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| 1 | Genetics of inflammatory bowel disease from multifactorial to monogenic forms显示文摘Inflammatory bowel disease(IBD) is a group of chronic multifactorial disorders. According to a recent study,the number of IBD association loci is increased to 201,of which 37 and 27 loci contribute specifically to the development of Crohn's disease and ulcerative colitis respectively. Some IBD associated genes are involved in innate immunity,in the autophagy and in the inflammatory response such as NOD2,ATG16L1 and IL23 R,while other are implicated in immune mediated disease(STAT3) and in susceptibility to mycobacterium infection(IL12B). In case of early onset of IBD(VEO-IBD) within the 6th year of age,the disease may be caused by mutations in genes responsible for severe monogenic disorders such as the primary immunodeficiency diseases. In this review we discuss how these monogenic disorders through different immune mechanisms can similarly be responsible of VEO-IBD phenotype. Moreover we would highlight how the identification of pathogenic genes by Next Generation Sequencing technologies can allow to obtain a rapid diagnosis and to apply specific therapies. | Anna Monica Bianco Martina Girardelli Alberto Tommasini | 2015 | World Journal of Gastroenterology2015，21，43： | 13 |
| 2 | Alternate Wetting and Drying of Rice Reduced CH4 Emissions but Triggered N2O Peaks in a Clayey Soil of Central Italy显示文摘Reducing CH_4 and N_2O emissions from rice cropping systems while sustaining production levels with less water requires a better understanding of the key processes involved. Alternate wetting and drying(AWD) irrigation is one promising practice that has been shown to reduce CH_4 emissions. However, little is known about the impact of this practice on N_2O emissions, in particular under Mediterranean climate. To close this knowledge gap, we assessed how AWD influenced grain yield, fluxes and annual budgets of CH_4 and N_2O emissions, and global warming potential(GWP) in Italian rice systems over a 2-year period. Overall, a larger GWP was observed under AWD, as a result of high N_2O emissions which offset reductions in CH_4 emissions. In the first year, with 70% water reduction, the yields were reduced by 33%, CH_4 emissions decreased by 97%, while N_2O emissions increased by more than 5-fold under AWD as compared to PF; in the second year, with a 40% water saving, the reductions of rice yields and CH_4 emissions(13% and11%, respectively) were not significant, but N_2O fluxes more than doubled. The transition from anaerobic to aerobic soil conditions resulted in the highest N_2O fluxes under AWD. The duration of flooding, transition to aerobic conditions, water level above the soil surface, and the relative timing between fertilization and flooding were the main drivers affecting greenhouse gas mitigation potential under AWD and should be carefully planned through site-specific management options. | Alessandra LAGOMARSINO Alessandro Elio AGNELLI Bruce LINQUIST Maria Arlene ADVIENTO-BORBE Alberto AGNELLI Giacomo GAVINA Stefano RAVAGLIA Rossana Monica FERRARA | 2016 | Pedosphere2016，26，4： | 8 |
| 3 | Neither hereditary periodic fever nor periodic fever, aphthae, pharingitis, adenitis: Undifferentiated periodic fever in a tertiary pediatric center显示文摘AIM To describe the frequency and clinical characteristics of patients with undifferentiated periodic fever(UPF) and to investigate whether a clinical classification of UPF based on the PRINTO-Eurofever score can help predicting the response to treatment and the outcome at follow-up.METHODS Clinical and therapeutic information of patients with recurrent fever who presented at a single pediatric rheumatology center from January 2006 through April 2016 were retrospectively collected. Patients with a clinical suspicion of hereditary periodic fever(HPF) syndrome and patients with clinical picture of periodic fever, aphthae, pharingitis, adenitis(PFAPA) who were refractory to tonsillectomy underwent molecular analysis of five HPF-related genes: MEFV(NM_000243.2), MVK(NM_000431.3), TNFRSF1 A(NM_001065.3), NLRP3(NM_001079821.2), NLRP12(NM_001277126.1). All patients who had a negative genetic result were defined as UPF and further investigated. PRINTO-Eurofever score for clinical diagnosis of HPF was calculated in all cases. RESULTS Of the 221 patients evaluated for periodic fever, twelve subjects with a clinical picture of PFAPA who were refractory to tonsillectomy and 22 subjects with a clinical suspicion of HPF underwent genetic analysis. Twenty-three patients(10.4%) resulted negative and were classified as UPF. The median age at presentation of patients with UPF was 9.5 mo(IQR 4-24). Patients with UPF had a higher frequency of aphthae(52.2% vs 0%, P = 0.0026) and musculoskeletal pain(65.2% vs 18.2%, P = 0.0255) than patients with genetic confirmed HPF. Also, patients with UPF had a higher frequency of aphthous stomatitis(52.2% vs 10.7%, P < 0.0001), musculoskeletal pain(65.2% vs 8,0%, P < 0.0001), and abdominal pain(52.2% vs 4.8%, P < 0.0001) and a lower frequency of pharyngitis(56.6% vs 81.3%, P = 0.0127) compared with typical PFAPA in the same cohort. Twenty-one of 23 patients with UPF(91.3%) received steroids, being effective in 16; 13(56.2%) were given colchicine, which was effective in 6. Symptoms resolution occurred in 2 patients with UPF at last follow-up. Classification according to the PRINTOEurofever score did not correlate with treatment response and prognosis. CONCLUSION UPF is not a rare diagnosis among patients with periodic fever. Clinical presentation place UPF half way on a clinical spectrum between PFAPA and HPF. The PRINTOEurofever score is not useful to predict clinical outcome and treatment response in these patients. | Silvia De Pauli Sara Lega Serena Pastore Domenico Leonardo Grasso Anna Monica Rosaria Bianco Giovanni Maria Severini Alberto Tommasini Andrea Taddio | 2018 | World Journal of Clinical Pediatrics2018，7，1： | 2 |
| 4 | 关于缺血性卒中后女性妊娠以及针对不育、避孕和绝经期进行激素治疗的共识文件显示文摘已有报道妊娠与缺血性卒中风险增高相关,妊娠期间发生卒中是导致孕产妇死亡的主要原因之一。Kuklina等对1994年至1995年与2006年至2007年的住院数据进行的比较显示,孕妇在产前发生任何类型卒中的风险增高47%(从0.15次/1000次分娩~0.22次/1000次分娩),在产后发生任何卒中的风险增高83%(从0.12次/1000次分娩~0.22次/1000次分娩)。 | Valeria Caso Alberto Falomi Cheryl D. Bushnell Monica Acciarresi Jose Ronohi Nikola Sprigg Sandro Gerli 李勍 景燕 李红燕 朱沂 | 2017 | 国际脑血管病杂志2017，25，8： | 2 |
| 5 | Mesenchymal stem cells secretome:The cornerstone of cell-free regenerative medicine显示文摘Mesenchymal stem cells(MSCs)are the most frequently used stem cells in clinical trials due to their easy isolation from various adult tissues,their ability of homing to injury sites and their potential to differentiate into multiple cell types.However,the realization that the beneficial effect of MSCs relies mainly on their paracrine action,rather than on their engraftment in the recipient tissue and subsequent differentiation,has opened the way to cell-free therapeutic strategies in regenerative medicine.All the soluble factors and vesicles secreted by MSCs are commonly known as secretome.MSCs secretome has a key role in cell-to-cell communication and has been proven to be an active mediator of immunemodulation and regeneration both in vitro and in vivo.Moreover,the use of secretome has key advantages over cell-based therapies,such as a lower immunogenicity and easy production,handling and storage.Importantly,MSCs can be modulated to alter their secretome composition to better suit specific therapeutic goals,thus,opening a large number of possibilities.Altogether these advantages now place MSCs secretome at the center of an important number of investigations in different clinical contexts,enabling rapid scientific progress in this field. | Alberto González-González Daniel García-Sánchez Monica Dotta JoséC Rodríguez-Rey Flor M Pérez-Campo | 2020 | World Journal of Stem Cells2020，12，12： | 2 |
| 6 | Diagnostic accuracy and reproducibility of pleural and lung ultrasound in discriminating cardiogenic causes of acute dyspnea in the Emergency Department显示文摘 | Gian Alfonso Cibinel Giovanna Casoli Fabrizio Elia Monica Padoan Emanuele Pivetta Enrico Lupia Alberto Goffi | 2012 | Internal and Emergency Medicine2012，，1： | 2 |
| 7 | Standardized endoscopic submucosal tunnel dissection for management of early esophageal tumors (with video)显示文摘 | Vitor Arantes Walton Albuquerque Carlos Alberto Freitas Dias Monica Maria Demas Alvares Cabral Hironori Yamamoto | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 8 | MicroRNA-130b Promotes Tumor Development and Is Associated with Poor Prognosis in Colorectal Cancer显示文摘 | Tommaso Colangelo Alessandra Fucci Carolina Votino Lina Sabatino Massimo Pancione Carmelo Laudanna Monica Binaschi Mario Bigioni Carlo Alberto Maggi Domenico Parente Nicola Forte Vittorio Colantuoni | 2013 | Neoplasia2013，，： | 1 |
| 9 | 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Isoprenylation Inhibitors Induce Apoptosis of Vascular Smooth Muscle Cells in Culture显示文摘 | Carlos Guijarro Luis Miguel Blanco-Colio Monica Ortego Covadonga Alonso Alberto Ortiz Juan Jose Plaza Cristina Diaz Gonzalo Hernandez Jesus Egido | 1998 | Circulation Research1998，，5： | 1 |
| 10 | Surgical treatment for gastric carcinoma in the elderly显示文摘 | Arianna Coniglio MD Guido Alberto Massimo Tiberio MD Monica Busti MD | 2004 | Surg Oneol2004，88，： | 1 |
| 11 | Hsp60 and Hsp10 increase in colon mucosa of Crohn’s disease and ulcerative colitis显示文摘 | Vito Rodolico Giovanni Tomasello Monica Zerilli Anna Martorana Alessandro Pitruzzella Antonella Marino Gammazza Sabrina David Giovanni Zummo Provvidenza Damiani Salvatore Accomando Everly Conway de Macario Alberto J. L. Macario Francesco Cappello | 2010 | Cell Stress and Chaperones2010，，6： | 1 |
| 12 | In vitro anticancer activity of docetaxel-loaded micelles based on poly(ethylene oxide)-poly(epsilon-caprolactone) block copolymers: Do nanocarrier properties have a role?显示文摘 | Luisanna Ostacolo Monica Marra Francesca Ungaro Silvia Zappavigna Giovanni Maglio Fabiana Quaglia Alberto Abbruzzese Michele Caraglia | 2010 | Journal of Controlled Release2010，，2： | 1 |
| 13 | Cellular and molecular pathways linking inflammation and cancer显示文摘 | Chiara Porta Paola Larghi Monica Rimoldi Maria Grazia Totaro Paola Allavena Alberto Mantovani Antonio Sica | 2009 | Immunobiology2009，，9： | 1 |
| 14 | Endoscopic ultrasonography and magnetic resonance in preoperative staging of rectal cancer: Comparison with histologic findings显示文摘 | Paolo P. Bianchi M.D. Chiara Ceriani M.D. Matteo Rottoli M.D. Guido Torzilli M.D. Giovanni Pompili M.D. Alberto Malesci M.D. Monica Ferraroni Ph.D. Marco Montorsi M.D | 2005 | Journal of Gastrointestinal Surgery2005，，9： | 1 |
| 15 | Fever tree revisited:From malaria to autoinflammatory diseases显示文摘Over the centuries the idea of recurrent fevers has mainly been associated with malaria, but many other fevers, such as typhoid and diphtheria were cause for concern. It is only in recent times, with the more severe forms of fever from infectious origin becoming less frequent or a cause for worry that we started noticing recurrent fevers without any clear infectious cause, being described as having a pathogenesis of autoinflammatory nature. The use of molecular examinations in many cases can allow a diagnosis where the cause is monogenic. In other cases, however the pathogenesis is likely to be multifactorial and the diagnostic-therapeutic approach is strictly clinical. The old fever tree paradigm developed to describe fevers caused by malaria has been revisited here to describe today's periodic fevers from the periodic fever adenitis pharyngitis aphthae syndrome to the more rare autoinflammatory diseases. This model may allow us to place cases that are yet to be identified which are likely to be of multifactorial origin. | Serena Pastore Josef Vuch Anna Monica Bianco Andrea Taddio Alberto Tommasini | 2015 | World Journal of Clinical Pediatrics2015，4，4： | 1 |
| 16 | Protective effect and relation structure-activity of nonivamide and iododerivatives in several models of lipid oxidation显示文摘 | Antonella Rosa Giovanni Appendino M. Paola Melis Monica Deiana Angela Atzeri Incani Alessandra Alberto Minassi M. Assunta Dessì | 2009 | Chemico-Biological Interactions2009，，2： | 1 |
| 17 | The PPAR-γ agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-β treated pancreatic cancer cells显示文摘 | Giovanni Vitale Silvia Zappavigna Monica Marra Alessandra Dicitore Stefania Meschini Maria Condello Giuseppe Arancia Sara Castiglioni Paola Maroni Paola Bendinelli Roberta Piccoletti Peter M. van Koetsveld Francesco Cavagnini Alfredo Budillon Alberto Abbr | 2011 | Biotechnology Advances2011，，1： | 1 |
| 18 | Obesity Cardiomyopathy: Is It a Reality? An Ultrasonic Tissue Characterization Study显示文摘 | Vitantonio Di Bello Ferruccio Santini Andrea Di Cori Andrea Pucci Caterina Palagi Maria Grazia Delle Donne Paola Fierabracci Alessandro Marsili Enrica Talini Monica Giannetti Ombretta Biadi Alberto Balbarini Mario Mariani Aldo Pinchera | 2006 | Journal of the American Society of Echocardiography2006，，8： | 1 |
| 19 | Heterogeneity of Triple-Negative Breast Cancer: Histologic Subtyping to Inform the Outcome显示文摘 | Emilia Montagna Patrick Maisonneuve Nicole Rotmensz Giuseppe Cancello Monica Iorfida Alessandra Balduzzi Viviana Galimberti Paolo Veronesi Alberto Luini Giancarlo Pruneri Luca Bottiglieri Mauro G. Mastropasqua Aron Goldhirsch Giuseppe Viale Marco Colleoni | 2012 | Clinical Breast Cancer2012，，： | 1 |
| 20 | Urinary incontinence after ischemic stroke: Clinical and urodynamic studies显示文摘 | Assunta Pizzi Catiuscia Falsini Monica Martini Mario Alberto Rossetti Sonia Verdesca Aldo Tosto | 2014 | Urodynam2014，，4： | 1 |
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