|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Puerarin protects brain tissue against cerebral ischemia/reperfusion injury by inhibiting the inflammatory response显示文摘Puerarin, a traditional Chinese medicine, exerts a powerful neuroprotective effect in cerebral ischemia/reperfusion injury, but its mechanism is unknown. Here, we established rat models of middle cerebral artery ischemia/reperfusion injury using the suture method. Puerarin(100 mg/kg) was administered intraperitoneally 30 minutes before middle cerebral artery occlusion and 8 hours after reperfusion. Twenty-four hours after reperfusion, we found that puerarin significantly improved neurological deficit, reduced infarct size and brain water content, and notably diminished the expression of Toll-like receptor-4, myeloid differentiation factor 88, nuclear factor kappa B and tumor necrosis factor-α in the ischemic region. These data indicate that puerarin exerts an anti-inflammatory protective effect on brain tissue with ischemia/reperfusion damage by downregulating the expression of multiple inflammatory factors. | Feng Zhou Liang Wang Panpan Liu Weiwei Hu Xiangdong Zhu Hong Shen Yuanyuan Yao | 2014 | Neural Regeneration Research2014，9，23： | 27 |
| 2 | Rocky Desertification Risk Zone Delineation in Karst Plateau Area:A Case Study in Puding County,Guizhou Province显示文摘Karst rocky desertification is a geo-ecological problem in Southwest China.The rocky desertification risk zone delineation could be used as a guide for the regional and hierarchical rocky desertification management and prevention.We chose the middle and lower reaches of the Houzhai underground basin on the karst plateau in Puding County, Guizhou Province, China as the study area and selected land use type, elevation, slope, aspect, lithology and settlement buffer as the main driving factors of the rocky desertification.The potential risk of rocky desertification was quantified with the factor-weights union method and statistical analysis method.Five grades of rocky desertification risk were delineated based on Geographic Information System.The extremely low, low, moderate, high and extremely high rocky desertification risk zones accounted for 5.01%, 44.17%, 33.92%, 15.59% and 1.30%, respectively.As a whole, the rocky desertification risk level was moderate because the area of low and moderate rocky desertification risk zones occupied 78.09% of the study area.However, more than half of the area(about 50.81%) was predicted to have moderate rocky desertification risk and above, indicating that the study area was subject to rocky desertification.Rocky desertification risk was higher in the southeast and lower in the northwest of the study area.Distinct differences in the distribution of rocky desertification risk zones corresponding to different factors have been found. | ZHANG Panpan HU Yuanman XIAO Duning LI Xiuzhen YIN Jie HE Hong S | 2010 | Chinese Geographical Science2010，20，1： | 15 |
| 3 | Increased leptin by hypoxic-preconditioning promotes autophagy of mesenchymal stem cells and protects them from apoptosis显示文摘Autophagy is the basic catabolic progress involved in cell degradation of unnecessary or dysfunctional cellular components.It has been proven that autophagy could be utilized for cell survival under stresses.Hypoxic-preconditioning(HPC)could reduce apoptosis induced by ischemia and hypoxia/serum deprivation(H/SD)in bone marrow-derived mesenchymal stem cells(BMSCs).Previous studies have shown that both leptin signaling and autophagy activation were involved in the protection against apoptosis induced by various stress,including ischemia-reperfusion.However,it has never been fully understood how leptin was involved in the protective effects conferred by autophagy.In the present study,we demonstrated that HPC can induce autophagy in BMSCs by increased LC3-II/LC3-I ratio and autophagosome formation.Interestingly,similar effects were also observed when BMSCs were pretreated with rapamycin.The beneficial effects offered by HPC were absent when BMSCs were incubated with autophagy inhibitor,3-methyladenine(3-MA).In addition,down-regulated leptin expression by leptin-shRNA also attenuated HPC-induced autophagy in BMSCs,which in turn was associated with increased apoptosis after exposed to sustained H/SD.Furthermore,increased AMP-activated protein kinase phosphorylation and decreased mammalian target of rapamycin phosphorylation that were observed in HPC-treated BMSCs can also be attenuated by down-regulation of leptin expression.Our data suggests that leptin has impact on HPC-induced autophagy in BMSCs which confers protection against apoptosis under H/SD,possibly through modulating both AMPK and mTOR pathway. | WANG LiHan HU XinYang ZHU Wei JIANG Zhi ZHOU Yu CHEN PanPan WANG JianAn | 2014 | Science China(Life Sciences)2014，57，2： | 8 |
| 4 | Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes显示文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients. | Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 5 | Geochronological Records of Oil-Gas Accumulations in the Permian Reservoirs of the Northeastern Ordos Basin显示文摘油气体累积(OGA ) 的地球年代学是在多周期的石油地质学的一个挑战性的题目附加的盆。由 K-Ar, authigenic illite (AI ) 和液体包括(FI ) 分析标明日期与磷灰石分裂轨道结合了(在船尾) 热建模,在东北 Ordos 盆(击) 抑制二叠的水库的 OGA 时间的案例研究在这份报纸被进行了。二叠的 oil-gas-bearing 沙岩核心样品标明日期的 AI 显示出 178108 妈的一个宽时间领域。AI 年龄的分发介绍主要 OGA 在二叠的水库处理的 2 阶段,它分别地与 165 妈和 130 妈的 2 山峰年龄在 175155 妈和 145115 妈的时间域发展了。现在二组织与的在船尾热的路径上的样品和他们的投射年龄的 FI 温度山峰不仅一低并且一座高山峰在 9078hallow 地下水的范围的温度能满足国家标准。(2 ) 从 coalbed 生产的水主要包含了 NaCl 獲漠 ? 慗整 ? 潃牰摯 ' 讚攥?潃污敢 ? 慇? 湡 ? 桓污潬 ? 片畯摮慷整 ? 湩 ? 畩楬? 潃污楦汥? 景 ? | CHEN Gang YANG Fu LI Shuheng ZHANG Huiruo HU Yanxu LEI Panpan | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 4 |
| 6 | Purification of starch and phosphorus wastewater using core-shell magnetic seeds prepared by sulfated roasting显示文摘Core-shell magnetic seeds with certain adsorption capacity that were prepared by sulfated roasting, served as the core of a magnetic separation technology for purification of starch wastewater. XRD and SEM results indicate that magnetite's surface transformed to be porous α-Fe_2O_3 structure. Compared with magnetite particles, the specific surface area was significantly improved to be 8.361 from 2.591 m^2/g, with little decrease in specific susceptibility. Zeta potential, FT-IR and XPS experiments indicate that both phosphate and starch adsorbed on the surface of the core-shell magnetic seeds by chemical adsorption, which fits well with the Langmuir adsorption model. The porous surface structure of magnetic seeds significantly contributes to the adsorption of phosphate and starch species, which can be efficiently removed to be 1.51 mg/L(phosphate) and 9.51 mg/L(starch) using magnetic separation. | Chunjie Du Jinsheng Yu Wei Sun Haisheng Han Yuehua Hu Pan Chen Panpan Hou Runqing Liu Li Wang Yue Yang Ruohua Liu Lei Sun | 2019 | Journal of Environmental Sciences2019，31，7： | 4 |
| 7 | Flow characteristics of tangential leakage in a scroll compressor for automobile heat pump with CO_(2)显示文摘Tangential leakage loss reduction has great significance on improving the performance of scroll compressors.In this study,the flow field of a scroll compressor working with CO_(2) was numerically investigated.The development characteristics of the tangential leakage flow in different working chambers were carried out,which was obtained by analyzing the field quantities distributions.The impacts of the radial clearances and sidewall roughness on the tangential leakage were also taken into consideration,in order to explore the feasible method of the flow control for the tangential leakage in scroll compressors.Results showed that the tangential leakage flow had various characteristics in the suction and compression chambers due to the different interactions between the tangential leakage flow and mainstream.Owing to little reverse pressure gradient,the tangential leakage flow maintained the typical jet form in the suction chambers.By contrast,the mixing of the tangential leakage flow and mainstream induced the passage vortex and secondary flows in the compression chamber.The secondary flow was the primary factor that results in the occurrence of localized high temperature region rather than the tangential leakage.With the increase of the radial clearance,the volumetric efficiency declined and the discharge temperature increased rapidly.In terms of flow control of the tangential leakage,the increase of sidewall roughness by 2μm could achieve the same effect as the decrease of the radial clearance by 4μm,while the volumetric efficiency increased by almost 5%and average discharge temperature decreased by 5K. | ZHENG SiYu WEI MingShan HU ChenXing SONG PanPan TIAN Ran | 2021 | Science China(Technological Sciences)2021，64，5： | 4 |
| 8 | Mendelian randomization studies on atherosclerotic cardiovascular disease: evidence and limitations显示文摘Epidemiological research has revealed a galaxy of biomarkers, such as genes, molecules or traits, which are associated with increased risk of atherosclerotic cardiovascular diseases(ASCVD). However, the etiological basis remains poorly characterized.Mendelian randomization(MR) involves the use of observational genetic data to ascertain the roles of disease-associated risk factors and, in particular, differentiate those reflecting the presence or severity of a disease from those contributing causally to a disease. Over the past decade, MR has evolved into a fruitful approach to clarifying the causal relation of a biomarker with ASCVD and to verifying potential therapeutic targets for ASCVD. In this review, we selected high-quality MR studies on ASCVD, examined the causal relationship of a series of biomarkers with ASCVD, and elucidated the role of MR in validating biomarkers as a therapeutic target by comparing the results from MR studies and randomized clinical trials(RCTs) for the treatment of ASCVD. The good agreement between the results derived by MR and RCTs suggests that MR could be performed as a screening process before novel drug development. However, when designing and interpreting a MR study, the assumptions and limitations inherent in this approach should be taken into account. Novel methodological developments, such as sensitivity analysis, will help to strengthen the validity of MR studies. | Qin Hu Panpan Hao Qiji Liu Mei Dong Yaoqin Gong Cheng Zhang Yun Zhang | 2019 | Science China(Life Sciences)2019，62，6： | 4 |
| 9 | Experimental study of a micro-scale solar organic Rankine cycle system based on compound cylindrical Fresnel lens solar concentrator显示文摘In the present study, a micro-scale solar organic Rankine cycle power generation system was developed. The system comprises of a solar collection system based on compound cylindrical Fresnel lens concentrator and an organic Rankine cycle power generation system integrated with a scroll expander. YD320 and R245 fa were used as the heat transfer fluid and the working fluid, respectively. The effects of the evaporation pressure, the degree of superheat, and the mass flow rate of the working fluid were analyzed to evaluate the solar collection efficiency, the electric power output, the thermal efficiency and exergy efficiency of the system. The results illustrate that both the increasing evaporation pressure and decreasing superheat degree have positive impacts on solar collection efficiency. The electric power increases as the evaporation pressure increases, while the thermal efficiency and the exergy efficiency decrease. However, the system overall efficiency decreases slowly due to the increase of solar collection efficiency. The electric power increases with the increment of the working fluid mass flow rate. The increasing mass flow rate has no visible impact on the thermal and exergy efficiencies of organic Rankine cycle subsystem, whereas a slightly increase of the thermal and exergy efficiencies of the integrated system. The electric power decreases with the increase of the superheat degree, whereas the thermal and the exergy efficiencies of the system increase. The system works more suitably with a higher degree of superheat for the small mass flow rate condition. | MENG Jia SONG PanPan WEI MingShan TIAN GuoHong ZHAO Meng ZHENG HongFei HU GuangDa | 2019 | Science China(Technological Sciences)2019，62，12： | 3 |
| 10 | Effects of inherent alkali and alkaline earth metals on nitrogen transformation during steam gasification of Shengli lignite显示文摘This work evaluated the effects of inherent alkali and alkaline earth metals on nitrogen transformation during steam gasification of Shengli lignite at the temperature of 873-1173 K in a fluidized-bed/fixed-bed quartz reactor. The results indicated that the alkali metal Na and alkaline earth metals Ca, Mg in coal have different effects on inherent nitrogen transformation to NH3, HCN and char-N during the lignite steam gasification. Specifically during the steam gasification of Shengli lignite, Na and Ca, Mg not only catalyze the inherent nitrogen conversions to NH3, but also promote the secondary reactions of the nascent char-N as well as the generation of NH3 from the generated HCN, meanwhile they also inhibited the inherent nitrogen conversion to HCN and char-N. The presence of Na, Ca and Mg hindered the formation of oxidized nitrogen (N-X) functional groups, but enhanced pyridinic nitrogen (N-6) and quaternary nitrogen's (N-Q) formation in char. | Panpan Zheng Yonggang Wang Chen Liu Weijie Guo Lei Bai Xiao Hu Xiongchao Lin | 2019 | International Journal of Coal Science & Technology2019，6，2： | 2 |
| 11 | An oncolytic adenovirus delivering TSLC1 inhibits Wnt signaling pathway and tumor growth in SMMC-7721 xenograft mice model显示文摘Tumor suppressor in lung cancer-1(TSLC1)was first identified as a tumor suppressor for lung cancer,and frequently downregulated in various types of cancers including hepatocellular carcinoma(HCC).The Wnt pathway plays a critical role in tumorigenesis,migration,and invasion in HCC.However,the function of TSLC1 in modulating Wnt signaling in HCC is unclear.In this study,we evaluated the effect of TSLC1-armed oncolytic adenovirus(S24-TSLC1)on the Wnt/β-catenin pathway,cell viability,invasion and migration abilities of HCC in vitro and the growth of SMMC-7721-xenografted tumor in mice model.We detected the expression of TSLC1 in tumor samples and HCC cell lines.The results showed that TSLC1 expression was low in HCC,but high in pericarcinomatous tissue and normal cells,which implied that TSLC1 is a tumor suppressor of liver cancer.S24-TSLC1 exhibited an antitumor effect on HCC cell growth in vitro,but did little damage to normal liver cells.Overexpression of TSLC1 downregulated the transcriptional activity of TCF4/β-catenin and inhibited the mRNA or protein expression of Wnt target genes cyclinD1 and c-myc.S24-TSLC1 also inhibited the invasion and migration of HCC cells.Animal experiments further confirmed that S24-TSLC1 significantly inhibited tumor growth of the SMMC-7721-xenografted tumor.In conclusion,TSLC1 could downregulate the Wnt signal pathway and suppress HCC cell growth,migration and invasion,suggesting that S24-TSLC1 may be a potent antitumor agent for future clinical trials in liver cancer treatment. | Yigang Wang Panpan Huang Yanping Hu Keni Guo Xiaoyuan Jia Biao Huang Xinyuan Liu Xianglei He Fang Huang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 2 |
| 12 | Preparation and Characterization of regenerated cellulose fibers from a novel solvent system 显示文摘 | Zhenguo Li Panpan Hu Junrong Yu Zuming Hu and Zhaofeng Liu | 2008 | Jourmal Macromolecular Science Part B: Physics2008，47，2： | 1 |
| 13 | Dissociation between source and item memory in Parkinson's disease显示文摘 | Hu Panpan Li Youhai Ma Huijuan Xi Chunhua Chen Xianwen Wang Kai | 2014 | Chinese Medical Journal2014，，18： | 1 |
| 14 | Rechargeable quasi-solid-state aqueous hybrid Al^(3+)/H^(+) battery with 10,000 ultralong cycle stability and smart switching capability显示文摘Safe and long lifespan batteries facilitate the development of portable electronics and electric vehicles.Owing to the low-cost,naturally abundance,and trivalent charge carrier of aluminum with the highest theoretical volumetric capacity,rechargeable aqueous aluminum-ion-based batteries are considered as promising next-generation secondary batteries.However,traditional electrolytes and frequent collapse of the host structure of electrode materials greatly jeopardize the cycle stability of the batteries.Here,we develop a novel hydrogel-based electrolyte coupled with stable layered intercalation electrodes for the first time to fabricate a highly safe and flexible rechargeable hybrid Al^(3^(+))/H^(+)battery.The as-fabricated hybrid-ion battery(HIB)delivers a high specific capacity of 125 mAh·g^(−1) at 0.1 A·g^(−1) and exhibits an unprecedented super long-term cycling stability with no capacity fading over 10,000 cycles at 2 A·g^(−1).In addition,the hydrogel-based electrolyte possesses smart function of thermoresponsive switching,which can effectively prevent thermal runaway for the batteries.The unprecedented long cycle stability,highly intrinsic safety as well as low-cost indicate that the flexible aqueous HIBs are promising for applications. | Hua Wang Panpan Wang Zhenyuan Ji Zhe Chen Jiaqi Wang Wei Ling Jie Liu Mengmeng Hu Chunyi Zhi Yan Huang | 2021 | Nano Research2021，14，11： | 1 |
| 15 | UAV Laser scanning technology:a potential cost-effective tool for micro-topography detection over wooded areas for archaeological prospection显示文摘Airborne laser scanning(ALS)has recently been identified as a potential tool in topographic mapping for archaeological prospection.However,most existing applications in this field refers to manned ALS systems,for which the high operation and maintenance costs limits its application in small-scale archaeological investigation.In this paper,we conducted an exploratory study on the application of the unmanned aerial vehicle(UAV)laser scanning(ULS)system in ancient micro-topography detection over wooded areas.Compared with manned ALS technology,we analyzed the advantages and potentials of ULS technology for archaeological applications.Then we outlined existing mainstream survey-grade UAV-based laser scanners,data processing and visualization approaches.Furthermore,we performed case studies in three cultural heritage sites in Zhejiang Province,China using two representative mainstream survey-grade ULS systems.Results were then verified by an in-site investigation.Finally,the correct selection of ULS devices,the planning of data acquisition missions and the use of appropriate data processing methods specifically for archaeological prospection were discussed.This paper provides a cost-effective and flexible solution for micro-topography detection in wooded areas.ULS technology,as demonstrated here,can be an important supplement to existing archaeological investigation methods,particularly for small-scale areas,and has promising prospects in archaeological applications. | Wei Zhou Fulong Chen Huadong Guo Mingyuan Hu Qi Li Panpan Tang Wenwu Zheng Jian’an Liu Rupeng Luo Kaikai Yan Ru Li Pilong Shi Sheng Nie | 2020 | International Journal of Digital Earth2020，13，11： | 1 |
| 16 | Kinetic determination of pyrogallol by a novel oscillating chemical reaction catalyzed by a tetraazamacrocyclic complex显示文摘 | Hu Gang Chen Panpan Wang Wei | 2007 | Electrochimica Acta2007，52，： | 1 |
| 17 | Immunoglobu-lin A nephropathy in horseshoe kidney: case reports and litera-ture review显示文摘 | Panpan Hu Meiling Jin Yuansheng Xie | 2014 | Nephrology2014，19，10： | 1 |
| 18 | Fish-Eye Image Distortion Correction Based on Adaptive Partition Fitting显示文摘The acquisition of images with a fish-eye lens can cause serious image distortion because of the short focal length of the lens.As a result,it is difficult to use the obtained image information.To make use of the effective information in the image,these distorted imagesmust first be corrected into the perspective of projection images in accordance with the human eye’s observation abilities.To solve this problem,this study presents an adaptive classification fitting method for fish-eye image correction.The degree of distortion in the image is represented by the difference value of the distances fromthe distorted point and undistorted point to the center of the image.The target points selected in the image are classified by the difference value.In the areas classified by different distortion differences,different parameter curves were used for fitting and correction.The algorithm was verified through experiments.The results showed that this method has a substantial correction effect on fish-eye images taken by different fish-eye lenses. | Yibin He Wenhao Xiong Hanxin Chen Yuchen Chen Qiaosen Dai Panpan Tuand Gaorui Hu | 2021 | Computer Modeling in Engineering & Sciences2021，，1： | 1 |
| 19 | Microtopographic modification conserves urban wetland water quality by increasing the dissolved oxygen in the wet season显示文摘Microtopography affects hydrological processes and forms different microhabitats.Our previous study uncovered that riparian zone microtopography created various microhabitats with different soil environments and runoff-infiltration patterns.However,how riparian microtopography and microtopography within the water area(waterfall and tributary)affects downstream water quality remains unclear.Therefore,water samples were taken almost monthly in both the main stream and the tributary,before and after waterfalls,and near the bottom of three microtopographic types from June 2016 to March 2017.Compared with the dry season,the fact that water quality worsened in the wet season and that there were positive correlations for nitrate(NO3-)between water and the corresponding soil samples suggested that the riparian-soil environment affected the adjacent water quality mainly in the wet season.Nevertheless,riparian microtopography did not influence water quality downstream because of the low rainfall frequency and the weak leaching process due to plant interception.In the wet season,both the tributary and the waterfall increased the dissolved oxygen in the water body and,therefore,lowered the risk of eutrophication.The tributary has two pathways for improving the water quality,by increased disturbance and flow velocity,while the waterfall only has the former.However,such effects were not significant in the dry season.We conclude that the application of microtopographic modification is useful in maintaining urban wetland water quality in wet seasons. | Yali Liu Jianqing Du Panpan Hu Mingzhu Ma Dan Hu | 2020 | Journal of Environmental Sciences2020，32，1： | 1 |
| 20 | Prehistoric damaging earthquake promoted the decline of'Heluo Ancient State'in Early China显示文摘The emergence of the'Ancient State'is considered an important stage in the discourse on human civilizations.Based on its complex and hierarchical social structure,the Shuanghuaishu site of Henan Province is regarded as an'Ancient state',specifically the'Heluo Ancient State'.The site is situated in the middle reaches of the Yellow River region and played a key role in prehistoric China.However,the reasons behind its decline are unclear.Here,we conducted an integrated investigation of the archaeological excavations and archaeoseismic analyses at the Shuanghuaishu site.We identified paleoseismic remains within paleo-artificial moats,which were formed owing to off-fault structures of soil liquefaction,hillslope landslides,and related ground fractures,along with shake-related wall disruption and building collapse in the residential zone.Charcoal dating was conducted to constrain the age for this earthquake event,which was determined to be approximately 5.0 cal kyr BP.Furthermore,based on the practical curve for earthquake-induced liquefaction,the preliminary estimate of the magnitude of this paleo seismic event is greater than M_(s)5.9-6.0.We propose that the Shuanghuaishu site experienced a recession after the earthquake event,which may have influenced the continuous development of the'Heluo Ancient State'as a regional center settlement. | Xiu HU Peng LU Youli LI Duowen MO Wanfa GU Qingri LIU Ailun GUO Panpan CHEN Hui WANG Yan TIAN Xu WANG Yayi HU Jiqin ZHANG Zhen WANG Quanxing LUO Junjie XU | 2023 | Science China Earth Sciences2023，66，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员