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| 1 | Second harmonic generation in a high-Q lithium niobate microresonator fabricated by femtosecond laser micromachining显示文摘We report on second harmonic generation(SHG) in on-chip high-Q(>105) lithium niobate(Li Nb O3, LN) microresonators fabricated by femtosecond laser micromachining. We examine the efficiency of SHG with either a continuous-wave(CW) or an ultrashort pulsed pump laser. The normalized conversion efficiencies of SHG obtained with the CW and pulsed pump lasers are measured to be 1.35×10?5 m W?1 and 2.30×10?6 m W?1, respectively. | LIN JinTian XU YingXin FANG ZhiWei WANG Min WANG NengWen QIAO LingLing FANG Wei CHENG Ya | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，11： | 25 |
| 2 | Effects of elevated CO_2 on the nutrient compositions and enzymes activities of Nilaparvata lugens nymphs fed on rice plants显示文摘Elevated CO 2 may reduce the tolerance of Nilaparvata lugen (N. lugens) to adverse environmental factors through the biological and physiological degeneration of N. lugens. In an artificial climate box, under 375 and 750 μL L 1 CO 2 levels, the rice stems nutrient content, the nutrient content and enzyme activities of N. lugens nymph fed on rice seedlings exposed to ambient and elevated CO 2 were studied. The results showed that rice stems had significantly higher protein and total amino acid levels under ambient than elevated CO 2 levels. Nymphs had significantly higher protein levels in the ambient CO 2 treatment, while their glucose levels were significantly lower under ambient CO 2 conditions. Significantly higher trypsin activity was observed in nymphs grown in elevated CO 2 . Significantly lower activities of the protective enzymes total superoxide dismutase and catalase were observed in the nymphs under ambient CO 2 . Meanwhile, the activity of the detoxification enzyme glutathione S-transferase was significantly higher in the ambient CO 2 treatment. Measuring how energy and resources were allocated to enzymes in N. lugens nymphs under elevated CO 2 conditions can provide a more meaningful evaluation of their metabolic tolerances to adverse climatic conditions. | ZENG YunYun HUANG WenKun SU Li WU Gang ZHUANG Jing ZHAO WanYun HUA HongXia LI JunSheng XIAO NengWen XIONG-YanFei | 2012 | Science China(Life Sciences)2012，55，10： | 7 |
| 3 | CD70-targeting CAR-T cells have potential activity against CD19-negative B-cell Lymphoma显示文摘To the Editor:CD19-targeting chimeric antigen receptor T(CAR-T)cell therapy is a revolutionary immunotherapy in treating relapsed or refractory B lineage malignancies.However,relapse with CD19-negative tumor after treatment with anti-CD19 CAR-T cells has been reported in different types of B-cell lymphoid malignancies,with a percentage exceeding 10% in patients with acute lymphoblastic leukemia[1]and up to 38% in patients with non-Hodgkin lymphoma(NHL)[2]. | Wenhai Deng Panpan Chen Wen Lei Yang Xu Nengwen Xu Jeffrey J.Pu Aibin Liang Wenbin Qian | 2021 | Cancer Communications2021，41，9： | 4 |
| 4 | A novel hyperbranched aromatic polyamide containing bithiazole: Synthesis,metal complexation and magnetic properties显示文摘Based on the polycondensation of bifunctional 2,2′-diamino-4,4′-bithiazole(DABT) and trifunctional 1,3,5-benzenetricarbonyl trichloride (BTC),a novel hyperbranched aromatic polyamide PBD was synthesized with excellent solubility and good thermal stability.The structure of the polymer was confirmed by FT-IR and 1H NMR spectrum.The calculated degree of branching of our product was 52%.By exploring the influence of several different solvent systems,the yield of the polymer increased in the solvent system of DMAc/LiCl.Two kinds of metal complexes were obtained by chelation of the polyamide with Cu2+ and Ni2+,and the metal contents of the complexes were determined by complexometric titration.The magnetic behaviors of the complexes were examined as a function of magnetic field strength at 5 K,and as a function of temperature (5–300 K) at a magnetic field strength of 2.4 × 106 A/m.The results indicated that the complexes were soft ferromagnetic materials with Curie-Weiss temperature at 102 K and 53 K,respectively. | DING NengWen LIN WeiHong SUN WeiLin SHEN ZhiQuan | 2011 | Science China Chemistry2011，54，2： | 3 |
| 5 | A New Brown Frog of the Genus Rana(Anura,Ranidae)from North China,with a Taxonomic Revision of the R.chensinensis Species Group显示文摘The Rana chensinensis species group is widely distributed throughout North China.However,its taxonomy and composition remain controversial.In recent field investigations of the Taihang Mountains,a series of Rana specimens were collected,which were once identified as R.chensinensis.However,these samples showed significant differences from R.chensinensis of the type locality(Shaanxi Province in the Qinling Mountains)in both morphology and genetics.In this paper,based on analyses of seventeen geographic populations from the Taihang and Qinling Mountains,we describe a new species(namely R.taihangensis sp.nov.)in the R.chensinensis species group.A phylogenetic analysis of the R.chensinensis species group based on mitochondrial genes—COI,16S rRNA and Cytb—revealed the monophyly of the cryptic species,which formed the sister taxon to R.kukunoris.Morphological comparisons indicated that the cryptic species can be distinguished from its congeners by a combination of characteristics.Additionally,the distribution patterns of the Rana species in North China were clarified.The populations of the southwestern Taihang Mountains,Xiaoqinling Mountains,and Funiu Mountains in Henan Province remain R.chensinensis,whereas the populations recorded as R.chensinensis in Beijing City,Hebei Province,and the southeastern Taihang Mountains of Henan Province should be revised as R.taihangensis sp.nov. | Huijun SHEN Mengyu XU Xinyue YANG Zhuo CHEN Nengwen XIAO Xiaohong CHEN | 2022 | Asian Herpetological Research2022，13，3： | 2 |
| 6 | Mothematical modeling of decarburisation and degassing during vacuum circulation refining process of molten steel Research显示文摘 | Wei Jihe Yu Nengwen | 2002 | 73 (4) : 135-1422002，73，4： | 1 |
| 7 | Mathenaatical modelind of decarburisation and degassing during bacuum circulaion refining process of molten steel:Application of the model and results 显示文摘 | Wei Jihe Yu Nengwen | 2002 | Steel Research2002，73，4： | 1 |
| 8 | Great blue-shift of luminescence of ZnO nanoparticle array con- structed from ZnO quantum dots 显示文摘 | WANG Nengwen YANG Yuhua YANG Guowei | 2011 | Nanoscale Research Letters2011，6，： | 1 |
| 9 | Continuous running stitch with one polypropylene monofilament suture-a novel safe technique for pancreaticojejunostomy显示文摘 | Mai G Chen YH Nengwen KE | 2013 | Pancreatology2013，13，： | 1 |
| 10 | Continuous versus interrupted suture techniques of pancreaticojejunostomy after pancreaticoduodenectomy显示文摘 | Yonghua Chen Nengwen Ke Chunlu Tan Hao Zhang Xing Wang Gang Mai Xubao Liu | 2014 | Journal of Surgical Research2014，，： | 1 |
| 11 | The Role of Organ Failure and Infection in Necrotizing Pancreatitis: A Prospective Study显示文摘 | Qiang Guo Ang Li Qing Xia Xubao Liu Bole Tian Gang Mai Zongwen Huang Guangyuan Chen Wenfu Tang Xiaodong Jin Weixia Chen Huimin Lu Nengwen KE Zhaoda Zhang Weiming HU | 2014 | Annals of Surgery2014，，6： | 1 |
| 12 | Effects of elevated CO2 and transgenic Bt rice on yeast-like en- dosymbiote and its host brown planthopper 显示文摘 | CHEN Xiaona WEI Hui XIAO Nengwen | 2011 | JAppl Entomol2011，135，5： | 1 |
| 13 | Improving the filtration performance of ZrO2 membrane in non-polar organic solvents by surface hydrophobic modification 显示文摘 | Gao Nengwen Li Mei Jing Wenheng | 2011 | J Membr Sci2011，375，12： | 1 |
| 14 | Two types of cinnamoyl-Co A reductase function divergently in accumulation of lignins,flavonoids and glucosinolates and enhance lodging resistance in Brassica napus显示文摘Brassica crops,which are of worldwide importance,provide various oil,vegetable and ornamental products,as well as feedstocks for animal husbandry and biofuel industry.Cinnamoyl-Co A reductase(CCR)is the entry point to the lignin pathway and a crucial locus in manipulation of associated traits,but CCRassociated metabolism and traits in Brassica crops have remained largely unstudied except in Arabidopsis thaliana.We report the identification of 16 CCR genes from Brassica napus and its parental species B.rapa and B.oleracea.The Bn CCR1 and Bn CCR2 subfamilies displayed divergent organ-specificity and participation in the yellow-seed trait.Their functions were dissected via overexpression of representative paralogs in B.napus.Bn CCR1 was expressed preferentially in G-and H-lignin biosynthesis and vascular development,while Bn CCR2 was expressed in S-lignin biosynthesis and interfascicular fiber development.Bn CCR1 showed stronger effects on lignification-related development,lodging resistance,phenylpropanoid flux control,and seed coat pigmentation,whereas Bn CCR2 showed a stronger effect on sinapate biosynthesis.Bn CCR1 upregulation delayed bolting and flowering time,while Bn CCR2 upregulation weakened the leaf vascular system in consequence of suppressed G-lignin accumulation.Bn CCR1 and Bn CCR2 were closely but almost oppositely linked with glucosinolate metabolism via inter-pathway crosstalk.We conclude that Bn CCR1 and Bn CCR2 subfamilies offer great but differing potential for manipulating traits associated with phenylpropanoids and glucosinolates.This study reveals the CCR1–CCR2 divergence in Brassicaceae and offers a resource for rapeseed breeding for lodging resistance,yellowseed traits,and glucosinolate traits. | Nengwen Yin Bo Li Xue Liu Ying Liang Jianping Lian Yufei Xue Cunmin Qu Kun Lu Lijuan Wei Rui Wang Jiana Li Yourong Chai | 2022 | The Crop Journal2022，10，3： | 1 |
| 15 | A novel secure communication scheme in vehicular ad hoc networks显示文摘 | Wang Nengwen Huang Yuemin Chen Weiming | 2008 | Computer Communications2008，，1： | 1 |
| 16 | B7-1 induces immunosuppression when expressed in cultured neonatal mice keratinocytes显示文摘 | Nengwen K Li F Li X | 2009 | Immunobiology2009，214，8： | 1 |
| 17 | Effects of elevated CO2 and transgenic Bt rice on yeast-like endosymbiote and its host brown planthopper 显示文摘 | CHEN Xiaona WEI Hui XIAO Nengwen | | J Appl Entomol0，135，5： | 1 |
| 18 | 温带草原生态系统土壤原核生物特征对自然水分梯度的响应显示文摘土壤水分是影响生态系统功能的重要因素,其不仅可以维持微生物的活性,还可以通过改变植被多样性,控制土壤养分的扩散和运输,最终改变微生物群落。为探索土壤含水量对土壤原核生物群落的影响,本研究在中国内蒙古呼伦湖南岸的草原生态系统中建立了一个覆盖自然土壤水分梯度的研究区域,并将其细分为高含水量(4.80%±1.18%)、中含水量(2.17%±0.09%)和低含水量(1.85%±0.14%)三个梯度。环境因子是通过实地调查和实验室分析获得的。土壤原核生物是通过高通量测序技术测定的。植被特征和土壤理化性质对原核生物丰富度多样性有显著影响,其中土壤含水量是最重要的影响因素。在中含水量梯度中,差异原核生物的数量最少,且门水平原核微生物的多样性和相对丰度最高。这表明中含水量梯度下的原核生物群落的内在变异较小,整体活性较高。此外,高含水量和低含水量梯度的原核生物多样性和门水平相对丰度较低。表型预测结果表明,这两组条件下的原核微生物群落具有更强的耐受性。总之,原核生物群落对呼伦湖南岸草地生态系统的自然水分梯度有明显响应,土壤水分过高或过低都会增加原核生物的抗逆性。 | Xin Chen Yujue Wang Yuting Shen Weiguo Sang Nengwen Xiao Chunwang Xiao | 2023 | Journal of Plant Ecology2023，16，6： | 0 |
| 19 | Knockdown of PGC1α suppresses dysplastic oral keratinocytes proliferation through reprogramming energy metabolism显示文摘Oral potentially malignant disorders(OPMDs)are precursors of oral squamous cell carcinoma(OSCC).Deregulated cellular energy metabolism is a critical hallmark of cancer cells.Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha(PGC1α)plays vital role in mitochondrial energy metabolism.However,the molecular mechanism of PGC1αon OPMDs progression is less unclear.Therefore,we investigated the effects of knockdown PGC1αon human dysplastic oral keratinocytes(DOKs)comprehensively,including cell proliferation,cell cycle,apoptosis,xenograft tumor,mitochondrial DNA(mtDNA),mitochondrial electron transport chain complexes(ETC),reactive oxygen species(ROS),oxygen consumption rate(OCR),extracellular acidification rate(ECAR),and glucose uptake.We found that knockdown PGC1αsignificantly inhibited the proliferation of DOKs in vitro and tumor growth in vivo,induced S-phase arrest,and suppressed PI3K/Akt signaling pathway without affecting cell apoptosis.Mechanistically,downregulated of PGC1αdecreased mtDNA,ETC,and OCR,while enhancing ROS,glucose uptake,ECAR,and glycolysis by regulating lactate dehydrogenase A(LDHA).Moreover,SR18292(an inhibitor of PGC1α)induced oxidative phosphorylation dysfunction of DOKs and declined DOK xenograft tumor progression.Thus,our work suggests that PGC1αplays a crucial role in cell proliferation by reprograming energy metabolism and interfering with energy metabolism,acting as a potential therapeutic target for OPMDs. | Yunkun Liu Nengwen Huang Xianghe Qiao Zhiyu Gu Yongzhi Wu Jinjin Li Chengzhou Wu Bo Li Longjiang Li | 2023 | International Journal of Oral Science2023，15，3： | 0 |
| 20 | Global Biodiversity Protection and China’s Role显示文摘Biological diversity both lays the foundation for human survival and development and provides the bloodline and basis for all life on Earth.At the Leaders'Summit of the 15th Meeting of the Conference of the Parties to the Convention on Biological Diversity(COP15),Chinese President Xi Jinping made the initiative of“joining hands and starting a new journey of high-quality development for humanity”,emphasizing that China is ready to work together with the international community in guarding the symbiosis of all things and pooling strength to build a community of all life on Earth.The COP15 adopted the Kunming Declaration,pledging to formulate,adopt and implement an effective“post-2020 framework for global biological diversity”,and to guarantee that biological diversity be on the road of restoration by 2030 at the latest.Facing the new situation. | Xiao Nengwen | 2021 | Contemporary World2021，，4： | 0 |
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