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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Gut microbiota contributes to the distinction between two traditional Chinese medicine syndromes of ulcerative colitis显示文摘BACKGROUND Ulcerative colitis(UC)is considered to be closely associated with alteration of intestinal microorganisms.According to the traditional Chinese medicine(TCM)theory,UC can be divided into two disease syndromes called Pi-Xu-Shi-Yun(PXSY)and Da-Chang-Shi-Re(DCSR).The relationships among gut microbiota,TCM syndromes,and UC pathogenesis have not been well investigated.AIM To investigate the role of gut microbiota in UC and the distinction of microbiota dysbiosis between PXSY and DCSR syndromes.METHODS From May 2015 to February 2016,UC patients presenting to LongHua Hospital who met the established inclusion and exclusion criteria were enrolled in this retrospective study.Fresh stool specimens of UC patients with PXSY or DCSR were collected.The feces of the control group came from the health examination population of Longhua Hospital.The composition of gut bacterial communities in stool samples was determined by the pyrosequencing of 16S ribosomal RNA.The high-throughput sequencing reads were processed with QIIME,and biological functions were predicted using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States.RESULTS The composition of gut bacterial communities in 93 stool samples(30 healthy controls,32 patients with PXSY syndrome,and 31 patients with DCSR syndrome)was determined by the pyrosequencing of 16S ribosomal RNA.Beta diversity showed that the composition of the microbiota was different among the three groups.At the family level,Porphyromonadaceae,Rikeneliaceae,and Lachnospiraceae significantly decreased while Enterococcus,Streptococcus,and other potential pathogens significantly increased in UC patients compared to healthy subjects.At the genus level,Parabacteroides,Dorea,and Ruminococcus decreased while Faeca-libacterium showed increased abundance in UC compared to healthy controls.Five differential taxa were identified between PXSY and DCSR syndromes.At the genus level,a significantly increased abundance of Streptococcus was observed in DCSR patients,while Lachnoclostridium increased in PXSY patients.The differential functional pathways of the gut microbiome between the PXSY and DCSR groups mainly included lipid metabolism,immunity,and the metabolism of polypeptides.CONCLUSION Our study suggests that the gut microbiota contributes to the distinction between the two TCM syndromes of UC. | Ya-Li Zhang Li-Ting Cai Jun-Yi Qi Yun-Zheng Lin Yan-Cheng Dai Na Jiao You-Lan Chen Lie Zheng Bei-Bei Wang Li-Xin Zhu Zhi-Peng Tang Rui-Xin Zhu | 2019 | World Journal of Gastroenterology2019，25，25： | 19 |
| 3 | Clinical study on the changes of the tumor target volume and organs at risk in helical tomotherapy for nasopharyngeal carcinoma显示文摘背景螺旋状的 tomotherapy ( HT )是学习是在螺旋状的 tomotherapy.Methods 期间与鼻咽的癌( NPC )在病人的风险(浆)在目标体积和机关评估变化的这的一个新指导图象的调制紧张的放射治疗( IMRT ) .The 目的有 NPC 的 43 个病人并且经由 HT 对待从2008年3月是考察 retrospectively.Repeated CT 扫描到2010年1月,计划改编在 radiotherapy.The 期间在 第20 部分被进行容量的 | LU Na FENG Lin-chun CAI Bo-ning HOU Jun WANG Yun-lai XIE Chuan-bin | 2012 | Chinese Medical Journal2012，，1： | 18 |
| 4 | Colorectal cancer incidence and mortality:the current status,temporal trends and their attributable risk factors in 60 countries in 2000–2019显示文摘Background:Globally,colorectal cancer(CRC)imposes a substantial burden on healthcare systems and confers considerable medical expenditures.We aimed to evaluate the global and regional burden in epidemiological trends and factors associated with the incidence and mortality of CRC.Methods:We used data from the GLOBOCAN database to estimate CRC incidence and mortality worldwide in 2020 and their association with the human development index(HDI).Trends of age-standardized rates of incidence and mortality in 60 countries(2000–2019)were evaluated by Joinpoint regression analysis using data of Global Burden of Disease 2019.The association between exposure to country-level lifestyle,metabolic and socioeconomic factors obtained from the World Health Organization Global Health Observatory and World Bank DataBank data and CRC incidence and mortality was determined by multivariable linear regression.Results:CRC incidence and mortality varied greatly in the 60 selected countries,and much higher incidence and mortality were observed in countries with higher HDIs,and vice versa.From 2000 to 2019,significant increases of incidence and mortality were observed for 33 countries(average annual percent changes[AAPCs],0.24–3.82)and 18 countries(AAPCs,0.41–2.22),respectively.A stronger increase in incidence was observed among males(AAPCs,0.36–4.54)and individuals<50 years(AAPCs,0.56–3.86).Notably,15 countries showed significant decreases in both incidence(AAPCs,0.24 to2.19)and mortality(AAPCs,0.84 to2.74).A significant increase of incidence among individuals<50 years was observed in 30 countries(AAPCs,0.28–3.62).Countries with higher incidence were more likely to have a higher prevalence of alcohol drinking,higher level of cholesterol level,higher level of unemployment,and a poorer healthcare system.Conclusions:Some high-HDI countries showed decreasing trends in CRC incidence and mortality,whereas developing countries that previously had low disease burden showed significantly increased incidence and mortality trends,especially in males and populations≥50 years,which require targeted preventive health programs. | Bin Lu Na Li Chen-Yu Luo Jie Cai Ming Lu Yu-Han Zhang Hong-Da Chen Min Dai | 2021 | Chinese Medical Journal2021，，16： | 13 |
| 5 | PI3K/AKT/mTOR signaling pathway inhibitors in proliferation of retinal pigment epithelial cells显示文摘AIM: To determine whether the PI3K/AKT/mTOR pathway is activated in proliferative vitreoretinopathy (PVR) in homo- sapiens. METHODS: The retina of controls and patients with PVR were collected and their levels of PI3K, phospho-AKT, phospho-mTOR, phospho-p70S6k and phospho-4EBP-1 were determined by Western blot. The cultured human retinal pigment epithelial cell line D407 was treated with a specific mTOR inhibitor, rapamycin (RAPA) or a PI3K inhibitor, LY294002, of various concentrations and durations. Cell morphology was observed by phase contrast microscopy and the proliferation and apoptosis of treated cells were determined by MTT assay and flow cytometry. RESULTS: Levels of PI3K, phospho-AKT, phospho-mTOR, phospho-P70S6K and phospho-4EBP1 was increased in the retina in PVR (P <0.05). In D407 cells, both RAPA and LY294002 significantly inhibited cell proliferation and cell cycle progression, and promoted apoptosis (P <0.05); mor- phologically, the cells became smaller. Both RAPA and LY294002 reduced levels of phospho-AKT, phospho-mTOR, phospho-p70S6k and phospho-4EBP1 expression (P <0.05). RAPA, but not LY294002, had no significant effect on PI3K expression. CONCLUSION: PI3K/AKT/mTOR signaling pathway is highly activated in the retinal pigment epithelial cells of PVR. The inhibitors of PI3K/AKT/mTOR signaling pathway, RAPA and LY294002, could inhibited the PI3K/AKT/mTOR signaling pathway by reducing the levels of phosphorylation of mTOR pathway components. | Na Cai Shun-Dong Dai Ning-Ning Liu Li-Min Liu Ning Zhao Lei Chen | 2012 | International Journal of Ophthalmology(English edition)2012，5，6： | 12 |
| 6 | Explicit analytical solutions of non-Fourier heat conduction equation for IC chip显示文摘Four basic explicit analytical solutions of non_Fourier heat conduction equation simulating IC chip thermal condition are derived. Some other analytical series solutions can also be derived with the above_mentioned basic solutions. Analytical solution has its own irreplaceable important meaning in theory. In addition, as the standard solution to check the accuracy, convergence and effectiveness of various numerical computational methods and their differencing schemes, grid generation ways and so on, the analytical solution is very useful also for the newly rapidly developing computational heat transfer. | Ruixian Cai Na Zhang | 1998 | Chinese Science Bulletin1998，43，13： | 11 |
| 7 | The Huashan risk calculators performed better in prediction of prostate cancer in Chinese population: a training study followed by a validation study显示文摘前列腺癌症预防试用(PCPT ) 的表演冒险计算器和其它风险计算器因为在中国人口的前列腺癌症(PCa ) 预言糟糕被理解。我们执行了这研究基于中国人口造风险计算器(Huashan 风险计算器) 并且验证了前列腺特定的抗原(PSA ) 的性能, PCPT 风险计算器,和在一个确认队的 Huashan 风险计算器。我们从在一个训练的队从 2006 年 1 月经历了起始的前列腺活体检视到 2010 年 12 月的 1059 个人基于数据造了 Huashan 风险计算器。然后,我们从 2011 年 1 月在观察确认研究验证了 PSA, PCPT 风险计算器,和 Huashan 风险计算器的性能到 2014 年 12 月。所有必要临床的信息在活体检视前被收集。结果证明 Huashan 冒险 1 和 2 超过了的计算器为在全部训练的队和成层的人口预言 PCa 的 PCPT 风险计算器(与到 20.0 ng m 的从 2.0 ng ml −1 的 PSA ) 。在确认学习, Huashan 风险计算器 1 仍然在全部确认队超过了 PCPT 风险计算器(0.849 对 0.779 在在操作特征的接收装置下面的区域弯[AUC ] 并且成层的人口。当 Huashan 风险计算器被使用时,不必要的活体检视(约 30%) 的可观的减小也被观察。因此,我们相信 Huashan 风险计算器(特别 Huashan 风险计算器 1 ) 可能为在中国人口预言 PCa 增加了价值。然而,这些结果仍然在更大的人口需要进一步的评估。 | Yi-Shuo Wu Ning Zhang Sheng-Hua Liu Jian-Feng Xu Shi-Jun Tong Ye-Hua Cai Li-Min Zhang Pei-De Bai Meng-Bo HU Hao-Wen Jiang Rong Na Qiang Ding Ying-Hao Sun | 2016 | Asian Journal of Andrology2016，18，6： | 7 |
| 8 | A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters显示文摘The manipulation of bile acid (BA) homeostasis by blocking the ileal apical Na+-dependent bile salt transporter (ASBT/SLC10A2) may have therapeutic effects in nonalcoholic fatty liver disease. We developed a novel ASBT inhibitor, an N-(3,4-o-dichlorophenyl)?2-(3-trifluoromethoxy) benzamide derivative referred to as IMB17–15, and investigated its therapeutic effects and the molecular mechanisms underlying the effects. Syrian golden hamsters were challenged with high-fat diet (HFD) to induce NAFLD and were subsequently administered 400 mg/kg IMB17–15 by gavage daily for 21 days. Serum, liver, and fecal samples were collected for further analysis. Plasma concentration-time profiles of IMB17–15 were also constructed. The human hepatocyte cell line HL-7702 was treated with Oleic acid (OA) with or without IMB17–15. Western blotting and real-time PCR were used to study the molecular mechanisms of IMB17–15. We found that IMB17–15 inhibited ASBT and subsequently suppressed ileal farnesoid X receptor (FXR) and FXR-activated fibroblast growth factor15/19 (FGF15/19) expression, which reduced the hepatic phosphorylated extracellular regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) levels and upregulated the cholesterol 7α-hydroxylase (CYP7A1) activity. Additionally, IMB17–15 stimulated adenosine monophosphate (AMP)-activated protein kinase (AMPKα) phosphorylation and enhanced peroxisome proliferator activated receptor α(PPARα) expression and thus promoted triglyceride (TG) oxidation and high-density lipoprotein cholesterol (HDL-c) metabolism through an ASBT-independent mechanism. In conclusion, a novel ASBT inhibitor known as IMB17–15 protected hamsters against HFD-induced NFALD by manipulating BA and lipid homeostasis. IMB17–15 also reduced lipid deposition in human hepatic cell lines, indicating that it may be useful as a therapy for NAFLD patients. | Mao-xu Ge Wei-xiao Niu Jin-feng Ren Shi-ying Cai Dong-ke Yu Hong-tao Liu Na Zhang Yi-xuan Zhang Yu-cheng Wang Rong-guang Shao Ju-xian Wang Hong-wei He | 2019 | Acta Pharmacologica Sinica2019，40，7： | 7 |
| 9 | Effects of Brassinosteroid Associated with Auxin and Gibberellin on Apple Tree Growth and Gene Expression Patterns显示文摘Brassinosteroid is an important hormone that interacts with auxin and gibberellin to regulate plant growth and development. However,there is currently a relative lack of information regarding brassinosteroid in apple. Previous study confirmed that exogenous brassinosteroid treatments increased growth and endogenous brassinosteroid, auxin, as well as gibberellin levels of apple nursery trees. Here we succeeded to find that exogenous brassinosteroid treatments upregulated the transcript expression of auxin biosynthesis, transport, and positive signal transduction genes as well as gibberellin biosynthesis genes. In contrast, the application of exogenous brassinosteroid downregulated the expression of genes encoding negative regulators of auxin and gibberellin signal transductions. Rapid responses of several brassinosteroid-,auxin-, and gibberellin-related genes to the brassinosteroid and brassinazole treatments inferred the crosstalk of BR and IAA or GA. Furthermore,the expression levels of cell growth-related genes were also enhanced by exogenous brassinosteroid. Auxin and gibberellin treatments also influenced growth of apple tree and enhanced the expression of brassinosteroid-and cell growth-related genes. These results indicate that the growth of apple tree is regulated by the interaction between brassinosteroid, auxin, and gibberellin. Our work opened new avenues for deep portfolio of apple tree growth and laid the foundation for future studies aimed at elucidating the mechanisms regulating hormone interactionsmediated growth in apple trees. | Liwei Zheng Cai Gao Caide Zhao Lizhi Zhang Mingyu Han Na An Xiaolin Ren | 2019 | Horticultural Plant Journal2019，5，3： | 7 |
| 10 | Protective effect of hydroxychloroquine on rheumatoid arthritis-associated atherosclerosis显示文摘Background: Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease. We examined the effect of gut microbiota in a mouse model of RA that develops atherosclerosis. Methods: We created three groups of K/BxN female mice that were positive for the anti‐glucose‐6‐phosphate isomerase (GPI) antibody: control diet (CD), high fat diet (HFD), and HFD with hydroxychloroquine (HFD + HCQ). Serological tests were used to detect the serum levels of total cholesterol (TCHO), low‐density lipoprotein cholesterol (LDL‐C), triglyceride (TG), high‐density lipoprotein cholesterol (HDL‐C), anti‐ GPI antibody titers, and serum cytokines. Atherosclerotic plaque was determined by histological analysis, and gut microbiota were determined by 16sV4 sequencing. Results: Relative to mice given the CD, those receiving the HFD had increased serum levels of LDL‐C, TCHO, and TG, decreased serum levels of HDL‐C, increased atherosclerotic lesions in the aortic root, and altered gut microbiota. Addition of HCQ to HFD decreased the serum levels of LDL‐C, TCHO, and TG, increased serum levels of HDL‐C, and decreased the atherosclerotic lesions in the aortic root. Mice receiving HFD + HCQ also had the greatest bacterial diversity among the three experimental groups. Moreover, HCQ treatment significantly increased the abundance of Akkermansia and Parabacteroides, and decreased the abundance of Clostridium sensu stricto cluster 1, and therefore may be responsible for the reduced RA‐associated atherosclerosis and dyslipidemia. Conclusion: Our mouse model of RA indicated that HFD increased ankle width and aggravated a therosclerosis a nd d yslipidemia, a nd t hat H CQ a lleviated t he d yslipidemia and atherosclerosis, but had no effect on ankle width. | Na Shi Shuangyue Zhang Gregg Silverman Mengtao Li Jun Cai Haitao Niu | 2019 | Animal Models and Experimental Medicine2019，2，2： | 6 |
| 11 | IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis显示文摘Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE. | Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，7： | 6 |
| 12 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 13 | Global and regional trends in incidence and mortality of female breast cancer and associated factors at national level in 2000 to 2019显示文摘Background: Female breast cancer (FBC) has become the most prevalent malignancy worldwide. We aimed to evaluate the global and regional burden in epidemiological trends and factors associated with the incidence and mortality of FBC.Methods: FBC incidence and mortality in 60 selected countries by cancer registry data integrity in 2020 were estimated from the GLOBOCAN database, and their association with the human development index (HDI) was further evaluated. Trends of age-standardized rates of incidence and mortality in 60 countries from 2000 through 2019 were evaluated by joinpoint regression analysis using data of Global Burden of Disease 2019. The association between potential behavioral, metabolic, and socioeconomic risk factor exposure at the nation level retrieved from the World Bank and Global Health Observatory and the incidence and mortality of FBC were evaluated by multivariate linear regression.Results: FBC incidence and mortality varied greatly in the 60 included countries. Higher incidence and mortality rates were typically observed in countries with higher HDIs and vice versa. During 2000 to 2019, significantly increasing trends in incidence and mortality were observed in 26 (average annual percent changes [AAPCs], 0.35-2.96) and nine countries (AAPC, 0.30-1.65), respectively, while significantly decreasing trends in both incidence and mortality were observed in 22 countries, most of which were high-HDI countries. Among the population aged ≥40 years, there were 26 and 11 countries showing significantly increased trends in incidence and mortality, respectively. Ecological analysis showed that countries with higher prevalence rates of high cholesterol and higher health expenditures were more likely to have higher FBC incidence, and countries with higher rates of obesity and poorer universal health coverage were more likely to have higher FBC mortality.Conclusions: Despite decreased or stabilized FBC incidence and mortality rates were observed in some countries with high HDI over the past decades, disease burden became even severer in developing countries, especially for the population aged ≥40 years. Effective targeted preventive programs are strongly encouraged to reduce the FBC disease burden worldwide. | Chenyu Luo Na Li Bin Lu Jie Cai Ming Lu Yuhan Zhang Hongda Chen Min Dai | 2022 | Chinese Medical Journal2022，，1： | 5 |
| 14 | Pollution level and human health risk assessment of some pesticides and polychlorinated biphenyls in Nantong of Southeast China显示文摘Food consumption is one of the key exposure routes of humans to contaminants.This article evaluated the residue levels of 51 pesticides and 16 polychlorinated biphenyls(PCBs) in selected fish and food items which were commonly consumed in the Nantong area of Jiangsu Province,Southeast China.The 51 pesticides and 16 PCBs were analyzed by highly sensitive gas chromatographytandem mass spectrometry(GC-MS/MS).The results showed that organochlorine pesticides such as dichlorodiphenyltrichloroethanes(DDTs),hexachlorocyclohexanes(HCHs),hexachlorobenzene(HCB) and mirex and other pesticides including chlorpyrifos,pyrethroid pesticides,metolachlor,pyridaben and trifluralin were frequently detected in the samples,which was consistent with the accumulation level and characteristics of these toxic chemicals in human adipose tissue of people living in Nantong.Meanwhile,correlation of the residue level of toxic chemicals with their physical chemical properties and historic use pattern in Nantong area was observed.Combined with dietary survey results at the same sampling locations,human health risk assessment of ingestion through the dietary route was performed.The results suggested that the non-cancer risks of the chemicals investigated can be considered negligible in the Nantong area,however,the cancer risks from lifetime dietary exposure to DDTs and HCB have exceeded the acceptable levels. | Na Wang Li Yi Lili Shi Deyang Kong Daoji Cai Donghua Wang Zhengjun Shan | 2012 | Journal of Environmental Sciences2012，24，10： | 5 |
| 15 | Transformation of human liver L-02 cells mediated by stable HBx transfection显示文摘 | Wei-ying ZHANG Na CAI Li-hong YE Xiao-dong ZHANG | 2009 | Acta Pharmacologica Sinica2009，30，8： | 5 |
| 16 | Multiple fields manipulation on nitride material structures in ultraviolet light-emitting diodes显示文摘As demonstrated during the COVID-19 pandemic,advanced deep ultraviolet(DUV)light sources(200–280 nm),such as AlGaN-based light-emitting diodes(LEDs)show excellence in preventing virus transmission,which further reveals their wide applications from biological,environmental,industrial to medical.However,the relatively low external quantum efficiencies(mostly lower than 10%)strongly restrict their wider or even potential applications,which have been known related to the intrinsic properties of high Al-content AlGaN semiconductor materials and especially their quantum structures.Here,we review recent progress in the development of novel concepts and techniques in AlGaNbased LEDs and summarize the multiple physical fields as a toolkit for effectively controlling and tailoring the crucial properties of nitride quantum structures.In addition,we describe the key challenges for further increasing the efficiency of DUV LEDs and provide an outlook for future developments. | Jinchai Li Na Gao Duanjun Cai Wei Lin Kai Huang Shuping Li Junyong Kang | 2021 | Light(Science & Applications)2021，10，7： | 4 |
| 17 | Original article Efficacy and safety of Changfu peritoneal dialysis solution: a multi-center prospective randomized controlled trial显示文摘 | ZHOU Jian-hui NI Zhao-hui MEI Chang-lin YU Xue-qing LIU Fu-you MIAO Li-ning LIU Zhi-hong YUAN Wei-jie ZHANG Ai-ping LIN Hong-li CHEN Meng-hua CHEN Jiang-hua ZHANG Jin-yuan HE Ya-ni CHEN Jian ZHAO Jiu-yang DING Xiao-qiang LI Ying LI Rong-shan XIE Ru-juan LIU Wen-hu XING Chang-ying WANG Rong DENG Yue-yi CAO Xue-ying CAI Guang-yan MOU Shan MAO Zhi-guo YANG Xiao LIU Hong SUN Jing YU Yu-sheng LIU Jun SHI Shu-mei LI Long-kai TIAN Na ZHANG Xiao-hui ZHOU Wei YANG Jie ZHANG Yong SUN Jing-di JI Jun ZHANG Tao YAN Yan LIU Xiao-gang WANG Gang ZHANG Li ZHANG Hong LUO Jian-hua CHEN Xiang-mei | 2013 | Chinese Medical Journal2013，，22： | 4 |
| 18 | Synthesis, characterization, thermodynamic and kinetic investigations on uranium(Ⅵ) adsorption using organic-inorganic composites: Zirconyl-molybdopyrophosphate-tributyl phosphate显示文摘Zirconyl-molybdopyrophosphate-tributyl phosphate(ZMPP-TBP)was a novel organic-inorganic composite adsorbent prepared by co-precipitation method and used in the adsorption of uranium from aqueous solution in batch adsorption experiments.The as-obtained product was characterized using SEM,energy dispersive X-ray spectroscopy(EDX),XRD and BET-N2adsorption measurements.The study had been conducted to investigate the effects of solution pH,temperature,contact time,initial concentration and coexisting ions.A maximum removal of 99.31%was observed for an initial concentration 5 mg/L,at pH6.0 and an adsorbent dose of 1.0 g/L.The isothermal data were fitted with both Langmuir and Freundlich equations,but the data fitted the former better than the latter.According to the evaluation using the Langmuir equation,the maximum adsorption capacity of uranium(Ⅵ)was 196.08 mg/g at 293 K and pH 6.0.The pseudo-first-order kinetic model and pseudo-second-order kinetic model were used to describe the kinetic data,and the pseudo-second-order kinetic model was better.The thermodynamic parameterΔG was calculated,the negativeΔG values of uranium(VI)at different temperature showed that the adsorption process was spontaneous.The good reusability of ZMPP-TBP also indicated that the ZMPP-TBP was a very promising adsorbent for uranium adsorption from aqueous solution. | ZHOU ShiMin CHEN BaiHua LI Yuan GUO JingWei CAI XiaoJiaoX CAI XiaoJiao QIN Zhi BAI Jing NA Ping | 2013 | Science China Chemistry2013，56，11： | 4 |
| 19 | Correlation between Cholinergic Innervation, Autophagy, and Etiopathology of Benign Prostatic Hyperplasia显示文摘 | Jian-Liang Cai Wei-Min Yao Yan-Qun Na | 2017 | Chinese Medical Journal2017，，16： | 4 |
| 20 | Cold Stress-induced Glucosyltransferase CsUGT78A15 is Involved in the Formation of Eugenol Glucoside in Camellia sinensis显示文摘Eugenol is a natural phenolic compound known for its health-promoting properties and its ability to add a floral scent to tea plants.Plant eugenol glycosides have been identified and shown to make important contributions to fruit floral quality.However,the details of their biosynthesis and metabolism in tea plants are still unknown.Here,eugenol glucoside was unambiguously identified as a native metabolite in the tea plant,and its biosynthesis was shown to be induced by low temperature treatment.Through the analysis of UGTs induced by low temperature,the glycosyltransferase CsUGT78A15 was identified in tea,and its encoded protein was shown to catalyze the glucosylation of eugenol.Vmax/Km ratios showed that eugenol was the most suitable substrate for CsUGT78A15.Sugar donor preference analysis showed that CsUGT78A15 had a higher selectivity for glucose,followed by galactose and glucuronic acid.The expression of CsUGT78A15was correlatedwith the accumulation of eugenol glucoside in different tissues and genotypes of tea.Down-regulation of CsUGT78A15 led to a decreased eugenol glucoside content under cold stress,indicating that CsUGT78A15 plays an important role in the biosynthesis of eugenol glucoside under cold stress.The identification of eugenol glucoside in the tea plant and the discovery of a cold stress-induced eugenol glucosyltransferase in tea provide the foundation for the improvement of tea flavor under cold stress and the biotechnological production of eugenol glucoside. | Mingyue Zhao Binbin Cai Jieyang Jin Na Zhang Tingting Jing Jingming Wang Yuting Pan Zixiang Zhou Yifan Zhao Yingying Feng Feng Yu Mengting Zhang Yating Li Zhonghua Liu Chuankui Song | 2020 | Horticultural Plant Journal2020，6，6： | 4 |
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