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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial显示文摘 | CUI Li-ying ZHUYi-cheng GAO Shan WANG Jian-ming PENG Bing NI Jun ZHOU Li-xin HE Jia MA Xiu-qiang | 2013 | Chinese Medical Journal2013，，18： | 71 |
| 3 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 4 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 5 | Identification and Bioinformatics Analysis of SnRK2 and CIPK Family Genes in Sorghum显示文摘Through bioinformatic data mining,10 SnRK2 and 31 CIPK genes were identified from sorghum genome.They are unevenly distributed in the sorghum chromosomes.Most SnRK2 genes have 8 introns,while the CIPK genes have a few(no intron or less than 3 introns) or more than 10 introns.Phylogenetic analysis revealed that SnRK2 genes belong to one cluster and CIPK genes form the other independent cluster.The sorghum SnRK2s are subgrouped into three parts,and CIPK into five parts.More than half SnRK2 and CIPK genes present in homologous pairs,suggesting gene duplication may be due to the amplification of SnRK family genes.The kinase domains of SnRK2 family are highly conserved with 88.40% identity,but those of the CIPK family are less conserved with 63.72% identity.And the identity of sorghum CBLinteracting NAF domains of CIPKs is 61.66%.What's more,regarding to the sorghum SnRK2 and CIPK kinases,they are characterized with distinct motifs and their subcellular localization is not necessarily the same,which suggests they may be divergent in functions.Due to less conserved sequences,complex subcellular localization,and more family members,sorghum CIPK genes may play more flexible and multiple biological functions.According to the phylogenetic analysis of SnRK genes and SnRK functional studies in other plants,it is speculated that sorghum SnRK2 and CIPK genes may play important roles in stress response,growth and development. | LI Li-bin ZHANG Yi-rong LIU Kai-chang NI Zhong-fu FANG Zhi-jun SUN Qi-xin GAO Jian-wei | 2010 | Agricultural Sciences in China2010，9，1： | 28 |
| 6 | Multiple Fading Factors Kalman Filter for SINS Static Alignment Application显示文摘解决当系统模型和随机的信息精确地是未知的时,标准 Kalman 过滤器不能给最佳的答案的问题,单个褪色因素 Kalman 过滤器对简单系统合适。要不是有多变量的复杂系统,把单个褪色的因素用作不能是足够的一更多样地为协变性矩阵。在这份报纸,过滤算法的新多重褪色因素 Kalman 被介绍。由用开窗术计算革新顺序协变性的不偏的估计,褪色的因素矩阵被获得。用使因素矩阵褪色调整预言错误 Pk|k-1 的协变性矩阵,算法提供为不同过滤器隧道褪色的不同的率。建议算法被用于 strapdown 惯性的航行系统(罪恶) 起始的排列,和模拟和试验性的结果表明那,当实际系统噪音特征与预设值不同时,排列精确性能戏剧性地被升级。新算法对无常噪音不太敏感并且有参数的更好的评价效果。因此,它具有在实际应用的重要价值。 | GAO Weixi MIAO Lingjuan NI Maolin | 2011 | Chinese Journal of Aeronautics2011，24，4： | 27 |
| 7 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 8 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 9 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 10 | Effects of Magnesium and Ferric Ions on Crystallization of Calcium Sulfate Dihydrate Under the Simulated Conditions of Wet Flue-gas Desulfurization显示文摘The influences of magnesium and ferric ions in their different ratios on the rate of gypsum crystallization were studied under the conditions similar to those of wet flue-gas desulfurization(WFGD). The results show that addition of both Mg2+ and Fe3+ increased induction time and decreased the growth efficiency up to 50% compared with the baseline(without impurities) depending on the concentration and the type of impurity. The effects of Mg2+ and Fe3+ on the surface energy and the rate of nucleation were estimated by employing the classical nucleation theory. The surface energy decreased by 8% and 14% with the addition of 0.02 mol/L magnesium or ferric ions, respectively, compared to the baseline. Mg2+ and Fe3+ made the growth rate of the (020), (021) and (040) faces of gypsum crystal a much greater reduction, which leads to the formation of needle crystals compared to the baseline which favors the formation of plate or flakes. Furthermore, an edge detection program was developed to quantify the effects of impurities on the filtration rate of gypsum product. The results show that the inhibition efficiency of the presence of 0.02 mol/L Mg2+ and Fe3+ on the filtration rate of gypsum crystal ranges from 22% to 39%. | GAO Xiang HUO Wang ZHONG Yi LUO Zhong-yang CEN Ke-fa NI Ming-jiang CHEN Le-ming | 2008 | Chemical Research in Chinese Universities2008，24，6： | 16 |
| 11 | Effects of inhaled nitric oxide in neonatal hypoxemic respiratory failure from a multicenter controlled trial显示文摘背景血氧不足的呼吸失败(HRF ) 是为要求好攻击的呼吸支持的新生的婴儿的最普通的原因之一。吸入的氮的氧化物(iNO ) 在发达国家作为附属物习惯性地被建立了到常规呼吸支持。学习是在资源与 HRF 在出生不满一月的婴儿调查 iNO 的效果的这的目的限制了状况没有或限制了表面活化剂的使用,高频率摆动的通风(HFOV ) 和身体外的膜 oxygenation.Methods A iNO 的功效的非使随机化的、开的、控制学习在 18 个月被进行。来自有 HRF (氧化索引 15 ) 的 28 所医院的合格术语和近期的出生不满一月的婴儿作为 iNO 或控制有希望地被注册进二个组。主要端点与 dosing 在关系被决定并且 iNO,内在的疾病的严厉,复杂并发症和负担预定的氧化改进和死亡。Intention-to-treat 原则为结果评价被采用。( ppm )对在 10 或 20 部分的 iNO 的反应被氧化在控制(在组之间)和比作 93 控制的基线(在内组) .Results 的参考每百万决定,在在 107 个对待的婴儿的 10 ppm 的 iNO 的起始的剂量显著地从第一个小时( P=0.046 )改进了氧化,与部分应答者的更多,非应答者不与随后的 20ppm 改进了氧化( P=0.018 )。在天坚持的这效果 1 和 3,并且而少数与表面活化剂(10% 对 27%) 被对待,导致了相对更低的死亡(11.2% 对 15%) , HFOV (5%) 或在两个的出生后的 corticosteroids (10%) 组织。在 28 天在的出生后的生活的全面结果对待 iNO 不与 perinatal 窒息,内在的疾病,血氧不足的严厉,或复杂并发症有关,但是到 iNO 的早使用。医院停留的费用不在新生的 HRF 在有表面活化剂或 HFOV 的相对有限的使用的两 groups.Conclusions 是显著地不同的,显著地,更多的应答者在在基线水平上在开始的三天内由改进氧化思考了的对待 iNO 的病人被发现。它为对适当预定和 iNO 的长期的结果的评价保证使随机化的、控制试用。 | WANG Yi-fei LIU Cui-qing GAO Xi-rong YANG Chang-yi SHAN Ruo-bing ZHUANG De-yi CHEN Dong-mei NI Li-ming WANG Hua XIA Shi-wen CHEN Chao | 2011 | Chinese Medical Journal2011，，8： | 16 |
| 12 | Changes of the proportion and mortality of pulmonary thromboembolism in hospitalized patients from 1974 to 2005显示文摘Background Pulmonary thromboembolism (PTE) has become a common disease that severely endangers people’s health. This study analysed the changes in proportion and mortality of PTE in hospitalized patients to provide data for prevention and management of the disease. Methods The data of 763 hospitalized patients with PTE from 1974 to 2005 in Fuwai Hospital were analysed. Results During the 1970s, 0.27% of patients in a cardiovascular hospital had PTE (< 5 cases per year); while so far this century the proportion is 0.94% (48 to 113 per year). The mortality of hospitalized PTE patients fell from 20.00% in the 1970s to 4.10% this century. Prior to 1990, the mortality of hospitalized PTE patients was 12.50%, and in the years after 1990 only 3.40%. The difference was statistically significant (P<0.005). People with this disease were mostly between the ages of 30 and 69 years. Men were most susceptible between the ages of 30 and 69 years, while women between the ages of 40 and 69 years. Men contracted PTE 10 years earlier than women. The mortality of male PTE patients was 4.70%, not significantly different from female patients, 5.06% (0.500.1). More people contracted the disease in winter than in other seasons (P<0.05). There was no obvious difference between the mortality in different seasons overall (0.75 | TAN Xiao-yan HE Jian-guo ZOU Zhi-peng ZHAO Yan-fen CHEN Bai-ping GAO Ying XIONG Chang-ming NI Xin-hai CHENG Xian-sheng | 2006 | Chinese Medical Journal2006，，12： | 16 |
| 13 | The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis显示文摘The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw material.Here,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the~1.47-Gb genome assembly into 18 pseudochromosomes.The chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and Manihot.We show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by~65.88%(~970 Mbp)of the whole rubber tree genome since the divergence from Manihot.We identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains~15.7 million high-quality single-nucleotide polymorphisms.We identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber biosynthesis.This genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production. | Jin Liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-Fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao Hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning Hong Guang-Yi Fan Yan Tong Dan Zhang Chang-Li Mao Yun-Long Liu Shi-Jie Hao Wei-Qing Liu Mei-Qi Lv Hai-Bin Zhang Yuan Liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin Liu Li-Zhi Gao | 2020 | Molecular Plant2020，13，2： | 15 |
| 14 | Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative virus of the coronavirus disease 2019(COVID-19)pandemic.To establish a safe and convenient assay system for studying entry inhibitors and neutralizing antibodies against SARS-CoV-2,we constructed a codon-optimized,full-length C-terminal mutant spike(S)gene of SARS-CoV-2.We generated a luciferase(Luc)-expressing pseudovirus containing the wild-type or mutant S protein of SARS-CoV-2 in the envelope-defective HIV-1 backbone.The key parameters for this pseudovirus-based assay,including the S mutants and virus incubation time,were optimized.This pseudovirus contains a Luc reporter gene that enabled us to easily quantify virus entry into angiotensin-converting enzyme 2(ACE2)-expressing 293T cells.Cathepsin(Cat)B/L inhibitor E64d could significantly block SARS-CoV-2 pseudovirus infection in 293T-ACE2 cells.Furthermore,the SARS-CoV-2 spike pseudotyped virus could be neutralized by sera from convalescent COVID-19 patients or recombinant ACE2 with the fused Fc region of human IgG1.Thus,we developed a pseudovirus-based assay for SARS-CoV-2,which will be valuable for evaluating viral entry inhibitors and neutralizing antibodies against this highly pathogenic virus. | Jie Hu Qingzhu Gao Changlong He Ailong Huang Ni Tang Kai Wang | 2020 | Genes & Diseases2020，7，4： | 15 |
| 15 | INTRACRANIAL ARTERIAL OCCLUSIVE LESION IN PATIENTS WITH GRAVES DISEASE显示文摘Objective To investigate the distribution and clinical manifestations of intracranial arterial occlusive lesions (IAOLs), and their correlation with thyroid function.Methods We enrolled 7 patients who had Graves’ disease (GD) with IAOLs screened and evidenced by transcranial Doppler, then further confirmed with digital substract angiography in 2 patients and magnetic resonance angiography in 5 patients. Brain magnetic resonance imaging (MRI) was performed in all 7 patients. Three patients were followed up. Results Among 7 patients, 1 was male and 6 were females. The mean age was 32.0±5.5 (range from 11 to 49) years old. Six of them had symptoms of GD but one was asymptomatic with abnormality of T3, T4, and thyroid stimulating hormone. The lesions of intracranial arteries were symmetrical bilaterally in the internal carotid artery system in 6 patients, as well as asymmetrical in 1 patient. Terminal internal carotid artery (TICA) were involved in all 7 patients. Middle cerebral artery (MCA) were involved in 3, anterior cerebral artery in 2, and basilar artery in 1 patient. Net-like collateral vessels and mimic moyamoya disease were observed in the vicinity of the occlusive arteries in 2 patients. All patients presented symptoms of ischemic stroke including transient ischemic attack and/or infarction while IAOLs were found. Three patients had obvious involuntary movements. Brain MRI revealed infarctions located in the cortex, basal ganglion, or hemiovular center in 5 patients. The remaining 2 patients had normal brain MRI. The neurological symptoms were improved concomitant with relief of the thyroid function in 2 patients, while IAOLs were aggravated with deterioration of the thyroid function in 1 patient.Conclusion IAOLs in patients with GD mainly involve intracranial arteries, especially the TICA and MCA, which is similar to moyamoya disease. The neurological symptoms and severity of involved arteries may relieve while the hyperthyroidism is gradually under control. | Jun Ni Shan Gao Li-ying Cui Shun-wei Li | 2006 | Chinese Medical Sciences Journal2006，21，3： | 14 |
| 16 | Haemoglobin,albumin,lymphocyte and platelet predicts postoperative survival in pancreatic cancer显示文摘BACKGROUND Systemic inflammation and nutrition status play an important role in cancer metastasis.The combined index of hemoglobin,albumin,lymphocyte,and platelet(HALP),consisting of haemoglobin,albumin,lymphocytes,and platelets,is considered as a novel marker to reflect both systemic inflammation and nutrition status.However,no studies have investigated the relationship between HALP and survival of patients with pancreatic cancer following radical resection.AIM To evaluate the prognostic value of preoperative HALP in pancreatic cancer patients.METHODS The preoperative serum levels of hemoglobin,albumin,lymphocyte counts,and platelet counts were routinely detected in 582 pancreatic adenocarcinoma patients who underwent radical resection.The relationship between postoperative survival and the preoperative level of HALP was investigated.RESULTS Low levels of HALP were significantly associated with lymph node metastasis(P=0.002),poor tumor differentiation(P=0.032),high TNM stage(P=0.008),female patients(P=0.005)and tumor location in the head of the pancreas(P<0.001).Low levels of HALP were associated with early recurrence[7.3 mo vs 16.3 mo,P<0.001 for recurrence-free survival(RFS)]and short survival[11.5 mo vs 23.6 mo,P<0.001 for overall survival(OS)]in patients with resected pancreatic adenocarcinoma.A low level of HALP was an independent risk factor for early recurrence and short survival irrespective of sex and tumor location.CONCLUSION Low levels of HALP may be a significant risk factor for RFS and OS in patients with resected pancreatic cancer. | Shuai-Shuai Xu Shuo Li Hua-Xiang Xu Hao Li Chun-Tao Wu Wen-Quan Wang He-Li Gao Wang Jiang Wu-Hu Zhang Tian-Jiao Li Quan-Xing Ni Liang Liu Xian-Jun Yu | 2020 | World Journal of Gastroenterology2020，26，8： | 14 |
| 17 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 18 | Mapping of Fertility Restoring Gene for Aegilops kotschyi Cytoplasmic Male Sterility in Wheat Using SSR Markers显示文摘LK783 was found to be a good fertility restorer for K-type male sterility of wheat. Microsatellite markers were employed to map the major restoring gene in LK783. Maintainer and restorer DNA pools were established using the extreme sterile and fertile plants among (KJ5418A//911289/LK783)F1 population,respectively. Seventy-nine sets of SSR primers were screened for polymorphism between the two pools, 6 of which were found polymorphic. Linkage analysis showed that Xgwm11, Xgwm18 , Xgwm264a and Xgwm273were linked to the restoring gene in LK783, while Xgwm11, Xgwm18 and Xgwm273 were co-segregated. The distance between the Rf gene in LK783 and the three co-segregated markers was 6.54±4.37 cM, the distance between Rf gene and Xgwm264a was 5.71±4.10 cM. The four SSR markers were located on chromosome 1BS by amplifying the DNA of nulli-tetrasomics and ditelosomics of CS with the 4 sets of primers, indicating that the major restoring gene in LK783 was located on 1BS, but the relative location of the gene was different from Rfv1, allelism of the two genes should be further investigated. The breeding for new fertility restorer lines of K-type cytoplasmic male sterility in wheat would be facilitated by using the four polymorphic markers. | LIU Bao-shen, SUN Qi-xin, GAO Qing-rong, SUN Lan-zhen, XIE Chao-jie, LI Chuan-you, NI Zhong-fu and DOU Bing-de( Agronomy Department, Shandong Agricultural University, Taian 271018, P.R.China Department of Plant Genetics and Breeding, China Agricultural University, Beijing 100094 , P. R . China ) | 2002 | Agricultural Sciences in China2002，1，8： | 13 |
| 19 | Esophageal cancer:Epidemiology,risk factors and screening显示文摘More than 600,000 people are diagnosed with esophageal cancer(EC)every year globally,and the five-year survival rate of EC is less than 20%.Two common histological subtypes of EC,esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC),have great geographical variations in incidence rates.About half of the world’s EC was diagnosed in China and a majority of which belong to ESCC.Globally,the overall incidence rate of EC is decreasing.In some high-risk Asian regions,such as China,the incidence rate of ESCC has generally declined,potentially due to economic growth and improvement of diet habits.In some European high-income countries and the United States,the decline is mainly attributed to the decrease in smoking and drinking.The risk factors of EC are not well understood,and the importance of environmental and genetic factors in the pathogenesis is also unclear.The incidence and mortality of advanced EC can be reduced through early diagnosis and screening.White light endoscopy is still the gold standard in the current screening technology.This article reviews the epidemiology,risk factors,and screening strategies of EC in recent years to help researchers determine the most effective management strategies to reduce the risk of EC. | Jiang Li Jianguo Xu Yadi Zheng Ya Gao Siyi He He Li Kaiyong Zou Ni Li Jinhui Tian Wanqing Chen Jie He | 2021 | Chinese Journal of Cancer Research2021，33，5： | 12 |
| 20 | Combined effect of the use of carbon fiber and seawater and the molecular structure on the tribological behavior of polymer materials显示文摘The combined effect of the use of carbon fiber and seawater and the molecular structure on the tribological behavior of various polymer materials under natural seawater lubrication was investigated. After the investigation, the wear morphology of the contact surface was observed by a laser scanning confocal microscope, and the texture of the wear scars and tracks were presented in 3 D profiles. Moreover, the mechanism of mixed lubrication and wear resistance was analyzed. The results demonstrated that the friction coefficient of carbon fiber-reinforced polyetheretherketone(CFRPEEK) is the lowest and fluctuates at approximately 0.11. Moreover, the seven polymer materials in ascending order of friction coefficients are CFRPEEK, carbon fiber-reinforced polyamide-imide, polytetrafluoroethylene, polyoxymethylene, polyetheretherketone(PEEK), acrylonitrile butadiene styrene resin, and glass fiber–epoxy resin. More critically, the simultaneous incorporation of deposition, polymeric scrap, hydrophilic groups, and seawater resulted in a decrease in the friction and wear of polymer materials under seawater lubrication. This observation implies that a synergistic friction-reducing and wear-resistant effect exists between carbon fiber, seawater, and the molecular structure of PEEK. As a result, a highly effective polymer material was discovered, CFRPEEK, which has the lowest friction coefficient of 0.11 and lowest wear rate of 2 × 10^(–5) mm^3?(N?m)^(-1) among the polymer materials; this validates the selection of dual friction pairs for seawater hydraulic components. | Zhiqiang WANG Jing NI Dianrong GAO | 2018 | Friction2018，6，2： | 11 |
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