazi Majidur Rahaman Mila Nu Nu Htay | 2023 | Asian Pacific Journal of Tropical Medicine2023，16，7： | 0 |
| 10 | Participation of private general practitioners in disease management of malaria in Myanmar显示文摘Objective:Myanmar has been trying to improve the disease management of malaria through public health services. The involvement of private general practitioners(GPs) is recognized as one of the key contributory issues in malaria control,but no one has yet made an attempt to study the efficiency of their role.This study aimed to assess the participation of GPs in improvement of disease management.Methods:The study was conducted with all 32 GPs practicing at three randomly selected townships with high malaria load situated in Upper Myanmar from June 2006 to March 2007 using a pretest-posttest design to assess their knowledge of the disease management prior to and after intervention.The intervention package consisted of a one-day workshop on diagnosis and treatment of malaria and the supply of facilities for microscopy.Questionnaires filled in before and after tests were compared to assess the change of knowledge after the intervention.Diagnosis and treatment practice during the study period was analysed by review of registers kept by GPs,together with a follow-up survey of their patients for the reliability of data.Results:An overall improvement of knowledge was observed and significant changes were apparent for three variables:the criteria for referral of severe malaria,the effect of incomplete treatment and recommended treatment of Plasmodium vivax.Pre-test results showed that only 65.6%of GPs perceived microscopy or Rapid Diagnostic Test kits(RDTs) for confirmation of malaria necessary,while only 15.6%and 40.6%of the GPs knew the recommended treatments of falciparum and vivax malaria,respectively. However,after intervention 92%of the patients were diagnosed as malaria by RDTs and 3%by microscopy throughout the study.The GPs prescribed artemisinin-based combination therapy(ACTs) to 95%of confirmed falciparum cases and treated 82.4%of RDT confirmed falciparum negatives with chloroquine and primaquine.Concurrent with our study,an international NGO,Population Service International,supplied GPs with RDTs and ACTs at subsidized rate which was helpful.Conclusion:The study suggests that participation of GPs may help improve the disease management of malaria and thus assist in the country’s effort to control ma- laria. | Thein Tun Zaw Win Tun Hla Soe Tint Khin Lin Thar Tun Kyaw Moe Kyaw Myint | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，5： | 0 |
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