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| 1 | Genetically modified mouse models for the study of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 diabetes.NAFLD represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) cirrhosis.The animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of NASH.The study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely understood.The different mouse models can be classified in two large groups.The first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological manipulation.Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of NAFLD.Ideal animal models for NASH should closely resemble the pathological characteristics observed in humans.To date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human disease.Therefore,it is important that the researchers choose the appropriate animal model.This review discusses various genetically modified animal models developed and used in research on NAFLD. | Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma | 2012 | World Journal of Gastroenterology2012，18，11： | 7 |
| 2 | Seasonal variations of phytoplankton diversity in the Coleroon coastal waters,southeast coast of India显示文摘The results of an investigation carried out during June 2005 to May 2007 on physico-chemical parameters,species composition and community structure of phytoplankton including Chlorophyll a(Chl-a) at the Coleroon coastal waters(Southeast coast of India) are reported.Air and surface water temperatures(°C) varied from 25.1 to 30.1 and from 24.5 to 28.5 respectively.Salinity values varied from 6 to 28.5 and the pH ranged between 7.0 and 8.3.Variation in dissolved oxygen content was from 3.1 to 7.5 mg/dm-3 while the light extinction coefficient values(LEC) ranged between 3.1 and 10.1 cm.The ranges of inorganic nutrients(μmol/dm-3) viz.,nitrate,nitrite,phosphate and silicate were 10.1-23.4,1.2-8.9,0.2-3.1 and 55-125,respectively.The ranges of Chlorophyll a(μg/dm-3) values was 2.0-7.5.Presently,124 phytoplankton species representing different classes viz:Bacillariophyceae(77),Dinophyceae(19),Cyanophyceae(15),Chlorophyceae(10) and Chrysophyceae(3) were recorded.The phytoplankton cell abundance varied from 0.290 to 111.662 cells/cm-3,with peak diversity(3.38 bits/ind.) during summer season.The maximum abundance was found during summer season coinciding with the stable hydrographical conditions.The seasonal distribution and abundance of phytoplankton are discussed in relation to hydrographical parameters.Canonical Correspondence Analysis(CCA) was applied in this paper for discriminating environmental factors having effect on phytoplankton community at species level.Coleroon coastal water is subjected to long term fluctuations in physico-chemical parameters depending upon the seasonal tidal amplitude and freshwater influx resulting in a continuous exchange of organic,inorganic,plant and animal matters. | Thillai Rajasekar K Rajkumar M SUN Jun Ashok Prabu V Perumal P | 2010 | Acta Oceanologica Sinica2010，29，5： | 3 |
| 3 | Functional role of P-glycoprotein in limiting peroral drug absorption:optimizing drug delivery显示文摘 | Varma M V Perumal O P Panchagnula R | 2006 | Curr Opin Chem Biol2006，10，4： | 1 |
| 4 | Proteomic analysis of cytoplasmic and surface proteins from yeast cells, hyphae, and biofilms of Candida albicans 显示文摘 | Montserrat M G Perumal P Mekala S | 2009 | Proteomics2009，9，8： | 1 |
| 5 | A study on the binding interaction between the imidazole derivative and bovine serum albumin by fluorescence spectroscopy显示文摘 | JAYABHARATHI J THANIKACHALAM V PERUMAL M V | 2012 | Journal of luminescence2012，132，3： | 1 |
| 6 | Early detection of tumor response to chemotherapy by 3′-deoxy-3′-[18 F]fluorothymidine positron emission tomography:the effect of cisplatin on a fibrosarcoma tumor model in vivo显示文摘 | Leyton J Latigo JR Perumal M | | 0，，： | 1 |
| 7 | Novel patterns of functional electrical stimulation have an immediate effect on dorsiflexor muscle function during gait for people poststroke显示文摘 | Kesar T M Perumal R Jancosko A | | 0，，01： | 1 |
| 8 | Interventional mana gement of chronic pain显示文摘 | Nocom G Ho KY Perumal M | | 0，，02： | 1 |
| 9 | Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity显示文摘 | Chan F Sun C Perumal M | 2007 | Mol Cancer Ther2007，6，121： | 1 |
| 10 | Functional electrical stimulation of ankle plantarflexor and dorsiflexor muscles effects on poststroke gait显示文摘 | Kesar T M Perumal i:< Reisman D S | 2009 | Stroke2009，40，12： | 1 |
| 11 | Photosynthesis and plant growth response of transgenic Bt cotton hybrids under field condition 显示文摘 | Hebbar K B Perumal N K Khadi B M | 2007 | Photosynthetica2007，45，2： | 1 |
| 12 | Molecular mapping ofCg1,a gene for resistanceto anthracnose(Colletotrichum subline-olum)in sorghum显示文摘 | Perumal R Menz M A Mehta P J | 2009 | Euphytica2009，165，： | 1 |
| 13 | Morin ameliorates chemically induced liver fibrosis in vivo and inhibits stellate cell proliferation in vitro by suppressing Wnt/β-cateninsignaling显示文摘 | Perumal MK Perumal NK Samidurai M | 2014 | Toxicology and Applied Pharmacology2014，277，： | 1 |
| 14 | A study on the binding interaction between the imidazole derivative and bovine serum albumin by fluorescence spectroscopy 显示文摘 | Jayabharathi J Thanikachalam V Perumal M V | 2012 | Lumin2012，132，3： | 1 |
| 15 | L-proline-catalysed novel tandem reactions of 1-substituted piperidin-4-ones with (E)-4-arylbut-3-en-2-ones:N-substituent mediated product selectivity and synthesis of novel nitrogen heterocycles 显示文摘 | Srinivasan M Perumal S | 2007 | Tetrahedron2007，63，： | 1 |
| 16 | Modulation of P- selection and platelet aggregation in chronic periodontitis: A clinical study 显示文摘 | Perumal R Rajendran M Krishnamurthy M | 2014 | J Indian Soc Periodontol2014，18，3： | 1 |
| 17 | Humidification studies on polymer electrolyte membrane fuel cell显示文摘 | Sridhar P Perumal R rajalakshmi N Raja M | 2001 | J Power Sources2001，101，1： | 1 |
| 18 | Formulation of rate-modulating pellets for the release of ibuprofen : an extrusion- spheronisation process 显示文摘 | LUTCHMAN D DANGOR C M PERUMAL D | 2005 | J Microencapsul2005，22，6： | 1 |
| 19 | The uptake of 3' -deoxy-3' -fluorothymidine into L5178Y tu- mours in vivo is dependent on thymidine kinase 1 protein levels 显示文摘 | BARTHEL H PERUMAL M LATIGO J | 2005 | Eur J Nucl Med Mol Imaging2005，32，3： | 1 |
| 20 | Structural analysis of mechanically alloyed nanocrystalline Fe75Si15Al10 powders显示文摘 | Kalita M P C Perumal A Srinivasan A | | 0，，03： | 1 |
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