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| 1 | From NAFLD to MAFLD:a“redefining”moment for fatty liver disease显示文摘The term non-alcoholic fatty liver disease(NAFLD)was coined in 1980 to characterize a disease similar to alcoholic fatty liver disease that developed in patients without a history of excessive alcohol intake.[1]Morphologically,NAFLD is characterized by excess fatty infiltration of the liver in the absence of known causes of liver disease(eg,alcohol,autoimmune liver disease,viral hepatitis,etc).The clinical manifestations of NAFLD(both hepatic and extrahepatic)depend on the outcome of complex interactions between its primary drivers including poor lifestyle habits and diet,a dysfunctional microbiota,genetic predisposition,and environmental cues that result in metabolic dysfunction and liver disease.However,bringing all patients with their markedly different clinical courses under the NAFLD umbrella belies its complexity and implies a homogeneous disease state that then negatively impacts clinical management and a deeper understanding of pathogenesis.With advances in current knowledge on the spectrum of fatty liver diseases,it is apparent that the fourdecade-old outdated term NAFLD can no longer serve to usefully describe a highly heterogeneous disease.The disease as we understand it today not only impacts patients who consume alcohol and those who do not,but also potentially impacts all patients with any form of liver disease,by acting as a disease modifier.[2] | Kenneth IZheng Jian-Gao Fan Jun-Ping Shi Vincent Wai-Sun Wong Mohammed Eslam Jacob George Ming-Hua Zheng | 2020 | Chinese Medical Journal2020，，19： | 14 |
| 2 | Macrophages in metabolic associated fatty liver disease显示文摘Metabolic associated fatty liver disease(MAFLD),formerly named non-alcoholic fatty liver disease is the most common liver disorder in many countries.The inflammatory subtype termed steatohepatitis is a driver of disease progression to cirrhosis,hepatocellular carcinoma,liver transplantation,and death,but also to extrahepatic complications including cardiovascular disease,diabetes and chronic kidney disease.The plasticity of macrophages in response to various environmental cues and the fact that they can orchestrate cross talk between different cellular players during disease development and progression render them an ideal target for drug development.This report reviews recent advances in our understanding of macrophage biology during the entire spectrum of MAFLD including steatosis,inflammation,fibrosis,and hepatocellular carcinoma,as well as for the extra-hepatic manifestations of MAFLD.We discuss the underlying molecular mechanisms of macrophage activation and polarization as well as cross talk with other cell types such as hepatocytes,hepatic stellate cells,and adipose tissue.We conclude with a discussion on the potential translational implications and challenges for macrophage based therapeutics for MAFLD. | Jawaher Alharthi Olivier Latchoumanin Jacob George Mohammed Eslam | 2020 | World Journal of Gastroenterology2020，26，16： | 5 |
| 3 | Biomarkers of Metabolic(Dysfunction)-associated Fatty Liver Disease:An Update显示文摘The prevalence of metabolic(dysfunction)-associated fatty liver disease(MAFLD)is rapidly increasing and affects up to two billion individuals globally,and this has also resulted in increased risks for cirrhosis,hepatocellular carcinoma,and liver transplants.In addition,it has also been linked to extrahepatic consequences,such as cardiovascular disease,diabetes,and various types of cancers.However,only a small proportion of patients with MAFLD develop these complications.Therefore,the identification of high-risk patients is paramount.Liver fibrosis is the major determinant in developing these complications.Although,liver biopsy is still considered the gold standard for the assessment of patients with MAFLD.Because of its invasive nature,among many other limitations,the search for noninvasive biomarkers for MAFLD remains an area of intensive research.In this review,we provide an update on the current and future biomarkers of MAFLD,including a discussion of the associated genetics,epigenetics,microbiota,and metabolomics.We also touch on the next wave of multiomic-based biomarkers. | Jawaher Alharthi Mohammed Eslam | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 3 |
| 4 | Endoscopic stapedotomy: Merits and demerits显示文摘This work is conducted in Mansoura University Hospitals,Egypt,to show the advantages and disadvantages of endoscopic stapedotomy in comparison to microscopic stapedotomy.The work described has not been published previously nor under consideration for publication elsewhere.The authors declare that there is no conflict of interest.This study is a part of a master degree thesis submitted by Eslam Mahmoud as partial fulfillment for a master degree.Institutional review board approval,Faculty of Medicine-Mansoura University,was obtained for the study(IRB:MS/15.09.49). | Waleed Moneir Ahmed Musaad Abd El-fattah Eslam Mahmoud Mohamed Elshaer | 2018 | Journal of Otology2018，13，3： | 2 |
| 5 | The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates显示文摘Malignant cells upregulate distinct energy metabolism programs that support their proliferation,migration,and adaptation to the stressful tumor microenvironment(TME).Additionally,this exaggerated metabolic activity allows cancer cells to hijack essential nutrients and outcompete neighboring infiltrating immune cells,thereby impairing antitumor immunity.During recent years,there has been great interest in the field to understand the tumor-induced energy metabolism signals that regulate the function of immune cells in individuals with cancer.Accordingly,it is now well accepted that uncovering the mechanisms that instruct the metabolic behavior of cancer cells and tumor-associated immune cells is an indispensable strategy for the development of new approaches to overcome immune suppression in tumors.Thus,in this minireview,we briefly discuss the interaction between particular metabolic signaling pathways and immunosuppressive activity in different subsets of myeloid cells within the TME.Additionally,we illustrate potential central mechanisms controlling the metabolic reprogramming of myeloid cells in response to tumor-derived factors. | Eslam Mohamed Amir A.Al-Khami Paulo C.Rodriguez | 2018 | Cellular & Molecular Immunology2018，15，5： | 2 |
| 6 | Interaction of IFNL3 with insulin resistance,steatosis and lipid metabolism in chronic hepatitis C virus infection显示文摘Metabolic changes are inextricably linked to chronic hepatitis C(CHC).Recently polymorphisms in the IFNL3(IL28B)region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus(HCV)infection.Further,circumstantial evidence suggests a link between IFNL3single nucleotide polymorphisms and lipid metabolism,steatosis and insulin resistance in CHC.The emerging picture suggests that the responder genotypes of IFNL3polymorphisms are associated with a higher serum lipid profile,and less frequent steatosis and insulin resistance.This review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression. | Mohammed Eslam David R Booth Jacob George Golo Ahlenstiel | 2013 | World Journal of Gastroenterology2013，19，41： | 2 |
| 7 | Metabolic associated fatty liver disease(MAFLD):a milestone in the history of fatty liver disease显示文摘With the widespread increase in energy intake and physical inactivity,the prevalence of metabolic health is declining.Consequently,metabolic associated fatty liver disease(MAFLD)[formerly known as non-alcoholic fatty liver disease(NAFLD)]has risen in prevalence and present a significant challenge to global health causing considerable morbidity and mortality,particularly when fibrosis is present(1). | Jawaher Alharthi Mohammed Eslam | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 1 |
| 8 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 9 | Sonographic gallbladder wall thickness measurement and the prediction of esophageal varices among cirrhotics显示文摘Acute variceal bleeding in patients with liver cirrhosis and portal hypertension(PHT) is the most serious emergency complication among those patients and could have catastrophic outcomes if not timely managed. Early screening by esophago-gastro-duodenoscopy(EGD) for the presence of esophageal varices(EVs) is currently recommended by the practice guidelines for all cirrhotic patients. Meanwhile, EGD is not readily accepted or preferred by many patients. The literature is rich in studies to investigate and validate non-invasive markers of EVs prediction aiming at reducing the unneeded endoscopic procedures. Gallbladder(GB) wall thickness(GBWT) measurement has been found promising in many published research articles. We aim to highlight the validity of sonographic GBWT measurement in the prediction of EVs based on the available evidence. We searched databases including Cochrane library, Pub Med, Web of Science and many others for relevant articles. GBWT is associated with the presence of EVs in cirrhotic patients with PHT of different etiologies. The cut-off of GBWT that can predict the presence of EVs varied in the literature and ranges from 3.1 mm to 4.35 mm with variable sensitivities of 46%-90.9% and lower cutoffs in viral cirrhosis compared to non-viral, however GBWT > 4 mm in many studies is associated with acceptable sensitivity up to 90%. Furthermore, a relation was also noticed with the degree of varices and portal hypertensive gastropathy.Among cirrhotics, GBWT > 3.5 mm predicts the presence of advanced(grade Ⅲ-Ⅳ) EVs with a sensitivity of 45%, the sensitivity increased to 92% when a cut-off ≥ 3.95 mm was used in another cohort. Analysis of these results should carefully be revised in the context of ascites, hypoalbuminemia and other intrinsic GB diseases among cirrhotic patients. The sensitivity for prediction of EVs improved upon combining GBWT measurement with other non-invasive predictors, e.g., platelets/GBWT. | Mohamed H Emara Mariam Zaghloul Ibrahim F Amer Aya M Mahros Mohammed Hussien Ahmed Mahmoud A Elkerdawy Eslam Elshenawy Abdelrahman M Ahmed Rasheda Tarik I Zaher Mona Talaat Haseeb Emad Hassan Emara Hassan Elbatae | 2023 | World Journal of Hepatology2023，15，2： | 1 |
| 10 | Influence of selbhealing mixing method and adding silica fume on mechanical properties of recycled aggregates con- crete 显示文摘 | All Abd Elhakam Abd Etmoaty Mohamed Eslam Awad | 2012 | Construction and Building Materials2012，35，： | 1 |
| 11 | Insulin Resistance Impairs Viral Dynamics Independently of Ethnicity or Genotypes显示文摘 | Mohammed Eslam Reyes Aparcero Youssef I. Mousa Lourdes Grande Yehia Shaker Ahmed Ali José A. del Campo Mahmoud A. Khattab Manuel Romero-Gomez | 2012 | Journal of Clinical Gastroenterology2012，，3： | 1 |
| 12 | Influence of self-healing, mixing method and adding silica fume on mechanical properties of recycled aggregates concrete显示文摘 | Ali Abd Elhakam Abd Elmoaty Mohamed Eslam Awad | 2012 | Construction and Building Materials2012，，： | 1 |
| 13 | Hepatic Steatosis in Genotype 4 Chronic Hepatitis C Patients: Implication for Therapy显示文摘 | Mahmoud Aboelneen Khattab Mohammed Emad Abdel-fattah Mohammed Eslam Asharf Abdelaleem Rabab Atef Abdelaleem Mohammed Shatat Ahmed Ali Lamia Hamdy Heba Tawfek | 2010 | Journal of Clinical Gastroenterology2010，，10： | 1 |
| 14 | Strain Echocardiography in Early Detection of Doxorubicin-Induced Left Ventricular Dysfunction in Children with Acute Lymphoblastic Leukemia显示文摘 | Mohammed Al-Biltagi Osama Abd Rab Elrasoul Tolba Mohammed Ramadan El-Shanshory Nagla Abd El-Aziz El-Shitany Eslam El-Sayed El-Hawary M. S. Anderson G. Siberry | 2012 | ISRN Pediatrics2012，，： | 1 |
| 15 | Metabolic associated fatty liver disease and cancer risk: causal role or epiphenomenon?显示文摘The majority of global deaths are attributed to one of the noncommunicable diseases(NCDs),and cancer is projected to be the leading cause of death worldwide in the 21st century(1).There were 18.1 million incident cancer cases worldwide in 2018,43.8 million are living with cancer and 9.6 million deaths from cancer.One in 6 deaths is due to cancer and these numbers are projected to rise to 13 million by 2030,more than that from tuberculosis,malaria and HIV/AIDS combined.In addition,the total annual global cost of cancer was estimated at around US$1.16 trillion,representing a significant burden on health care systems and families(1). | Ali Bayoumi Mohammed Shatat Mohammed Eslam | 2020 | Hepatobiliary Surgery and Nutrition2020，9，6： | 1 |
| 16 | The Role of TiO2 Anatase Nano-Filler to Enhance the Physical and Electrochemical Properties of PVA-Based Polymer Electrolyte for Magnesium Battery Applications显示文摘 | B.M. Abdel-Samiea A. Basyouni R. Khalil Eslam Mohamed Sheha H. Tsuda T. Matsui | 2013 | 材料科学与工程(中英文A版)2013，3，10： | 1 |
| 17 | Is hepatitis C subtyping still relevant in the era of direct-acting antiviral therapy?显示文摘 | Mohammed Eslam Jacob George | 2015 | Hepatology International2015，，1： | 1 |
| 18 | Geochemistry of magnetite in beach sands, stream sediments,and in situ magnetites in surrounding rocks at north Taiwan island显示文摘The geochemistry of magnetite provides constraints on the source(s) of the magnetite and other ore minerals. In this study, we constructed a magnetite distribution map, compared the chemical composition of magnetite present in hard rocks with that present in sand beach and stream deposits to determine magnetite’s provenance,investigated relationships among different trace elements,examined variations in the concentrations of trace elements present in magnetite, and identified the type of studied magnetite. Laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS) and inductively coupled plasma mass spectrometry/inductively coupled plasma atomic emission spectroscopy was used to analyze samples available in small and large amounts, respectively. The average magnetite compositions of beach and river samples were substantially similar to those of andesite rocks,revealing that the magnetite samples may have originated from surrounding andesite rocks;this finding is consistent with the chemical composition of the samples analyzed using LA-ICP-MS. Some of the andesite rocks found in the study area were the primary source of magnetite aggregations in the beach sands and stream sands near or slightly away from these rocks. High Ti–V magnetites lie within the fields of Fe–Ti–V bearing magnetite and titanomagnetite(ulv?spinel). These titanomagnetites may be undergoing transformation to spinel minerals such as galaxite,gahnite, magnesiochromite, and chromite, which are characterized by the high concentrations of Al, Ti, Mg, Cr,Ni, Mn, and Zn. The positive correlation between Fe and Ti, Cr and Ni, and also the negative correlation between Fe and Mg, Mn and Zn can be attributed to various magnetite phases present in the study area. V, Co, Mo, Nb, Ga, Sn,and Ta exhibited a positive correlation with Fe and a negative correlation with Al. The positive correlation between Fe and these elements indicates the enrichment of these elements in the magnetite series. We observed a negative correlation between Fe and Li, Rb, Ca, Ba, Sr, Cu,Cd, Sb, As, Sc, Y, REE, U, and Th. A positive correlation between Al and these elements indicates the enrichment of these elements in the spinel series. | Eslam Mohammed Ali Mitwally Bing-Sheng Yu | 2022 | Acta Geochimica2022，41，3： | 0 |
| 19 | Evaluation of the chemical constituents,antioxidant and enzyme inhibitory activities of six Yemeni green coffee beans varieties显示文摘Coffee arabica L.is an economical crop cultivated in many countries including Yemen.The present study evaluated the phytochemical contents of the methanolic extracts,prepared by maceration,of six Yemeni green coffee beans varieties namely Esmaeli,Hamadi,Harazi,Mattari,Odaini and Yafei.Antioxidant(phosphomolybdenum,antiradical,reducing power and ferrous chelating),and enzyme inhibition activity of the extracts against acetylcholinesterase butyrylcholinesterase,tyrosinase,α-glucosidase,andα-amylase were also studied.Quantification of total phenols revealed that all green beans varieties were richer in their total polyphenolic(63.77-110.98 mg gallic acid equivalent per g of extract)content than their flavonoids one(2.86-5.57 mg rutin equivalent per g of extract).HPLC-MS/MS analysis of 30 selected bioactive compounds showed that all varieties had the same types of phytoconstituents with differences in their relative abundance.Caffeine(1613.89-2466.38μg/g)followed by 5-caffeoylquinic acid(1017.63-1313.39μg/g)were the dominant compounds in all varieties with caffeine more abundant in Esmaeli variety while 5-caffeoylquinic acid in Odaini variety.All varieties displayed a pronounced antioxidant property in all the in vitro assays with Odaini variety significantly(p<0.05)exerted the highest anti-DPPH radicals(253.96 mg Trolox equivalent(TE)/g),metal chelating(19.73 mg Disodium edetate equivalents/g),Cu^(2+)(441.11 mg TE/g)and Fe3+(221.04 mg TE/g)reducing activities.Furthermore,the majority of green coffee beans varieties showed comparable enzyme inhibition property with highest activity recorded against tyrosinase(39.35-46.96 mg kojic acid equivalents/g)and acetylcholinesterase(1.80-2.17 mg galanthamine equivalents/g)enzymes.In conclusion,all Yemeni green coffee beans varieties have proven to be rich source of biochemicals with beneficial impact on human health and could be of significant applications in food,pharmaceutical and cosmetics industry. | Ammar Mohammed Ahmed Ali Sakina Yagi Ahmed A.Qahtan Abdurrahman A.Alatar Simone Angeloni Filippo Maggi Giovanni Caprioli Eslam M.Abdel-Salam Kouadio Ibrahime Sinan Gokhan Zengin | 2022 | Food Bioscience2022，46，2： | 0 |
| 20 | Conventional generation emulation for power grids with a high penetration of wind power显示文摘Integrating large-scale wind plants with the electricity grids has many challenges for grid operators.Besides the variability and uncertainty of wind power,coordinating between different technologies of generation in the same grid can be considered the main problem,specifically for short-term frequency stability.Therefore,a large penetration of wind power generation in modern power grids has a risky influence on the power-system frequency.Wind-generation plants have contradictory behaviour compared to classic thermal plants,especially in active generated power-shortage events due to the variable nature of wind power.Existing experience in wind plants keeps part of the available wind power unloaded,using what are known as deloading techniques.Different deloading techniques are usually applied to emulate the thermal-plant-governor function and confirm a proper spinning reserve for any active-power shortages.These techniques decrease the generated power from wind plants continuously from maximum point tracking ones.Consequently,the practical capacity,annual generated energy and economical income of wind plants are reduced.In addition,grid-protection and control sub-schemes are set and designed according to the well-known conventional responses of thermal plants,which increase the need for thermal-plant-behaviour emulation.In this paper,instead of the usual deloading methods,a supercapacitors scheme is proposed with wind turbines to emulate the response of conventional power plants.The study discusses the technical and economic benefits of the proposed addition of supercapacitors in the wind-plant-planning phase.Restricted frequency grid-code indices are selected to evaluate studied behaviours.Simulation results of the IEEE four-generation two-area system determines the effectiveness of suggested schemes technically.The System Advisor Model(SAM)program estimates the economic benefits of a typical US study case compared with the existing wind-deloading technique. | Rasha El-Azab Eslam M.Wazeer Mohamed Daowd A.M.Abdel Ghany | 2021 | Clean Energy2021，5，1： | 0 |
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