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| 1 | IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome显示文摘Increased numbers of T follicular helper(Tfh)cells have been implicated in the development of autoimmune diseases including primary Sjögren’s syndrome(pSS),but how the Tfh cell response is regulated during autoimmune pathogenesis remains largely unclear.Here,we first found negative correlations between IL-10^(+)regulatory B(Breg)cell numbers and Tfh cell responses and disease activity in patients with pSS and mice with experimental Sjögren’s syndrome(ESS).Moreover,we detected high expression of IL-10 receptor on Tfh cells and their precursors in both humans and mice.In culture,IL-10 suppressed human and murine Tfh cell differentiation by promoting STAT5 phosphorylation.By using an adoptive transfer approach and two-photon live imaging,we found significantly increased numbers of Tfh cells with enhanced T cell homing into B cell follicles in the draining cervical lymph nodes of RAG-2−/−mice transferred with IL-10-deficient B cells during ESS development compared with those of RAG-2−/−mice transferred with wild-type B cells.In ESS mice,CD19^(+)CD1d^(hi)CD5^(+)Breg cells with decreased IL-10 production exhibited severely impaired suppressive effects on T cell proliferation.Consistently,CD19^(+)CD24^(+)CD38^(hi) Breg cells from pSS patients showed significantly reduced IL-10 production with defective inhibitory function in the suppression of autologous Tfh cell expansion.Furthermore,the adoptive transfer of IL-10-producing Breg cells markedly suppressed the Tfh cell response and ameliorated ESS progression in ESS mice.Together,these findings demonstrate a critical role for IL-10-producing Breg cells in restraining the effector Tfh cell response during pSS development. | Xiang Lin Xiaohui Wang Fan Xiao Kongyang Ma Lixiong Liu Xiaoqi Wang Dong Xu Fei Wang Xiaofei Shi Dongzhou Liu Yan Zhao Liwei Lu | 2019 | Cellular & Molecular Immunology2019，16，12： | 13 |
| 2 | Microstructure and domain engineering of lithium niobate crystal films for integrated photonic applications显示文摘Recently,integrated photonics has attracted considerable interest owing to its wide application in optical communication and quantum technologies.Among the numerous photonic materials,lithium niobate film on insulator(LNOI)has become a promising photonic platform owing to its electro-optic and nonlinear optical properties along with ultralow-loss and high-confinement nanophotonic lithium niobate waveguides fabricated by the complementary metal-oxide-semiconductor(CMOS)-compatible microstructure engineering of LNOI.Furthermore,ferroelectric domain engineering in combination with nanophotonic waveguides on LNOI is gradually accelerating the development of integrated nonlinear photonics,which will play an important role in quantum technologies because of its ability to be integrated with the generation,processing,and auxiliary detection of the quantum states of light.Herein,we review the recent progress in CMOS-compatible microstructure engineering and domain engineering of LNOI for integrated lithium niobate photonics involving photonic modulation and nonlinear photonics.We believe that the great progress in integrated photonics on LNOI will lead to a new generation of techniques.Thus,there remains an urgent need for efficient methods for the preparation of LNOI that are suitable for large-scale and low-cost manufacturing of integrated photonic devices and systems. | Dehui Sun Yunwu Zhang Dongzhou Wang Wei Song Xiaoyan Liu Jinbo Pang Deqiang Geng Yuanhua Sang Hong Liu | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 3 | IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis显示文摘Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE. | Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，7： | 6 |
| 4 | Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjögren’s syndrome显示文摘Immunoproteasome activation in immune cells is involved in the modulation of immune responses.Increasing evidence indicates that proteasome inhibitors show beneficial effects in treating autoimmune diseases,but it remains unclear whether proteasome inhibition is an effective approach for suppressing autoimmune development in Sjögren’s syndrome(SS).Our previous work has demonstrated a critical role for Th17 cells in the development of experimental SS(ESS)in mice.In this study,we detected high levels of low-molecular-weight protein 7(LMP7),a key subunit of the immunoproteasome,in Th17 cells from ESS mice.Moreover,treatment with bortezomib(BTZ),a proteasome inhibitor,markedly suppressed Th17 differentiation in both murine and human naive T cells in culture.Furthermore,ESS mice treated with BTZ displayed significantly higher saliva flow rates and a reduction in tissue destruction in the salivary glands compared with vehicle-treated ESS mice.Notably,BTZ-treated ESS mice showed markedly decreased Th17 cells,germinal center B cells and plasma cells in the peripheral lymphoid organs.In addition,adoptively transferred wild type naive CD4+T cells rapidly differentiated into Th17 cells and induced salivary dysfunction in IL-17-deficient mice immunized for ESS induction.However,BTZ treatment profoundly suppressed the donor T-cell-derived Th17 response and ameliorated the reduction in salivary secretion in IL-17-deficient recipient mice.Taken together,our findings demonstrate that proteasome inhibition can effectively ameliorate ESS by suppressing the Th17 response,which may contribute to the development of a novel therapeutic strategy for the treatment of SS. | Fan Xiao Xiang Lin Jie Tian Xiaohui Wang Qian Chen Ke Rui Jie Ma Shengjun Wang Qingwen Wang Xiaoqi Wang Dongzhou Liu Lingyun Sun Liwei Lu | 2017 | Cellular & Molecular Immunology2017，14，11： | 6 |
| 5 | Control of the morphology of micro/nanostructures of polycarbonate via electrospinning显示文摘Many of the applications proposed for bioassays, scaffolds for tissue engineering, filtrations, and supports for catalysts require polymeric membranes with large specific surface areas. Polycarbonate (PC) is a possible candidate for these applications because of its excellent mechanical performance and good biocompatibility. Electrospinning is a simple and effective method for large-scale fabrication of micro-/nanofibrous membranes with large specific surface areas. How to control the morphology of electrospun PC fibers, however, has not been systematically investigated. We describe the controllable fabrication of continuous and uniform PC fibers. We electrospin PC/chloroform solutions doped with different types of surfactants including anionic, zwitterionic, nonionic and cationic surfactants. Only cationic surfactants can lead to the successful fabrication of uniform PC fibers. After the analysis of the correlation between solution properties such as viscosity, surface tension, and conductivity and the morphology of electrospun fibers, we conclude that the addition of cationic surfactants such as cetane trimethyl ammonium bromide (CTAB) that leads to a decrease in viscosity is the main factor responsible for the formation of PC fibers. The demonstration of the fabrication of uniform PC fibers will lend experience to processing other polymers into fibers via electrospinning. | YANG Da Yong WANG Yang ZHANG DongZhou LIU YingYi JIANG XingYu | 2009 | Chinese Science Bulletin2009，54，17： | 6 |
| 6 | Ecto-mesenchymal stem cells: a new player for immune regulation and cell therapy显示文摘Extensive studies have demonstrated that mesenchymal stem cells(MSCs)are multipotent mesoderm-derived stromal cells that can differentiate into a variety of cell types,including adipocytes,osteoblasts,chondrocytes,myocytes and neuronal cells.1 MSCs are found in numerous organs and tissues,including bone marrow,heart,lung,muscle,peripheral blood,adipose tissue,cartilage,synovium,dental pulp,tonsil,umbilical cord,placenta,thymus and olfactory mucosa.1 MSCs have been shown to possess potent immunosuppressive functions and tissue repair capacities,which have facilitated the clinical applications of MSCs in treating a diverse range of disorders involving angiogenesis and fibrosis,including rheumatic diseases and graft-versus-host diseases.2,3 Here,we provide a brief commentary on newly emerging evidence of the immunoregulatory function and potential application of ecto-mesenchymal stem cells. | Ke Rui Xiang Lin Jie Tian Xiaohui Wang Lingyun Sun Xiaoping Hong Dongzhou Liu Shengjun Wang Liwei Lu | 2018 | Cellular & Molecular Immunology2018，15，1： | 4 |
| 7 | The expanding functional diversity of plasma cells in immunity and inflammation显示文摘The generation and function of plasma cells have been well recognized as the central events in humoral immunity.In particular,long-lived plasma cells,characterized by a long lifespan and the lack of cell division,persistently secrete high-affinity antibodies to maintain serum antibody titers in the immune response and autoimmune inflammation.Although the significant expansion of plasma cells is observed during the aging process,autoimmune diseases and chronic infections,the expanding functional diversity and underlying mechanisms of plasma cells remain incompletely understood.Here,we describe recent advances in revealing new functional subsets and phenotypic features of plasma cells in aging and autoimmunity. | Kongyang Ma Xiaohui Wang Xiaofei Shi Xiang Lin Fan Xiao Xin Ma Dongzhou Liu Liwei Lu | 2020 | Cellular & Molecular Immunology2020，17，4： | 2 |
| 8 | Prediction model of volume average diameter and analysis of atomization characteristics in electrostatic atomization minimum quantity lubrication显示文摘Minimum quantity lubrication(MQL)is a relatively efficient and clean alternative to flooding workpiece machining.Electrostatic atomization has the merits of small droplet diameter,high uniformity of droplet size,and strong coating,hence its superiority to pneumatic atomization.However,as the current research hotspot,the influence of jet parameters and electrical parameters on the average diameter of droplets is not clear.First,by observing the shape of the liquid film at the nozzle outlet,the influence law of air pressure and voltage on liquid film thickness(h)and transverse and longitudinal fluctuations are determined.Then,the mathematical model of charged droplet volume average diameter(VAD)is constructed based on three dimensions of the liquid film,namely its thickness,transverse wavelength(λ_(h)),and longitudinal wavelength(λ_(z)).The model results under different working conditions are obtained by numerical simulation.Comparisons of the model results with the experimental VAD of the droplet confirm the error of the mathematical model to be less than 10%.The droplet diameter distribution span value Rosin–Rammler distribution span(R.S)and percentage concentrations of PM10(particle size of less than 10μm)/PM2.5(particle size of less than 2.5μm)under different working conditions are further analyzed.The results show that electrostatic atomization not only reduces the diameter distribution span of atomized droplets but also significantly inhibits the formation of PM10 and PM2.5 fine-suspension droplets.When the air pressure is 0.3 MPa,and the voltage is 40 kV,the percentage concentrations of PM10 and PM2.5 can be reduced by 80.72%and 92.05%,respectively,compared with that under the pure pneumatic atomization condition at 0.3 MPa. | Dongzhou JIA Changhe LI Jiahao LIU Yanbin ZHANG Min YANG Teng GAO Zafar SAID Shubham SHARMA | 2023 | Friction2023，11，11： | 1 |
| 9 | Analytical dynamic impact study based on correlated road roughness 显示文摘 | Liu Chunhua Huang Dongzhou Wang T L | 2002 | Computers and Structures2002，80，2021： | 1 |
| 10 | Analyticaldyna mic impact study based on correlated road roughness显示文摘 | Liu Chunhua Huang Dongzhou Wang.T L | | 0，，20： | 1 |
| 11 | Ana- lytical dynamic impact study based on correlated road roughness显示文摘 | Liu Chunhua Huang Dongzhou Wang Ton-Lo | 2002 | Computers and Structures2002，80，： | 1 |
| 12 | Wavelength-tunable organic semiconductor lasers based on elastic distributed feedback gratings显示文摘Wavelength-tunable organic semiconductor lasers based on mechanically stretchable polydimethylsiloxane (PDMS) gratings were developed. The intrinsic stretchability of PDMS was explored to modulate the period of the distributed feedback gratings for fine tuning the lasing wavelength. Notably, elastic lasers based on three typical light-emitting molecules show com-parable lasing threshold values analogous to rigid devices and a continuous wavelength tunability of about 10 nm by mechanic-al stretching. In addition, the stretchability provides a simple solution for dynamically tuning the lasing wavelength in a spec-tral range that is challenging to achieve for inorganic counterparts. Our work has provided a simple and efficient method of fab-ricating tunable organic lasers that depend on stretchable distributed feedback gratings, demonstrating a significant step in the advancement of flexible organic optoelectronic devices. | Chengfang Liu He Lin Dongzhou Ji Qun Yu Shuoguo Chen Ziming Guo Qian Luo Xu Liu Wenyong Lai | 2023 | Journal of Semiconductors2023，44，3： | 0 |
| 13 | Expression profiling of immune cells in systemic lupuserythematosus by single-cell RNA sequencing显示文摘Systemic lupus erythematosus(SLE)is a systemic autoimmune disease characterized by abnormal cellular and humoral immune responses and excessive autoantibody production.The precise pathologic mechanism of SLE remains elusive.The advent of single-cell RNA sequencing(scRNA-seq)enables unbiased analysis of the molecular differences of cell populations at the single-cell level.We used scRNA-seq to profile the transcriptomes of peripheral blood mononuclear cells from an SLE patient compared with a healthy control(HC).A total of 16,021 cells were analyzed and partitioned into 12 distinct clusters.The marker genes of each cluster and the four major immune cell types(B cells,CD4+T cells,CD8+T cells,myeloid cells,and NK cells)were determined.Moreover,several genes involved in antigen processing and presentation through MHCII were highly enriched.GO enrichment analyses revealed abnormal gene expression patterns and signaling pathways in SLE.Of note,pseudotime analysis revealed that there was a different lineage hierarchy in the peripheral blood mononuclear cells(PBMCs)of the SLE patient,indicating that the cell states were substantially altered under disease conditions.Our analysis provides a comprehensive map of the cell types and states of the PBMCs of SLE patients at the single-cell level for a better understanding of the pathogenesis,diagnosis,and treatment of SLE. | XIANLIANG HOU DONGE TANG FENGPING ZHENG MINGLIN OU YONG XU HUIXUAN XU XIAOPING HONG XINZHOU ZHANG WEIER DAI DONGZHOU LIU YONG DAI | 2020 | BIOCELL2020，44，4： | 0 |
| 14 | Thermal Equation of State of Natural F-Rich Topaz up to 29 GPa and 750 K显示文摘Subducting oceanic sediments and crusts,originating from the Earth's surface and descending into its deep interior,are important carriers of volatiles.The volatiles have significant effects on materials cycling and the dynamic evolution of the subduction zones.A simplified Al_(2)O_(3)-SiO_(2)-H_(2)O(ASH)ternary system models the relationship of minerals in the hydrated and alumina-silica rich sedimentary layer.Topaz Al_(2)SiO_(4)(F,OH)_(2)is an important mineral in the ASH system and comprises two volatiles:H_(2)O and fluorine(F).In this study,the thermoelasticity of a natural F-rich topaz was investigated using synchrotron-based single-crystal X-ray diffraction combined with diamond anvil cells up to 29.1 GPa and 750 K.The pressure-volume-temperature data were fitted to a third-order Birch-Murnaghan Equation of state with V_(0)=343.15(7)Å3,K_(0)=166(1)GPa,K_(0)'=3.0(1),(∂K_(0)/∂T)P=-0.015(9)GPa/K andα_(0)=3.9(5)×10^(-5)K^(-1).The isothermal bulk modulus increases with the F content in topaz,and the various F contents present significant effects on its anisotropic compressibility.Our results further reveal that the isothermal bulk modulus K_(0)of the minerals in ASH system increases with density.F and H contents in hydrous minerals might greatly affect their properties(e.g.,compressibility and stability),providing more comprehensive constraints on the subduction zones. | Yungui Liu Xiang Li Haipeng Song Jingui Xu Dongzhou Zhang Junfeng Zhang Xiang Wu | 2023 | Journal of Earth Science2023，34，3： | 0 |
| 15 | The effect of nitrogen on the compressibility and conductivity of iron at high pressure显示文摘Although nitrogen in the Earth’s interior has attracted significant attention recently,it remains the most enigmatic of the light elements in the Earth’s core.In this work,synchrotron X-ray diffraction(XRD)and electrical conductivity experiments were conducted on iron nitrides(Fe_(2)N and Fe_(4)N)in diamond anvil cells(DACs)up to about 70 GPa at ambient temperature.These results show that iron nitrides are stable up to at least 70 GPa.From the equation of state(EOS)parameters,iron nitrides are more compressible than iron carbides.Moreover,using the van der Pauw method and Wiedemann-Franz law,the electrical and thermal conductivity of samples were determined to be much lower than that of iron carbides.The conductivities of Fe_(2)N and Fe_(4)N were similar at 20–70 GPa,suggesting no evident effects by varying the N stoichiometries in iron nitrides.Iron nitrides are less dense and conductive but more compressible than carbides at 0–70 GPa.This study indicates that less nitrogen than carbon can explain geophysical phenomena in the deep Earth,such as the density deficit. | Yukai Zhuang Xiaowan Su Nilesh P.Salke Zhongxun Cui Qingyang Hu Dongzhou Zhang Jin Liu | 2021 | Geoscience Frontiers2021，12，2： | 0 |
| 16 | B1-cell-produced anti-phosphatidylserine antibodies contribute to lupus nephritis development via TLR-mediated Syk activation显示文摘Autoantibodies produced by B cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). However, both the cellular source of antiphospholipid antibodies and their contributions to the development of lupus nephritis (LN) remain largely unclear. Here, we report a pathogenic role of anti-phosphatidylserine (PS) autoantibodies in the development of LN. Elevated serum PS-specific IgG levels were measured in model mice and SLE patients, especially in those with LN. PS-specific IgG accumulation was found in the kidney biopsies of LN patients. Both transfer of SLE PS-specific IgG and PS immunization triggered lupus-like glomerular immune complex deposition in recipient mice. ELISPOT analysis identified B1a cells as the main cell type that secretes PS-specific IgG in both lupus model mice and patients. Adoptive transfer of PS-specific B1a cells accelerated the PS-specific autoimmune response and renal damage in recipient lupus model mice, whereas depletion of B1a cells attenuated lupus progression. In culture, PS-specific B1a cells were significantly expanded upon treatment with chromatin components, while blockade of TLR signal cascades by DNase I digestion and inhibitory ODN 2088 or R406 treatment profoundly abrogated chromatin-induced PS-specific IgG secretion by lupus B1a cells. Thus, our study has demonstrated that the anti-PS autoantibodies produced by B1 cells contribute to lupus nephritis development. Our findings that blockade of the TLR/Syk signaling cascade inhibits PS-specific B1-cell expansion provide new insights into lupus pathogenesis and may facilitate the development of novel therapeutic targets for the treatment of LN in SLE. | Kongyang Ma Wenhan Du Shiyun Wang Fan Xiao Jingyi Li Jie Tian Yida Xing Xiaodan Kong Ke Rui Rencai Qin Xiaoxia Zhu Jing Wang Cainan Luo Haijing Wu Yun Zhang Chengping Wen Lan He Dongzhou Liu Hejian Zou Qianjin Lu Lijun Wu Liwei Lu | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
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