|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material显示文摘Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades.However,optimal cell types and transplantation methods remain unclear.This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell(hUCMSC)sheet on myocardial infarction(MI).Methods:hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of cells.We applied a temperature-responsive cell culture surface-based method to form the hUCMSC sheet.Cell retention was evaluated using an in vivo bio-luminescent imaging tracking system.Unbiased transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC sheet.Echocardiography and pathological analyses of heart sections were performed to evaluate cardiac function,angiogenesis and left ventricular remodelling.Results:When transplanted to the infarcted mouse hearts,hUCMSC sheet significantly improved the retention and survival compared with cell suspension.At the early stage of MI,hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages,preserving the cardiomyocytes from acute injury.Moreover,the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue,providing mechanical support and routes for revascularsation.These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI.Conclusions:hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs,mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart.Translational perspective:Due to its excellent availability as well as superior local cellular retention and survival,allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs,such as modulating inflammation and enhancing angiogenesis.Moreover,the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial,further improving its clinical applicability. | Rui Guo Feng Wan Masatoshi Morimatsu Qing Xu Tian Feng Hang Yang Yichen Gong Shuhong Ma Yun Chang Siyao Zhang Youxu Jiang Heqing Wang Dehua Chang Hongjia Zhang Yunpeng Ling Feng Lan | 2021 | Bioactive Materials2021，6，9： | 6 |
| 2 | Clearance of vancomycin during high-volume heamofiltration: impact of pre-dilution 显示文摘 | Uchino S Cole L Morimatsu H | 2002 | Intensive Care Med2002，，28： | 2 |
| 3 | Study of Unsteady Flow Simulation of Backward Impeller with Non-uniform Casing显示文摘The flow characteristics of the centrifugal fans with different blade outlet angles are basically discussed on steady and unsteady simulations for a rectangular casing fan. The blade outlet angles of the impellers are 35° and 25° respectively. The unsteady flow behavior in the passage of the impeller 35° is quite different from that in the steady flow behavior. The large flow separation occurs in the steady flow field and unsteady flow field of the impeller 35°, the flow distribution in the circumferential direction varies remarkably and the flow separation on the blade occurs only at the back region of the fan; but the steady flow behavior in the impeller 25° is almost consistent with the unsteady flow behavior, the flow distribution of the circumferential direction doesn't vary much and the flow separation on the blade hardly occurs. When the circumferential variation of the flow in the impeller is large, the steady flow simulation is not coincident to the unsteady flow simulation. | War War Min Swe Hiroya MORIMATSU Hidechito HAYASHI Tetsuya OKUMURA Ippei ODA | 2017 | Journal of Thermal Science2017，26，3： | 2 |
| 4 | A case of septicemia type vibrio vulnificus infection with necrotizing fasciitis rescued by lower extremity arnputation显示文摘 | Morimatsu Y Akiyoshi H Aizawa H | 2003 | Assoc Infect Dis2003，77，3： | 1 |
| 5 | Recurrent ADEM or MS?显示文摘 | Morimatsu M | 2004 | Intern Med2004，43，8： | 1 |
| 6 | A variety of cerebral amyloid depoits in thebrains of the Alzheimer's type dementia denonstrate by beta protein immunostaining显示文摘 | Yamaguchi H Hirai S Morimatsu M | 1988 | Acta Neuropathol( Berl)1988，76，6： | 1 |
| 7 | Superficial punctate keratitis and corneal abrasion due to amantadine hydrochloride 显示文摘 | Nogaki H Morimatsu M | 1993 | J Neurol1993，240，6： | 1 |
| 8 | A novel ser-um chitinase that is expressed in bovine liver显示文摘 | Suzuki M Morimatsu M Yamashita T | 2001 | FEBS Lett2001，506，2： | 1 |
| 9 | Increasing renal blood flow :low-dose dopamine or medium-dose norepinephrine显示文摘 | Di Giantomasso D Morimatsu H May CN | 2004 | Chest2004，125，6： | 1 |
| 10 | Looper H Infinity Control for Hot Strip Mills显示文摘 | Imanari H Morimatsu Y Sekiguchi K | 1997 | IEEE Transactions on Indus try Applications1997，33，3： | 1 |
| 11 | Asymmetricreduction of a 1,5-benzothiazepine derivative with sodiumborohydride-(3)-a-amino acids: an efficient synthesis ofa key intermediate of diltiazem 显示文摘 | Yamada S Mori Y Morimatsu K | 1996 | J Org Chem1996，61，24： | 1 |
| 12 | Corticobasal degeneration显示文摘 | | 1997 | Nippon Rinsho1997，55，1： | 1 |
| 13 | Unsteady flows in a porous, elastic, circular tube--part 1 : the wall contracting or expanding in an axial direction 显示文摘 | Ohki Morimatsu | 1980 | Bulletin of the JSME1980，23，179： | 1 |
| 14 | External validation of severity scoring systems for acute renal failure using a multinational database显示文摘 | Uchino S Bellomo R Morimatsu H | 2005 | Crit Care Med2005，33，9： | 1 |
| 15 | Anti-GTla IgG in Guillain-Barre syndrome显示文摘 | Koga M Yoshino H Morimatsu M | | 0，，： | 1 |
| 16 | The effect of albumin concentration on plasma sodium and chloride measurements in critically ill patients显示文摘 | Morimatsu H Egi M | 2007 | Anesth Analg2007，104，4： | 1 |
| 17 | Develop- ment and characterization of an animal model of severe pulmonary arterial hypertension显示文摘 | Morimatsu Y Sakashita N Komohara Y | 2012 | J Vasc Res2012，49，1： | 1 |
| 18 | 2-Carboxyethylgermanium sesquioxide, a synthetic organogermanium compound, as an inducer of contrasuppressor T cells显示文摘 | K. Ikemoto M. Kobayashi T. Fukumoto M. Morimatsu R. B. Pollard F. Suzuki | 1996 | Experientia1996，，2： | 1 |
| 19 | Bactericidal activity of electrolyzed acid water from solution containing sodium chloride at low concentration, in comparison with that at high concentration显示文摘 | Hiromasa Kiura Kouichi Sano Shinichi Morimatsu Takashi Nakano Chizuko Morita Masaki Yamaguchi Toyoyuki Maeda Yoji Katsuoka | 2002 | Journal of Microbiological Methods2002，，3： | 1 |
| 20 | Bactericidal activity ofelectrolyzed acid water from solution containing sodium chloride atlow concentration, in comparison with that at high concentration显示文摘 | KIURA H SANO K MORIMATSU S | 2002 | Journal of Microbiological Method2002，49，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员