|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pravastatin alleviates lipopolysaccharide-induced placental TLR4 over-activation and promotes uterine arteriole remodeling without impairing rat fetal development显示文摘Preeclampsia is associated with over-activation of the innate immune system in the placenta,in which toll-like receptor 4(TLR4) plays an essential part.With their potent anti-inflammatory effects,statins have been suggested as potential prevention or treatment of preeclampsia,although evidence remains inadequate.Herewith,we investigated whether pravastatin could ameliorate preeclampsia-like phenotypes in a previously established lipopolysaccharide(LPS)-induced rat preeclampsia model,through targeting the TLR4/NF-κB pathway.The results showed that pravastatin reduced the blood pressure [maximum decline on gestational day(GD) 12,(101.33±2.49) mmHg vs.(118.3±1.37) mmHg,P<0.05] and urine protein level [maximum decline on GD9,(3,726.23± 1,572.86) μg vs.(1,991.03 ±609.37)μg,P< 0.05],which were elevated following LPS administration.Pravastatin also significantly reduced the rate of fetal growth restriction in LPS-treated rats(34.10% vs.8.99%,P<0.05).Further pathological analyses suggested a restoration of normal spiral artery remodeling in preeclampsia rats by pravastatin treatment.These effects of pravastatin were associated with decreased TLR4/NF-κB protein levels in the placenta and IL-6/MCP-1 levels in serum.Additionally,no obvious abnormalities in fetal liver,brain,and kidney were found after administration of pravastatin.These results provide supportive evidence for use of pravastatin in preventing preeclampsia. | Muyi Yang Zhenyu Diao Zhiyin Wang Guijun Yan Guangfeng Zhao Mingming Zheng Anyi Dai Yimin Dai Yali Hu | 2018 | The Journal of Biomedical Research2018，32，4： | 5 |
| 2 | Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway显示文摘 | Yuejuan Zheng Yang Yang Yuhu Li Limin Xu Yi Wang Ziyi Guo Haiyan Song Muyi Yang Beier Luo Aoxiang Zheng Ping Li Yan Zhang Guang Ji Yizhi Yu | 2013 | Cellular & Molecular Immunology2013，10，4： | 4 |
| 3 | Estrogen induces androgen‐repressed SOX4 expression to promote progression of prostate cancer cells显示文摘 | Muyi Yang Jing Wang Lin Wang Chengwu Shen Bo Su Mei Qi Jing Hu Wei Gao Weiwei Tan Bo Han | 2015 | Prostate2015，，13： | 1 |
| 4 | Reusable sensor based on high magnetization carboxyl-modified graphene oxide with intrinsic hydrogen peroxide catalytic activity for hydrogen peroxide and glucose detection,Biosensors and Bioelectronics显示文摘 | Yang Hungwei Hua Muyi Chen Shilian | 2013 | 41:172-1792013，41，： | 1 |
| 5 | Characterization of EGFR family gene aberrations in cholangiocarcinoma显示文摘 | Xiaoqing Yang Weishan Wang Chunni Wang Lin Wang Muyi Yang Mei Qi Hong Su Xiubin Sun Zhiyan Liu Juan Zhang Xiaomin Qin Bo Han | 2014 | Oncology Reports2014，，2： | 1 |
| 6 | Assessment for surface water quality in Lake Taihu Tiaoxi River Basin China based on support vector machine显示文摘 | Wei Li Muyi Yang Zhiwei Liang | 2013 | Stochastic Environmental Research and Risk Assessment2013，27，： | 1 |
| 7 | ERG–SOX4 interaction promotes epithelial–mesenchymal transition in prostate cancer cells显示文摘 | Lin Wang Yanjiang Li Xiaoqing Yang Huiqing Yuan Xiangzhi Li Mei Qi Yannicca W.Y. Chang Chunni Wang WeiWei Fu Muyi Yang Juan Zhang Bo Han | 2014 | Prostate2014，，6： | 1 |
| 8 | Policy entry points forfacilitating a transition towards alow-carbonelectricityfuture显示文摘This study extends the ambit of the debate on electricity transitionby specifically identifying possible policy entry points through which transformative and enduring changes can be made in the electricity and socio-economic systems to facilitate the transition process.Guided by the'essence'of the multi-level perspective-a prominent framework for the study of energy transition,four such entry points have been identified:1)destabilising the dominant,fossil fuel-based electricity regime to create room for renewable technologies tobreak through;2)reconfiguring the electricity regime,which encompasses technology,short-term operational practices and long-term planning processes,to improve flexibility for accommodating large outputs from variable renewable sources whilst maintaining supply security;3)addressing the impactofcoal power phase-outon coal mining regions in terms of economic development and jobs;and 4)facilitating a shift in transition governance towards a learning-based,reflexive process.Specific areas for policy interventions within each of these entry points have also been discussed in the paper. | Muyi YANG Deepak SHARMA Xunpeng SHI | 2022 | Frontiers of Engineering Management2022，9，3： | 0 |
| 9 | Performance and robustness analysis of a fuzzy-immune flow controller in ATM networks with time-varying multiple time-delays显示文摘For the Asynchronous Transfer Mode (ATM) networks with time-varying multiple time-delays,a more realistic model for the available bit rate (ABR) traffic class with explicit rate feedback is introduced. A fuzzy-immune con-troller is designed,which can adjust the rates of ABR on-line,overcome the bad effect caused by the saturation nonlinearity and satisfy the weighted fairness. Also,the sufficient condition that guarantees the stability of the closed-loop system with a fuzzy-immune controller is presented in theory for the first time. The algorithm exhibits good performance,and most importantly,has a solid theoretical foundation and can be implemented in practice easily. Simulation results show that the control system is rapid,adaptive,robust,and meanwhile,the quality of service (QoS) is guaranteed. | Tao REN Zhenhua GAO Weiming KONG Yuanwei JING Muyi YANG Georgi M. DIMIROVSKI | 2008 | 控制理论与应用(英文版)2008，6，3： | 0 |
| 10 | Renewable energy in Australia:a wider policy discourse显示文摘This paper assesses the evolution of generation technology-mix in Australia,with specific emphasis on understanding how such evolution has been shaped by wider political and socioeconomic influences.This assessment is predicated on the argument that the contemporary,quintessentially techno-economic,policy discourse on renewable energy is deficient,as it ignores climacteric political and socio-economic influences on generation technology-mix.The methodological framework employed in this paper is informed by the core tenets of technological change theory.The assessment suggests that generation technology-mix in Australia has historically been overwhelmingly influenced by the underlying technological paradigm of the electricity industry;and that this technological paradigm essentially draws its imprimatur from the wider political and socio-economic contexts.By implication,it suggests that a rapid uptake of renewables will have widespread ramifications,extending into political,socio-economic and cultural realms of a society.Clearly,existing policy discourse-that tends to focus on technical potentials,cost competitiveness,externalities and risks of various renewable technologies-is deficient.A much broader discourse is needed.This paper also made an attempt to develop a basis for such a discourse by reviewing broader aspects of the Australian society that would be affected by a rapid uptake of renewables. | Muyi Yang Suwin Sandu Wenbo Li Muhammad Talal Khalid | 2019 | Chinese Journal of Population,Resources and Environment2019，17，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员