|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical characteristics and outcome of hepatocellular carcinoma in alcohol related and cryptogenic cirrhosis: a prospective study显示文摘BACKGROUND: Non-alcoholic fatty liver disease(NAFLD) is becoming a leading cause of chronic liver disease. Hepatocellular carcinoma(HCC) is one of its complications. Although the pathophysiology is unclear, it is reasonable to expect that cryptogenic cirrhosis related HCC(cryptogenic HCC) behaves differently to other types of HCC. This study prospectively compared patients with cryptogenic HCC and those with HCC related to alcoholic cirrhosis. METHODS: A total of 150 consecutive patients with HCC(89 cryptogenic HCC and 61 alcohol related HCC) referred to our unit over a 23-month period were studied. Their demographic data, liver function, tumor characteristics and outcomes were compared.RESULTS: Alcohol related HCC was seen only in males. Compared with cryptogenic HCC, alcohol related HCC had significantly higher aspartate aminotransferase/alanine aminotransferase(AST/ALT) ratio(1.7 vs 1.4, P=0.002), model for endstage liver disease score(13 vs 11, P=0.018) and Child's score(7 vs 6, P=0.037). No significant difference was seen in platelet counts, serum sodium and AST to platelet ratio index. Single nodular tumors were more common in cryptogenic HCC,while diffuse type tumors and macroscopic vascular invasion were common in alcohol related HCC. In patients who could not be offered any treatment because of advanced tumors or poor liver function, alcohol related HCC had a significantly lower median survival(5.3 months) compared with cryptogenic HCC(9.3 months, P=0.034).CONCLUSIONS: Compared with cryptogenic HCC, alcohol related HCC had worse liver function and aggressive tumor morphology at presentation, and a higher proportion was untreatable. In patients who could not be treated, median survival was lower in patients with alcohol related HCC than in those with cryptogenic HCC. | Rohan C Siriwardana Maduni A Niriella Anuradha S Dassanayake Chandika Liyanage Bhagya Gunathilaka Subani Jayathunge Hithanadura J de Silva | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，4： | 5 |
| 2 | Prevalence of Acanthosis Nigricans in an urban population in Sfi Lanka and its utility to detect metabolic syndrome显示文摘 | Dassanayake AS Kasturiratne A Niriella MA Kalubovila U Rajindrajith S de Silva AP | 2011 | BMC Res Notes2011，4，1： | 1 |
| 3 | Is acanthosis nigricans a useful clinical screening test for non-alcoholic fatty liver disease (NAFLD) in resource poor settings显示文摘 | Niriella MA Dassanayake AS Kalubovila KVU | | Journal of Hepatology0，，： | 1 |
| 4 | Genetic associations of inflammatory bowel disease in a South Asian population显示文摘AIM To estimate prevalence and phenotypic associations of selected inflammatory bowel disease(IBD)-associated genetic variants among Sri Lankan patients. METHODS A case study of histologically confirmed ulcerative colitis(UC) or Crohn's disease(CD) patients with ≥ 1 year disease duration, who were compared to unrelated, gender-matched, healthy individuals as controls, was conducted at four major centers in Sri Lanka. Phenotypic data of the cases were obtained and all participants were genotyped for 16 selected genetic variants: IL12 B :rs1045431, IL23 R :rs11805303, ARPC2 :rs12612347, IRGM :rs13361189, IL26/IL22 :rs1558744, CDH1 :rs1728785, IL10 :rs3024505, FCGR2 A :rs3737240, PTGER4 :rs4613763, IL17 REL/PIM3 :rs5771069, HNF4 a :rs6017342, STAT3 :rs744166, SMURF1 :rs7809799, LAMB1 :rs886774, HLA-DRB5, DQA1, DRB1, DRA :rs9268853, MST1, UBA7, and APEH :rs9822268. The genotypes of all variants were in Hardy-Weinberg Equilibrium(P > 10^(-3)). To account for multiple hypothesis testing, P-values < 0.003 were considered significant.RESULTS A total of 415 patients and 465 controls were recruited. Out of the single nucleotide polymorphisms(SNPs) tested, the majority were not associated with IBD in Sri Lankans. Significant positive associations were noted between rs886774(LAMB1-gene) and UC(odds ratio(OR) = 1.42, P = 0.001). UC patients with rs886774 had mild disease(OR = 1.66, P < 0.001) and remained in remission(OR = 1.48, P < 0.001). A positive association was noted between rs10045431(IL 12 B gene) and upper gastrointestinal involvement in CD(OR = 4.76, P = 0.002). CONCLUSION This confirms the heterogeneity of allelic mutations in South Asians compared to Caucasians. Most SNPs and disease associations reported here have not been described in South Asians. | Madunil Anuk Niriella Isurujith Kongala Liyanage Senerath Kuleesha Kodisinghe Arjuna Priyadarsin De Silva Nimna Rajapakshe Sunali D Nanayakkara Dunya Luke Thilakshi Silva Metthananda Nawarathne Ranjith K Peiris Udaya P Kalubovila Sujeewa R Kumarasena Vajira Harshadeva Weerabaddana Dissanayake Rohan W Jayasekara Hithanadura Janaka de Silva | 2018 | World Journal of Clinical Cases2018，6，15： | 1 |
| 5 | Prevalence of acanthosis Nigricans in an urban population in Sri Lanka and its utility to detect metabolic syndrome显示文摘 | Dassanayake AS kasturiratne A Niriella MA | | 0，，01： | 1 |
| 6 | Early Course of Inflammatory Bowel Disease in a Population-Based Inception Cohort Study From 8 Countries in Asia and Australia显示文摘 | Siew C. Ng Zhirong Zeng Ola Niewiadomski Whitney Tang Sally Bell Michael A. Kamm Pinjin Hu H. Janaka de Silva Madunil A. Niriella W.S.A.A. Yasith Udara David Ong Khoon Lin Ling Choon Jin Ooi Ida Hilmi Khean Lee Goh Qin Ouyang Yu Fang Wang Kaichun Wu Xin W | 2015 | Gastroenterology2015，，： | 1 |
| 7 | The long-term outcomes of a cohort of Sri Lankan patients with ulcerative colitis: a retrospective study at two national referral centers and review of literature显示文摘 | Sudul Senanayake Amanda Ranaweera Wijesinghe Madunil Niriella ANR Fernandopulle H Janaka de Silva A P de Silva Nawarathne Pathmeswaran Mufeena | 2013 | Clinical and Experimental Gastroenterology (default)2013，，： | 1 |
| 8 | Prevalence of Acanthosis Nigricans in an urban pop~ation in Sri Lanka and its utihty to detect metabolic syndrome显示文摘 | Dassanayake AS Kasturiratne A Niriella MA | 2011 | BMC Res Notes2011，4，1： | 1 |
| 9 | Neosphincter in the management of faecal incontinence 显示文摘 | NIRIELLA D A DEEN K I | 2000 | Br J Surg2000，87，： | 1 |
| 10 | REHABILITATION AND RE-INTEGRATION OF JUVENILE OFFENDERS IN SRI LANKA显示文摘 | Jeeva Niriella | 2011 | US-China Law Review2011，8，5： | 0 |
| 11 | Effective prison rehabilitation system: Special reference to Sri Lanka显示文摘 | Muth ukuda Arachchige Dona Shiroma Jeeva Shirajanie Niriella | 2010 | US-China Law Review2010，7，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员