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| 1 | Interventional treatment for unresectable hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the sixth most common cancer and third leading cause of cancer-related death in the world. The Barcelona clinic liver cancer classification is the current standard classification system for the clinical management of patients with HCC and suggests that patients with intermediate-stage HCC benefit from transcatheter arterial chemoembolization(TACE). Interventional treatments such as TACE, balloon-occluded TACE, drug-eluting bead embolization, radioembolization, and combined therapies including TACE and radiofrequency ablation, continue to evolve, resulting in improved patient prognosis. However, patients with advanced-stage HCC typically receive only chemotherapy with sorafenib, a multi-kinase inhibitor, or palliative and conservative therapy. Most patients receive palliative or conservative therapy only, and approximately 50% of patients with HCC are candidatesfor systemic therapy. However, these patients require therapy that is more effective than sorafenib or conservative treatment. Several researchers try to perform more effective therapies, such as combined therapies(TACE with radiotherapy and sorafenib with TACE), modified TACE for HCC with arterioportal or arteriohepatic vein shunts, TACE based on hepatic hemodynamics, and isolated hepatic perfusion. This review summarizes the published data and data on important ongoing studies concerning interventional treatments for unresectable HCC and discusses the technical improvements in these interventions, particularly for advanced-stage HCC. | Satoru Murata Takahiko Mine Fumie Sugihara Daisuke Yasui Hidenori Yamaguchi Tatsuo Ueda Shiro Onozawa Shin-ichiro Kumita | 2014 | World Journal of Gastroenterology2014，20，37： | 38 |
| 2 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 3 | Imanishi, The selective serotonin reuptake inhibitor fluvoxamine suppresses post-feeding hyperactivity induced by food restriction in rats显示文摘 | Yokoyama F Onozawa K Kakui N | 2007 | Pharmacol Biochem Behav2007，87，1： | 1 |
| 4 | Clinical study of varicocele :statistical analysis and the results of long-term follow-up显示文摘 | Onozawa M Endo F Suetomi T | 2002 | Int J Urol2002，9，8： | 1 |
| 5 | Elective nodal irradiation (ENI) in definitive chemoradiotherapy (CRT) for squamous cell carcinoma of the thoracic esophagus显示文摘 | Onozawa M Nihei K Ishikura S | 2009 | Radiother Oncol2009，92，： | 1 |
| 6 | Glue embolization for endoscopically unmanageable gastrointestinal haemorrhage显示文摘 | Murata S Onozawa S Nakazawa K | 2012 | Hepatogastroenterology2012，59，11： | 1 |
| 7 | A Retrospective Analysis of Allogeneic Hematopoietic Stem Cell Transplantation for Adult T Cell Leukemia/Lymphoma (ATL): Clinical Impact of Graft-versus-Leukemia/Lymphoma Effect显示文摘 | Souichi Shiratori Atsushi Yasumoto Junji Tanaka Akio Shigematsu Satoshi Yamamoto Mitsufumi Nishio Satoshi Hashino Rena Morita Mutsumi Takahata Masahiro Onozawa Kaoru Kahata Takeshi Kondo Shuichi Ota Kentaro Wakasa Junichi Sugita Takao Koike Masahiro Asaka | 2008 | Biology of Blood and Marrow Transplantation2008，，7： | 1 |
| 8 | Analysis of the effect of hydrogen-radical annealing for SiO2 passivation显示文摘 | H Ikeda H Nagayoshi Y Onozawa | 1997 | Solar Energy Materials and Solar Cells1997，48，： | 1 |
| 9 | Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high-affinity nerve growth factor receptors显示文摘 | Kakeya H Onozawa C Sato M | 1997 | J Med Chem1997，40，4： | 1 |
| 10 | Modified folfox-6 therapy for heavily pretreated advanced gastric cancer refractory to fluorouracil, irinotecan, cisplatin and taxanes: A retrospective study显示文摘 | Tsuji K Yasui H Onozawa Y | 2012 | Japanese Journal of Clinical Oncology2012，42，8： | 1 |
| 11 | Elective nodal irradia- tion (END in definitive chemoradiotherapy (CRT) for squamous cell carcinoma of the thoracic esophagus显示文摘 | Onozawa M Nihei K Ishikura S | 2009 | Radiother Oncol2009，92，2： | 1 |
| 12 | HB vac- cination in the prevention of viral reactivation in allogeneic hematopoietic stem cell transplantation recipients with pre- vious HBV infection 显示文摘 | ONOZAWA M HASHINO S DARMANIN S | 2008 | Biol Blood Marrow Transplangt2008，14，： | 1 |
| 13 | Elective nodal irradiation (ENI) in definitive chemoradiotherapy (CRT) for squamous cell carcinoma of the thoracic esophagus 显示文摘 | Onozawa M Nihei K Ishikura S | 2009 | Radiotherapy and Oncology2009，92，2： | 1 |
| 14 | Effects of soybean isoflavones on cell growth and apoptosis of the hu- man prostatic cancer cell line LNCap显示文摘 | ONOZAWA M FUKUDA K OHTAN M | 1998 | Jpn Jclin Oncol1998，28，： | 1 |
| 15 | Evaluation of welding process in diffusion welding joints of dissimilar metals显示文摘 | Tamura K Onozawa M | 1998 | 7th European Conference on Non destructive Testing1998，，5： | 1 |
| 16 | Rainfall interception in a Moso bamboo (PhyUostachys pubescens) forest 显示文摘 | ONOZAWA Y CHIWA M KOMATSU H | 2009 | Journal of Forest Research2009，14，： | 1 |
| 17 | Weekly paclitaxel for heavily treated advanced or recurrent gastric cancer refractory to fluorouracil, irinotecan, and cisplatin显示文摘 | Rai Shimoyama Hirofumi Yasui Narikazu Boku Yusuke Onozawa Shuichi Hironaka Akira Fukutomi Kentaro Yamazaki Keisei Taku Takashi Kojima Nozomu Machida Akiko Todaka Hideharu Tomita Takeshi Sakamoto Takahiro Tsushima | 2009 | Gastric Cancer2009，，4： | 1 |
| 18 | Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vi- vo and in vitro studies显示文摘 | Swellam T Miyanaga N Onozawa M | 2003 | Imernational Journal of Urology2003，10，4： | 1 |
| 19 | Endoscopic biliary drainage using guidewire cannulation in a case with severe duodenal stenosis caused by duodenal undifferentiated carcinoma显示文摘 | Matsubayashi H Kakushima N Onozawa Y | 2010 | Case Rep Gastroenterol2010，4，1： | 1 |
| 20 | HB vaccination in the prevention of viral reactivation in allogenic hematopietic stem cell transplantation re- cipients with previous HBV infection显示文摘 | ONOZAWA M HASHINO S DARMANIN S | 2008 | Biol Blood Marrow Transplant2008，14，： | 1 |
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