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| 1 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 2 | A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction显示文摘Hyperhomocysteinemia(HHcy)is an independent risk factor for cardiovascular diseases and increases mortality in type 2 diabetic patients.HHcy induces endoplasmic reticulum(ER)stress and oxidative stress to impair endothelial function.The glucagon-like peptide 1(GLP-1)analog exendin-4 attenuates endothelial ER stress,but the detailed vasoprotective mechanism remains elusive.The present study investigated the beneficial effects of exendin-4 against HHcy-induced endothelial dysfunction.Exendin-4 pretreatment reversed homocysteine-induced impairment of endothelium-dependent relaxations in C57BL/6 mouse aortae ex vivo.Four weeks subcutaneous injection of exendin-4 restored the impaired endothelial function in both aortae and mesenteric arteries isolated from mice with diet-induced HHcy.Exendin-4 treatment lowered superoxide anion accumulation in the mouse aortae both ex vivo and in vivo.Exendin-4 decreased the expression of ER stress markers(e.g.,ATF4,spliced XBP1,and phosphorylated eIF2α)in human umbilical vein endothelial cells(HUVECs),and this change was reversed by cotreatment with compound C(CC)(AMPK inhibitor).Exendin-4 induced phosphorylation of AMPK and endothelial nitric oxide synthase in HUVECs and arteries.Exendin-4 increased the expression of endoplasmic reticulum oxidoreductase(ERO1α),an important ER chaperone in endothelial cells,and this effect was mediated by AMPK activation.Experiments using siRNA-mediated knockdown or adenoviral overexpression revealed that ERO1αmediated the inhibitory effects of exendin-4 on ER stress and superoxide anion production,thus ameliorating HHcy-induced endothelial dysfunction.The present results demonstrate that exendin-4 reduces HHcy-induced ER stress and improves endothelial function through AMPK-dependent ERO1αupregulation in endothelial cells and arteries.AMPK activation promotes the protein folding machinery in endothelial cells to suppress ER stress. | Chak Kwong Cheng Jiang-Yun Luo Chi Wai Lau William Chi-shing Cho Chi Fai Ng Ronald Ching Wan Ma Xiao Yu Tian Yu Huang | 2021 | Acta Pharmacologica Sinica2021，42，10： | 6 |
| 3 | Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia显示文摘 | Wen Liang Pan Jack Ho Wong Evandro Fei Fang Yau Sang Chan Tzi Bun Ng Randy Chi Fai Cheung | 2014 | Biochemical Pharmacology2014，，： | 1 |
| 4 | From Skeleton to Cytoskeleton: Osteocalcin Transforms Vascular Fibroblasts to Myofibroblasts Via Angiotensin II and Toll-Like Receptor 4显示文摘 | Chi Yung Yuen Siu Ling Wong Chi Wai Lau Suk-Ying Tsang Aimin Xu Zhiming Zhu Chi Fai Ng Xiaoqiang Yao Siu Kai Kong Hung Kay Lee Yu Huang | 2012 | Circulation Research2012，，3： | 1 |
| 5 | A Preliminary Analysis of Combined Liver Resection With New Chemotherapy for Synchronous and Metachronous Colorectal Liver Metastasis显示文摘 | Wilson Wing Chi Ng Yue Sun Cheung John Wong Kit Fai Lee Paul Bo San Lai | 2009 | Asian Journal of Surgery2009，，4： | 1 |
| 6 | Dipeptidyl Peptidase 4 Inhibitor Sitagliptin Protects Endothelial Function in Hypertension Through a Glucagon–Like Peptide 1–Dependent Mechanism显示文摘 | Limei Liu Jian Liu Wing Tak Wong Xiao Yu Tian Chi Wai Lau Yi-Xiang Wang Gang Xu Yunfei Pu Zhiming Zhu Aimin Xu Karen S.L. Lam Zhen Yu Chen Chi Fai Ng Xiaoqiang Yao Yu Huang | 2012 | Hypertension2012，，3： | 1 |
| 7 | Surgical management of renal cell carcinoma with inferior vena cava thrombus显示文摘 | Hon‐Ting Lok Eddie S.Y. Chan Simon S.M. Hou Sidney K.H. Yip Chi‐Fai Ng | 2014 | Surgical Practice2014，，： | 1 |
| 8 | Ginsenoside R b3 attenuates oxidative stress and preserves endothelial function in renal arteries from hypertensive rats显示文摘 | Youhua Wang Jinghui Dong Ping Liu Chi Wai Lau Zhen Gao Duan Zhou Jingyi Tang Chi Fai Ng Yu Huang | 2014 | Br J Pharmacol2014，，13： | 1 |
| 9 | PROTECTIVE EFFECTS OF VERBASCOSIDE ON STATIN-INDUCED MYOTOXICITY IN ZEBRAFISH EMBRYOS显示文摘Myotoxicity is a well-known side effect of statins,the common lipid-lowering drug.Herba Cistanches(HC,Cistanche deserticola)is a Chinese herb traditionally used for muscle problems.Recent studies demonstrated that HC could reduce muscle damage in post-exercised rats.Verbascoside(Vb)was fournd as the major constituent in the active fraction of HC and is known to be muscle protective, | Elaine Wat Hin Fai Kwok Chun Fai Ng Chi Man Koon Ysé Sallé de Chou Jessica Ferriere Brian Tomlinson Clara BS Lau | 2015 | World Journal of Traditional Chinese Medicine2015，1，4： | 0 |
| 10 | Time trend and characteristics of prostate cancer diagnosed in Hong Kong(China)in the past two decades显示文摘Dear Editor, Prostate cancer is an important disease worldwide)In 2015 it was the third most common cancer diagnosed in male in Hong Kong (China) and the incidence of prostate cancer has been rising in the past 15 years. Meanwhile,with increasing public awareness,health education, presentation,and detection of prostate cancer maybe changed.Therefore, we would like to review how the epidemiology of prostate cancer in Hong Kong (China)had changed in the past two decades. | Ho-Fai Wong Chi-Hang Yee Jeremy YC Teoh Samson YS Chan Peter KF Chiu Ho-Yuen Cheung Simon SM Hou Chi Fai Ng | 2019 | Asian Journal of Andrology2019，21，1： | 0 |
| 11 | Consensus on safety management of novel hormonal therapy for advanced prostate cancer显示文摘Prostate cancer(PCa)is one of the most prevalent malignant tumors in men,accompanied by high incidence and mortality rates.Novel hormonal therapy(NHT)has emerged as the primary treatment for advanced PCa,providing noticeable clinical benefits.However,the diverse range of adverse events(AEs)associated with NHT may influence both treatment efficacy and patients'quality of life.In light of the latest international clinical research evidence and recommendations from domestic and foreign guidelines,this consensus aims to provide a comprehensive overview of the common AEs experienced during NHT for advanced PCa patients.Additionally,it seeks to develop a hierarchical approach to more efficiently manage AEs,presenting valuable insights for clinical medication and adverse reaction management. | Sujun Han Shudong Cheng Degang Ding Jianming Guo Zhisong He Baiye Jin Zhigang Ji Tianxin Lin Yuanjie Niu Weijun Qin Benkang Shi Jinkai Shao Xi'nan Sheng Qiang Wei Xin Wang Xinghuan Wang Shujie Xia Wanhai Xu Qing Zou Xiongbing Zu Renu Eapen Chi‐Fai Ng Hirotsugu Uemura Hiroji Uemura Cheol Kwak Jae Young Joung Marniza Saad Edmund Chiong Nianzeng Xing | 2023 | UroPrecision2023，1，2： | 0 |
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