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| 1 | Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs显示文摘AIM:To study the effects of 5-hydroxytryptamine(5-HT)receptor antagonists on normal colonic motor activity in conscious dogs.METHODS:Colonic motor activity was recorded using a strain gauge force transducer in 5 dogs before and after 5-HT2B,5-HT3 and 5-HT4 receptor antagonist administration.The force transducers were implanted on the serosal surfaces of the gastric antrum,terminal ileum,ileocecal sphincter and colon.Test materials or vehicle alone was administered as an intravenous bolus injection during a quiescent period of the whole colon in the interdigestive state.The effects of these receptor antagonists on normal gastrointestinal motor activity were analyzed.RESULTS:5-HT2B,5-HT3 and 5-HT4 receptor antagonists had no contractile effect on the fasting canine terminal ileum.The 5-HT3 and 5-HT4 receptor antagonists inhibited phaseⅢof the interdigestive motor complex of the antrum and significantly inhibited colonic motor activity.In the proximal colon,the inhibitory effect was dose dependent.Dose dependency,however,was not observed in the distal colon.The 5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity.CONCLUSION:The 5-HT3 and 5-HT4 receptor antagonists inhibited normal colonic motor activity.The5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity. | Hiroki Morita Erito Mochiki Nobuyuki Takahashi Kiyoshi Kawamura Akira Watanabe Toshinaga Sutou Atsushi Ogawa Mitsuhiro Yanai Kyoichi Ogata Takaaki Fujii Tetsuro Ohno Souichi Tsutsumi Takayuki Asao Hiroyuki Kuwano | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Improved techniques for double-balloon-enteroscopy-assisted endoscopic retrograde cholangiopancreatography显示文摘AIM: To investigate the clinical outcome of double balloon enteroscopy (DBE)-assisted endoscopic retrograde cholangiopancreatography (DB-ERCP) in patients with altered gastrointestinal anatomy. METHODS: Between September 2006 and April 2011, 47 procedures of DB-ERCP were performed in 28 patients with a Roux-en-Y total gastrectomy (n = 11), Billroth Ⅱ gastrectomy (n = 15), or Roux-en-Y anastomosis with hepaticojejunostomy (n = 2). DB-ERCP was performed using a short-type DBE combined with several technical innovations such as using an endoscope attachment, marking by submucosal tattooing,selectively applying contrast medium, and CO2 insufflations. RESULTS: The papilla of Vater or hepaticojejunostomy site was reached in its entirety with a 96% success rate (45/47 procedures). There were no significant differences in the success rate of reaching the blind end with a DBE among Roux-en-Y total gastrectomy (96%), Billroth Ⅱ reconstruction (94%), or pancreatoduodenectomy (100%), respectively (P = 0.91). The total successful rate of cannulation and contrast enhancement of the target bile duct in patients whom the blind end was reached with a DBE was 40/45 procedures (89%). Again, there were no significant differences in the success rate of cannulation and contrast enhancement of the target bile duct with a DBE among Roux-en-Y total gastrectomy (88 %), Billroth Ⅱ reconstruction (89%), or pancreatoduodenectomy (100%), respectively (P = 0.67). Treatment was achieved in all 40 procedures (100%) in patients whom the contrast enhancement of the bile duct was successful. Common endoscopic treatments were endoscopic biliary drainage (24 procedures) and extraction of stones (14 procedures). Biliary drainage was done by placement of plastic stents. Stones extraction was done by lithotomy with the mechanical lithotripter followed by extraction with a basket or by the balloon pull-through method. Endoscopic sphincterotomy was performed in 14 procedures with a needle precutting knife using a guidewire. The mean total duration of the procedure was 93.6 ± 6.8 min and the mean time required to reach the papilla was 30.5 ± 3.7 min. The mean time required to reach the papilla tended to be shorter in Billroth Ⅱ reconstruction (20.9 ± 5.8 min) than that in Roux-en-Y total gastrectomy (37.1 ± 4.9 min) but there was no significant difference (P = 0.09). A major complication occurred in one patient (3.5%); perforation of the long limb in a patient with Billroth Ⅱ anastomosis.CONCLUSION: Short-type DBE combined with several technical innovations enabled us to perform ERCP in most patients with altered gastrointestinal anatomy. | Takashi Osoegawa Yasuaki Motomura Kazuya Akahoshi Naomi Higuchi Yoshimasa Tanaka Terumasa Hisano Souichi Itaba Junya Gibo Mariko Yamada Masaru Kubokawa Yorinobu Sumida Hirotada Akiho Eikichi Ihara Kazuhiko Nakamura | 2012 | World Journal of Gastroenterology2012，18，46： | 7 |
| 3 | Hepatitis B virus reactivation with a rituximab-containing regimen显示文摘Rituximab is currently used not only in the treatment of B-cell lymphoma but also for various other diseases, including autoimmune diseases, post-transplant graft vs host disease, and rejection following kidney transplants. Due to rituximab's widespread use, great progress has been made regarding research into complications that arise from its use, one of the most serious being the reactivation of hepatitis B virus(HBV), and efforts continue to establish guidelines for preventive treatment against this occurrence. This report discusses preventive measures against rituximab-induced HBV reactivation and future objectives. | Yutaka Tsutsumi Yoshiya Yamamoto Shinichi Ito Hiroyuki Ohigashi Souichi Shiratori Hirohito Naruse Takanori Teshima | 2015 | World Journal of Hepatology2015，7，21： | 5 |
| 4 | Galectin-9 expression links to malignant potential of cervical squamous cell carcinoma显示文摘 | Meiyan Liang Masaki Ueno Souichi Oomizu Tomohiro Arikawa Rika Shinonaga Shulan Zhang Akira Yamauchi Mitsuomi Hirashima | 2008 | Journal of Cancer Research and Clinical Oncology2008，，8： | 1 |
| 5 | A Retrospective Analysis of Allogeneic Hematopoietic Stem Cell Transplantation for Adult T Cell Leukemia/Lymphoma (ATL): Clinical Impact of Graft-versus-Leukemia/Lymphoma Effect显示文摘 | Souichi Shiratori Atsushi Yasumoto Junji Tanaka Akio Shigematsu Satoshi Yamamoto Mitsufumi Nishio Satoshi Hashino Rena Morita Mutsumi Takahata Masahiro Onozawa Kaoru Kahata Takeshi Kondo Shuichi Ota Kentaro Wakasa Junichi Sugita Takao Koike Masahiro Asaka | 2008 | Biology of Blood and Marrow Transplantation2008，，7： | 1 |
| 6 | Interaction of N ecl‐4/ CADM 4 with E rb B 3 and integrin α6β4 and inhibition of E rb B 2/ E rb B 3 signaling and hemidesmosome disassembly显示文摘 | Hirokazu Sugiyama Kiyohito Mizutani Souichi Kurita Naomasa Okimoto Yohei Shimono Yoshimi Takai | 2013 | Genes Cells2013，，6： | 1 |
| 7 | Kinetic study of the quenching reaction of singlet oxygen by tea catechins in ethanol solution显示文摘 | Kazuo Mukai Souichi Nagai Keishi Ohara | 2005 | Free Radical Biology and Medicine2005，，6： | 1 |
| 8 | Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice显示文摘 | Tsuneaki Kawashima Yasutaka Inuzuka Junji Okuda Takao Kato Shinichiro Niizuma Yodo Tamaki Yoshitaka Iwanaga Akira Kawamoto Michiko Narazaki Tetsuya Matsuda Souichi Adachi Genzou Takemura Toru Kita Takeshi Kimura Tetsuo Shioi | 2011 | Journal of Molecular and Cellular Cardiology2011，，6： | 1 |
| 9 | A weight average method to improve the uncertainty of length measurement in a two-color interferometer 显示文摘 | ZENG Lijiang Souichi Telada Katuo Sta: et a/ | 2001 | OPtics Commulllcaltons (S0030-4018)2001，187，： | 1 |
| 10 | Nifedipine and arotinolol in combination for accelerated malignant hypertension:result of one year follow-up显示文摘 | Hidetoma N Hironori Souichi S | 1999 | Hypertens Res1999，22，2： | 1 |
| 11 | Synthesis of Pep tide analogues containing (2-aminoethyl) phosphonic acid显示文摘 | SOUICHI OHTSUKI MASAYOSHI KINOSHITA | 1984 | J Org Chem1984，49，： | 1 |
| 12 | Nifedipine and arotinolol in combination for accelerated malignant hypertension; result of one year follow-up显示文摘 | Hidetomal N Hironori Souichi S | 1999 | Hypertens Res1999，22，2： | 1 |
| 13 | Endoscopic clip application for closure of esophageal perforations caused by EMR显示文摘 | Yuichi Shimizu Mototsugu Kato Junji Yamamoto Souichi Nakagawa Yoshito Komatsu Hiroyuki Tsukagoshi Masahiro Fujita Masao Hosokawa Masahiro Asaka | 2004 | Gastrointestinal Endoscopy2004，，4： | 1 |
| 14 | Increased interlenkin-6 levels in peritoneal fluid of infertile patients with active endometriosis显示文摘 | Harada T Hiroki Y Souichi Y | 1997 | Am J Obstet Gynecol1997，176，3： | 1 |
| 15 | Comparison of the free and DNA-complexed folans of the DNA-binding domain of c-MYB显示文摘 | KAZUHIRO O SOUICHI M HARUKI N HIRONOBU H SHOKO Y RUOHENG Z SABURO A YUKO A ZENZO H AKINORI S N SHUNSUKE I YOSHIFUMI N | 1995 | Natural Structural Biology1995，2，10： | 1 |
| 16 | Macrophage-acti vating lipopeptide-2 induces cyclooxygenase-2 and prostaglandin E2 via toll-like receptor 2 in human placental trophoblast cells 显示文摘 | Masahiro Mitsunari Souichi Yoshida | 2006 | J Reprod lmmunol2006，71，12： | 1 |
| 17 | Cell surface galectin-9 expressing Th ceils regulate Thl7 and Foxp3+ Treg development by galectin-9 secretion显示文摘 | Souichi O Tomohiro A Toshiro N | 2012 | PLoS One2012，7，48： | 1 |
| 18 | Activation of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Induces Apoptosis in Cultured Neonatal Rat Cardiac Myocytes显示文摘 | Eri Iwai-Kanai Koji Hasegawa Tatsuya Sawamura Masatoshi Fujita Tetsuhiko Yanazume Shinya Toyokuni Souichi Adachi Yasuki Kihara Shigetake Sasayama | 2001 | Circulation: Journal of the American Heart Association2001，，24： | 1 |
| 19 | Comparison of polybrominated diphenyl ethers in fish, vegetables, and meats and levels in human milk of nursing women in Japan显示文摘 | Souichi Ohta Daisuke Ishizuka Hajime Nishimura Teruyuki Nakao Osamu Aozasa Yoshiko Shimidzu Fumie Ochiai Takafumi Kida Masatoshi Nishi Hideaki Miyata | 2002 | Chemosphere2002，，： | 1 |
| 20 | Cementless Total Hip Arthroplasty in Hip Dysplasia with an Extensively Porous-Coated Cylindrical Stem Modified for Asians: A 12-Year Follow-Up Study显示文摘 | Tsutomu Kato Takuya Otani Hajime Sugiyama Tetsuo Hayama Souichi Katsumata Keishi Marumo | 2015 | The Journal of Arthroplasty2015，，6： | 1 |
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