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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Effects of essential oils on Aedes aegypti larvae: Alternatives to environmentally safe insecticides显示文摘 | W.J. Silva G.A.A. Dória R.T. Maia R.S. Nunes G.A. Carvalho A.F. Blank P.B. Alves R.M. Mar?al S.C.H. Cavalcanti | 2007 | Bioresource Technology2007，，8： | 2 |
| 3 | Correlation between brain injury and dysphagia in adult patients with stroke 显示文摘 | Nunes MC Jurkiewiez AL Santos RS | 2012 | Int Arch Oto- rhinolaryngol2012，16，3： | 1 |
| 4 | Evaluation of basal FSHserum levels in infertile patients with deep ovarian endo- metriosis who underwent surgery显示文摘 | Frankfurt S Nunes AL Reis AD | 2009 | Rev Bras Ginecol Ob- stet2009，319，5： | 1 |
| 5 | Pos-infectious bronchiolitis obliterans in children显示文摘 | Lobo AL Guardiano M Nunes T | 2007 | Bey Port Pneumol2007，13，4： | 1 |
| 6 | N- terminal proB- NP levels in patients with chagas disease:A marker of systolic and diastolie dysfunction of the left ventricle显示文摘 | Barbosa MM Nunes Mdo C Riheiro AL | 2007 | Eur J Eehocardiogr2007，8，3： | 1 |
| 7 | Effect of pacing-induced ventricular dyssynchrony on right ventricular func-tion显示文摘 | Nunes MC Abreu CD Ribeiro AL | | 0，，2： | 1 |
| 8 | N-terminal proBNP levels in patients with Chagas disease:a marker of systolic and diastolic dysfunction of the left ventricle显示文摘 | Barbosa MM Nunes Mdo C Ribeiro AL | | 0，，3： | 1 |
| 9 | N-terminal proBNP levels in patients with Chagas disease:a marker of systolic and diastolic dysfunction of the left ventricle显示文摘 | Barbosa MM Nunes Mdo C Ribeiro AL | 2007 | Eur J Echocardiogr2007，8，3： | 1 |
| 10 | Effect of pacing-induced ventrieular dyssyuchrony on right ventricular function显示文摘 | Nunes MC Abreu CD Ribeiro AL | 2011 | PACE2011，34，2： | 1 |
| 11 | Pos-infectious bronchiolitis obliterans in children 显示文摘 | Lobo AL Guardiano M Nunes T Azevedo I Vaz LG | 2007 | Rev Port Pneumol2007，13，4： | 1 |
| 12 | Effect of CNSL resin on the erystallinity of polypropylene in PP/NBR mixtures 显示文摘 | Sereda L Lopes L Nunes R C R et'al | 2001 | Polym Plast Teehnol Eng2001，40，3： | 1 |
| 13 | Pos - infectious bronchiolitis ob-litesrans in children 显示文摘 | Lobo AL Guardiano M Nunes T | 2007 | Rev Port Pneumd2007，13，4： | 1 |
| 14 | N-terminal proBNP levels in patients with Chagas disease :a marker of systolic and diastolic dysfunction of the left ventricle 显示文摘 | Barbosa MM Nunes Mdo C Ribeiro AL | 2007 | Eur J Echocardiogr2007，8，3： | 1 |
| 15 | Influence of the Doping and Annealing Atmosphere on Zinc Oxide Thin Films Deposited by Spray Pyrolysis 显示文摘 | Nunes P Malik Al | 1999 | Vacuum1999，52，12： | 1 |
| 16 | Effect of pacing in- duced ventrieuiar dyssynchrony on right ventrieular function 显示文摘 | Nunes MC Abreu CD Ribeiro AL | 2011 | Pacing Clin Electrophysiol2011，4，2： | 1 |
| 17 | Tissue-specific regulation of early steps in insulin action in septic rats显示文摘 | Nunes AL Carvalheira JB Carvalho CR | 2001 | Life Sci2001，69，18： | 1 |
| 18 | Posinfectious bron- chiolitis obliterans in children显示文摘 | Lobo AL Guardiano M Nunes T | 2007 | Rev Port Pneumol2007，13，4： | 1 |
| 19 | Chagas disease: an over-view of clinical and epidemiological aspects 显示文摘 | Nunes MC Dones W Morillo CA ef al | 2013 | J Am CollCardiol2013，62，9： | 1 |
| 20 | Functional biomarker signatures of circulating T-cells and its association with distinct clinical status of leprosy patients and their respective household contacts显示文摘Background: Leprosy is a chronic infectious disease classified into two subgroups for therapeutic purposes:paucibacillary(PB)and multibacillary(MB),closely related to the host immune responses.In this context it is noteworthy looking for immunological biomarkers applicable as complementary diagnostic tools as well as a laboratorial strategy to follow-up leprosy household contacts.Methods:: The cross-sectional study enrolled 49 participants,including 19 patients and 30 healthy controls.Peripheral blood mononuclear cells(PBMC)were isolated and incubated in the presence of Mycobacterium leprae bacilli.The cells were prepared for surface(CD4+and CD8+)and intracytoplasmic cytokine staining(IFN-γ,IL-4 and IL-10).Multiple comparisons amongst groups were carried out by ANOVA,Kruskal–Wallis,Student T or Mann–Whitney test.Comparative analysis of categorical variables was performed by Chi-square.Functional biomarker signature analysis was conducted using the global median values for each biomarker index as the cut-off edge to identify the proportion of subjects with high biomarker levels.Results: The cytokine signature analysis demonstrated that leprosy patients presented a polyfunctional profile of T-cells subsets,with increased frequency of IFN-γ+T-cell subsets along with IL-10+and IL-4+from CD4+T-cells,as compared to health Controls(Venn diagram report).Moreover,statistical analysis was carried out using parametric or non-parametric variance analysis followed by pairwise multiple comparisons,according to the data normality distribution.L(PB)displayed a polyfunctional profile characterized by enhanced percentage of IFN-γ+,IL-10+and IL-4+produced by most T-cell subsets,as compared to L(MB)that presented a more restricted cytokine functional profile mediated by IL-10+and IL-4+T-cells with minor contribution of IFN-γproduced by CD4+T-cells.Noteworthy was that HHC(MB)exhibited enhanced frequency of IFN-γ+T-cells,contrasting with HHC(PB)that presented a cytokine profile limited to IL-10 and IL-4.Conclusions: Our data demonstrated that L(PB)displayed enhanced percentage of IFN-γ+,IL-10+and IL-4+as compared to L(MB)that presented functional profile mediated by IL-10+and IL-4+T-cells and HHC(MB)exhibited enhanced frequency of IFN-γ+T-cells,contrasting with HHC(PB).Together,our findings provide additional immunological features associated with leprosy and household contacts.These data provide evidence that biomarkers of immune response can be useful complementary diagnostic/prognostic tools as well as insights that household contacts should be monitored to access putative subclinical infection. | Pedro Henrique Ferreira Marçal Rafael Silva Gama Lorena Bruna Pereira de Oliveira Olindo Assis Martins-Filho Roberta Olmo Pinheiro Euzenir Nunes Sarno Milton Ozório Moraes Lucia Alves de Oliveira Fraga | 2020 | Infectious Diseases of Poverty2020，9，6： | 1 |
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