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| 1 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 2 | Impact of antiviral therapy on post-hepatectomy outcome for hepatitis B-related hepatocellular carcinoma显示文摘The outcome after curative resection for hepatocellular carcinoma(HCC)remains unsatisfactory due to the high recurrence rate after surgery.In patients with hepatitis B virus(HBV)-related HCC,which is the majority of patients with HCC in Asia,a high viral load is a strong risk factor for HCC recurrence.It is logical to believe that antiviral therapy may improve the postoperative outcome by promoting viral clearance and hepatocyte regeneration,as well as improving residual liver volume in HCC patients with hepatitis B.However,the effect of antiviral therapy on clinical outcomes after liver resection in patients with HBV-related HCC remains to be established.There are two main groups of antiviral treatment for HBV-oral nucleos(t)ide analogues and interferon.Interferon treatment reduces the overall incidence of HBV-related HCC in sustained re-sponders.However,side effects may limit its long-term clinical application.Nucleos(t)ide analogues carry fewer side effects and are potent in terms of viral suppression when compared to interferon and are typically implemented for patients with more advanced liver diseases.They may also improve the outcome after curative resection for HBV-related HCC.There are increasing evidence to suggest that antiviral therapy could suppress HBV,decrease the perioperative reactivation of viral replication,reduce liver injury,preserve the liver function before and after operation,and may lower the risk of HCC recurrence.After all,antiviral therapy may improve the survival after liver resection by reducing recurrence and delaying the liver damage by the virus,resulting in a higher chance of receiving aggressive salvage therapy during HCC recurrence. | Charing Ching Ning Chong Grace Lai Hung Wong Paul Bo San Lai | 2014 | World Journal of Gastroenterology2014，20，20： | 15 |
| 3 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 4 | FLIC: Fast linear iterative clustering with active search显示文摘In this paper, we reconsider the clustering problem for image over-segmentation from a new perspective. We propose a novel search algorithm called'active search' which explicitly considers neighbor continuity. Based on this search method, we design a back-and-forth traversal strategy and a joint assignment and update step to speed up the algorithm. Compared to earlier methods, such as simple linear iterative clustering(SLIC) and its variants, which use fixed search regions and perform the assignment and the update steps separately, our novel scheme reduces the number of iterations required for convergence,and also provides better boundaries in the oversegmentation results. Extensive evaluation using the Berkeley segmentation benchmark verifies that our method outperforms competing methods under various evaluation metrics. In particular, our method is fastest,achieving approximately 30 fps for a 481 × 321 image on a single CPU core. To facilitate further research, our code is made publicly available. | Jiaxing Zhao Ren Bo Qibin Hou Ming-Ming Cheng Paul Rosin | 2018 | Computational Visual Media2018，4，4： | 12 |
| 5 | “Autoinflammatory psoriasis”-genetics and biology of pustular psoriasis显示文摘Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical presentations.Plaque psoriasis,which is the most common manifestation of psoriasis,is located on one end of the spectrum,dominated by adaptive immune responses,whereas the rarer pustular psoriasis lies on the opposite end,dominated by innate and autoinflammatory immune responses.In recent years,genetic studies have identified six genetic variants that predispose to pustular psoriasis,and these have highlighted the role of IL-36 cytokines as central to pustular psoriasis pathogenesis.In this review,we discuss the presentation and clinical subtypes of pustular psoriasis,contribution of genetic predisposing variants,critical role of the IL-36 family of cytokines in disease pathophysiology,and treatment perspectives for pustular psoriasis.We further outline the application of appropriate mouse models for the study of pustular psoriasis and address the outstanding questions and issues related to our understanding of the mechanisms involved in pustular psoriasis. | Ranjitha Uppala Lam C.Tsoi Paul W.Harms Bo Wang Allison C.Billi Emanual Maverakis J.Michelle Kahlenberg Nicole L.Ward Johann E.Gudjonsson | 2021 | Cellular & Molecular Immunology2021，18，2： | 7 |
| 6 | Latest Wuchiapingian to Earliest Triassic Conodont Zones and δ13 Ccarb Isotope Excursions from Deep-Water Sections in Western Hubei Province, South China显示文摘Deep-water facies sections have advantages of recording complete information across the Permian-Triassic boundary(PTB). Here we present a detailed study on the conodont biostratigraphy and carbon isotope profile ranges from the Wuchiapingian-Changhsingian boundary(WCB) to the PTB of two deep-water facies sections at Zhuqiao and Shiligou in the Middle Yangtze region, western Hubei, South China. Fifteen species and three genera are identified. Eight conodont zones are recognized which in ascending order are the Clarkina orientalis, C. wangi, C. subcarinata, C. changxingensis, C. yini, C. meishanensis, Hindeodus parvus and Isarcicella isarcica zones. The onset of deposition of the deep-water siliceous strata of Dalong Formation in western Hubei began in the Late Wuchiapingian and persisted to the Late Changhsingian. Carbon isotope negative excursions occur near both the WCB and PTB in both sections. The WCB δ13 Ccarb negative excursion is in the C. orientalis and C. wangi zones. The PTB δ13 Ccarb negative excursion began in the C. yini Zone and extended to the I. isarcica Zone. The absence of several Changhsingian zones may indicate the difficulty of extracting conodonts from siliceous strata or the presence of an intra-Changhsingian hiatus. | Bo Yang Hanxiao Li Paul B. Wignall Haishui Jiang Zhijun Niu Qian Ye Qiong Wu Xulong Lai | 2019 | Journal of Earth Science2019，30，5： | 5 |
| 7 | Catalytic microwave assisted pyrolysis of aspen显示文摘The effect of catalysts on the microwave pyrolysis of aspen pellets was studied.A range of chlorides,nitrates and metal-oxides were added at 2%of the aspen mass(air dry aspen pellet weight basis).Chlorides in particular were found to favor liquid yield,especially the yield of water phase residue.Average liquid yield with added chlorides was 41%mass of the total biomass input,compared to 35%mass without catalyst.Metal-oxides were found to favor pyrolysis heavy oil,and thus total oil yield,since the yield of light oils seemed to be fairly constant.Nitrates were found to favor pyrolysis gas production.Pure light oils and light oils blended with diesel were found to be a potential diesel fuel substitute. | Johannes Moen Changyan Yang Bo Zhang Hanwu Lei Kevin Hennessy Yiqin Wan Zhiping Le Yuhuan Liu Paul Chen Roger Ruan | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 5 |
| 8 | Integrative taxonomy of the Russet Bush Warbler Locustella mandelli complex reveals a new species from central China显示文摘Background: The Russet Bush Warbler Locustella(previously Bradypterus) mandelli complex occurs in mountains in the eastern Himalayas, southern China, Vietnam, the Philippines, and Indonesia. The taxonomy has been debated,with one(L. seebohmi) to four(L. seebohmi, L. mandelli, L. montis and L. timorensis) species having been recognised.Methods: We used an integrative approach, incorporating analyses of morphology, vocalizations and a molecular marker, to re-evaluate species limits in the L. mandelli complex.Results: We found that central Chinese L. mandelli differed from those from India through northern Southeast Asia to southeast China in plumage, morphometrics and song. All were easily classified by song, and(wing + culmen)/tail ratio overlapped only marginally. Both groups were reciprocally monophyletic in a mitochondrial cytochrome b(cytb) gene tree, with a mean divergence of 1.0 ± 0.2%. They were sympatric and mostly altitudinally segregated in the breeding season in southern Sichuan province. We found that the Mt Victoria(western Myanmar) population differed vocally from other L. mandelli, but no specimens are available. Taiwan Bush Warbler L. alishanensis was sister to the L. mandelli complex, with the most divergent song. Plumage, vocal and cytb evidence supported the distinctness of the south Vietnamese L. mandelli idonea. The Timor Bush Warbler L. timorensis, Javan Bush Warbler L.montis and Benguet Bush Warbler L. seebohmi differed distinctly in plumage, but among-population song variation in L. montis exceeded the differences between some populations of these taxa, and mean pairwise cytb divergences were only 0.5–0.9%. We also found that some L. montis populations differed morphologically.Conclusions: We conclude that the central Chinese population of Russet Bush Warbler represents a new species,which we describe herein, breeding at mid elevations in Sichuan, Shaanxi, Hubei, Hunan and Guizhou provinces.The taxonomic status of the other allopatric populations is less clear. However, as they differ to a degree comparable with that of the sympatric L. mandelli and the new species, we elevate L. idonea to species status, and retain L. seebohmi and L. montis as separate species, the latter with timorensis as a subspecies. Further research should focus on different populations of L. montis and the Mt Victoria population of L. mandelli. | Per Alstrom Canwei Xia Pamela C Rasmussen Urban Olsson Bo Dai Jian Zhao Paul J Leader Geoff J Carey Lu Dong Tianlong Cai Paul I Holt Hung Le Manh Gang Song Yang Liu Yanyun Zhang Fumin Lei | 2015 | Chinese Birds2015，，2： | 4 |
| 9 | Mapping Quantitative Trait Loci Associated with Aluminum Toxin Tolerance in NJRIKY Recombinant Inbred Line Population of Soybean (Glycine max)显示文摘To investigate the genetic mechanism of Al-tolerance in soybean, a recombinant inbred line population (RIL) with 184 F2:7:11 lines derived from the cross of Kefeng No.1 × Nannong 1138-2 (Al-tolerant × Al-sensitive) were tested in pot experiment with sand culture medium in net room in Nanjing. Four traits, i.e. plant height, number of leaves, shoot dry weight and root dry weight at seedling stage, were evaluated and used to calculate the average membership index (FAi) as the indicator of Al-tolerance. The composite interval mapping (CIM) under WinQTL Cartographer v. 2.5 detected five QTLs (i.e. qFAi-1, qFAi- 2, qFAi-3, qFAi-4 and qFAi-5), explaining 5.20%-9.07% of the total phenotypic variation individually. While with the multiple interval mapping (MIM) of the same software, five QTLs (qFAi-1, qFAi-5, qFAi-6, qFAi-7, and qFAi-8) explaining 5.7%-24.60% of the total phenotypic variation individually were mapped. Here qFAi-1 and qFAi-5 were detected by both CIM and MIM with the locations in a same ?anking marker region, GMKF046-GMKF080 on B1 and satt278-sat_95 on L, respectively. While qFAi-2 under CIM and qFAi-6 under MIM both on D1b2 were located in neighboring regions with their confidence intervals overlapped and might be the same locus. Segregation analysis under major gene plus polygene inheritance model showed that Al-tolerance was controlled by two major genes (h2mg = 33.05%) plus polygenes (h2pg = 52.73%). Both QTL mapping and segregation analysis confirmed two QTLs responsible for Al-tolerance with relatively low heritability, and there might be a third QTL, confounded with the polygenes in segregation analysis. | Bo Qi Paul Korir Tuanjie Zhao Deyue Yu Shouyi Chen Junyi Gai | 2008 | Journal of Integrative Plant Biology2008，50，9： | 4 |
| 10 | Fractionation and characterization of bio-oil from microwave-assisted pyrolysis of corn stover显示文摘Bio-oil from thermochemical conversion of biomass is a complex mixture of polar and non-polar compounds,and cannot be used directly as a combustion engine fuel due to its low heating value,high viscosity,chemical instability,and incomplete volatility.Mixed-solvent extraction was developed to fractionate bio-oils from microwave-assisted pyrolysis of corn stover to produce light oil(a mixture of light and inflammable fuel oil components from bio-oil)with low viscosity and low combustion residue,and high value chemicals.Different fractions from bio-oil were characterized using GC/MS and TG,and a major chemical(hydroxy-butanedioic acid diethyl ester)was separated. | Changyan Yang Bo Zhang Johannes Moen Kevin Hennessy Yuhuan Liu Xiangyang Lin Yiqin Wan Hanwu Lei Paul Chen Roger Ruan | 2010 | International Journal of Agricultural and Biological Engineering2010，3，3： | 4 |
| 11 | Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway显示文摘Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases. | Bo Huang Yufeng Qian Shujun Xie Xianhua Ye Hanwen Chen Zhifeng Chen Lihuan Zhang Jinming Xu Hu Hu Shenglin Ma Paul Héroux Di Wang Han-Ming Shen Yihua Wu Dajing Xia | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
| 12 | The influence of key chemical constituents in activated sludge on surface and flocculating properties显示文摘 | Britt-Marie Wilén Bo Jin Paul Lant | 2002 | Water Research2002，，9： | 3 |
| 13 | Ages and Hf isotopes of detrital zircons from the Permian strata in the engbatu area(Inner Mongolia) and tectonic implications显示文摘The Central Asian Orogenic Belt(CAOB) was built up through protracted accretion and collision of a variety of terranes/micro-continents during Neoproterozoice Mesozoic time. To understand potential links among Paleozoic subduction and accretionary processes that were operative during the development of the southeastern CAOB, we conducted a combined U-Pb and Hf-isotope analysis of detrital zircons from previously defined Devonian, Carboniferous and Early Permian strata in the Bengbatu area,Inner Mongolia. Detrital zircons from(meta-) sandstones in these strata commonly yield major Paleozoic age populations at ca. 300-261 Ma, 351-300 Ma and 517-419 Ma, and also give several Precambrian ages that range from 2687 Ma to 544 Ma. The youngest ages redefine the deposition of all these strata to be in the Middle Permian(Wordiane Capitanian) or later, much younger than previously considered.These ages, coupled with regional magmatic records, support an interpretation of most surrounding areas as possible detritus sources, including the Mongolian arcs to the north, the Northern Accretionary Orogen to the south, and the intervening Erenhote Hegenshan Ophiolite Belt. Zircons with magmatic ages of ca. 500-350 Ma and ca. 300-261 Ma display a large range of εHf(t) values(-13.97 to +15.31),whereas ca. 350-300 Ma zircons are dominated by positive εHf(t) values(+0.14 to +16.00). These results support the occurrence of two significant shifts of the zircon εHf(t) values, which has tectonic implications for the understanding of the Carboniferouse Permian evolution of the southeastern CAOB. A marked shift from mixed to positive zircon εHf(t) values at 350 -330 Ma likely manifests the incipient opening of the Hegenshan Ocean, due to the slab rollback of the subducting Paleo-Asian Oceanic lithosphere. Another shift from positive to mixed zircon εHf(t) values at ca. 300 Ma likely corresponds to a tectonic switch from syn-orogenic subduction-related to post-orogenic extensional setting, genetically related to the tectonic collapse of a formerly overthickened crust. | Bing Xu Guochun Zhao Jianhua Li Dongxing Liu Bo Wang Yigui Han Paul R. Eizenhofer Xiaoran Zhang Wenzhu Hou Qian Liu | 2019 | Geoscience Frontiers2019，10，1： | 2 |
| 14 | Multiplexed cytokine detection on plasmonic gold substrates with enhanced near-infrared fluorescence显示文摘 | Bo Zhang Jordan Price Guosong Hong Scott M. Tabakman Hailiang Wang Justin A. Jarrell Ju Feng Paul J. Utz Hongjie Dai | 2013 | Nano Research2013，6，2： | 2 |
| 15 | Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification显示文摘The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical,biological,or physical cues within a local tissue microenvironment.Deeper understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue engineering.This study aims to investigate that the regulation of magnesium cationic(Mg^2+)tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous ossification.It was discovered that moderate Mg^2+content niche(~4.11 mM)led to superior bone regeneration,while Mg^2+-free and strong Mg^2+content(~16.44 mM)discouraged cell adhesion,proliferation and osteogenic differentiation,thereby bone formation was rarely found.When magnesium ions diffused into free Mg zone from concentrated zone in late time point,new bone formation on free Mg zone became significant through intramembranous ossification.This study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue regeneration.The knowledge of how a Mg^2+cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissuerepairing biomaterials. | Jie Shen Bo Chen Xinyun Zhai Wei Qiao Shuilin Wu Xuanyong Liu Ying Zhao Changshun Ruan Haobo Pan Paul K.Chu Kenneth M.C.Cheung Kelvin W.K.Yeung | 2021 | Bioactive Materials2021，6，2： | 2 |
| 16 | Impacts of morphological, physical and chemical properties of sludge flocs on dewaterability of activated sludge显示文摘 | Bo Jin Britt-Marie Wilén Paul Lant | 2003 | Chemical Engineering Journal2003，，1： | 2 |
| 17 | Nanotrap-enabled quantification of KRAS-induced peptide hydroxylation in blood for cancer early detection显示文摘Circulating peptide is a potential source of biomarkers for cancer detection.However,the existence of large molecular weight proteins in plasma have a disastrous effect on circulating peptides isolating and detecting.Herein,nanotrap fractionation following by mass spectrometry have been applied to quantify the levels of bradykinin (BK) and hydroxylated bradykinin (Hyp-BK) as a relative measure of KRAS-regulated prolyl-4-hydroxylase alpha-1 (P4HA1) which may serve as early diagnosis marker for pancreatic ductal adenocarcinoma (PDAC).We found that P4HA1 can be upregulated by KRASG12v,which is a PDAC driver mutation,using HPNE/KRAS and HPNE cells.And we revealed that P4HA1 is overexpressed in PDAC tumors,compared to normal and inflamed pancreatic tissues.RNA interference revealed that P4HA1 activity was primarily responsible for Hyp-BK production.Mass spectrometry analysis revealed that plasma Hyp-BK/BK ratio was higher in PDAC than pancreatitis patients and healthy controls,while the area under the receiver operating characteristic (ROC) curve (AUC) is 0.8209 (95%Cl,0.7269-0.9149).The Hyp-BK/BK association with PDAC was reproduced in another cohort,where this ratio was found to increase with advancing tumor stage.These novel findings paved the way for wider applications of Nanotrap coupled mass spectrometry as a powerful tool for revealing biosignatures from plasma. | Zaian Deng Zhen Zhao Bo Ning Jeffery Basilio Karen Mann Jie Fu Yajun Gu Yuanqing Ye Xifeng Wu Jia Fan Paul Chiao Tony Hu | 2019 | Nano Research2019，12，6： | 2 |
| 18 | Development of FBMINC model for particle diffusion in fluids显示文摘An accurate particle tracking method using FBMINC (new fractional Brownian motion) is outlined. It generates non-Fickian diffusion rather than Fickian diffusion as traditional particle tracking model does. The FBMINC model is based on fractional Brownian motion (fBm) which is generalization of regular Brownian motion. The two models of fBms (FBM model and FBMINC model) were explored and the differences of the two models are compared from the three aspects: the standard deviation of each step, the small memory and the effect of the number of particles in the cloud. The results show the FBMINC model is a better model as it produces more accurate statistics. The effect of simple shear dispersion for both Brownian and fBm was investigated. The power law scaling of fBm shear dispersion was correctly identified. In addition, a scaling coefficient was found numerically. The FBMINC model is then used for producing both superdiffusive and subdiffusive particle paths, therefore, the non-Fickian diffusion of soil particle clouds can be modelled. The particle clouds represent soil contaminant are released in an idealised coastal bay and the fBm particle tracking method is used for simulation the particle cloud spreading in the bay. There is a noticeable increase in the spreading rate of the cloud. In addition, owning to the spreading rate of the cloud, a noticeable part of it has escaped the bay area and transported downstream. The variation of the Hurst exponent can lead to an area of the flow being affected by a contaminant cloud which is not picked up by the regular Brownian motion models. The purpose of this paper is to bring soil transport engineers a new angle on soil particle transport research in fluids. Using FBMINC particle tracking model allows more flexibility in simulation of diffusion in soil contaminant spread in coastal bay or ocean surface. | Bo QU Paul S ADDISION | 2009 | International Journal of Sediment Research2009，24，4： | 2 |
| 19 | The influence of key chemicalconstituents in activated sludge on surface and flocculatingproperties显示文摘 | Wilen Britt marie Jin Bo Lant Paul | 2003 | Water Research2003，37，9： | 1 |
| 20 | Direct fermentation of potato starch wastewater to lactic acid by Rhizopus oryzae and Rhizopus arrhizus显示文摘 | Li Ping Huang Bo Jin Paul Lant | 2005 | Bioprocess Biosyst Eng2005，27，： | 1 |
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