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| 1 | Transition of electric activity of neurons induced by chemical and electric autapses显示文摘Autapse connected to the neuron can change the electric activity of neuron. The effect of autapse on neuronal activity is often described by adding an additive forcing current along a close loop, which is described by a time-delayed feedback on the membrane potential. Neuron often responds to electric autapse forcing sensitively and quickly, while the chemical autapse changes the electric activity of neuron slowly. By applying external forcing, a shift transition of electric activity can be more easily induced by the electric autapse than the chemical autapse. Our results confirm that chemical autapse can enhance and/or suppress the transition of electric activity with excitable or inhibitory type driven by electric autapse, vice versa. It indicates that an appropriate switch-off-on for autapse can make the neuron give different types of response to external forcing. Particularly, cooperation and competition between chemical and electric autapse help neuron response to external forcing in the most reliable way. | SONG XinLin WANG ChunNi MA Jun TANG Jun | 2015 | Science China(Technological Sciences)2015，58，6： | 21 |
| 2 | Immunohistochemical prognostic markers of esophageal squamous cell carcinoma:a systematic review显示文摘Background: Esophageal squamous cell carcinoma(ESCC) is an aggressive malignancy, with a high incidence and poor prognosis. In the past several decades, hundreds of proteins have been reported to be associated with the prognosis of ESCC, but none has been widely accepted to guide clinical care. This study aimed to identify proteins with great potential for predicting prognosis of ESCC.Methods: We conducted a systematic review on immunohistochemical(IHC) prognostic markers of ESCC according to the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA) Guidelines. Literature related to IHC prognostic markers of ESCC were searched from PubMed, Embase, Web of Science, and Cochrane Library until January 30 th, 2017. The risk of bias of these original studies was evaluated using the Quality in Prognosis Studies(QUIPS) tool.Results: We identified 11 emerging IHC markers with reproducible results, including eight markers [epidermal growth factor receptor(EGFR), Cyclin D1, vascular endothelial growth factor(VEGF), Survivin, Podoplanin, Fascin,phosphorylated mammalian target of rapamycin(p-mTOR), and pyruvate kinase M2(PKM2)] indicating unfavorable prognosis and 3 markers(P27, P16, and E-cadherin) indicating favorable prognosis of ESCC.Conclusion: Strong evidence supports that these 11 emerging IHC markers or their combinations may be useful in predicting prognosis and aiding personalized therapy decision-making for ESCC patients. | Chunni Wang Jingnan Wang Zhaoli Chen Yibo Gao Jie He | 2017 | Chinese Journal of Cancer2017，36，11： | 16 |
| 3 | Dynamics of electric activities in neuron and neurons of network induced by autapses显示文摘The effect of autapse on adjusting the membrane of potentials of neuron is described by imposing a time-delayed feedback on the membrane of neuron in a close loop type,and the Hindmarsh-Rose(HR)neuron under autapse is investigated.Firstly,the electric activity of single HR neuron under electric autapse and chemical autapse is investigated.It is found that quiescent neuron is activated due to appropriate time delay and feedback gain in the autapse,and the autapse plays an important role in waking up neuron.The parameter region for periodic,chaotic activity of neuron under autapse is calculated in a numerical way,and transition from spiking to bursting is observed by increasing the feedback gain and time delay carefully.Furthermore,the collective electric activities of neurons in a ring network is investigated and abundant electric activities are observed due to the competition between the autapse and the time-delayed coupling between adjacent neurons in the network,and time delay in coupling between neurons also plays an important role in enhancing synchronization in the network. | QIN HuiXin MA Jun JIN WuYin WANG ChunNi | 2014 | Science China(Technological Sciences)2014，57，5： | 15 |
| 4 | Autapse-induced target wave, spiral wave in regular network of neurons显示文摘Autapse is a type of synapse that connects axon and dendrites of the same neuron, and the effect is often detected by close-loop feedback in axonal action potentials to the owned dendritic tree. An artificial autapse was introduced into the Hindmarsh-Rose neuron model, and a regular network was designed to detect the regular pattern formation induced by autapse. It was found that target wave emerged in the network even when only a single autapse was considered. By increasing the(autapse density) number of neurons with autapse, for example, a regular area(2×2, 3×3, 4×4, 5×5 neurons) under autapse induced target wave by selecting the feedback gain and time-delay in autapse. Spiral waves were also observed under optimized feedback gain and time delay in autapses because of coherence-like resonance in the network induced by some electric autapses connected to some neurons. This confirmed that the electric autapse has a critical role in exciting and regulating the collective behaviors of neurons by generating stable regular waves(target waves, spiral waves) in the network. The wave length of the induced travelling wave(target wave, spiral wave), because of local effect of autapse, was also calculated to understand the waveprofile in the network of neurons. | QIN HuiXin MA Jun WANG ChunNi CHU RunTong | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，10： | 12 |
| 5 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 6 | SPECIAL ISSUE: MIGRANT WORKERS IN THE COURSE OF URBANIZATON Wages for migrant workers in the Pearl River Delta: determining factors显示文摘本文通过对珠江三角洲农民工问卷调查资料的回归分析,试图检验在市场转型下的企业制度和社会环境对农民工工资的影响。研究发现,人力资本中的教育年限、本企业工龄等变量对农民工工资有显著的正向影响,年龄和性别也有显著影响;企业制度中的工种对工资有显著影响,表现出明显的等级性。企业所属行业、规模和企业性质对工资没有显著影响,是否签订劳动合同和缺工情况同样如此。社会资本变量和社会环境变量对农民工工资水平没有显著影响。文章由此认为,农民工的工资是处于分割的二元劳动力市场一端,是高度市场化的,缺乏企业内部劳动力市场或晋升机制,也少受劳动力市场用工情况变化影响,没有地区性差异,是一个实实在在的、刚性的低工资。 | Liu Linping Zhang Chunni | 2008 | Social Sciences in China2008，29，3： | 6 |
| 7 | Phase coupling synchronization of FHN neurons connected by a Josephson junction显示文摘Avariety of nonlinear circuits can be tamed to reproduce the main dynamical properties in neural activities for biological neurons while designing reliable artificial synapses for connecting these neural circuits becomes a challenge.In this paper,a Josephson junction is used to build coupling channel for connecting two FitzHugh-Nagumo neural circuits driven by periodical voltage source.The hybrid synapse is designed by using a linear resistor paralleled with a Josephson junction,which can estimate the effect of external magnetic field by generating additive phase error between the junction.Indeed,it activates nonlinear coupling due to phase diversity in the Josephson junction.The coupled circuits are estimated in dimensionless dynamical systems by applying scale transformation on the variables and parameters in neural circuits.In fact,the intrinsic parameters of coupling channel are adjusted to detect the occurrence of synchronization.Bifurcation analysis is calculated to predict and confirm the occurrence of synchronization between two neural circuits.It is found that synchronization can be stabilized between two FHN neural circuits by selecting appropriate values for parameters in the Josephson junction involved in the coupling channel.It gives useful guidance for implementing artificial synapse for signal processing in neural circuits. | ZHANG Yin WANG ChunNi TANG Jun MA Jun REN GuoDong | 2020 | Science China(Technological Sciences)2020，63，11： | 6 |
| 8 | Long-term effects of silver nanoparticles on performance of phosphorus removal in a laboratory-scale vertical flow constructed wetland显示文摘Silver nanoparticles(AgNPs)have been widely used in many fields,which raised concerns about potential threats to biological sewage treatment systems.In this study,the phosphorus removal performance,enzymatic activity and microbial population dynamics in constructed wetlands(CWs)were evaluated under a long-term exposure to Ag NPs(0,50,and 200μg/L)for 450 days.Results have shown that Ag NPs inhibited the phosphorus removal efficiency in a short-term exposure,whereas caused no obviously negative effects from a long-term perspective.Moreover,in the coexisting CW system of Ag NPs and phosphorus,competition exhibited in the initial exposure phase,however,cooperation between them was observed in later phase.Enzymatic activity of acid-phosphatase at the moderate temperature(10–20℃)was visibly higher than that at the high temperature(20–30℃)and CWs with Ag NPs addition had no appreciable differences compared with the control.High-throughput sequencing results indicated that the microbial richness,diversity and composition of CWs were distinctly affected with the extension of exposure time at different Ag NPs levels.However,the phosphorus removal performance of CWs did not decline with the decrease of polyphosphate accumulating organisms(PAOs),which also confirmed that adsorption precipitation was the main way of phosphorus removal in CWs.The study suggested that Ag NPs and phosphorus could be removed synergistically in the coexistence system.This work has some reference for evaluating the influences of Ag NPs on the phosphorus removal and the interrelation between them in CWs. | Juan Huang Jun Xiao Yang Guo Wenzu Guan Chong Cao Chunni Yan Mingyu Wang | 2020 | Journal of Environmental Sciences2020，32，1： | 5 |
| 9 | Emergence of target waves in neuronal networks due to diverse forcing currents显示文摘The electric activities of neurons could be changed when ion channel block occurs in the neurons.External forcing currents with diversity are imposed on the regular network of Hodgkin-Huxley(HH) neuron,and target waves are induced to occupy the network.The forcing current I1 is imposed on neurons in a local region with m 0 ×m 0 nodes in the network,neurons in other nodes are imposed with another forcing current I2.Target wave could be developed to occupy the network when the gradient forcing current(I1-I2) exceeds certain threshold,and the formation of target wave is independent of the selection of boundary condition.It is also found that the developed target wave can decrease the negative effect of ion channel block and suppress the spiral wave,and thus channel noise is also considered.The potential mechanism of formation of target wave could be that the gradient forcing current(I1-I2) generates quasi-periodical signal in local area,and the propagation of quasi-periodical signal induces target-like wave due to mutual coupling among neurons in the network. | MA Jun WANG ChunNi YING HePing WU Ying CHU RunTong | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 4 |
| 10 | A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis显示文摘 | Rui Liu Chunni Zhang Zhibin Hu Gou Li Cheng Wang Cuihua Yang Dingzhi Huang Xi Chen Haiyang Zhang Rui Zhuang Ting Deng Hua Liu Jingjing Yin Sufen Wang Ke Zen Yi Ba Chen-Yu Zhang | 2010 | European Journal of Cancer2010，，5： | 3 |
| 11 | Cellular automaton modeling of austenite formation from ferrite plus pearlite microstructures during intercritical annealing of a C-Mn steel显示文摘A mesoscopic cellular automaton model was developed to study the microstructure evolution and solute redistribution of austenization during intercritical annealing of a C-Mn steel. This model enables a depiction of three-stage kinetics of the transformation combined with the thermodynamic analysis:(1) the rapid austenite growth accompanied with pearlite degeneration until the pearlite dissolves completely;(2) the slower austenite growth into ferrite with a rate limiting factor of carbon diffusion in austenite;and(3) the slow austenite growth in control of the manganese diffusion until the final equilibrium reached for ferrite and austenite. The effect of the annealing temperature on the transformation kinetics and solute partition is also quantitatively rationalized using this model. | Chunni Jia Chengwu Zheng Dianzhong Li | 2020 | Journal of Materials Science & Technology2020，47，12： | 2 |
| 12 | Serum MicroRNA Expression Profile as a Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer显示文摘 | Liu Rui Chen Xi Du Yiqi Yao Weiyan Shen Lin Wang Cheng Hu Zhibin Zhuang Rui Ning Guang Zhang Chunni Yuan Yaozong Li Zhaoshen Zen Ke Ba Yi Zhang Chen-Yu | 2012 | Clinical Chemistry2012，，3： | 2 |
| 13 | Ultra-Fine Heterogeneous Microstructure Enables High Strength-Ductility in a Cold-Rolled Medium Mn Steel显示文摘The objective of the present study is to develop heterogeneous microstructure in cold-rolled medium Mn steels(MMSs)annealing strategy.The cold-rolled Fe-4.7Mn-0.15C(wt%)steel is annealed twice at different temperatures to produce an ultra-fine heterogeneous microstructure with lath-shaped and granular-shaped retained austenite.Excellent mechanical behavior of significant strength enhancement with negligible ductility loss can be achieved.The high strength-ductility properties are attributed to the active transformation induced plasticity effect over a broad strain range owing to dispersive mechanical stabilities of the heterogeneous austenite.Furthermore,the typical yield point elongation phenomenon which is commonly observed in cold-rolled MMSs can be effectively reduced by this microstructural strategy. | Baojia Hu Chengwu Zheng Qinyuan Zheng Peng Liu Chunni Jia Dianzhong Li | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，10： | 2 |
| 14 | Inhibitory effects of Rosa roxburghii Tratt juice on in vitro oxidative modification of low density lipoprotein and on the macrophage growth and cellular cholesteryl ester accumulation induced by oxidized low density lipoprotein 显示文摘 | ZHANG Chunni LIU Xiaozhuan QIANG Hongjuan | 2001 | Clin Chim Acta2001，313，2： | 1 |
| 15 | Expression Profile of MieroRNAs in Serum: A Fingerprint for Esophageal Squamous Cell Carcinoma显示文摘 | Chunni Zhang Cheng Wang Xi Chen | 2010 | Clinical Chemistry2010，56，18： | 1 |
| 16 | Effect of hypoalbuminemia on the increased serum cholesteryl ester transfer protein concentration in children with idiopathic nephrotic syndrome 显示文摘 | Chunni Zhang Min Yao Xiangdong Wang | 2007 | Clin Biochem2007，40，12： | 1 |
| 17 | A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis显示文摘 | Rui Liu Chunni Zhang Zhibin Hu Gou Li Cheng Wang Cuihua Yang Dingzhi Huang Xi Chen Haiyang Zhang Rui Zhuang Ting Deng Hua Liu Jingjing Yin Sufen Wang Ke Zen Yi Ba Chen-Yu Zhang | 2010 | European Journal of Cancer2010，，5： | 1 |
| 18 | Inhibitory effects of rosa roxburghii tratt juice on in vitro oxidative modification of low density lipoprotein and on the macrophage growth and cellular cholesteryl ester accumulation induced by oxidized low density lipoprotein显示文摘 | Chunni Zhang Xiaozhuan Liu Hongduan Qiang | 2001 | Clinica Chimica Acta2001，313，1： | 1 |
| 19 | Characterization of EGFR family gene aberrations in cholangiocarcinoma显示文摘 | Xiaoqing Yang Weishan Wang Chunni Wang Lin Wang Muyi Yang Mei Qi Hong Su Xiubin Sun Zhiyan Liu Juan Zhang Xiaomin Qin Bo Han | 2014 | Oncology Reports2014，，2： | 1 |
| 20 | Saikosaponin aand its epimer Saikosaponin d exhibit anti-inflammatory activityby suppressing activation of NF- k B signaling pathway 显示文摘 | LU Chunni YUAN Ziguo ZHANG Xiaoli | 2012 | Inter-national Immunopharmacology2012，14，1： | 1 |
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