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| 1 | Cancer statistics in China and United States,2022:profiles,trends,and determinants显示文摘Background:The cancer burden in the United States of America(USA)has decreased gradually.However,China is experiencing a transition in its cancer profiles,with greater incidence of cancers that were previously more common in the USA.This study compared the latest cancer profiles,trends,and determinants between China and USA.Methods:This was a comparative study using open-source data.Cancer cases and deaths in 2022 were calculated using cancer estimates from GLOBOCAN 2020 and population estimates from the United Nations.Trends in cancer incidence and mortality rates in the USA used data from the Surveillance,Epidemiology,and End Results program and National Center for Health Statistics.Chinese data were obtained from cancer registry reports.Data from the Global Burden of Disease 2019 and a decomposition method were used to express cancer deaths as the product of four determinant factors.Results:In 2022,there will be approximately 4,820,000 and 2,370,000 new cancer cases,and 3,210,000 and 640,000 cancer deaths in China and the USA,respectively.The most common cancers are lung cancer in China and breast cancer in the USA,and lung cancer is the leading cause of cancer death in both.Age-standardized incidence and mortality rates for lung cancer and colorectal cancer in the USA have decreased significantly recently,but rates of liver cancer have increased slightly.Rates of stomach,liver,and esophageal cancer decreased gradually in China,but rates have increased for colorectal cancer in the whole population,prostate cancer in men,and other seven cancer types in women.Increases in adult population size and population aging were major determinants for incremental cancer deaths,and case-fatality rates contributed to reduced cancer deaths in both countries.Conclusions:The decreasing cancer burden in liver,stomach,and esophagus,and increasing burden in lung,colorectum,breast,and prostate,mean that cancer profiles in China and the USA are converging.Population aging is a growing determinant of incremental cancer burden.Progress in cancer prevention and care in the USA,and measures to actively respond to population aging,may help China to reduce the cancer burden. | Changfa Xia Xuesi Dong He Li Maomao Cao Dianqin Sun Siyi He Fan Yang Xinxin Yan Shaoli Zhang Ni Li Wanqing Chen | 2022 | Chinese Medical Journal2022，，5： | 827 |
| 2 | Analysis of Factors Associated with Death in Maintenance Hemodialysis Patients: A Multicenter Study in China显示文摘 | Kang-Kang Song De-Long Zhao Yuan-Da Wang Yong Wang Xue-Feng Sun Li-Ning Miao Zhao-Hui Ni Hong-Li Lin Fu-You Liu Ying Li Ya-Ni He Nian-Song Wang Cai-Li Wang Ai-Hua Zhang Meng-Hua Chen Xiao-Ping Yang Yue-Yi Deng Feng-Min Shao Shu-Xia Fu Jing-Ai Fang Guang-Yan Cai Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，8： | 39 |
| 3 | Multispherical interactions and their effects on the Tibetan Plateau's earth system: a review of the recent researches显示文摘The Tibetan Plateau(TP) is a regional Earth system showing very strong interactions among its lithosphere, hydrosphere, cryosphere, biosphere, atmosphere, and anthrosphere. hese interactions manifest TP's impact on surrounding regions and relect TP's response to the global change. Quantifying the multispherical interactions is critically important to understand the TP environment. Our recent years researches including the ongoing program entitled ‘Tibetan Multi-Spheres Interactions and heir Resource-Environment Signiicance(TIMI)', the completed program entitled. ‘Paleo-Altitudes of Tibetan Plateau and Environment(PATE)', as well as the other relating projects have focused on multidisciplinary research approaches and emphasized on three major pathways: Eurasia-Indian plates collision on deep-Earth dynamics, uplit impact on Earth's mantle–crust dynamics, and contemporary interface on land surface and atmospheric dynamics. Our researches have taken in situ measurement as priority and developed several platforms of data acquisition and analysis, including the platforms of water-phase transformations, and ecosystem observations. Our ield investigations have been conducted to obtain data about stratum, paleontology, paleoenvironment, genetic diferentiation of animals and plants. We have developed conceptual and mathematical models for crust uplit formation, paleoclimate, glacial melt,water–air interface lux, vegetation climate, and soil erosion. We have also assessed the anthropogenic impacts on environment. Our researches have achieved new and reliable redating of the mantle–crust interaction and initial formation of the TP, found the interaction between tectonics and uplit of the TP and resultant paleoaltitude acting as a spreading source; discovered the interaction between the westerlies and Indian monsoon acting as a control chain that dominates the TP's contemporary environment. he scientiic results can play fundamental roles in supporting the TP's resource exploration and societal sustainable development. | Tandong Yao Fuyuan Wu Lin Ding Jimin Sun Liping Zhu Shilong Piao Tao Deng Xijun Ni Hongbo Zheng Hua Ouyang | 2015 | National Science Review2015，2，4： | 35 |
| 4 | Meta-analysis of radiofrequency ablation in combination with transarterial chemoembolization for hepatocellular carcinoma显示文摘AIM: To compare radiofrequency ablation (RFA) and transcatheter arterial chemoembolization (TACE) with RFA monotherapy in hepatocellular carcinoma (HCC). METHODS: We searched PubMed, Medline, Embase and Chinese databases (CBMdisc and Wanfang data) for randomized controlled trails comparing RFA plus TACE and RFA alone for treatment of HCC from January 2000 to December 2012. The overall survival rate, re-currence-free survival rate, tumor progression rate, and safety were analyzed and compared. The analysis was conducted on dichotomous outcomes and the standard meta-analytical techniques were used. Pooled odds ratios (ORs) with 95%CIs were calculated using either the fixed-effects or random-effects model. For each meta-analysis, the χ2 and I2 tests were first calculated to assess the heterogeneity of the included trials. For P<0.05 and I 2>50%, the assumption of homogeneity was deemed invalid, and the random-effects model wasused; otherwise, data were assessed using the fixed-effects model. All statistical analysis was conducted us-ing Review manager (version 4.2.2.) from the Cochrane collaboration. RESULTS: Eight randomized controlled trials were identified as eligible for inclusion in this analysis and included 598 patients with 306 treated with RFA plus TACE and 292 with RFA alone. Our data analysis indicated that RFA plus TACE was associated a sig-nificantly higher overall survival rate (OR 1-year=2.96, 95%CI: 1.84-7.74, P<0.001; OR 2-year=3.72, 95%CI: 1.24-11.16, P=0.02; OR 3-year=2.65, 95%CI: 1.81-3.86, P<0.001) and recurrence-free survival rate (OR 3-year=3.00, 95%CI: 1.75-5.13, P<0.001; OR 5-year=2.26, 95%CI: 1.43-3.57, P=0.0004) vs that of RFA alone. The tumor progression rate in patients treated with RFA alone was higher than that of RFA plus TACE (OR=0.60, 95%CI: 0.42-0.88, P=0.008) and there was no significant difference on major complications between two different kinds of treatment (OR=1.20, 95%CI: 0.31-4.62, P=0.79). Additionally, the meta-analysis data of subgroups revealed that the survival rate was significantly higher in patients with intermediate-and large-size HCC underwent RFA plus TACE than in those underwent RFA monotherapy; however, there was no significant difference between RFA plus TACE and RFA on survival rate for small HCC. CONCLUSION: The combination of RFA with TACE has advantages in improving overall survival rate, and pro-vides better prognosis for patients with intermediate-and large-size HCC. | Jia-Yan Ni Shan-Shan Liu Lin-Feng Xu Hong-Liang Sun Yao-Ting Chen | 2013 | World Journal of Gastroenterology2013，19，24： | 34 |
| 5 | Cloning and expression profiles of 15 genes encoding WRKY transcription factor in wheat (Triticum aestivem L.)显示文摘WRKY proteins are involved in various physiological processes,including biotic and abiotic stress responses,hormone responses and development.However,no systematic identification,expression and function analysis of WRKY genes in wheat were reported.In this study,we isolated 15 wheat cDNAs with complete open reading frame(ORF)encoding putative WRKY proteins using in silico cloning.Phylogenetic analysis indicated that the 15 wheat WRKY genes belonged to three major WRKY groups.Expression analysis revealed that most genes expressed drastically in leaf,except TaWRKY10 which expressed in crown intensively.Four genes were strongly up-reg-ulated with the senescence of leaves.Eight genes were responsive to low temperature,high temperature,NaCl or PEG treatment.More-over,dierential expression patterns were also observed between wheat hybrid and its parents,and some genes were more responsive to PEG treatment in the hybrid.These results demonstrated that wheat WRKY genes are involved in leaf senescing and abiotic stresses.And the changed expression of these WRKY genes in hybrid might contribute to the heterosis by improving the stress tolerance in hybrids. | Hualing Wu Zhongfu Ni Yingyin Yao Ganggang Guo Qixin Sun | 2008 | Progress in Natural Science:Materials International2008，18，6： | 34 |
| 6 | Preparation of hierarchical mesoporous Zn/HZSM-5 catalyst and its application in MTG reaction显示文摘The hierarchical mesoporous Zn/ZSM-5 zeolite catalyst was prepared by NaOH treatment and Zn impregnation, and its application in the conversion of methanol to gasoline (MTG) was studied. N2 adsorption-desorption results showed that the mesopores with sizes of 2–20 nm in HZ5/0.3AT was formed by 0.3 M NaOH alkali treatment. The zeolite samples after modification were also characterized by XRF, AAS, XRD, SEM and NH3-TPD methods. Zn impregnated catalyst Zn/HZ5/0.3AT exhibited dramatic improvements in catalytic lifetime and liquid hydrocarbons yield. The selectivity of aromatic hydrocarbons was also improved after Zn impregnation. It is suggested that the mesopores of Zn/HZ5/0.3AT enhanced the synergetic effect of Zn species and acid sites and the capability to coke tolerance, which were confirmed by the results of catalytic test and TGA analysis, respectively. | Youming Ni Aiming Sun XiaolingWu Guoliang Hai Jianglin Hu Tao Li Guangxing Li | 2011 | Journal of Natural Gas Chemistry2011，20，3： | 31 |
| 7 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 8 | Application and study in aluminum melt degassing technologies显示文摘The classification, characteristics and current situation of aluminum melt hydrogen-removal methods and technologies have been summarized. The latest studies and research results of aluminum melt degassing technology have been summed up. The tendency and prospect of aluminum degassing technology was discussed. | ~*H. J. Ni~(1,2), M. Y. Huang~1, Y. Zhu~1, P. Liao~1, R. Z. WU~2, B. D. Sun~2(1. Department of Mechanical Engineering, Nantong Institute of Technology, Nantong 226007, Jingsu, P. R. China 2. School of Material Science and Engineering, Shanghai Jiaotong University, Shanghai 200030, P. R. China) | 2004 | China Foundry2004，1，S1： | 27 |
| 9 | Identification and Bioinformatics Analysis of SnRK2 and CIPK Family Genes in Sorghum显示文摘Through bioinformatic data mining,10 SnRK2 and 31 CIPK genes were identified from sorghum genome.They are unevenly distributed in the sorghum chromosomes.Most SnRK2 genes have 8 introns,while the CIPK genes have a few(no intron or less than 3 introns) or more than 10 introns.Phylogenetic analysis revealed that SnRK2 genes belong to one cluster and CIPK genes form the other independent cluster.The sorghum SnRK2s are subgrouped into three parts,and CIPK into five parts.More than half SnRK2 and CIPK genes present in homologous pairs,suggesting gene duplication may be due to the amplification of SnRK family genes.The kinase domains of SnRK2 family are highly conserved with 88.40% identity,but those of the CIPK family are less conserved with 63.72% identity.And the identity of sorghum CBLinteracting NAF domains of CIPKs is 61.66%.What's more,regarding to the sorghum SnRK2 and CIPK kinases,they are characterized with distinct motifs and their subcellular localization is not necessarily the same,which suggests they may be divergent in functions.Due to less conserved sequences,complex subcellular localization,and more family members,sorghum CIPK genes may play more flexible and multiple biological functions.According to the phylogenetic analysis of SnRK genes and SnRK functional studies in other plants,it is speculated that sorghum SnRK2 and CIPK genes may play important roles in stress response,growth and development. | LI Li-bin ZHANG Yi-rong LIU Kai-chang NI Zhong-fu FANG Zhi-jun SUN Qi-xin GAO Jian-wei | 2010 | Agricultural Sciences in China2010，9，1： | 28 |
| 10 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 11 | Hydrothermal ore deposits in collisional orogens显示文摘Hydrothermal ore deposits at convergent plate boundaries represent extraordinary metal enrichment in the continental crust. They are generally associated with felsic magmatism in extensional settings at high thermal gradients. Although their formation is common during accretionary orogeny, more and more ore deposits have been discovered recently in the collisional orogens of China. Because collisional orogeny was operated in a compressional regime at low thermal gradients, it is not favorable for mobilization of ore-forming elements and thus for the production of hydrothermal ore deposits. Nevertheless, continental collision is generally preceded by oceanic subduction, which enables the preliminary enrichment of ore-forming elements in the mantle wedge due to chemical metasomatism by subducting slab-derived fluids. This gave rise to metal pre-enriched domains in the overriding lithosphere, which may be reactivated by extensional tectonism for hydrothermal mineralization either immediately during accretionary orogeny or at a later time during and after collisional orogeny. It is these tectonic processes that have resulted in the progressive enrichment of ore-forming elements through the geochemical differentiation of the subducting oceanic crust, the metasomatic mantle domains and the mafic juvenile crust, respectively, at different depths. Finally, the reactivation of metal pre-enriched domains by continental rifting in the orogenic lithosphere is the key to the metallogenesis of collisional orogens. | Yongfei Zheng Jingwen Mao Yanjing Chen Weidong Sun Pei Ni Xiaoyong Yang | 2019 | Science Bulletin2019，64，3： | 26 |
| 12 | Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-KB inflammatory signaling pathway显示文摘Xyloketal B (Xyl-B ) 是从红树属植物真菌 Xylaria sp 孤立的新奇海洋的混合物。我们以前证明有 Xyl-B 的那个预告的处理施加了 neuroprotective 效果并且在新生的老鼠稀释了 hypoxic-ischemic 大脑损害。在现在的学习,我们调查了预告的处理的 neuroprotective 效果并且与在用短暂中间的成年老鼠的 Xyl-B 处理以后服的动脉吸藏(tMCAO ) 模型,并且探索了内在的机制。成年男 C57 老鼠受到 tMCAO 外科。为预告的处理, Xyl-B 经由多重注射被给(12.5, 25,和 50 mg ?@ | Ni PAN Liu-yi LU Mei LI Guo-hao WANG Fang-yu n SUN Hong-shuo SUN Xue-jun WEN Jian-ding CHENG Jian- wen CHEN Ji-yan PANG Jie LIU Yong-yuan GUAN Li-yan ZHAO Wen-liang CHEN Guan-lei WANG | 2017 | Acta Pharmacologica Sinica2017，38，9： | 24 |
| 13 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 14 | Heat and power load dispatching considering energy storage of district heating system and electric boilers显示文摘As one of promising clean and low-emission energy, wind power is being rapidly developed in China.However, it faces serious problem of wind curtailment,particularly in northeast China, where combined heat and power(CHP) units cover a large proportion of the district heat supply. Due to the inherent strong coupling between the power and the heat load, the operational flexibility of CHP units is severely restricted in winter to meet the heat supply demand, which imparts considerable stress on the wind power connection to the grid. To promote the integration of wind power and enhance the flexibility of CHP units, this paper presented a method of heat and power load dispatching by exploring the energy storage ability of electric heating boilers and district heating systems. The optimization results indicate that the proposed method can integrate additional wind power into the grid and reduce the coal consumption of CHP units over the optimized period. Furthermore, the thermal inertia of a district heating system is found to contribute more to the reduction of coal consumption, whereas the electric heating boilers contribute to lower wind curtailment. | Xianzheng HUANG Zhaofeng XU Yong SUN Yali XUE Zhe WANG Zhijun LIU Zhenyuan LI Weidou NI | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，5： | 20 |
| 15 | Identification of coastal wetlands of international importance for waterbirds:a review of China Coastal Waterbird Surveys 2005–2013显示文摘Background:China's coastal wetlands belong to some of the most threatened ecosystems worldwide.The loss and degradation of these wetlands seriously threaten waterbirds that depend on wetlands.Methods:The China Coastal Waterbird Census was organized by volunteer birdwatchers in China's coastal region.Waterbirds were surveyed synchronously once every month at 14 sites,as well as irregularly at a further 18 sites,between September 2005 and December 2013.Results:A total of 75 species of waterbirds met the 1 % population level Ramsar listing criterion at least once at one site.The number of birds of the following species accounted for over 20 % of the total flyway populations at a single site:Mute Swan(Cygnus olor),Siberia Crane(Grus leucogeranus),Far Eastern Oystercatcher(Haematopus osculans),Bar-tailed Godwit(Limosa lapponica),Spotted Greenshank(Tringa guttifer),Great Knot(Calidris tenuirostris),Spoon-billed Sandpiper(Calidris pygmeus),Saunders' s Gull(Larus saundersi),Relict Gull(Larus relictus),Great Cormorant(Phalacrocorax carbo),Eurasian Spoonbill(Platalea leucorodia),Black-faced Spoonbill(Platalea minor) and Dalmatian Pelican(Pelecanus crispus).A total of 26 sites supported at least one species of which their number met the1 % criterion.Forty-two species met the 1 % criterion in the Yellow River Delta,Shandong;29 at the Cangzhou coast,Hebei and 26 species at the Lianyungang coast,Jiangsu.Conclusions:The results highlight the international importance of China's coastal wetlands for waterbirds.This study also demonstrates that participation of local birdwatchers in waterbird surveys results in data that are invaluable not only for understanding the current status of waterbirds in China's coastal regions but also for waterbird conservation and management. | Qingquan Bai Jianzhong Chen Zhihong Chen Guotai Dong Jiangtian Dong Wenxiao Dong Vivian Wing Kan Fu Yongxiang Han Gang Lu Jing Li Yang Liu Zhi Lin Derong Meng Jonathan Martinez Guanghui Ni Kai Shan Renjie Sun Suixing Tian Fengqin Wang Zhiwei Xu Yat-tung Yu Jin Yang Zhidong Yang Lin Zhang Ming Zhang Xiangwu Zeng | 2015 | Chinese Birds2015，，3： | 20 |
| 16 | Effects of hypoxia-inducible factor-1α silencing on the proliferation of CBRH-7919 hepatoma cells显示文摘AIM:To study the effects of hypoxia-inducible factor1α(HIF-1α) silencing on the proliferation of hypoxic CBRH-7919 rat hepatoma cells.METHODS:The CBRH-7919 rat hepatoma cell line was used in this study and the hypoxic model was constructed using CoCl2.The HIF-1α-specific RNAi sequences were designed according to the gene coding sequence of rat HIF-1α obtained from GeneBank.The secondary structure of the HIF-1α gene sequence was analyzed using RNA draw software.The small interfering RNA(siRNA) transfection mixture was produced by mixing the siRNA and Lipofectamine2000TM,and transfected into the hypoxic hepatoma cells.Real time reverse transcription-polymerase chain reaction(RTPCR) and Western blotting assay were used to detect the expression levels of mRNA and protein.HIF-1α and vascular endothelial growth factor(VEGF) mRNA was determined using real time RT-PCR;the protein expression levels of AKT,p-AKT,p21 and cyclinD1 were determined using Western blotting.The proliferation of hepatoma cells was observed using the methyl thiazolyl tetrazolium(MTT) assay and the bromodeoxyuridine(BrdU) incorporation cell proliferation assay.RESULTS:Under induced hypoxia,the viability of the hepatoma cells reached a minimum at 800 μmol/L CoCl2;the viability of the cells was relatively high at CoCl2 concentrations between 100 μmol/L and 200 μmol/L.Under hypoxia,the mRNA and protein expression levels of HIF-1α and VEGF were significantly higher than that of hepatoma cells that were cultured in normaxia.HIF-1α-specific RNAi sequences were successfully transfected into hepatoma cells.The transfection of specific siRNAs significantly inhibited the mRNA and protein expression levels of HIF-1α and VEGF,along with the protein expression levels of p-AKT and cyclinD1;the protein expression of p21 was significantly increased,and there was no significant difference in the expression of AKT.The MTT assay showed that the amount of hepatoma cells in S phase in the siRNA transfection group was obviously smaller than that in the control group;in the siRNA transfection group,the amount of hepatoma cells in G1 phase was more than that in the control group.The BrdU incorporation assay showed that the number of BrdU positive hepatoma cells in the siRNA transfection group was less than that in the control group.The data of the MTT assay and BrdU incorporation assay suggested that HIF-1α silencing using siRNAs significantly inhibited the proliferation of hepatoma cells.CONCLUSION:Hypoxia increases the expression of HIF-1α,and HIF-1α silencing significantly inhibits the proliferation of hypoxic CBRH-7919 rat hepatoma cells. | Lin-Feng Xu Jia-Yan Ni Hong-Liang Sun Yao-Ting Chen Yu-Dan Wu | 2013 | World Journal of Gastroenterology2013，19，11： | 18 |
| 17 | Prognostic factors for survival after transarterial chemoembolization combined with microwave ablation for hepatocellular carcinoma显示文摘AIM:To analyze prognostic factors for survival after transarterial chemoembolization(TACE)combined with microwave ablation(MWA)for hepatocellular carcinoma(HCC).METHODS:Clinical data of 86 patients who underwent TACE combined with MWA between January 2006and December 2013 were retrospectively analyzed in this study.Survival curves were detected using log-rank test.Univariate analysis was performed using log-rank test with respect to 13 prognostic factors affecting survival.All statistically significant prognostic factors identified by univariate analysis were entered into a Cox proportion hazards regression model to identify independent predictors of survival.P values were two-sided and P<0.05 was considered statistically significant.RESULTS:Median follow-up time was 47.6 mo,andmedian survival time of enrolled patients was 21.5 mo.The 1-,2-,3-and 5-year overall survival rates were72.1%,44.1%,31.4%and 13.9%,respectively.Tumor size(χ2=14.999,P=0.000),Barcelona Clinic Liver Cancer(BCLC)stage(χ2=29.765,P=0.000),ChildPugh class(χ2=51.820,P=0.000),portal vein tumor thrombus(PVTT)(χ2=43.086,P=0.000),arteriovenous fistula(χ2=29.791,P=0.000),MWA therapy times(χ2=12.920,P=0.002),Eastern Cooperative Oncology Group(ECOG)score(χ2=28.660,P=0.000)and targeted drug usage(χ2=10.901,P=0.001)were found to be significantly associated with overall survival by univariate analysis.Multivariate analysis identified that tumor size(95%CI:1.608-4.962,P=0.000),BCLC stage(95%CI:1.016-2.208,P=0.020),PVTT(95%CI:2.062-9.068,P=0.000),MWA therapy times(95%CI:0.402-0.745,P=0.000),ECOG score(95%CI:1.012-3.053,P=0.045)and targeted drug usage(95%CI:1.335-3.143,P=0.001)were independent prognostic factors associated with overall survival.CONCLUSION:Superior performance status,MWA treatment and targeted drug were favorable factors,and large HCC,PVTT and advanced BCLC stage were risk factors for survival after TACE-MWA for HCC. | Jia-Yan Ni Hong-Liang Sun Yao-Ting Chen Jiang-Hong Luo Dong Chen Xiong-Ying Jiang Lin-Feng Xu | 2014 | World Journal of Gastroenterology2014，20，46： | 18 |
| 18 | Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma显示文摘瞄准:调查在里面 vitro 并且在 vivo 活动和 apogossypolone (ApoG2 ) 的相关机制独自或在有对人的 hepatocellular 癌(HCC ) 的 adriamycin (ADM ) 的联合。方法:在 vitro 的 ApoG2 的 IC 50 被 WST 试金测试,并且 synergistic 效果用 CalcuSyn 方法被分析。房间 apoptosis 用 4',6-diamidino-2-phenylindole 染色和流动 cytometric 分析被决定。西方的弄污被用来决定 apoptosis 相关的蛋白质的表示。在 vivo,活动在裸体老鼠在异种皮移植模特儿被评估,并且在肿瘤纸巾的 apoptosis 被终端 deoxynucleotidyl 决定标记的调停 transferase 的 digoxigenin-dUTP 刻痕结束(TUNEL ) 试金。结果:在 HCC 房间的 ApoG2 的 IC 50 是 17.28 30.63 μmol/L。当 ApoG2 与 ADM 被相结合时,增加的 cytotoxicity 和 apoptosis 独自与 ApoG2 与处理相比在 SMMC-7721 房间被观察。西方的弄污结果显示 ApoG2 在 SMMC-7721 房间导致了 apoptosis 由在调整 anti-apoptotic 蛋白质 Bcl-2, Mcl-1,和 Bcl-X L , 起来调整的 pro-apoptotic 蛋白质 Noxa,并且支持 caspases-9 和 -3 的活动。当没有引起损坏到正常纸巾, ApoG2 口头上地被管理时,异种皮移植 SMMC-7721 的肿瘤生长在裸体老鼠被禁止。在里面当在 100 或 200 mg/kg 剂量的 ApoG2 在 5.5 mg/kg 和 ADM 被使用时, vivo 学习也显示了增加的 anti-tumoral 效果,与相对肿瘤增长,率(T/C ) 分别地 0.456 和 0.323 珍视。与 ADM 独自一个或联合的 ApoG2 在 vivo 导致的 Apoptosis 被 TUNEL 试金在肿瘤纸巾证实。结论:ApoG2 是在调整 Noxa 上面导致 apoptosis 由的一个潜在的无毒的目标代理人,当禁止 anti-apoptotic 蛋白质并且在 HCC 支持化疗代理人 ADM 的效果时。 | Jin-xia MI Guang-feng WANG Heng-bang WANG Xiao-qing SUN Xin-yan NI Xiong-wen ZHANG Jia-ming TANG Da-jun YANG | 2008 | Acta Pharmacologica Sinica2008，29，12： | 16 |
| 19 | Clinical trial of thalidomide combined with radiotherapy in patients with esophageal cancer显示文摘AIM:To investigate the short-term efficacy and tolerability of radiotherapy plus thalidomide in patients with esophageal cancer(EC).METHODS:Serum samples from 86 EC patients were collected before,during,and after radiotherapy,and the vascular endothelial growth factor(VEGF)level was examined by ELISA.According to the change in serum VEGF level during radiotherapy,the patients were divided into two groups:in the drug group,VEGF level was increased or remained unchanged,and thalidomide was administered up to the end of radiotherapy;in the non-drug group,VEGF level was decreased and radiotherapy was given alone.Thirty healthy volunteers served as controls.The efficacy and safety of radiotherapy plus thalidomide therapy were investigated.RESULTS:The 86 EC patients had a significantly higher level of VEGF compared with the 30 healthy controls before radiotherapy(P<0.01),and the VEGF level was significantly correlated with primary tumor size,lymph node metastasis,histopathologic type,and clinical stage(P<0.01).Of 83 evaluable cases,VEGF level was significantly decreased after radiotherapy in32 patients in the drug group(P<0.05),with an effective rate of 71.88%.The incidence of dizziness and/or burnout in the drug group and non-drug group was62.50%and 15.69%,respectively(P=0.000),and the incidence of somnolence was 12.50%and 0%,respectively(P=0.019).No significant differences were observed.CONCLUSION:Thalidomide can down-regulate serum VEGF level in EC patients,and combined with radiotherapy may improve treatment outcome.Thalidomide was well tolerated by EC patients. | Jing-Ping Yu Su-Ping Sun Zhi-Qiang Sun Xin-Chu Ni Jian Wang Yi Li Li-Jun Hu Dong-Qing Li | 2014 | World Journal of Gastroenterology2014，20，17： | 16 |
| 20 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
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