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| 1 | 临床营养中糖溶液的最新进展显示文摘葡萄糖是肠外营养时最常选用的能量来源。虽然葡萄糖供能最符合生理情况,但在应激病人,如术后、严重感染及烧伤病人,葡萄糖对机体代谢有不利影响。为了改善治疗效果和减轻碳水化合物在代谢方面的不利影响,我们在动物和临床研究中观察了碳水化合物在代谢中的作用。利用14C标记的碳水化合物在大鼠中进行的示踪实验表明,在包括糖尿病的所有状态下,葡萄糖是最快转化为CO2的碳水化合物。给予应激状态(手术、糖尿病、严重感染)的兔和大鼠等热卡的碳水化合物溶液,这些溶液由葡萄糖、果糖和木糖醇以不同比例混合而成。在葡萄糖浓度低的一组,术后早期血清葡萄糖水平也低。在葡萄糖、果糖和木糖醇以8:4:2比例供给的一组,尿中葡萄糖和总糖的排出明显减少,而且这组的氮平衡较其它比例组为好。利用14C标记的葡萄糖进行的同位素示踪实验结果表明,葡萄糖、果糖和木糖醇以8:4:2比例供给在术后早期可增加葡萄糖的利用。利用15N标记的甘氨酸进行的同位素示踪实验结果表明,葡萄糖、果糖和木糖醇以8:4:2比例供给比单独使用葡萄糖明显增加术后肝脏的蛋白质合成。研究结果表明,葡萄糖、果糖和木糖醇以8:4:2比例供给有最好的代谢效应。这是因为:①输入液的葡萄糖浓度较低,血清葡萄糖水平也低;②较低? | Harumasa Ohyanagi MD.Ph.D 刘卫 | 2000 | 中国临床营养杂志2000，8，1： | 3 |
| 2 | An alternative,zeaxanthin epoxidase-independent abscisic acid biosynthetic pathway in plants显示文摘Abscisic acid(ABA)is an important carotenoid-derived phytohormone that plays essential roles in plant response to biotic and abiotic stresses as well as in various physiological and developmental processes.In Arabidopsis,ABA biosynthesis starts with the epoxidation of zeaxanthin by the ABA DEFICIENT 1(ABA1)enzyme,leading to epoxycarotenoids;e.g.,violaxanthin.The oxidative cleavage of 9-cis-epoxycaro-tenoids,a key regulatory step catalyzed by 9-C/S-EPOXYCAROTENOID DIOXYGENASE,forms xanthoxin,which is converted in further rea.ctions mediated by ABA DEFICIENT 2(ABA2),ABA DEFICIENT 3(ABA3),and ABSCISIC ALDEHYDE OXIDASE 3(AAO3)into ABA.By combining genetic and biochemical approaches,we unravel here an ABA1-independent ABA biosynthetic pathway starting upstream of zeaxanthin.We iden-tified the carotenoid cleavage products(i.e.,apocarotenoids,β-apo-11-carotenal,9-cis-β-apo-11-carotenal,3-OH-β-apo-11-carotenal,and 9-cis-3-OH-β-apo-11-carotenal)as intermediates of this ABA1-independent ABA biosynthetic pathway.Using labeled compounds,we showed thatβ-apo-11-carotenal,9-cis-β-apo-11-carotenal,and 3-OH-β-apo-11-carotenal are successively converted into 9-cis-3-OH-β-apo-11-carotenal,xanthoxin,and finally into ABA in both Arabidopsis and rice.When applied to Arabidopsis,theseβ-apo-11-carotenoids exert ABA biological functions,such as maintaining seed dormancy and inducing the expression of ABA-responsive genes.Moreover,the transcdptomic analysis revealed a high overlap of differentially expressed genes regulated byβ-apo-11-carotenoids and ABA,suggesting thatβ-apo-11-carot-enoids exert ABA-independent regulatory activities.Taken together,our study identifies a biological function for the common plant metabolites,β-apo-11-carotenoids,extends our knowledge about ABA biosynthesis,and provides new insights into plant apocarotenoid metabolic networks. | Kun-Peng Jia Jianing Mi Shawkat Ali Hajime Ohyanagi Juan C.Moreno Abdugaffor Ablazov Aparna Balakrishna Lamis Berqdar Alessia Fiore Gianfranco Diretto Claudio Martínez Angel R.de Lera Takashi Gojobori Salim Al-Babili | 2022 | Molecular Plant2022，15，1： | 2 |
| 3 | Graded material of diamond dispersed TiB2-Si composite by SHS/dynamic pseudo isostatic compaction显示文摘 | Ohyanagi M Tsujikami T Koizumi M | 1999 | Materials Science Forum1999，，： | 1 |
| 4 | Quantitative PCRfor detection of femtogran quantities of inierleukin-8 mRNA expression mi-crobiol显示文摘 | Ixutani R Ohyanagi H Macdermott P | 1994 | Immunol1994，38，3： | 1 |
| 5 | Pancreatic fistula after pancreatic head resection, incidence, significance and management 显示文摘 | Hashimoto N Yasude C Ohyanagi H | 2003 | Hepatogastrcentetology2003，50，53： | 1 |
| 6 | The effect of electrie field and pressure on the synthesis and consolidification of materials: a review of the spark plasma sintering method 显示文摘 | MUNIR Z A ANSELMI-TAMBURINI U OHYANAGI M | 2006 | Mater Sci2006，41，10： | 1 |
| 7 | Pancreatic fistula after pancreatic head resection,incidence,significance and management显示文摘 | Hashimoto N Yasude C Ohyanagi H | 2003 | Hepatogastroentetology2003，50，53： | 1 |
| 8 | Soybean proteome database: A data resource for plant differential proteamics显示文摘 | Sakata K Ohyanagi H Nobori H | 2009 | Journal of Proteome Research2009，8，7： | 1 |
| 9 | Acute gefitinib -induced pneumonitis显示文摘 | Ohyanagi F Ando Y Nagashima F | 2004 | Int J Clin Oncol2004，9，5： | 1 |
| 10 | Mechanism of increased alpha-adrenoceptor-mediated contraction in small resistance arteries of rats with heart failure显示文摘 | Koida S Ohyanagi M Ueda A | | 0，，1： | 1 |
| 11 | Pancreatic fistula after pancreatic head resection:incidence,significance and management显示文摘 | Hashimoto N Yasuda C Ohyanagi H | 2003 | Hepatogastroenterology2003，50，53： | 1 |
| 12 | Transient increase in plasma brain (B-type) natriuretic peptide after percutaneous transluminal coronary angioplasty 显示文摘 | Tateishi J Masutani M Ohyanagi M | 2000 | Clin Cardiol2000，23，： | 1 |
| 13 | A phase II study of S?1 in relapsed small cell lung cancer显示文摘 | Keita Kudo Fumiyosi Ohyanagi Atsushi Horiike Eisaku Miyauchi Hisashi Tahanaka Noriko Yanagitani Ryouta Saito Kyouhei Kaburaki Toshio Sakatani Takeshi Horai Makoto Nishio | 2013 | Molecular and Clinical Oncology2013，，2： | 1 |
| 14 | Soybean proteome database 2012: update on the comprehensive data repository for soybean proteomics显示文摘 | Ohyanagi H Sakata K Komatsu S | 2012 | Frontiers in plant science2012，3，3： | 1 |
| 15 | Pancreatic fistula afterpancreatic head resection:incidence,significance and manage-ment显示文摘 | Hashimoto N Yasuda C Ohyanagi H | 2003 | Hepatogas- troenterology2003，50，53： | 1 |
| 16 | Graded material of diamond dispersed TiB2-Si composite by SHS/ dynamic pseudo isostatic compaction 显示文摘 | OHYANAGI M TSUJIKAMI T SUGAHARA S | 1999 | Materials Science Forum1999，，： | 1 |
| 17 | Pemetrexed and cisplatin for advanced non-squamous non-small cell lung cancer in Japanese patients:phase Ⅱ study显示文摘 | Kawano Y Ohyanagi F Yanagitani N | 2013 | Anticancer Res2013，33，8： | 1 |
| 18 | Hepatobiliary scintigraphy after biliary reconstruction-a comparative study on Roux-Y and ESCD显示文摘 | Hashimoto N Ohyanagi H | 2000 | Hepatogastroenterology2000，47，35： | 1 |
| 19 | Effects of endothelium-derived hyperpolarizing factor and nitric oxide on endothelial function in femoral resistance arteries of spontaneously hypertensive rats显示文摘 | Yoshitomo MORI Mitsumasa OHYANAGI Satsuki KOIDA | 2006 | Hypertens Res2006，29，： | 1 |
| 20 | Clinical studies of perfluorochemical whole substitute (Fluosol - DA )显示文摘 | Harumasa Ohyanagi MD | 1982 | Ann Surg Jan1982，195，： | 1 |
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