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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 3 | A worldwide phylogenetic (Gramineae) II: An update classifications classification of the Poaceae and a comparison of two 2015显示文摘我们在场在 768 个类, 12 个亚科,七 supertribes, 52 个部落,五 supersubtribes,和 90 subtribes 的 11506 草种类的一个新全球种系发生的分类;并且比较在 2015 出版的草家庭的二个种系发生的分类(Soreng 等。并且凯洛格) 。亚科(在基于种的数字下顺序) 是有在 202 个类, 15 个部落,和 30 subtribes 的 3968 种类的 Pooideae;有在 247 个类, 13 个部落,和 19 subtribes 的 3241 种类的 Panicoideae;有在 125 个类,三个部落,和 15 subtribes 的 1670 种类的 Bambusoideae;有在 124 个类,五个部落,和 26 subtribes 的 1602 种类的 Chloridoideae;有在三个类的 367 种类的 Aristidoideae,和一个部落;有在 19 个类的 292 种类的 Danthonioideae,和一个部落;有在八个类的 184 种类的 Micrairoideae,和三个部落;有在 19 个类,四个部落,和二 subtribes 的 115 种类的 Oryzoideae;有在 14 个类,二个部落,和二 subtribes 的 40 种类的 Arundinoideae;有在三个类的 12 种类的 Pharoideae,和一个部落;有在二个类的 11 种类的 Puelioideae,和二个部落;并且有在二个类的四种的 Anomochlooideae,和二个部落。我们也包括在 subtribes,部落,和亚科之中说明层次关系的一棵光线的树。最新描述的 taxa 包括:supertribes Melicodae 和 Nardodae;supersubtribes Agrostidodinae, Boutelouodinae, Gouiniodinae, Loliodinae,和 Poodinae;并且 subtribes Echinopogoninae 和 Ventenatinae。 | Robert J. Soreng Paul M. Peterson Konstantin Romaschenko Gerrit Davidse Jordan K. Teisher Lynn G. Clark Patricia Barbera Lynn J. Gillespie Fernando O. Zuloaga | 2017 | Journal of Systematics and Evolution2017，55，4： | 11 |
| 4 | FAIR Data Reuse-the Path through Data Citation显示文摘One of the key goals of the FAIR guiding principles is defined by its final principle-to optimize data sets for reuse by both humans and machines.To do so,data providers need to implement and support consistent machine readable metadata to describe their data sets.This can seem like a daunting task for data providers,whether it is determining what level of detail should be provided in the provenance metadata or figuring out what common shared vocabularies should be used.Additionally,for existing data sets it is often unclear what steps should be taken to enable maximal,appropriate reuse.Data citation already plays an important role in making data findable and accessible,providing persistent and unique identifiers plus metadata on over 16 million data sets.In this paper,we discuss how data citation and its underlying infrastructures,in particular associated metadata,provide an important pathway for enabling FAIR data reuse. | Paul Groth Helena Cousijn Tim Clark Carole Goble | 2020 | Data Intelligence2020，2，1： | 8 |
| 5 | Pushing the boundaries of diode-pumped solid-state lasers for high-energy applications显示文摘We report on the successful demonstration of a 150 J nanosecond pulsed cryogenic gas cooled,diode-pumped multi-slab Yb:YAG laser operating at 1 Hz.To the best of our knowledge,this is the highest energy ever recorded for a diodepumped laser system. | Saumyabrata Banerjee Paul Mason Jonathan Phillips Jodie Smith Thomas Butcher Jacob Spear Mariastefania De Vido Gary Quinn Danielle Clarke Klaus Ertel Cristina Hernez-Gomez Chris Edwards John Collier | 2020 | High Power Laser Science and Engineering2020，8，2： | 4 |
| 6 | Genetic Risk Factors for Post-Infectious Irritable Bowel Syndrome Following a Waterborne Outbreak of Gastroenteritis显示文摘 | Alexandra–Chloé Villani Mathieu Lemire Marroon Thabane Alexandre Belisle Geneviève Geneau Amit X. Garg William F. Clark Paul Moayyedi Stephen M. Collins Denis Franchimont John K. Marshall | 2010 | Gastroenterology2010，，4： | 4 |
| 7 | The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer显示文摘 | Craig P. Carden Adam Stewart Parames Thavasu Emma Kipps Lorna Pope Mateus Crespo Susana Miranda Gerhardt Attard Michelle D. Garrett Paul A. Clarke Paul Workman Johann S. de Bono Martin Gore Stan B Kaye Udai Banerji | 2012 | Molecular Cancer Therapeutics2012，，7： | 2 |
| 8 | Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome显示文摘 | Paul J. Kennedy Gerard Clarke Eamonn M.M. Quigley John A. Groeger Timothy G. Dinan John F. Cryan | 2011 | Neuroscience and Biobehavioral Reviews2011，，1： | 2 |
| 9 | 中英大学教育管理比较及对中国应用型大学改革的启示——基于英国南威尔士大学的访学考察显示文摘在高等教育趋向国际化的背景下,选取苏州科技大学和南威尔士大学这两所办学理念、学校定位、特色专业相近的中英高校作为考察对象,比较中英大学在教育行政管理、学时、专业和课程设置、课堂教学内容和教学方法、教学考核和监督、教学辅助、教师职位和职称、学生管理和实践教学环节等领域的异同,为中国应用型大学改革拓宽思路、探寻方法。 | 徐天舒 Paul Peachey Owen Clark | 2017 | 苏州教育学院学报2017，34，6： | 2 |
| 10 | Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation显示文摘AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral consistently achieving purity. Rat heterotopic cardiac transplantation and mixed lymphocyte reactivity were done using genetically inbred strains of PVG(donor) and DA(recipient). For the mixed lymphocyte reaction stimulator cells were irradiated with 3000 rads using a linear accelerator. Cyclosporin A was administered by gavage and venous blood collected 2 h later(C_2). The blood levels of Cs A(Neoral) were measured by immunoassay which consisted of a homogeneous enzyme assay(EMIT) on Cobas Mira. Statistical analyses of interactions were done by an acceleratedfailure time model with Weibull distribution for allograft survival and logistic regression for the mixed lymphocyte reactivity.RESULTS: Castanospermine prolonged transplant survival times as a function of dose even at relatively low doses. Cyclosporin A also prolonged transplant survival times as a function of dose particularly at doses above 2 mg/kg. There were synergistic interactions between castanospermine and Cs A in the prolongation of cardiac allograft survival for dose ranges of Cs A by castanospermine of(0 to 2) mg/kg by(0 to 200) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) and(0 to 3) mg/kg by(0 to 100) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) respectively. The addition of castanospermine did not significantly increase the levels of cyclosporin A on day 3 or day 6 for all doses of Cs A. On the contrary, cessation of castanospermine in the presence of Cs A at 2 mg/kg significantly increased the Cs A level(P = 0.002). Castanospermine inhibited mixed lymphocyte reactivity in a dose dependent manner but without synergistic interaction. CONCLUSION: There is synergistic interaction between castanospermine and Cs A in rat cardiac transplantation. Neither the mixed lymphocyte reaction nor the metabolism of Cs A provides an explanation. | Adrian D Hibberd David A Clark Paul R Trevillian Patrick Mcelduff | 2016 | World Journal of Transplantation2016，6，1： | 2 |
| 11 | 循证医学与发展中国家相关吗?——系统评价尚需被发展中国家的医护人员有效利用显示文摘 | Paul Chinnock Nandi Siegfried Mike Clarke 杜亮 | 2005 | 中国循证医学杂志2005，5，9： | 2 |
| 12 | Plant species identification using digital morphometrics: A review显示文摘 | James S. Cope David Corney Jonathan Y. Clark Paolo Remagnino Paul Wilkin | 2012 | Expert Systems With Applications2012，，8： | 2 |
| 13 | Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β显示文摘 | Quanlong Lu Zhigang Lu Qinying Liu Li Guo He Ren Jingyan Fu Qing Jiang Paul R Clarke Chuanmao Zhang | 2012 | Cell Research2012，22，11： | 2 |
| 14 | Synthesis and activity of a new catalystfor hydroprocessingtungsten phosphide显示文摘 | Paul Clark Wei Li Oyama S T | 2000 | Journal of catalysis2000，200，： | 1 |
| 15 | Modeling of modified atmosphere packaging based on designs with a membrane and perforations显示文摘 | PAUL D R CLARKE R | 2002 | Journal of Membrane Science2002，208，： | 1 |
| 16 | Nicotinic binding in rat brain: autoradiographic comparison of nicotine, and -alpha-bungarotoxin显示文摘 | Clarke PB Schwartz RD Paul SM | 1985 | J Neurosci1985，5，5： | 1 |
| 17 | High sensitivity mapping of methylated cytosines显示文摘 | Clark SJ Harrison J Paul CL | | 0，，： | 1 |
| 18 | Recurrent postmenopausal bleeding: a prospective cohort study显示文摘 | Paul P. Smith Siobhan O’Connor Janesh Gupta T Justin Clark | 2014 | The Journal of Minimally Invasive Gynecology2014，，： | 1 |
| 19 | Alliances,networks and competitive strategy:Rethinking clusters of innovation显示文摘 | Tracy Paul Clark Gordon L | 2003 | Growth & Change2003，34，1： | 1 |
| 20 | Optimization of the enzyme-linked lectin assay for enhanced glycoprotein and glycoconjugate analysis显示文摘 | Roisin Thompson Aileen Creavin Michael O'Connell Brendan O'Connor Paul Clarke | 2011 | Analytical Biochemistry2011，，2： | 1 |
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