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1Preoperative diagnosis of gastrointestinal stromal tumor by endoscopic ultrasound-guided fine needle aspiration显示文摘瞄准:在胃肠的基质肿瘤(大意) 的外科手术前的诊断评估内视镜的指导 ultrasonography 的好针渴望(EUS-FNA ) 的角色。方法:从 2002 年 9 月到 2006 年 6 月,有到合适的肌肉层的连续性的上皮的低亚硫酸钠拟声肿瘤由标准 EUS 作为大意怀疑了的官方补给的道潜水艇的 53 连续 EUS-FNAs 有希望地被评估。为最后的诊断的参考标准是外科(n = 31 ) ,或临床的后续(n = 22 ) 。另外,标本的免疫 phenotyping 由 EUS-FNA 获得了,外科的切除术标本被比较。结果:因为解剖问题,没在 2 情况刺被执行。从官方补给的道的足够的标本的收集率与连续性代替上皮的低亚硫酸钠拟声肿瘤到合适的肌肉层是 82%(42/51 ) 。为肿瘤的诊断的率不到 2 厘米, 2 ~ 4 厘米,和 4 厘米或更多是 71%(15/21 ) , 86%(18/21 ) ,并且 100%(9/9 ) 分别地。在 29 通过手术用免疫的 EUS-FNA 的 resected 盒子,敏感,特性,积极预兆的价值,否定预兆的价值,和诊断精确性大意的组织化学的分析是100%( 24/24 ),80%( 4/5 ),96%( 24/25 ),100%( 4/4 ),并且97%( 28/29 )分别地。没有主要复杂并发症被遇到。结论:有免疫的 EUS-FNA 组织化学的分析是在大意的 prethera-peutic 诊断的一个安全、精确的方法。它应该在决策被考虑,特别在跟随为大意的最小的侵略外科的早诊断。Kazuya Akahoshi Yorinobu Sumida Noriaki Matsui Masafumi Oya Rie Akinaga Masaru Kubokawa Yasuaki Motomura Kuniomi Honda Masayuki Watanabe Takashi Nagaie 2007World Journal of Gastroenterology2007,13,14:34
2为用离合器切割器的食道的小粒的房间肿瘤的内视镜的 submucosal 解剖显示文摘 Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure associated with a high complication rate.The shortcomings of this method are the deficiencies of fixing the knife to the target lesion,and of compressing it.These shortcomings can lead to major complications such as perforation and bleeding.To reduce the risk of complications related to ESD,we developed a new grasping type scissors forceps (Clutch Cutter,Fujifilm,Japan) which can grasp and incise the targeted tissue using an electrosurgical current.Esophagogastroduodenoscopy on a 59-year-old Japanese man revealed a 16mm esophageal submucosal nodule with central depression.Endoscopic ultrasonography demonstrated a hypoechoic solid tumor limited to the submucosa without lymph node involvement.The histologic diagnosis of the specimen obtained by biopsy was granular cell tumor.It was safely and accurately resected without unexpected incision by ESD using the CC.No delayed hemorrhage or perforation occurred.Histological examination confirmed that the granular cell tumor was completely excised with negative resection margin.We report herein a case of esophageal granular cell tumor successfully treated by an ESD technique using the CC.Keishi Komori Kazuya Akahoshi Yoshimasa Tanaka Yasuaki Motomura Masaru Kubokawa Soichi Itaba Terumasa Hisano Takashi Osoegawa Naotaka Nakama Risa Iwao Masafumi Oya Kazuhiko Nakamura 2012World Journal of Gastrointestinal Endoscopy2012,4,1:8
3Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders显示文摘Inflammation and immune activation in the gut are usually accompanied by alteration of gastrointestinal(GI) motility.In infection,changes in motor function have been linked to host defense by enhancing the expulsion of the infectious agents.In this review,we describe the evidence for inflammation and immune activation in GI infection,inflammatory bowel disease,ileus,achalasia,eosinophilic esophagitis,microscopic colitis,celiac disease,pseudo-obstruction and functional GI disorders. We also describe the possible mechanisms by which inflammation and immune activation in the gut affect GI motility.GI motility disorder is a broad spectrum disturbance of GI physiology.Although several systems including central nerves,enteric nerves,interstitial cells of Cajal and smooth muscles contribute to a coordinated regulation of GI motility,smooth muscle probably plays the most important role.Thus,we focus on the relationship between activation of cytokines induced by adaptive immune response and alteration of GI smooth muscle contractility.Accumulated evidence has shownthat Th1 and Th2 cytokines cause hypocontractility and hypercontractility of inflamed intestinal smooth muscle. Th1 cytokines downregulate CPI-17 and L-type Ca 2+ channels and upregulate regulators of G protein signaling 4,which contributes to hypocontractility of inflamed intestinal smooth muscle.Conversely,Th2 cytokines cause hypercontractilty via signal transducer and activator of transcription 6 or mitogen-activated protein kinase signaling pathways.Th1 and Th2 cytokines have opposing effects on intestinal smooth muscle contraction via 5-hydroxytryptamine signaling.Understanding the immunological basis of altered GI motor function could lead to new therapeutic strategies for GI functional and inflammatory disorders.Hirotada Akiho Eikichi Ihara Yasuaki Motomura Kazuhiko Nakamura 2011World Journal of Gastrointestinal Pathophysiology2011,2,5:8
4Double-balloon endoscopy in the diagnosis and management of GI tract diseases:Methodology,indications,safety,and clinical impact显示文摘AIM: To prospectively evaluate the indications, method-ology, safety, and clinical impact of double-balloon en-doscopy.METHODS: A total of 60 patients with suspected or documented small- or large-bowel diseases were investi-gated by double balloon endoscopy. A total of 103 proce-dures were performed (42 from the oral route, 60 from the anal route, and 1 from the stoma route). The main outcome measurements were the time of insertion and the entire examination, complications, diagnostic yields, and the ability to successfully perform treatment.RESULTS: Observation of the entire small intestine was possible in 10 (40%) of 25 patients with total enteros-copy. The median insertion time was 122 min (range, 74-199 min). Observation of the entire colon was possi-ble in 13 (93%) of 14 patients after failure of total colo-noscopy using a conventional colonoscope. Small-intes-tine abnormalities were found in 20 (43%) of 46 patients with indications of suspected or documented small bowel diseases, obscure GI tract bleeding, or a history of ileus. Endoscopic procedures including tattooing (n = 33), bite biopsy (n = 17), radiographic examination (n = 7), EUS (n = 5), hemostasis (n = 1), polypectomy (n = 5), balloon dilatation (n = 1), endoscopic mucosal resection (n = 1) and lithotripsy (n = 1) were all successfully performed. No relevant technical problems or severe complications were encountered.CONCLUSION: Double balloon endoscopy is a feasible technique that allows adequate small and large bowel examination and potentially various endoscopic proce-dures of small-intestinal lesions. It is safe, useful, and also provides a high clinical impact.Kazuya Akahoshi Masaru Kubokawa Masahiro Matsumoto Shingo Endo Yasuaki Motomura Jiro Ouchi Mitsuhide Kimura Atsuhiko Murata Michiaki Murayama 2006World Journal of Gastroenterology2006,12,47:8
5Prognostic factors associated with mortality in patients with gastric fundal variceal bleeding显示文摘AIM To determine the prognostic factors associated with mortality in patients with gastric fundal variceal (GFV) bleeding.METHODS In total, 42 patients were endoscopically diagnosed with GFV bleeding from January 2000 to March 2014. We retrospectively reviewed the patients' medical records and assessed their history, etiology of liver cirrhosis, disease conditions, treatment options for GFV bleeding, medications administered before and after onset of GFV bleeding, blood test results(hemoglobin, albumin, and bilirubin concentrations), and imaging results(including computed tomography and abdominal ultrasonography). We also assessed the prognostic factors associated with short-term mortality(up to 90 d) and long-term mortality in all patients.RESULTS Multivariate analysis showed that prophylactic administration of antibiotics was an independent prognostic factor associated with decreases in short-term mortality (OR = 0.08, 95%CI: 0.01-0.52) and longterm mortality (OR = 0.27, 95%CI: 0.08-0.91) in patients with GFV bleeding. In contrast, concurrent hepatocellular carcinoma (HCC) and regular use of proton pump inhibitors (PPI) were independent prognostic factors associated with increases in shortterm mortality(HCC: OR = 15.4, 95%CI: 2.08-114.75; PPI: OR = 12.76, 95%CI: 2.13-76.52) and long-term mortality (HCC: OR = 7.89, 95%CI: 1.98-31.58; PPI: OR = 10.91, 95%CI: 2.86-41.65) in patients with GFV bleeding. The long-term overall survival rate was significantly lower in patients who regularly used PPI than in those who did not use PPI(P = 0.0074).CONCLUSION Administration of antibiotics is associated with decreased short- and long-term mortality, while concurrent HCC and regular PPI administration are associated with increased short- and long-term mortality.Keishi Komori Masaru Kubokawa Eikichi Ihara Kazuya Akahoshi Kazuhiko Nakamura Kenta Motomura Akihide Masumoto 2017World Journal of Gastroenterology2017,23,3:7
6Indicators of sorafenib efficacy in patients with advanced hepatocellular carcinoma显示文摘AIM:To determine significant indicators for the efficacy of sorafenib in patients with advanced hepatocellular carcinoma(HCC).METHODS:A total of 46 patients with Barcelona Clinic Liver Cancer stage C who received sorafenib for more than 30 d at the Iizuka Hospital from June 2009 to December 2012 were enrolled in this study.Multivariate and univariate analyses were performed to evaluate the associations of hepatic function according to Child-Pugh grade,location and size of the largest tumor and adverse events of sorafenib treatment,such as hand-foot syndrome(HFS),hypertension,diarrhea,and alopecia,with the efficacy of treatment,as measured by overall survival(OS)and time to progression(TTP).RESULTS:Patients included 39 men and 7 women whose ages ranged from 48 to 85 years(70.6±9.6years).HCC was classified according to etiology as follows:hepatitis C virus(n=26),hepatitis B virus(n=9),and other(n=11).Liver function in patients was categorized as Child-Pugh grade A(n=30)or B(n=16).Tumors were categorized by size[<5 cm(n=33)or>5 cm(n=13)]and the location of the largest tumor was used to categorize patients with intrahepatic(n=28)or extrahepatic(n=18)HCC.HFS,hypertension,diarrhea,and alopecia were present in22(47.8%),19(41.3%),15(32.6%)and 7 patients(15.2%),respectively.The median OS of all patients was 373 d and the median TTP was 112 d.The etiology of HCC did not correlate with the median OS and TPP.The median OS of patients with tumors<5 cm was significantly longer than those with larger tumors(496 vs 245 d;HR=0.19,95%CI:0.07-0.48;P<0.01).According to the results of a multivariate analysis,the size of the largest tumor affected OS(HR=0.22,95%CI:0.08-0.59;P<0.01).The median TTP was significantly longer in patients with extrahepatic compared to intrahepatic major HCC(224 vs 98 d;HR=0.32;95%CI:0.14-0.67;P<0.01).The median TTP of patients with HFS was significantly longer than those without it(195 d vs 83 d;HR=0.41,95%CI:0.20-0.82;P<0.05),and the median TTP was significantly longer in patients with hypertension(195 d vs84 d;HR=0.43,95%CI:0.21-0.84;P<0.05).According to the results of the multivariate analysis,extrahepatic major HCC(HR=0.36,P<0.01)and HFS(HR=0.44,P<0.05)prolonged TTP.CONCLUSION:Extrahepatic major HCC and HFS are associated with prolonged TTP and are useful indicators for judging the efficacy of sorafenib treatment.Masayoshi Yada Akihide Masumoto Kenta Motomura Hirotaka Tajiri Yusuke Morita Hideo Suzuki Takeshi Senju Toshimasa Koyanagi 2014World Journal of Gastroenterology2014,20,35:7
7Improved techniques for double-balloon-enteroscopy-assisted endoscopic retrograde cholangiopancreatography显示文摘AIM: To investigate the clinical outcome of double balloon enteroscopy (DBE)-assisted endoscopic retrograde cholangiopancreatography (DB-ERCP) in patients with altered gastrointestinal anatomy. METHODS: Between September 2006 and April 2011, 47 procedures of DB-ERCP were performed in 28 patients with a Roux-en-Y total gastrectomy (n = 11), Billroth Ⅱ gastrectomy (n = 15), or Roux-en-Y anastomosis with hepaticojejunostomy (n = 2). DB-ERCP was performed using a short-type DBE combined with several technical innovations such as using an endoscope attachment, marking by submucosal tattooing,selectively applying contrast medium, and CO2 insufflations. RESULTS: The papilla of Vater or hepaticojejunostomy site was reached in its entirety with a 96% success rate (45/47 procedures). There were no significant differences in the success rate of reaching the blind end with a DBE among Roux-en-Y total gastrectomy (96%), Billroth Ⅱ reconstruction (94%), or pancreatoduodenectomy (100%), respectively (P = 0.91). The total successful rate of cannulation and contrast enhancement of the target bile duct in patients whom the blind end was reached with a DBE was 40/45 procedures (89%). Again, there were no significant differences in the success rate of cannulation and contrast enhancement of the target bile duct with a DBE among Roux-en-Y total gastrectomy (88 %), Billroth Ⅱ reconstruction (89%), or pancreatoduodenectomy (100%), respectively (P = 0.67). Treatment was achieved in all 40 procedures (100%) in patients whom the contrast enhancement of the bile duct was successful. Common endoscopic treatments were endoscopic biliary drainage (24 procedures) and extraction of stones (14 procedures). Biliary drainage was done by placement of plastic stents. Stones extraction was done by lithotomy with the mechanical lithotripter followed by extraction with a basket or by the balloon pull-through method. Endoscopic sphincterotomy was performed in 14 procedures with a needle precutting knife using a guidewire. The mean total duration of the procedure was 93.6 ± 6.8 min and the mean time required to reach the papilla was 30.5 ± 3.7 min. The mean time required to reach the papilla tended to be shorter in Billroth Ⅱ reconstruction (20.9 ± 5.8 min) than that in Roux-en-Y total gastrectomy (37.1 ± 4.9 min) but there was no significant difference (P = 0.09). A major complication occurred in one patient (3.5%); perforation of the long limb in a patient with Billroth Ⅱ anastomosis.CONCLUSION: Short-type DBE combined with several technical innovations enabled us to perform ERCP in most patients with altered gastrointestinal anatomy.Takashi Osoegawa Yasuaki Motomura Kazuya Akahoshi Naomi Higuchi Yoshimasa Tanaka Terumasa Hisano Souichi Itaba Junya Gibo Mariko Yamada Masaru Kubokawa Yorinobu Sumida Hirotada Akiho Eikichi Ihara Kazuhiko Nakamura 2012World Journal of Gastroenterology2012,18,46:7
8Semisolid casting with ultrasonically melt-treated billets of Al-7mass%Si alloys显示文摘The demand for high performance cast aluminum alloy components is often disturbed by increasing impurity elements,such as iron accumulated from recycled scraps.It is strongly required that coarse plate-like iron compound of β-Al5FeSi turns into harmless form without the need for applying refining additives or expensive virgin ingots.The microstructural modification of Al-7mass%Si alloy billets with different iron contents was examined by applying ultrasonic vibration during the solidification.Ultrasonically melt-treated billets were thixocast right after induction heating up to the semisolid temperature of 583 oC,the microstructure and tensile properties were evaluated in the thixocast components.Globular primary α-Al is required to fill up a thin cavity in thixocasting,so that the microstructural modification by ultrasonic melt-treatment was firstly confirmed in the billets.With ultrasonic melt-treatment in the temperature range of 630 oC to 605 oC,the primary α-Al transforms itself from dendrite into fine globular in morphology.The coarse plate-like β-Al5FeSi compound becomes markedly finer compared with those in non-treated billets.Semisolid soaking up to 583 oC,does not appreciably affect the size of β-Al5FeSi compounds;however,it affects the solid primary α-Al morphology to be more globular,which is convenient for thixocasting.After thixocasting with preheated billets,eutectic silicon plates are extremely refined due to the rapid solidification arising from low casting temperature.The tensile strength of thixocast samples with different iron contents does not change much even at 2mass% of iron,when thixocast with ultrasonically melt-treated billets.However,thixocast Al-7mass%Si-2mass%Fe alloy with non-treated billets exhibits an inferior strength of 80MPa,compared with 180MPa with ultrasonically melt-treated billets.The elongation is also improved by about a factor of two in thixocastings with ultrasonically melt-treated billets for all iron contents of Al-7mass%Si alloys,for example,the elongation of 11% in thixocast of Al-7mass%Si-0.5mass%Fe alloy with ultrasonically melt-treated billets,5% in that with non-treated billets.Yoshiki Tsunekawa Masahiro Okumiya Takahiro Motomura 2012China Foundry2012,9,1:7
9Safety advantage of endocut mode over endoscopic sphincterotomy for choledocholithiasis显示文摘瞄准:评估一个自动地控制的切割系统(endocut 模式) 是否能与常规混合切割模式相比在 EST 以后减少内视镜的括约肌切开术(EST ) 和浆液血淀粉酶过多的复杂并发症率。方法:从 2001 年 1 月到 2003 年 10 月,有胆总管石病的 134 个病人在括约肌切开术的时候被分到任何一个 endocut 模式组或常规混合切割模式组。二个组回顾地在 EST 和浆液淀粉酶以后为复杂并发症被比较水平在前和在过程以后的 24 h。结果:对待的 134 个病人, 79 被分到常规混合切割模式组, 55 组织到 endocut 模式。在年龄,性别,和在在二个组之间的 EST 前的浆液淀粉酶水平没有有效差量。复杂并发症在 endocut 模式组(9%) 的 5 个病人被发现:血淀粉酶过多(比正常高 5 倍) 在 4 并且在 1 的中等胰腺炎。复杂并发症在常规混合切割模式组(16%) 的 13 个病人被发现:在 12 的血淀粉酶过多和在 1 的中等胰腺炎。浆液淀粉酶层次在两个组被提高在 EST (P<0.02 ) 以后的 24 h。在在常规混合切割模式的 EST 以后的 24 h 组织的平均浆液淀粉酶水平在 endocut 模式组(P<0.05 ) 比那显著地高。结论:Endocut 模式由减少血淀粉酶过多在 EST 以后为胰腺炎在常规混合切割模式上提供一个安全优点。Hirotada Akiho Yorinobu Sumida Kazuya Akahoshi Atsuhiko Murata Jiro Ouchi Yasuaki Motomura Taisuke Toyomasu Mitsuhide Kimura Masaru Kubokawa Masahiro Matsumoto Shingo Endo Kazuhiko Nakamura 2006World Journal of Gastroenterology2006,12,13:6
10Immediate detection of endoscopic retrograde cholangiopancreatographyrelated periampullary perforation: Fluoroscopy or endoscopy?显示文摘AIM:To investigate the causes and intraoperative detection of endoscopic retrograde cholangiopancreatography(ERCP)-related perforations to support immediate or early diagnosis.METHODS:Consecutive patients who underwent ERCP procedures at our hospital between January2008 and June 2013 were retrospectively enrolled in the study(n=2674).All procedures had been carried out using digital fluoroscopic assistance with the patient under conscious sedation.For patients showing alterations in the gastrointestinal anatomy,a short-type double balloon enteroscope had been applied.Cases of perforation had been identified by the presence of air in or leakage of contrast medium into the retroperitonealspace,or upon endoscopic detection of an abdominal cavity related to the perforated lumen.For patients with ERCP-related perforations,the data on medical history,endoscopic findings,radiologic findings,diagnostic methods,management,and clinical outcomes were used for descriptive analysis.RESULTS:Of the 2674 ERCP procedures performed during the 71-mo study period,only six(0.22%)resulted in perforations(male/female,2/4;median age:84 years;age range:57-97 years).The cases included an endoscope-related duodenal perforation,two periampullary perforations related to endoscopic sphincterotomy,two periampullary perforations related to endoscopic papillary balloon dilation,and a periampullary or bile duct perforation secondary to endoscopic instrument trauma.No cases of guidewire-related perforation occurred.The video endoscope system employed in all procedures was only able to immediately detect the endoscope-related perforation;the other five perforation cases were all detected by subsequent digital fluoroscope applied intraoperatively(at a median post-ERCP intervention time of 15 min).Three out of the six total perforation cases,including the single case of endoscope-related duodenal injury,were surgically treated;the remaining three cases were treated with conservative management,including trans-arterial embolization to control the bleeding in one of the cases.All patients recovered without further incident.CONCLUSION:ERCP-related perforations may be difficult to diagnose by video endoscope and digital fluoroscope detection of retroperitoneal free air or contrast medium leakage can facilitate diagnosis.Yasuaki Motomura Kazuya Akahoshi Junya Gibo Kenji Kanayama Shinichiro Fukuda Shouhei Hamada Yoshihiro Otsuka Masaru Kubokawa Kiyoshi Kajiyama Kazuhiko Nakamura 2014World Journal of Gastroenterology2014,20,42:5
11Endoscopic submucosal dissection of a rectal carcinoid tumor using grasping type scissors forceps显示文摘Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure associated with a high complication rate. The shortcomings of this method are the inability to fix the knife to the target lesion, and compression of the lesion. These can lead to major complications such as perforation and bleeding. To reduce the risk of complications related to ESD, we developed a new grasping type scissors forceps (GSF), which can grasp and incise the targeted tissue using electrosurgical current. Colonoscopy on a 55-year-old woman revealed a 10-mm rectal submucosal nodule. The histological diagnosis of the specimen obtained by biopsy was carcinoid tumor. Endoscopic ultrasonography demonstrated a hypoechoic solid tumor limited to the submucosa without lymph node involvement. It was safely and accurately resected without unexpected incision by ESD using a GSF. No delayed hemorrhage or perforation occurred. Histological examination confirmed the carcinoid tumor was completely excised with negative resection margin.Kazuya Akahoshi Yasuaki Motomura Masaru Kubokawa Noriaki Matsui Manami Oda Risa Okamoto Shingo Endo Naomi Higuchi Yumi Kashiwabara Masafumi Oya Hidefumi Akahane Haruo Akiba 2009World Journal of Gastroenterology2009,15,17:4
12Near-Infrared Imaging Using a High-Speed Monitoring Near Infrared Hyperspectral Camera(Compovision)显示文摘This review paper reports near-infrared(NIR)imaging studies using a newly-developed NIR camera,Compovision.Compovision can measure a significantly wide area of 150mm×250mm at high speed of between 2and 5s.It enables a wide spectral region measurement in the 1 000~2 350nm range at 6nm intervals.We investigated the potential of Compovision in the applications to industrial problems such as the evaluation of pharmaceutical tablets and polymers.Our studies have demonstrated that NIR imaging based on Compovision can solve several issues such as long acquisition times and relatively low sensitivity of detection.NIR imaging with Compovision is strongly expected to be applied not only to pharmaceutical tablet monitoring and polymer characterization but also to various applications such as those to food products,biomedical substances and organic and inorganic materials.Daitaro Ishikawa Asako Motomura Yoko Igarashi Yukihiro Ozaki 2015光谱学与光谱分析2015,35,4:3
13Predictors of Extrahepatic Recurrence After Curative Hepatectomy for Hepatocellular Carcinoma显示文摘Akinobu Taketomi Takeo Toshima Dai Kitagawa Takashi Motomura Kazuki Takeishi Yohei Mano Hiroto Kayashima Keishi Sugimachi Shinichi Aishima Yoichi Yamashita Toru Ikegami Tomonobu Gion Hideaki Uchiyama Yuji Soejima Takashi Maeda Ken Shirabe Yoshihiko Maehar 2010Annals of Surgical Oncology2010,,10:2
14Tumor-Associated Macrophage Promotes Tumor Progression via STAT3 Signaling in Hepatocellular Carcinoma显示文摘Mano Yohei Aishima Shinichi Fujita Nobuhiro Tanaka Yuki Kubo Yuichiro Motomura Takashi Taketomi Akinobu Shirabe Ken Maehara Yoshihiko Oda Yoshinao 2013Pathobiology2013,,3:2
15Role of tumor-associated macrophages in the progression of hepatocellular carcinoma显示文摘Ken Shirabe Yohei Mano Jun Muto Rumi Matono Takashi Motomura Takeo Toshima Kazuki Takeishi Hidekaki Uchiyama Tomoharu Yoshizumi Akinobu Taketomi Masaru Morita Shunichi Tsujitani Yoshihisa Sakaguchi Yoshihiko Maehara 2012Surgery Today2012,,1:2
16One-step reconstruction of the right inferior hepatic veins using auto-venous grafts in living donor liver transplantation显示文摘Toru Ikegami Ken Shirabe Shohei Yoshiya Yuji Soejima Tomoharu Yoshizumi Hideaki Uchiyama Takeo Toshima Takashi Motomura Yoshihiko Maehara 2013Surgery Today2013,,7:2
17Application of sentinel node biopsy to gastric cancer surgery显示文摘Masahiro Hiratsuka Isao Miyashiro Osamu Ishikawa Hiroshi Furukawa Kazuyoshi Motomura Hiroaki Ohigashi Masao Kameyama Yo Sasaki Toshiyuki Kabuto Shingo Ishiguro Shingi Imaoka Hiroki Koyama 2001Surgery2001,,3:2
18Phantom bite syndrome:Revelation from clinically focused review显示文摘Phantom bite syndrome(PBS),also called occlusal dysesthesia,is characterized by persistent non-verifiable occlusal discrepancies.Such erroneous and unshakable belief of a“wrong bite”might impel patients to visit multiple dental clinics to meet their requirements to their satisfaction.Subsequently,it takes a toll on their quality of life causing,career disruption,financial loss and suicidal thoughts.In general,patients with PBS are quite rare but distinguishable if ever encountered.Since Marbach reported the first two cases in 1976,there have been dozens of published cases regarding this phenomenon,but only a few original studies were conducted.Despite the lack of official classification and guidelines,many authors agreed on the existence of a PBS“consistent pattern”that clinicians should be made aware.Nevertheless,the treatment approach has been solely based on incomplete knowledge of etiology,in which none of the proposed theories are fully explained in all the available cases.In this review,we have discussed the critical role of enhancing dental professionals’awareness of this phenomenon and suggested a comprehensive approach for PBS,provided by a multidisciplinary team of dentists,psychiatrists and exclusive psychotherapists.Trang Thi Huyen Tu Motoko Watanabe Gayatri Krishnakumar Nayanar Yojiro Umezaki Haruhiko Motomura Yusuke Sato Akira Toyofuku 2021World Journal of Psychiatry2021,11,11:2
19Controversies in breast conservation treatment for breast cancer 显示文摘Motomura K Egawa C Komoike Y 2004Gan To Kagaku Ryoho2004,31,2:1
20Clonal analysis of fibroadenoma and Phyllodes tumor of the breast by means of polymerase chain reaction显示文摘Noguchi S Motomura K InaJi H 1993Cancer Res1993,53,:1
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