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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | 择期脊柱手术术后输血相关感染并发症的风险显示文摘异体输血在脊柱手术中应用广泛,但存在许多潜在风险,如手术切口感染(surgical site infection,SSI)、免疫系统功能下降、费用增加等.尽管其负面影响已被逐渐认知,但对于脊柱手术患者所面临的与输血相关的风险,人们却知之甚少。 | Kato S Chikuda H Ohya J 胡玮 杨进城 | 2016 | 中国骨科临床与基础研究杂志2016，8，2： | 10 |
| 3 | Influence of non‐alcoholic fatty liver disease on the development of diabetes mellitus显示文摘 | Anuradhani Kasturiratne Sanjaya Weerasinghe Anuradha S Dassanayake Shaman Rajindrajith Arjuna P Silva Norihiro Kato A Rajitha Wickremasinghe H Janaka Silva | 2012 | J Gastroenterol Hepatol2012，，1： | 2 |
| 4 | Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology显示文摘 | Okamoto H Nishizawa T Kato N | | 0，，： | 2 |
| 5 | Molercular orbital theroy 显示文摘 | FUJUMOTO H KATO S YAMABE S | 1974 | J Chem Phy1974，60，： | 2 |
| 6 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | Protective effect of Irsogladine on monochloramineinduced gastric mucosallesions in rats:a comparative study with rebamipide显示文摘AIM To examine the effect of irsogladine, a novel antiulcer drug, on the mucosal ulcerogenic response to monochloramine (NH 2Cl) in rat stomach, in comparison with rebamipide, another antiulcer drug with cytoprotective activity. METHODS AND RESULTS Oral administration of NH 2Cl (120*!mM) produced severe hemorrhagic lesions in unanesthetized rat stomachs. Both irsogladine ( 1*!mg/*!kg - 10*!mg/*!kg , po ) and rebamipide ( 30*!mg/*!kg - 100*!mg/*!kg , po ) dose dependently prevented the development of these lesions in response to NH 2Cl, the effect of irsogladine was significant at 3*!mg/*!kg or greater, and that of rebamipide only at 100*!mg/*!kg . The protective effect of irsogladine on NH 2Cl induced gastric lesions was significantly reduced by N G nitro L arginine methyl ester (L NAME) but not by indomethacin, while that of rebamipide was significantly mitigated by indomethacin but not by L NAME. Topical application of NH 2Cl (20*!mM) caused a marked reduction of potential difference (PD) in ex vivo stomachs. This PD reduction was not affected by mucosal application of irsogladine, but significantly prevented by rebamipide. The mucosal exposure to NH 4OH (120*!mM) also caused a marked PD reduction in the ischemic stomach (bleeding from the carotid artery), resulting in gastric lesions. These ulcerogenic and PD responses caused by NH 4OH plus ischemia were also significantly mitigated by rebamipide, in an indomethacin sensitive manner, while irsogladine potently prevented such lesions without affecting the PD response, in a L NAME sensitive manner. CONCLUSION These results suggest that ① NH 2Cl generated either exogenously or endogenously damages the gastric mucosa, ② both irsogladine and rebamipide protect the stomach against injury caused by NH 2Cl, and ③ the mechanism underlying the protective action of irsogladine is partly mediated by endogenous nitric oxide, while that of rebamipide is in part mediated by endogenous prostaglandins. | H Yamamoto, M Umeda, H Mizoguchi, S Kato and K Takeuchi | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 8 | Cell cycle protein expression in proliferating microglia and astrocytes following transient global cerebral ischemia in the rat显示文摘 | Kato H Takahashi A Itoyama Y | 2003 | Brain Res Bul2003，60，： | 2 |
| 9 | Lack of effect of aciclovir on metabolism of theophylline and expression of hepatic cytochrome p450 1A2 in rats显示文摘 | Nadai, M Kato, M Yasui, K Kimura, M Zhao, YL Ueyama, J Tsunekawa, Y Yoshizumi, H Hasegawa, T | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 10 | A therapeutic strategy based on histological assessment of hyperpigmented skin lesions in Asians 显示文摘 | Kurita M Kato H Yoshimura K | 2008 | Plast Reconstr Aesthet Surg2008，19，： | 1 |
| 11 | Visible-Light-Induced H -2 Evolution from an Aqueous Solution Containing Sulfide and Sulfite over a ZnS- CuInS2 - AgInS2 Solid-Solution Photocatalyst 显示文摘 | Tsuji I Kato H Kudo A | 2005 | Angewandte Chemie-International Edition2005，44，23： | 1 |
| 12 | Helicobacter pylori infection in gastric remnant cancer after gastrectomy显示文摘 | Kato T Motoyama H | 2005 | Nippon Rinsbo2005，27，： | 1 |
| 13 | Effect of rootstock on the yield, mineral nutrition and hormone level in xylem sap in eggplant 显示文摘 | Kato T Lou H | 1989 | J Jpn Soc Hortic Sci1989，58，2： | 1 |
| 14 | Stress-strain behavior and shape memory effect in power metallurgy TiNi alloy 显示文摘 | Kato h Kokizane M Miura S | 1994 | Acta Metall Mater1994，42，4： | 1 |
| 15 | Caspases cleave the amino-terminal calpain inhibitory unit of calpastatin during apoptosis in human Jurkat T cells 显示文摘 | Nonaka T Maki M Kikuchi H Imajoh-Ohmi S | 2000 | J Biochem2000，127，2： | 1 |
| 16 | Effects of pretreatment with sublethal ischemia on the extracellular glutamate concentrations during secondary ischemia in the gerbil hippocampus evaluated with intracerebral microdialysis显示文摘 | Kato H Liu Y | 1992 | Neurosci Lett1992，138，： | 1 |
| 17 | Temporal profile of the effects of pretreatment with brief cerebral ischemia on the neuronal damage following secondary ischemic in-sult in the gerbil: cumulative damage and protective effects显示文摘 | Kato H Liu Y Araki T | 1991 | Brain R1991，553，： | 1 |
| 18 | Effect of soybean soluble polysaccharides on the stability of milk protein under acidic condition 显示文摘 | NAKAMURA A FURUTA H KATO M | 2003 | Food Hydrocollids2003，17，： | 1 |
| 19 | Photocatalytic O2 evolution under visible light irradiation on BiVO4 in aqueous AgNO3 solution 显示文摘 | Kudo A Ueda K Kato H Mikami I | 1998 | Catal Lett1998，，53： | 1 |
| 20 | Lateral vibration of a rotating shaft driven by a universal joint(1st report: Generation of even multiple vibrations by secondary moment) 显示文摘 | OTA H KATO M | 1984 | Bulletin of JSME1984，27，231： | 1 |
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