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| 1 | Transjugular intrahepatic portosystemic shunt vs endoscopic therapy in preventing variceal rebleeding显示文摘AIM:To compare early use of transjugular intrahepatic portosystemic shunt(TIPS) with endoscopic treatment(ET) for the prophylaxis of recurrent variceal bleeding.METHODS:In-patient data were collected from 190 patients between January 2007 and June 2010 who suffured from variceal bleeding.Patients who were older than 75 years;previously received surgical treatment or endoscopic therapy for variceal bleeding;and complicated with hepatic encephalopathy or hepatic cancer,were excluded from this research.Thirty-five cases lost to follow-up were also excluded.Retrospective analysis was done in 126 eligible cases.Among them,64 patients received TIPS(TIPS group) while 62 patients received endoscopic therapy(ET group).The relevant data were collected by patient review or telephone calls.The occurrence of rebleeding,hepatic encephalopathy or other complications,survival rateand cost of treatment were compared between the two groups.RESULTS:During the follow-up period(median,20.7 and 18.7 mo in TIPS and ET groups,respectively),rebleeding from any source occurred in 11 patients in the TIPS group as compared with 31 patients in the ET group(Kaplan-Meier analysis and log-rank test,P = 0.000).Rebleeding rates at any time point(6 wk,1 year and 2 year) in the TIPS group were lower than in the ET group(Bonferroni correction α' = α/3).Eight patients in the TIPS group and 16 in the ET group died with the cumulative survival rates of 80.6% and 64.9%(Kaplan-Meier analysis and log-rank test c2 = 4.864,P = 0.02),respectively.There was no significant difference between the two groups with respect to 6-wk survival rates(Bonferroni correction α' = α/3).However,significant differences were observed between the two groups in the 1-year survival rates(92% and 79%) and the 2-year survival rates(89% and 64.9%)(Bonferroni correction α' = α/3).No significant differences were observed between the two treatment groups in the occurrence of hepatic encephalopathy(12 patients in TIPS group and 5 in ET group,KaplanMeier analysis and log-rank test,c2 = 3.103,P = 0.08).The average total cost for the TIPS group was higher than for ET group(Wilcxon-Mann Whitney test,52 678 RMB vs 38 844 RMB,P < 0.05),but hospitalization frequency and hospital stay during follow-up period were lower(Wilcxon-Mann Whitney test,0.4 d vs 1.3 d,P = 0.01;5 d vs 19 d,P < 0.05).CONCLUSION:Early use of TIPS is more effective than endoscopic treatment in preventing variceal rebleeding and improving survival rate,and does not increase occurrence of hepatic encephalopathy. | Hui Xue Meng Zhang Jack XQ Pang Fei Yan Ying-Chao Li Liang-Shan Lv Jia Yuan Muna Palikhe Wei-Zhi Li Zhi-Lun Wang | 2012 | World Journal of Gastroenterology2012，18，48： | 17 |
| 2 | A hydrocarbon enrichment model and prediction of favorable accumulation areas in complicated superimposed basins in China显示文摘The geologic conditions of superimposed basins in China are very complicated. This is mainly shown by multi-phase structural evolution,multiple sets of source-reservoir-cap rock combinations,multiple stages of hydrocarbon generation and expulsion from source rocks,multi-cycle hydrocarbon enrichment and accumulation,and multi-phase reservoir adjustment and reconstruction. The enrichment,accumulation and distribution of hydrocarbon is mainly controlled by the source rock kitchen,paleoanticline,regional cap rock and intensity of tectonic movement. In this paper,the T-BCMS model has been developed to predict favorable areas of hydrocarbon accumulation in complicated superimposed basins according to time and spatial relationships among five key factors. The five factors include unconformity surface representing tectonic balancing(B) ,regional cap rock representing hydrocarbon protection(C) ,paleo-anticline representing hydrocarbon migration and accumulation(M) ,source rock kitchen representing hydrocarbon generation and expulsion(S) and geological time(T) . There are three necessary conditions to form favorable areas of hydrocarbon accumulation. First,four key factors BCMS should be strictly in the order of BCMS from top to bottom. Second,superimposition of four key factors BCMS in the same area is the most favorable for hydrocarbon accumulation. Third,vertically ordered combination and superimposition in the same area of BCMS should occur at the same geological time. The model has been used to predict the most favorable exploration areas in Ordovician in the Tarim Basin in the main hydrocarbon accumulation periods. The result shows that 95% of the discovered Ordovician hydrocarbon reservoirs are located in the predicted areas,which indicates the feasibility and reliability of the key factor matching T-BCMS model for hydrocarbon accumulation and enrichment. | Pang Xiongqi Meng Qingyang Jiang Zhenxue Liu Luofu Lu Xiuxiang | 2010 | Petroleum Science2010，7，1： | 16 |
| 3 | One-phase treatment for calculous pyonephrosis by percutaneous nephrolithotomy assisted by EMS LithoClast master显示文摘The one-phase therapy for calculous pyonephrosis through percutaneous nephrolithotomy (PCNL) is currently vigorously debated.After a definite preoperative diagnosis of pyonephrosis,the traditional approach1 has been initial drainage through puncture and nephrostomy.Upon the stabilization of symptoms,a second-phase operation is performed.If pus is discovered during an intra-operative puncture,a nephrostomy tube is deposited until a second elective operation.With the advancements of science and technology,the third generation EMS LithoClast master is capable of not only efficiently crushing and removing the stones,but also lowering the intra-pelvic pressure through vacuum suction.Thus the surgical risks have been greatly reduced so that many one-phase operations for calculous pyonephrosis may be completed.2 Ever since the application of EMS LithoClast master at our department since 2006,a total of 128 patients with calculous pyonephrosis have been surgically cured within one single phase.No overt complication was observed.In conjunction with the study results of high-pressure perfusion in animal models of pyonephrosis,a report was compiled as below. | WANG Jian ZHOU Da-qing HE Meng LI Wen-gang PANG Xiang YU Xiao-xiang JIANG Bo | 2013 | Chinese Medical Journal2013，，8： | 15 |
| 4 | Myofibroblastic sarcomas:a clinicopathological study of 20 cases显示文摘背景 Myofibroblastic 肉瘤是是一个争论的瘤。这研究调查了 myofibroblastic 肉瘤在不同 locations.Methods 产生的 20 个案例的 clinicopathological 特征从有 myofibroblastic 肉瘤的病人的 20 个案例的嵌入石蜡的织物样品 immunohistochemically 被染色,并且 5 个案例由电子显微镜学检验了。学生的 t 测试被用来分析组织学地把在等级 1 和等级 2 myofibroblastic sarcomas.Results 之间的索引标记的 Ki-67 的差别,肿瘤是有嗜曙红的细胞质的苗条锭子房间镇静、纺锤形、尖端细、起浪,或丰满卵形;小囊的原子核和小中央嗜曙红的 nucleoli。Immunohistochemically,表示的肿瘤房间弄平肌肉肌动朊(18/20 ) ,肌肉特定的肌动朊(16/20 ) , fibronectin (20/20 ) 和 desmin (2/20 ).Ultrastructurally,肿瘤房间表明丰富的不平的 endoplasmic 蜂窝胃和纵在细胞质与焦点的密度安排了好细丝。19 个病人的临床的后续证明 2 个案例经历了本地复发和远转移 6 个月到在起始的手术以后的 4 年。九个盒子局部地复发了在起始的切除以后的 17 ~ 46 个月,和 9 个盒子没有肉瘤,展出多样的组织学的外观,能容易作为良性的肿瘤被误诊的 disease.Conclusions Myofibroblastic 的证据是活着的。Myofibroblastic 肉瘤是有经常的复发的本地破坏损害,并且可以转移远地。 | MENG Guo-zhao ZHANG Hong-ying BU Hong ZHANG Xian-liang PANG Zong-guo KE Qi LIU Xi YANG Guo | 2007 | Chinese Medical Journal2007，，5： | 11 |
| 5 | Pregnancy outcomes and risk factors for low birth weight and preterm delivery among HIV-infected pregnant women in Guangxi, China显示文摘在中国的背景六省在 2009 和五个省在这个国家说明了所有报导 HIV/AIDS 案例的 70-80 说明了属于的 HIV cases.Because Guangxi 的 78 所有报导 mother-to-child 传播( MTCT )两个组,加节目的 Mother-to-Child 传播( PMTCT )的预防在那里被建立理解更好低的出生重量( LBW )和 preterm 交货( PD )出生结果和他们的联系风险因素 better.Methods 怀孕结果被检验在之中95 CI 1.11-25.55 ) 并且 CD4 房间计数 100-199 cells/l (AOR 3.40;95 Cl 1.03-11.25,与 CD4 房间计数 350 cells/l 相比) , gestational 年龄 37 星期(AOR 4.38;95 CI 1.29-14.82,与 37 个星期相比) ,母亲的重量 45 kg (AOR 5.64;95 Cl 1.09-29.07 ) 并且母亲的重量 45-54 kg (AOR 3.55;95 Cl 1.31-9.60,与 55 kg 相比) 在注册,和 HIV RNA 100 在注册的 000 copies/ml (AOR 4.22;95 Cl 1.24-14.32 ) 并且 20 000-99 999 (AOR 2.77;95 CI 1.01-7.77,与 20 000 copies/ml 相比) 与 LBW.For PD 的更高的风险被联系,仅仅母亲的注射药使用作为 HIV 传播的线路(AOR 5.30; 95 CI 1.33-21.14 ,与通过性传播感染 HIV 的那些相比)显著地与 PD.Conclusions 更低的 CD4 房间计数的更高的风险被联系,在注册的更高的 HIV RNA 病毒的负担与 LBW.Optimal 胎儿的照顾被联系包括更早胎儿的屏蔽和 HIV 诊断,对更早的 PMTCT 预防或 HIV treatent 批评阻止 HIV 的传播到婴儿并且也阻止 LBW 怀孕结果。 | Yu Lan Li Wen-ying Chen, Ray Y. Tang Zhi-rong Pang Jun Gui Xiu-zhi Meng Xiu-ning Zhang Fu-jie | 2012 | Chinese Medical Journal2012，，3： | 10 |
| 6 | A bHLH transcription activator regulates defense signaling by nucleo-cytosolic trafficking in rice显示文摘Crosstalk between plant hormone signaling pathways is vital for controlling the immune response during pathogen invasion.Salicylic acid(SA)and jas-monic acid(JA)often play important but antagonistic roles in the immune responses of higher plants.Here,we identify a basic helix-loop-helix transcription acti-vator,OsbHLH6,which confers disease resistance in rice by regulating SA and JA signaling via nucleo-cytosolic trafficking in rice(Oryza sativa).OsbHLH6 expression was upregulated during Magnaporthe oryzae infection.Transgenic rice plants overexpressing OsbHLH6 display increased JA responsive gene expression and enhanced disease susceptibility to the pathogen.Nucleus-localized OsbHLH6 activates JA signaling and suppresses SA signaling;however,the SA regulator OsNPR1(Nonexpressor of PR genes 1)sequesters OsbHLH6 in the cytosol to alleviate its effect.Our data suggest that OsbHLH6 controls disease re-sistance by dynamically regulating SA and JA signaling. | Fanwei Meng Chao Yang Jidong Cao Huan Chen Jinhuan Pang Qiqi Zhao Zongyi Wang Zheng Qing Fu Jun Liu | 2020 | Journal of Integrative Plant Biology2020，62，10： | 10 |
| 7 | Sorafenib inhibits proliferation and invasion of human hepatocellular carcinoma cells via up- regulation of p53 and suppressing FoxM1显示文摘目的: Forkhead 盒子 M1 (FoxM1 ) 是在人的癌症的致病和前进起重要作用的一个抄写因素,包括 hepatocellular 癌(HCC ) 。这研究的目的是在 sorafenib 的反癌症行动检验 FoxM1 的参与,一个 multikinase 禁止者,在人的 HCC 房间。 | Ji-chao WEI Fan-di MENG Kai QU Zhi-xin WANG Qi-fei WU Ling-qiang ZHANG Qing PANG Chang LIU | 2015 | Acta Pharmacologica Sinica2015，36，2： | 9 |
| 8 | The multi-factor recombination and processes superimposition model for hydrocarbon accumulation:application to the Silurian in the Tarim Basin显示文摘鉴于结构的进化, source-reservoir-seal 集合的多重集合,烃累积的多重周期和在建筑群的重新调整和重建的多重事件的多重事件的地质的特征附加了的烃,为烃累积的多因素再结合和过程重迭模型被提出在中国的盆。它是包括能帮助预言有利探索区域的理论和方法的一个系统。根据这个模型的意见,为在附加的盆的烃产生,进化和分发的基本纪律能在多因素再结合,过程重迭,油充满的多重阶段和最近的阶段保藏被总结。与是的 Tarim 盆的志留纪一个例子基于控制烃累积的四个因素(paleo背斜,来源岩石,地区性的帽子岩石和运动学的平衡带)的进化历史的重建,这个模特儿被收养预言有利的烃累积区域和在油充满的三个阶段跟随结构的破坏的有利探索区域,到在 Tarim basi | Meng Qingyang Pang Xiongqi Gao Jianbo | 2008 | Petroleum Science2008，5，1： | 8 |
| 9 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 10 | Multiple-Element Matching Reservoir Formation and Quantitative Prediction of Favorable Areas in Superimposed Basins显示文摘在韦斯特中国的附加的盆经历了多级式的构造事件和 multicycle 烃水库形成,并且复杂的烃水库在这种类型的盆广泛地被发现了。大多数复杂的烃水库被重定位,规模重建,部件变化和阶段国家转变描绘,并且他们的分布是很困难的预言。研究显示出那地区性的 caprock (C) ,高质量的沉积外形(存款, D ) , paleohighs (山, M ) 并且来源岩石(S) 是贡献复杂的烃水库形成和西方的附加的盆的分发的四个地质的元素。四个元素的纵的顺序的联合控制烃水库形成的阶层,并且平面重迭和联合控制烃水库的范围,他们在 geohistory 的同时的联合效果决定烃水库形成的时间。多重元素的匹配水库形成介绍水库形成的一个基本模式在里面附加的盆,和我们建议它被表示为 T-CDMS。基于多重元素的匹配水库形成模式,一个全面水库形成索引(Tcdms ) 在这篇论文被开发描绘水库形成条件,和一个方法被介绍在附加的盆预言水库形成范围和出现的概率。通过新理论,方法和技术的申请,在奥陶纪的出现的有利水库形成范围和概率在四个不同水库形成时期在 Tarim 盆指向地区被预言。结果证明中央 Tarim, Yinmaili 和 Lunnan 是奥陶纪油和煤气的地可能形成了的三个很有利的区域。有当前发现的烃水库的预言结果的巧合到达 97% 。这反映新理论,方法和技术的有效性和可靠性。 | WANG Huaijie PANG Xiongqi WANG Zhaoming YU Qiuhua HUO Zhipeng MENG Qingyang | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 8 |
| 11 | Principles of the roof cut short-arm beam mining method (110 method) and its mining-induced stress distribution显示文摘Since the 1960 s, mining science and technology in China has experienced two technical innovations, i.e.the ‘‘Masonry Beam Theory(MBT)' and ‘‘Transfer Rock Beam Theory(TRBT)'. Based on those theories, the conventional mining method(being called the 121 mining method) was established, consisting of excavating two tunnels with a pillar left for mining a working panel. However, with increasing mining depth,engineering geological disasters in the underground caverns have been frequently encountered. In addition, the use of the coal-pillar mining results in a large amount of coal resources unexploited. In order to address the problems above, the ‘‘Roof Cut Short-Arm Beam Theory(RCSBT), being called the 110 mining method)' was proposed by He Manchao in 2008. The 110 mining method features the mining of one coal seam panel, excavating necessarily only one roadway tunnel and leaving no pillars. Realization of the 110 mining method includes the following steps:(1) directional pre-splitting roof cutting,(2) supporting the roof by using high Constant Resistance Large Deformation bolt/cable(CRLD), and(3) blocking gangue by hydraulic props. This paper presents an overview of the principles, techniques and application of the 110 mining method. Special emphasis is placed on the numerical simulation of the geostress distribution found in the mining panel using the 110 method compared to that of the 121 method. In addition, the stress distribution on the ‘‘short beam' left by the roof cutting when performing the 110 method was also investigated using both numerical simulation and theoretical formulation. | Tao Zhigang Song Zhigang He Manchao Meng Zhigang Pang Shihui | 2018 | International Journal of Mining Science and Technology2018，28，3： | 8 |
| 12 | Formation Sites and Microscopic Conformation Study on the Konjac Glucomannan Molecular Helices显示文摘In this work,the formation sites,helical parameters and hydrogen bond positions of Konjac glucomannan molecular helices were investigated using molecular dynamic simulation method.To our interest,the KGM chain is mainly composed by local left and right helix structures. The formation sites of KGM chain might locate at the chain-segments containing acetyl groups,and the left helix is the favorable conformation of KGM.Temperature-dependent molecule conformation study indicates that the right helix is dominant when the temperature is lower than 343 K,above which,however,the left helix is dominating(right helix disappears).In addition,intramolecular hydrogen bonds in the left helix can be found at the-OH groups on C(2),C(4)and C(6)of mannose residues;comparably,the intramolecular hydrogen bonds in the right helix can be mainly observed at the-OH groups on C(4)and C(6)of the mannose residues and C(3)of the glucose residues.In conclusion,molecular dynamic simulation is an efficient method for the microscopic conformation study of glucomannan molecular helices. | JIAN Wen-Jie WANG Meng YAO Min-Na PANG Jie | 2010 | Chinese Journal of Structural Chemistry2010，29，7： | 7 |
| 13 | Molecular Dynamics Simulations of the Interactions Between Konjac Glucomannan and Soy Protein Isolate显示文摘The interactions between konjac glucomannan(KGM)and soy protein isolate(SPI)were studied with the method of molecular dynamics simulation.Part representative structures segments of KGM and SPI were used as mode,and the force-field was FF03.The stability and sites of KGM/SPI interactions in water were researched at 363 K with the following results:the potential energy(EPOT)of the mixed gel dropped,while that of single KGM gel increased.The surface area(SA)of KGM in the mixed system was decreased to 401.41 from 1 267.54 ?2,and that of SPI to 484.94 from 1 943.28 ?2.The sum potential energy of KGM and soy protein in the mixed system was decreased to-13 402.41 from-5 768.56 kcal mol-1.The variations of two parameters showed that the stability of compound gel KGM/SPI was improved,which was consistent with the previous studies.The sites of interactions in the mixed gel were the-OH groups on C(2)in KGM mannose and glucose,and the amide linkage group on Histidine,Asparagine and Leucine in SPI.The hydrogen bond was formed directly or indirectly by the bridge of waters. | WANG Meng YAO Min-na JIAN Wen-lie SUN Yu-jing PANG Jie | 2010 | Agricultural Sciences in China2010，9，10： | 7 |
| 14 | LncRNA AFAP1-AS1/miR-27b-3p/VEGF-C axis modulates stemness characteristics in cervical cancer cells显示文摘Background:Long non-coding RNA(lncRNA)actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1)functions as a competing endogenous RNA to regulate target genes expression by sponging microRNAs(miRs)to play cancer-promoting roles in cancer stem cells.However,the regulatory mechanism of AFAP1-AS1 in cervical cancer(CC)stem cells is unknown.The present study aimed to provide a new therapeutic target for the clinical treatment of CC.Methods:Hyaluronic acid receptor cluster of differentiation 44 variant exon 6(CD44v6)(+)CC cells were isolated by flow cytometry(FCM).Small interfering RNAs of AFAP1-AS1(siAFAP1-AS1)were transfected into the(CD44v6)(+)cells.The levels of AFAP1-AS1 were measured by quantitative real-time PCR(qRT-PCR).Sphere formation assay,cell cycle analysis,and Western blotting were used to detect the effect of siAFAP1-AS1.RNA pull-down and luciferase reporter assay were used to verify the relationship between miR-27b-3p and AFAP1-AS1 or vascular endothelial growth factor(VEGF)-C.Results:CD44v6(+)CCcells had remarkable stemness and a high level ofAFAP1-AS1.However,AFAP1-AS1knockdownwithsiAFAP1-AS1suppressed the cell cycle transitionofG(1)/S phase and inhibited self-renewal ofCD44v6(+)CCcells,the levels of the stemnessmarkers octamer-binding transcription factor 4(OCT4),osteopontin(OPN),and cluster of differentiation 133(CD133),and the epithelialmesenchymal transition(EMT)-related proteins Twist1,matrix metalloprotease(MMP)-9,and VEGF-C.In the mechanism study,miR-27b-3p/VEGF-C signaling was demonstrated to be a key downstream of AFAP1-AS1 in the CD44v6(+)CC cells.Conclusions:LncRNA AFAP1-AS1 knockdown inhibits the CC cell stemness by upregulating miR-27b-3p to suppress VEGF-C. | Meng Xia Li-Jun Duan Bi-Nan Lu Yu-Zhou Pang Zong-Ran Pang | 2021 | Chinese Medical Journal2021，，17： | 6 |
| 15 | Compression-related EMIC waves drive relativistic electron precipitation显示文摘With coordinated observations of the NOAA 15 satellite and OUL magnetometer station in Finland, we report that the electromagnetic ion cyclotron(EMIC) waves which were stimulated by the compression of the magnetosphere drive relativistic electron precipitation in geoquiescence on 1 Jan 2007. After an enhancement of solar wind dynamic pressure(SWDP), a dayside Pc1 pulsation was observed by the OUL station. Such a Pc1 pulsation is caused by an EMIC wave which propagates from the generation source to lower altitudes. Simultaneously, the NOAA 15 satellite registered an enhancement of precipitating electron count rates with energies >3 Me V within the anisotropic zone of protons. This phenomenon is coincident with the quasi-linear theoretical calculation presented in this paper. Our observations suggest that after a positive impulse of solar wind, the compression-related EMIC waves can drive relativistic electrons precipitation and play a pivotal role in the dynamic of radiation belts. | WANG De Dong YUAN Zhi Gang DENG Xiao Hua ZHOU Meng HUANG Shi Yong LI Ming LI Hui Min LI Hai Meng RAITA Tero PANG Ye | 2014 | Science China(Technological Sciences)2014，57，12： | 6 |
| 16 | Xyloketal B exerts antihypertensive effect in renovascular hypertensive rats via the NO-sGC-cGMP pathway and calcium signaling显示文摘Xyloketal B (Xyl-B ) 是从红树属植物真菌 Xylaria sp 孤立的新奇海洋的混合物。(没有 2508 ) 。我们以前证明 Xyl-B 支持了 endothelial 没有版本并且通过 Akt/eNOS 小径免于动脉粥样硬化。脉管没有生产在中央、外部的动脉调整血管缩小并且在血压控制起一个重要作用。在这研究,我们检验了 Xyl-B 是否在一个高血压的老鼠模型施加了 antihypertensive 效果,并且进一步探索了位于它的 antihypertensive 行动下面的可能的机制。Xyl-B 的管理(20 mg 档浥慩爯灥牥畦楳湯?? | Li-yan ZHAO Jie LI Xiong-qing HUANG Guo-hao WANG Xiao-fei LV Wei-feng MENG Wen-liang CHEN Ji-yan PANG Yong-cheng LIN Hong-shuo SUN Guan-lei WANG Yao-min DU | 2018 | Acta Pharmacologica Sinica2018，39，5： | 5 |
| 17 | Putrescine, spermidine, and spermine play distinct roles in rice salt tolerance显示文摘Polyamines(PAs) play diverse roles in plant growth and development,as well as responses to environmental stimuli.In this study,the effects of PAs on rice salt tolerance were investigated.Salt stress resulted in the alteration of endogenous PAs levels in rice roots and leaves,where spermidine(Spd) and spermine(Spm) contents were increased,and putrescine(Put) content was decreased.RT-qPCR analysis revealed that PAs biosynthesis-related genes ADC1,ODC,and Arginase were significantly downregulated by salt treatment;however,SAMDC transcription was significantly upregulated.Exogenous Spm enhanced rice salt tolerance remarkably;however,exogenous Put and Spd undermined rice salt tolerance.Transgenic rice plants overexpressing SAMDC display a higher ratio of Spm/(Put+Spd) and enhanced salt tolerance.Salt stress also increased polyamine oxidase activities in rice,resulting in elevated reactive oxygen species(ROS) production.Our findings revealed that accumulation of Put and Spd substantially reduced salt tolerance in rice,likely by facilitating ROS production;whereas,conversion of Put and Spd to Spm contributes to rice salt tolerance. | Md Azizul ISlam PANG Jin-huan MENG Fan-wei LI Ya-wen XU Ning YANG Chao LIU Jun | 2020 | Journal of Integrative Agriculture2020，19，3： | 5 |
| 18 | A free-standing superhydrophobic film for highly efficient removal of water from turbine oil显示文摘A free-standing superhydrophobic film is prepared by sequentially dip-coating a commercially available filter paper with nano SiO2 suspension, epoxy emulsion, and octyltrimethoxysilane solution. A surface with micro- or nano-roughness is formed because SiO2 nanoparticles are uniformly and firmly adhered on the backbone of the filter paper by the cured epoxy resin. Furthermore, the surface energy is significantly reduced because of introducing octytrimethoxysilane. Such a surface structure makes the prepared film a superhydrophobic material. Due to its free-standing nature, this superhydrophobic film can be used to remove water from turbine oil by filtration. The efficiency of water removal is high (up to 94.1%), and the filtration process is driven solely by gravity without extra energy consumption. Because of the facile fabrication process and the high efficiency of water removal, this free-standing superhydrophobic film may find application in power industry. | Fan Shu Meng Wang Jinbo Pang Ping Yu | 2019 | Frontiers of Chemical Science and Engineering2019，13，2： | 5 |
| 19 | Clinical guidelines of non-alcoholic fatty liver disease: A systematic review显示文摘AIM To perform a systematic review to grade guidelines and present recommendations for clinical management of non-alcoholic fatty liver disease(NAFLD).METHODS A database search was conducted on Pub Med for guidelines published before May 2016, supplemented by reviewing relevant websites. The Appraisal of Guidelines for Research and Evaluation(ARGEE) instrument Ⅱ was a tool designed to appraise the methodological rigor and transparency in which a clinical guideline is developed and it is used internationally. it was used to appraise the quality of guidelines in this study. The inclusion criteria include: clinical NAFLD guidelines for adults, published in English, and released by governmental agencies or key organizations.RESULTS Eleven guidelines were included in this study. Since 2007, guidelines have been released in Asia(3 in China, 1 in South Korea, and 1 in Japan), Europe(1 in italy),America(1 in United States and 1 in Chile) and three international agencies [European associations joint, Asia-Pacific Working Party and World Gastroenterology Organization(WGO)]. Using the ARGEE Ⅱ instrument, we found US 2012 and Europe 2016 had the highest scores, especially in the areas of rigor of development and applicability. Additionally, italy 2010 and Korea 2013 also presented comprehensive content, rigorous procedures and good applicability. And WGO 2014 offered various algorithms for clinical practice. Lastly, a practical algorithm for the clinical management was developed, based on the recommended guidelines.CONCLUSION This is the first systematic review of NAFLD guidelines. it may yield insights for physicians and policy-makers in the development and application of guidelines. | Jin-Zhou Zhu Kelseanna Hollis-Hansen Xing-Yong Wan Su-Juan Fei Xun-Lei Pang Fan-Dong Meng Chao-Hui Yu You-Ming Li | 2016 | World Journal of Gastroenterology2016，22，36： | 5 |
| 20 | Thermal comfort assessment in civil aircraft cabins显示文摘Aircraft passengers are more and demanding in terms of thermal comfort. But it is not yet easy for aircraft crew to control the environment control system(ECS) that satisfies the thermal comfort for most passengers due to a number of causes. This paper adopts a corrected predicted mean vote(PMV) model and an adaptive model to assess the thermal comfort conditions for 31 investigated flights and draws the conclusion that there does exist an uncomfortable thermal phenomenon in civil aircraft cabins, especially in some short-haul continental flights. It is necessary to develop an easy way to predict the thermal sensation of passengers and to direct the crew to control ECS. Due to the assessment consistency of the corrected PMV model and the adaptive model, the adaptive model of thermal neutrality temperature can be used as a method to predict the cabin optimal operative temperature. Because only the mean outdoor effective temperature ET* of a departure city is an input variable for the adaptive model, this method can be easily understood and implemented by the crew and can satisfy 80–90% of the thermal acceptability levels of passengers. | Pang Liping Qin Yue Liu Dong Liu Meng | 2014 | Chinese Journal of Aeronautics2014，27，2： | 5 |
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