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| 1 | Curcumin suppresses gastric NF-κB activation and macromolecular leakage in Helicobacter pylori-infected rats显示文摘AIM:To investigate whether curcumin could attenuate nuclear factor(NF)-κB p65 expression and macromolecular leakage in the gastric mucosa of Helicobacter pylori(H.pylori)-infected rats.METHODS:Twenty-five male Sprague-Dawley rats were equally divided into five groups:control rats(Control),control rats supplemented with 600 mg/kg curcumin,H.pylori-infected rats(Hp),H.pylori-infected rats supplemented with 200 mg/kg curcumin(Hp + curIn H.pylori-infected groups,rats were inoculated with H.pylori suspension twice a day at an interval of 4 h for 3 d.Two weeks later,200 or 600 mg/kg curcumin was given once daily to curcuminsupplemented groups for 7 d.On the day of the experiment,macromolecular leakage in gastric mucosa was examined by intravital fluorescence microscopy.The stomach tissue was removed to examine NF-κB p65 expression in gastric epithelial cells by immunohistochemistry.RESULTS:The expression of NF-κB p65 in gastric epithelial cells and the macromolecular leakage from gastric mucosal microcirculation significantly increased in the Hp group compared with the Control group.The percentages of NF-κB p65 immunoreactive cells in Control and Hp groups were 10.72% ± 2.10% vs 16.02% ± 2.98%,P = 0.004,respectively.The percentages of macromolecular leakage in Control and Hp groups were 10.69% ± 1.43% vs 15.41% ± 2.83%,P = 0.001,respectively.Curcumin supplementation in Hp + cur-CONCLUSION:H.pylori-induced gastric inflammation in rats is associated with increased NF-κB activation and macromolecular leakage which can be reduced by curcumin supplementation. | Kawiya Sintara Duangporn Thong-Ngam Suthiluk Patumraj Naruemon Klaikeaw Tanittha Chatsuwan | 2010 | World Journal of Gastroenterology2010，16，32： | 28 |
| 2 | Effects of Aloe vera and sucralfate on gastric microcirculatory changes,cytokine levels and gastric ulcer healing in rats显示文摘瞄准:在胃的微循环变化, cytokine 层次并且胃溃疡愈合上比较芦荟 vera 和 sucralfate 的效果。方法:男 Spraque-Dawley 老鼠(n=48 ) 被划分成四个组。作为控制组,服务的 Group1 是组织 2 没有处理的胃溃疡组,与 sucralfate 和芦荟 vera 作为胃溃疡处理组组织 3 和 4。从每个组的老鼠为白血球坚持, TNF-alpha 和 IL-10 层次并且胃溃疡在天愈合的学习被划分成 2 亚群 1 和 8 在由 20% 乙酸的胃溃疡的正式就职以后。结果:在在胃溃疡的正式就职以后的白天 1 上,在帖子的白血球坚持(P<0.05 ) 当时,毛状的小静脉显著地在溃疡组被增加与控制组相比。TNF-alpha 的水平被提高, IL-10 的水平被减少。在与 sucralfate 和芦荟 vera 对待的溃疡组,白血球坚持在柱子被减少毛状的小静脉。IL-10 的水平被提高,但是 TNF-alpha 的水平没有有效差量。在白天 8 上,在毛状的小静脉和 TNF-alpha 的水平仍然是的柱子的白血球坚持增加了,没有处理, IL-10 的水平在溃疡组被减少。与 sucralfate 和芦荟 vera 对待的溃疡在毛状的小静脉和 TNF-alpha 铺平的柱子有更低的白血球坚持。没有处理, IL-10 的水平仍然与溃疡组相比被提高。而且,在 1 和 8 在胃溃疡的正式就职以后显示出的天的胃的组织病理学说的检查那胃的纸巾与发炎被损坏。在在天与 sucralfate 和芦荟 vera 对待的溃疡组 1 和 8,胃的发炎被减少的、上皮的房间增长被提高,胃腺变得伸长。没有处理,溃疡尺寸也与溃疡组相比被减少。结论:20% 乙酸罐头的管理导致胃的发炎,在毛状的小静脉和 TNF-alpha 铺平的柱子的增加白血球坚持和还原剂 IL-10 水平。芦荟 vera 处理能减少白血球坚持和 TNF-alpha 水平,提高 IL-10 水平并且支持胃溃疡愈合。 | Kallaya Eamlamnam Suthiluk Patumraj Naruemon Visedopas Duangporn Thong-Ngam | 2006 | World Journal of Gastroenterology2006，12，13： | 20 |
| 3 | Visceral fat and insulin resistance as predictors of non-alcoholic steatohepatitis显示文摘AIM: To examine whether visceral fat is associated with non-alcoholic steatohepatitis (NASH),to assess for parameters associated with visceral adiposity and to investigate for factors associated with fibrotic severity in NASH. METHODS: Thirty NASH and 30 control subjects underwent biochemical tests,anthropometric assessment,bioelectrical impedance,dual energy X-ray absorptiometry and abdominal fat study by CT scan. Liver biopsies were graded according to the Brunt criteria. RESULTS: NASH subjects had elevated blood pressure,body mass index,waist circumference and waist-to-hip ratio. A greater number of diabetes mellitus,impaired glucose tolerance test and HOMA-IR > 3.5 were found in NASH patients. HOMA-IR > 2.8 (OR 20.98,95% CI 3.22-136.62; P < 0.001) and visceral fat area > 158 cm2 (OR 18.55,95% CI 1.60-214.67; P = 0.019) were independent predictors for NASH. Advanced stage of NASH was found in 15 (50%) patients. HOMA-IR > 3.5 (OR 23.12,95% CI 2.00-266.23; P = 0.012) and grading of portal inflammation (OR 7.15,95% CI 1.63-31.20; P = 0.009) were determined as independent risk factors for advanced stage of NASH. CONCLUSION: Obesity (especially central obesity) and metabolic syndrome are common in Thai NASH. Insulin resistance and elevated visceral fat are risk factors for the presence of NASH. The advanced stage of thedisease is related to insulin resistance. | Abhasnee Sobhonslidsuk Sutipong Jongjirasiri Ammarin Thakkinstian Naruemon Wisedopas Pongamorn Bunnag Gobchai Puavilai | 2007 | World Journal of Gastroenterology2007，13，26： | 17 |
| 4 | Non-sequential narrow band imaging for targeted biopsy and monitoring of gastric intestinal metaplasia显示文摘AIM: To evaluate the efficacy of non-sequential narrow band imaging (NBI) for a better recognition of gastric intestinal metaplasia (GIM). METHODS: Previously diagnosed GIM patients underwent targeted biopsy from areas with and without GIM, as indicated by NBI, twice at an interval of 1 year. The authors compared the endoscopic criteria such as light blue crest (LBC), villous pattern (VP), and large long crest (LLC) with standard histology. The results from two surveillance endoscopies were compared with histology results for sensitivity, specif icity, positive predic-tive value (PPV), negative predictive value (NPV), and likelihood ratio of positive test (LR+). The number of early gastric cancer cases detected was also reported. RESULTS: NBI targeted biopsy was performed in 38 and 26 patients during the first and second surveillance endoscopies, respectively. There were 2 early gastric cancers detected in the first endoscopy. No cancer was detected from the second study. Surgical and endoscopic resections were successfully performed in each patient. Sensitivity, specifi city, PPV, NPV, and LR+ of all 3 endoscopic criteria during the first/second surveillances were 78.8%/91.3%, 82.5%/89.1%, 72.8%/77.8%, 86.8%/96.1, and 4.51/8.4, respectively. LBC provided the highest LR+ over VP and LLC. CONCLUSION: Non-sequential NBI is useful for GIM targeted biopsy. LBC provides the most sensitive reading. However, the optimal duration between two surveillances requires further study. | Rungsun Rerknimitr Boonlert Imraporn Naruemon Klaikeaw Wiriyaporn Ridtitid Sukprasert Jutaghokiat Yuwadee Ponauthai Pradermchai Kongkam Pinit Kullavanijaya | 2011 | World Journal of Gastroenterology2011，17，10： | 7 |
| 5 | Lactobacillus plantarum B7 inhibits Helicobacter pylori growth and attenuates gastric inflammation显示文摘AIM:To determine the anti-Helicobacter property of Lactobacillus plantarum B7(L.plantarum)B7 supernatants in vitro and the protective effects of L.plantarum B7 on serum tumor necrosis factor-alpha(TNF-?),gastric malondialdehyde(MDA)level,apoptosis,and histopathology in Helicobacter pylori(H.pylori)-induced gastric inflammation in rats. METHODS:In vitro,the inhibition of H.pylori growth was examined using L.plantarum B7 supernatants at pH 4 and pH 7 and at the concentration of 1×,5×and 10×on plates inoculated with H.pylori.The inhibitory effect of H.pylori was interpreted by the size of the inhibition zone.In vitro,male Sprague-Dawley rats were randomly divided into four groups including group 1(control group),group 2(H.pylori infected group), group 3(H.pylori infected with L.plantarum B7 106 CFUs/mL treated group)and group 4(H.pylori infected with L.plantarum B7 1010 CFUs/mL treated group).One week after H.pylori inoculation,L.plantarum B7 106 CFUs/mL or 10 10 CFUs/mL were fed once daily to group 3 and group 4,respectively,for one week.Blood and gastric samples were collected at the end of the study. RESULTS:In vitro,at intact pH 4,mean inhibitory zone diameters of 8.5 mm and 13 mm were noted at concentrations of 5×and 10×of L.plantarum B7 supernatant disks,respectively.At adjusted pH 7, L.plantarum B7 supernatants at concentrations of 5 ×and 10×yielded mean inhibitory zone diameters of 6.5 mm and 11 mm,respectively.In the in vitro study, in group 2,stomach histopathology revealed mild to moderate H.pylori colonization and inflammation.The level of gastric MDA and epithelial cell apoptosis were significantly increased compared with group 1.The serum TNF-??level was significant decreased in group 3 compared with group 2(P<0.05).In addition,L.plantarum B7 treatments resulted in a significant improvement in stomach pathology,and decreased gastric MDA level and apoptotic epithelial cells. CONCLUSION:L.plantarum B7 supernatant inhibits H.pylori growth.This inhibition was dose-dependent and greater at pH 4.Moreover,L.plantarum B7 attenuated H.pylori-induced gastric inflammation. | Chompoonut Sunanliganon Duangporn Thong-Ngam Somying Tumwasorn Naruemon Klaikeaw | 2012 | World Journal of Gastroenterology2012，18，20： | 6 |
| 6 | Forward-viewing radial-array echoendoscope for staging of colon cancer beyond the rectum显示文摘AIM:To evaluate feasibility of the novel forward-viewing radial-array echoendoscope for staging of colon cancer beyond rectum as the first series.METHODS:A retrospective study with prospectively entered database.From March 2012 to February 2013,a total of 21 patients(11 men)(mean age 64.2 years)with colon cancer beyond the rectum were recruited.The novel forward-viewing radial-array echoendoscope was used for ultrasonographic staging of colon cancer beyond rectum.Ultrasonographic T and N staging were recorded when surgical pathology was used as a gold standard.RESULTS:The mean time to reach the lesion and the mean time to complete the procedure were 3.5 and 7.1min,respectively.The echoendoscope passed through the lesions in 13 patients(61.9%)and reached the cecum in 10 of 13 patients(76.9%).No adverse events were found.The lesions were located in the cecum(n=2),ascending colon(n=1),transverse colon(n=2),descending colon(n=2),and sigmoid colon(n=14).The accuracy rate for T1(n=3),T2(n=4),T3(n=13)and T4(n=1)were 100%,60.0%,84.6%and 100%,respectively.The overall accuracy rates for the T and N staging of colon cancer were 81.0%and52.4%,respectively.The accuracy rates among traversable lesions(n=13)and obstructive lesions(n=8)were 61.5%and 100%,respectively.endoscopic ultrasound and computed tomography had overall accuracy rates of 81.0%and 68.4%,respectively.CONCLUSION:The echoendoscope is a feasible staging tool for colon cancer beyond rectum.However,accuracy of the echoendoscope needs to be verified by larger systematic studies. | Pradermchai Kongkam Sittikorn Linlawan Satimai Aniwan Narisorn Lakananurak Suparat Khemnark Chucheep Sahakitrungruang Jirawat Pattanaarun Supakij Khomvilai Naruemon Wisedopas Wiriyaporn Ridtitid Manoop S Bhutani Pinit Kullavanijaya Rungsun Rerknimitr | 2014 | World Journal of Gastroenterology2014，20，10： | 5 |
| 7 | Unusual manifestations of gastric inflammatory fibroid polyp in a child显示文摘AIM:Inflammatory fibroid polyp (IFP) is a rare benign lesion that may occur throughout the digestive tract. IFP is more commonly found in the antrum of the stomach in particular.It mostly affects adults at the average age of 60 years. These polyps are able to cause abdominal pain, gastrointestinal bleeding, intestinal obstruction or intussusception. In bhis paper we report a case of gastric IFP with unusual presenting features. | Voranush Chongsrisawat Phisek Yimyeam Naruemon Wisedopas Dusit Viravaidya Yong Poovorawan | 2004 | World Journal of Gastroenterology2004，10，3： | 3 |
| 8 | Curcumin attenuated paracetamol overdose induced hepatitis显示文摘AIM: To investigate whether curcumin could attenuate hepatitis in mice with paracetamol overdose. METHODS: Male mice were divided into four groups. Group 1 (control, n = 8); was fed with distilled water; Group 2 [N-acetyl-P-aminophenol (APAP), n = 8]; was fed with a single dose of 400 mg/kg APAP dissolved in distilled water; Group 3 [APAP + curcumin (CUR) 200, n = 8], was fed with a single dose of 400 mg/kg APAP and 200 mg/kg CUR; Group 4 (APAP + CUR 600, n = 8), was fed with a single dose of 400 mg/kg APAP and 600 mg/ kg CUR. Twenty-four hours later, the liver was removed to examine hepatic glutathione (GSH), hepatic malondialdehyde (MDA), and histopathologically. Then whole blood was withdrawn from heart to determine transaminase (serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase) and inflammatory cytokines [interleukin (IL)-12 and IL-18] levels by enzyme linked immunosorbent assay.RESULTS: Serum transaminase, hepatic MDA, and inflammatory cytokines increased significantly in the APAP compared with the control group. Curcumin supplementation in APAP + CUR 200 and APAP + CUR 600 groups significantly decreased these parameters compared with the APAP group. The level of GSH decreased significantly in the APAP compared with the control group. Curcumin supplementation in APAP + CUR 200 and APAP + CUR 600 groups significantly increased these parameters compared with the APAP group. The histological appearance of the liver in the control group showed normal. In the APAP-treated group, the liver showed extensive hemorrhagic hepatic necrosis at all zones. Curcumin supplementation in APAP + CUR 200 and APAP + CUR 600 groups, caused the liver histopathology to improve. In the APAP + CUR 200 group, the liver showed focal necrosis and but the normal architecture was well preserved in APAP + CUR 600 group. CONCLUSION: APAP overdose can cause liver injury. Results indicate that curcumin prevents APAP-induced hepatitis through the improvement of liver histopathology by decreased oxidative stress, reduced liver inflammation, and restoration of GSH. | Kanjana Somanawat Duangporn Thong-Ngam Naruemon Klaikeaw | 2013 | World Journal of Gastroenterology2013，19，12： | 3 |
| 9 | Curcumin prevents indomethacin-induced gastropathy in rats显示文摘AIM:To investigate the effects of curcumin on gastric microcirculation and inflammation in rats with indomethacin-induced gastric damage.METHODS:Male Sprague-Dawley rats were randomly divided into three groups.Group 1(control group,n =5)was fed with olive oil and 5%NaHCO3-(vehicle).Group 2[indomethacin(IMN)group,n=5]was fed with olive oil 30 min prior to indomethacin 150 mg/kg body weight(BW)dissolved in 5%NaHCO3-at time 0th and 4th h.Group 3(IMN+Cur group,n=4)was fed with curcumin 200 mg/kg BW dissolved in olive oil 0.5 mL,30 min prior to indomethacin at 0th and 4th h.Leukocyte-endothelium interactions at postcapillary venules were recorded after acridine orange injection.Blood samples were determined for intercellular adhesion molecule(ICAM)-1 and tumor necrosis factor(TNF)-αlevels using enzyme linked immunosorbent assay method.Finally,the stomach was removed for histopathological examination for gastric lesions and grading for neutrophil infiltration.RESULTS:In group 2,the leukocyte adherence in postcapillary venules was significantly increased compared to the control group(6.40±2.30 cells/frame vs 1.20±0.83 cells/frame,P=0.001).Pretreatment with curcumin caused leukocyte adherence to postcapillary venule to decline(3.00±0.81 cells/frame vs 6.40 ±2.30 cells/frame,P=0.027).The levels of ICAM-1 and TNF-αincreased significantly in the indomethacintreated group compared with the control group(1106.50 ±504.22 pg/mL vs 336.93±224.82 pg/mL,P=0.011 and 230.92±114.47 pg/mL vs 47.13±65.59 pg/mL,P =0.009 respectively).Pretreatment with curcumin significantly decreased the elevation of ICAM-1 and TNF-α levels compared to treatment with indomethacin alone(413.66±147.74 pg/mL vs 1106.50±504.22 pg/mL,P =0.019 and 58.27±67.74 pg/mL vs 230.92±114.47 pg/mL,P=0.013 respectively).The histological appearance of the stomach in the control group was normal.In the indomethacin-treated group,the stomachs showed a mild to moderate neutrophil infiltration score.Gastric lesions were erosive and ulcerative.In rats treated with indomethacin and curcumin,stomach histopathology improved and showed only a mild neutrophil infiltration score and fewer erosive lesions in the gastric mucosa.CONCLUSION:The results indicate that curcumin prevents indomethacin-induced gastropathy through the improvement of gastric microcirculation by attenuating the level of ICAM-1 and TNF-α. | Duangporn Thong-Ngam Sakonwan Choochuai Suthiluk Patumraj Maneerat Chayanupatkul Naruemon Klaikeaw | 2012 | World Journal of Gastroenterology2012，18，13： | 3 |
| 10 | One stop shop IV: taxonomic update with molecular phylogeny for important phytopathogenic genera: 76-100 (2020)显示文摘This is a continuation of a series focused on providing a stable platform for the taxonomy of phytopathogenic fungi and fungus-like organisms.This paper focuses on one family:Erysiphaceae and 24 phytopathogenic genera:Armillaria,Barrio-psis,Cercospora,Cladosporium,Clinoconidium,Colletotrichum,Cylindrocladiella,Dothidotthia,,Fomitopsis,Ganoderma,Golovinomyces,Heterobasidium,Meliola,Mucor,Neoerysiphe,Nothophoma,Phellinus,Phytophthora,Pseudoseptoria,Pythium,Rhizopus,Stemphylium,Thyrostroma and Wojnowiciella.Each genus is provided with a taxonomic background,distribution,hosts,disease symptoms,and updated backbone trees.Species confirmed with pathogenicity studies are denoted when data are available.Six of the genera are updated from previous entries as many new species have been described. | Ruvishika S.Jayawardena Kevin D.Hyde Yi Jyun Chen Viktor Papp Balázs Palla Dávid Papp Chitrabhanu S.Bhunjun Vedprakash G.Hurdeal Chanokned Senwanna Ishara S.Manawasinghe Dulanjalee L.Harischandra Ajay Kumar Gautam Shubhi Avasthi Boontiya Chuankid Ishani D.Goonasekara Sinang Hongsanan XiangYu Zeng Kapila K.Liyanage NingGuo Liu Anuruddha Karunarathna Kalani K.Hapuarachchi Thatsanee Luangharn Olivier Raspé Rashika Brahmanage Mingkwan Doilom Hyang B.Lee Liu Mei Rajesh Jeewon Naruemon Huanraluek Napalai Chaiwan Marc Stadler Yong Wang | 2020 | Fungal Diversity2020，，4： | 2 |
| 11 | N-acetylcysteine attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis显示文摘AIM: To evaluate attenuating properties of N-acetylcysteine (NAC) on oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis (NASH). METHODS: Male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control, n = 8) was free accessed to regular dry rat chow (RC) for 6 wk. Group 2 (NASH, n = 8) was fed with 100% fat diet for 6 wk. Group 3 (NASH + NAC20, n = 9) was fed with 100% fat diet plus 20 mg/kg per day of NAC orally for 6 wk. All rats were sacrificed to collect blood and liver samples at the end of the study. RESULTS: The levels of total glutathione (GSH) and hepatic malondialdehyde (MDA) were increased significantly in the NASH group as compared with the control group (GSH; 2066.7 ± 93.2 vs 1337.5 ± 31.5 μmol/L and MDA; 209.9± 43.9 vs 3.8 ±1.7 μmol/g protein, respectively, P < 0.05). Liver histopathology from group 2 showed moderate to severe macrovesicular steatosis, hepatocyte ballooning, and necroinflammation. NAC treatment improved the level of GSH (1394.8 ± 81.2 μmol/L, P < 0.05), it did not affect MDA (150.1 ± 27.0 μmol/g protein), but led to a decrease in fat deposition and necroinflammation. CONCLUSION: NAC treatment could attenuate oxidative stress and improve liver histology in rats with NASH. | Duangporn Thong-Ngam Suchittra Samuhasaneeto Onanong Kulaputana Naruemon Klaikeaw | 2007 | World Journal of Gastroenterology2007，13，38： | 2 |
| 12 | Fault-toler-ant embedded system design and optimization considering reliability estimation uncertainty显示文摘 | Wattanapongskorn Naruemon Coit D W | 2007 | Reliability Engineering and System Safety2007，92，4： | 1 |
| 13 | Effect of gamma - irradiation frozen shrimps for decontamination of pathogenic bacteria 显示文摘 | Hitoshi Ito Harun Or Rashid Naruemon Sangthong Takasaki | 2002 | Radiation Chemistry Research Establelishment2002，28，8： | 1 |
| 14 | Circulating Cytokines and Histological Liver Damage in Chronic Hepatitis B Infection显示文摘 | Kittiyod Poovorawan Pisit Tangkijvanich Chintana Chirathaworn Naruemon Wisedopas Sombat Treeprasertsuk Piyawat Komolmit Yong Poovorawan Piero Luigi Almasio | 2013 | Hepatitis Research and Treatment2013，，： | 1 |
| 15 | Practical real-time intrusion detection using machine learning approaches 显示文摘 | Phurivit Sangkatsanee Naruemon Wattanapongsakom Chalermpol Charnsripinyo | 2011 | Computer Communications2011，34，18： | 1 |
| 16 | The effect of boroniz- ing on metallic for automotive applications 显示文摘 | Roumiana S Petrova Naruemon | 2008 | Journal of Ma- terials Engineering and Performance2008，17，3： | 1 |
| 17 | Aloe vera attenuated gastric injury on indomethacin-induced gastropathy in rats显示文摘AIM:To evaluate the protective effects of Aloe vera on gastric injury in rats with indomethacin(IMN)-induced gastropathy.METHODS:Male Sprague-Dawley rats were randomly divided into three groups.Group 1(control,n=6)was given distilled water(DW)orally.Group 2(IMN,n=6)was given oral IMN(150 mg/kg)dissolved in5%sodium bicarbonate(Na HCO3-)at time 0 and 4 h.Group 3(Aloe vera-treated,n=6)was given oral Aloevera(150 mg/kg)dissolved in DW and IMN at time 0and 4 h.Eight hours later,the stomach was removed to determine gastric malondialdehyde(MDA),the number of interleukin(IL)-18 positive stained cells(%)by immunohistochemistry,and for histopathological examination.Then,the serum was collected to determine tumor necrosis factor(TNF)-αand cytokineinduced neutrophil chemoattractant(CINC)-1 by sandwich enzyme linked immunosorbent assay method.RESULTS:In the IMN group,serum TNF-α,CINC-1and gastric MDA were significantly increased when compared to the control group(27.78±1.52 pg/m L vs 85.07±49.11 pg/m L,P=0.009;104.55±45.80pg/m L vs 1054.70±20.38 pg/m L,and 1.74±0.21nmol/mg vs 9.36±1.07 nmol/mg protein,P=0.000,respectively).The mean level of TNF-α,CINC-1 and gastric MDA in the Aloe vera-treated group were improved as compared with the IMN group(85.07±49.11 pg/m L vs 35.19±1.61 pg/m L,P=0.021;1054.70±20.38 pg/m L vs 813.56±239.04 pg/m L,P=0.025;and 9.36±1.07 nmol/mg vs 2.67±0.64 nmol/mg protein,P=0.000,respectively).The number of IL-18 positive stained cells(%)in the gastric epithelial cells of the IMN group was significantly higher than the control group(5.01%±3.73%vs 30.67%±2.03%,P=0.000,respectively).In contrast,Aloe vera treatment decreased the number of IL-18 positive stained cells(%)significantly when compared with the IMN group(30.67%±2.03%vs 13.21%±1.10%,P=0.000,respectively).Most rats in the IMN group developed moderate to severe gastric inflammation and erosions.The gastric erosions and neutrophil infiltration scores were significantly reduced in the Aloe veratreated group.CONCLUSION:Aloe vera attenuated IMN-induced gastropathy in rats by the reduction of oxidative stress,inflammation,and improvement of gastrichistopathology. | Duangporn Werawatganon Narisorn Rakananurak Sasipim Sallapant Piyapan Prueksapanich Kanjana Somanawat Naruemon Klaikeaw Rungsun Rerknimitr | 2014 | World Journal of Gastroenterology2014，20，48： | 1 |
| 18 | Anti-inflammatory effects of Aloe vera on leukocyte–endothelium interaction in the gastric microcirculation of Helicobacter pylori-infected rats显示文摘 | Ratsamee Prabjone Duangporn Thong-Ngam Naruemon Wisedopas Thanitta Chatsuwan Suthiluk Patumraj | 2006 | Clinical Hemorheology and Microcirculation2006，，3： | 1 |
| 19 | The effect of boronizing on metallic alloys for automotive applications 显示文摘 | Roumiana S Petrova Naruemon Suwattananont Veljko Samardzic | 2008 | Journal of Materials Engineering and Performance2008，17，3： | 1 |
| 20 | Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis显示文摘BACKGROUND Aloe vera exerts several biological activities,such as,anti-inflammatory,antioxidant,and antimicrobial effects.It was recently shown to reduce insulin resistance and triglyceride level.We hypothesized that aloe vera would have beneficial effects in alleviating non-alcoholic steatohepatitis(NASH)in rats.AIM To examine the therapeutic effects of aloe vera in NASH rats.METHODS All rats were randomly divided into 3 groups(n=6 in each group).Rats in the control group were fed ad libitum with a standard diet for 8 wk.Rats in the NASH group were fed ad libitum with a high-fat high-fructose diet(HFHFD)for 8 wk.Rats in the aloe vera group were fed ad libitum with a HFHFD and aloe vera in dimethylsulfoxide(50 mg/kg)by gavage daily for 8 wk.Liver samples were collected at the end of the treatment period.RESULTS Hepatic malondialdehyde(MDA)levels increased significantly in the NASH group as compared with the control group(377±77 nmol/mg vs 129±51 nmol/mg protein,respectively,P<0.001).Glutathione(GSH)levels were significantly lower in the NASH group than the control group(9±2 nmol/mg vs 24±8 nmol/mg protein,respectively,P=0.001).The expression of interleukin-18 (IL-18), nuclear factor-kappa β, and caspase-3 increased, while peroxisomeproliferator-activated receptor gamma decreased in the NASH group comparedwith the controls. Following aloe vera administration, MDA levels decreased (199± 35 nmol/mg protein) and GSH increased (18 ± 4 nmol/mg protein) markedly.Steatosis, hepatocyte ballooning, lobular inflammation and increased hepatocyteapoptosis were observed in the NASH group. Aloe vera treatment attenuatedthese changes in liver histology.CONCLUSIONAloe vera attenuated oxidative stress, hepatic inflammation and hepatocyteapoptosis, thus improving liver pathology in rats with NASH. | Naruemon Klaikeaw Jutamas Wongphoom Duangporn Werawatganon Maneerat Chayanupatkul Prasong Siriviriyakul | 2020 | World Journal of Hepatology2020，12，7： | 1 |
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