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| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | 副睾低级别子宫内膜间质肉瘤:1例报道并分子证实JAZF1/SUZ12易位显示文摘发生在睾丸及其附件起源于苗勒管样浆液型或黏液型的肿瘤极其罕见,近年来也被逐渐认识。伴或不伴卵巢样间质的囊腺瘤、交界性肿瘤或囊腺癌是主要的类型。尽管有少数子宫内膜样腺癌的报道,但据作者所知,目前文献仍没有子宫内膜间质肿瘤的报道。作者报道1例发生在59岁男性左侧阴囊内直径2 cm的肿块,超声检测该肿块位于附睾尾,血供丰富。该患者平素体健,无重大疾病史,无内分泌疾病或外用激素治疗史。睾丸肿瘤标志物指标(β-HCG,AFP)正常。 | Agaimy A Moskalev E A Weisser W 赵芳 魏建国 | 2018 | 临床与实验病理学杂志2018，34，9： | 4 |
| 3 | Left atrial appendage aneurysm: A case report显示文摘BACKGROUND An aneurysm of the left atrial appendage is one of the rare but potentially hazardous heart defects.The risk of lethal complications grows with its size.To date,about 150 cases of this defect have been described in the literature.We present a case of left atrial appendage aneurysm with the deformation of the mitral valve and the left main coronary and circumflex artery,which required mitral valve annuloplasty and bifurcation stenting.CASE SUMMARY A 58-year-old man presented to our hospital complaining of shortness of breath,general weakness,dizziness during physical exertion,and fatigue.Based on the results of echocardiography,an aneurysm of the left atrium was suspected.A free-breathing real-time cine magnetic resonance imaging with electrocardiograph synchronization confirmed the diagnosis of left atrial appendage aneurysm.The patient underwent an aneurysmectomy via a median sternotomy with cardiopulmonary bypass.Intraoperative transesophageal echocardiography revealed relative mitral insufficiency that was corrected with an annuloplasty ring.Intraoperative coronary angiogram showed impaired blood flow in the left main coronary and circumflex artery and 60%stenosis.For this reason,bifurcation stenting was performed.The patient had an uneventful postoperative clinical course and was discharged from the hospital on the 10th day in a satisfactory condition.CONCLUSION Left atrial appendage aneurysm is a rare and dangerous heart pathology that requires surgery to prevent related complications. | Dmitry Vladimirovich Belov Vladimir Ivanovich Moskalev Dmitry Victorovich Garbuzenko Nikolay Olegovich Arefyev | 2020 | World Journal of Clinical Cases2020，8，19： | 3 |
| 4 | Anti-aging effects of chlorpropamide depend on mitochondrial complex-Ⅱ and the production of mitochondrial reactive oxygen species显示文摘Sulfonylureas are widely used oral anti-diabetic drugs.However,its long-term usage effects on patients’lifespan remain controversial,with no reports of influence on animal longevity.Hence,the anti-aging effects of chlorpropamide along with glimepiride,glibenclamide,and tolbutamide were studied with special emphasis on the interaction of chlorpropamide with mitochondrial ATP-sensitive K+(mito K-ATP)channels and mitochondrial complex II.Chlorpropamide delayed aging in Caenorhabditis elegans,human lung fibroblast MRC-5 cells and reduced doxorubicin-induced senescence in both MRC-5 cells and mice.In addition,the mitochondrial membrane potential and ATP levels were significantly increased in chlorpropamide-treated worms,which is consistent with the function of its reported targets,mito K-ATP channels.Increased levels of mitochondrial reactive oxygen species(mt ROS)were observed in chlorpropamide-treated worms.Moreover,the lifespan extension by chlorpropamide required complex II and increased mt ROS levels,indicating that chlorpropamide acts on complex II directly or indirectly via mito K-ATP to increase the production of mt ROS as a pro-longevity signal.This study provides mechanistic insight into the anti-aging effects of sulfonylureas in C.elegans. | Zhifan Mao Wenwen Liu Yunyuan Huang Tianyue Sun Keting Bao Jiali Feng Alexey Moskalev Zelan Hu Jian Li | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 5 | South Korean Chaebols and Value-Based Management显示文摘 | Moskalev S Park S C | | 0，，01： | 1 |
| 6 | The role of D-GADD45 in oxidative, thermal and genotoxic stress resistance显示文摘 | MOSKALEV A PLYUSNINA E SHAPOSHNIKOV M | 2012 | Cell Cycle2012，11，22： | 1 |
| 7 | Genetics and epigenetics of aging and longevity显示文摘 | Moskalev AA Aliper AM Smit-Mc Bride Z | 2014 | Cell Cycle2014，13，7： | 1 |
| 8 | Ultrasound-guided intramuralinoculation of orthotopic bladder cancer xenografts: a novelhigh-precision approach 显示文摘 | Jager W Moskalev I Janssen C | 2013 | PLoS One2013，8，59： | 1 |
| 9 | Hydrothermal fauna of the Mid-Atlantic Ridge显示文摘 | Galkin S V Moskalev L I | 1990 | Oceanology1990，30，5： | 1 |
| 10 | The role of DNA damage and repair in aging through the prism of Koch-like criteria显示文摘 | Alexey A. Moskalev Mikhail V. Shaposhnikov Ekaterina N. Plyusnina Alex Zhavoronkov Arie Budovsky Hagai Yanai Vadim E. Fraifeld | 2013 | Ageing Research Reviews2013，，2： | 1 |
| 11 | Mutation status ofthe mediator complex subunit 12 (MED12) in uterineleiomyomas and concurrent/metachronous multifocal peritonealsmooth muscle nodules (leiomyomatosis peritonealisdisseminata)显示文摘 | Rieker RJ Agaimy A Moskalev EA | 2013 | Pathology2013，45，4： | 1 |
| 12 | The role of DNA damage and repair in aging through the prism of Koch- like criteria显示文摘 | Moskalev AA Shaposhnikov MV Plyusnina EN | 2013 | Ageing Res Rev2013，12，2： | 1 |
| 13 | Methodic approaches to treatment of the chronic generalized parodontitis in elderly and senile patients显示文摘 | Iordanishvili AK Soldatov SV Moskalev AV | 2011 | Adv Gerontol2011，24，3： | 1 |
| 14 | RNA directed epigenomic reprogramming: an emerging principle of a more targeted cancer ther- apy 显示文摘 | Moskalev EA Schubert M Hobciselj D | 2012 | Genes Chromosomes Cancer2012，51，2： | 1 |
| 15 | Radiation-induced life span alteration of Drosophila lines with genotype differences显示文摘 | Moskalev A | 2007 | Biogerontology2007，8，： | 1 |
| 16 | 显示文摘 | Martyshkin D V Kim C Moskalev I S | 2008 | IEEE2008，16，7： | 1 |
| 17 | DNA methylation profi- ling in cancer: from single nucleotides towards methylome显示文摘 | Moskalev EA Eprintsev AT Hoheisel JD | 2007 | Mol Biol (Mosk)2007，41，5： | 1 |
| 18 | Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia显示文摘 | Moskalev EA Luckert K Vorobjev IA | 2012 | BMC Cancer2012，12，： | 1 |
| 19 | Complexes of scandium with phthalocyanine显示文摘 | I S Kirin P N Moskalev N V Ivannikova | 1967 | Russ J Inorg Chem1967，12，： | 1 |
| 20 | RNA-directed epigenomic reprogramming:an emerging principle of a more targeted cancer therapy?显示文摘 | MOSKALEV E A SCHUBERT M HOHEISEL J D | 2012 | Genes Chromosomes Cancer2012，51，2： | 1 |
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