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| 1 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 2 | Alcohol Consumption Decreases Rat Hepatic Creatine Biosynthesis Via Altered Guanidinoacetate Methyltransferase Activity显示文摘 | Kusum K. Kharbanda Sandra L. Todero Jordan C. Moats Ryan M. Harris Natalia A. Osna Paul G. Thomes Dean J. Tuma | 2014 | Alcohol Clin Exp Res2014，，3： | 2 |
| 3 | Developing a global interconnected power system model显示文摘Decarbonizing the power sector is a necessary step towards a low-carbon future. Interconnecting power systems on different continents could be a method to contribute to such a future, by utilizing highly efficient renewable resources around the globe, while simultaneously providing additional benefits of power system integration. In this paper, we describe the process of constructing and simulating a global interconnected power system model with high technical and temporal resolution. Being the first of its kind on the global scale, this paper is designed to showcase the proof of concept as an intermediate step to a high resolution global model, by integrating an existing European power system model with the North-American continent. The work to date has been focused on testing the methodology and building up necessary knowledge to realistically simulate the functionality of a possible future global grid. Some initial results are analysed to support the viability of the model and the concept in general. Furthermore, key factors influencing the development and optimal performance of the global interconnected power system model are identified. | Maarten Brinkerink Paul Deane Seán Collins Brian Ó Gallachóir | 2018 | Global Energy Interconnection2018，1，3： | 2 |
| 4 | Fluocinolone Acetonide Intravitreal Implant for Diabetic Macular Edema: A 3-Year Multicenter, Randomized, Controlled Clinical Trial显示文摘 | P. Andrew Pearson Timothy L. Comstock Michael Ip David Callanan Lawrence S. Morse Paul Ashton Brian Levy Eric S. Mann Dean Eliott | 2011 | Ophthalmology2011，，8： | 2 |
| 5 | Transgastric instrumentation and bacterial contamination of the peritoneal cavity显示文摘 | Vimal K. Narula Jeffrey W. Hazey David B. Renton Kevin M. Reavis Christopher M. Paul Kristen E. Hinshaw Bradley J. Needleman Dean J. Mikami E. Christopher Ellison W. Scott Melvin | 2008 | Surgical Endoscopy2008，，3： | 2 |
| 6 | Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor immune microenvironment显示文摘 | Aleksandar D. Kostic Eunyoung Chun Lauren Robertson Jonathan N. Glickman Carey Ann Gallini Monia Michaud Thomas E. Clancy Daniel C. Chung Paul Lochhead Georgina L. Hold Emad M. El-Omar Dean Brenner Charles S. Fuchs Matthew Meyerson Wendy S. Garrett | 2013 | Cell Host & Microbe2013，，： | 1 |
| 7 | CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver显示文摘 | Ye Htun Oo Vanessa Banz Dean Kavanagh Evaggelia Liaskou David R. Withers Elizabeth Humphreys Gary M. Reynolds Laura Lee-Turner Neena Kalia Stefan G. Hubscher Paul Klenerman Bertus Eksteen David H. Adams | 2012 | Journal of Hepatology2012，，5： | 1 |
| 8 | Role of Raman spectroscopy and surface enhanced Raman spectroscopy in colorectal cancer显示文摘Colorectal cancer(CRC) is the fourth most commoncancer in the United Kingdom and is the second largest cause of cancer related death in the United Kingdom after lung cancer.Currently in the United Kingdom there is not a diagnostic test that has sufficient differentiation between patients with cancer and those without cancer so the current referral system relies on symptomatic presentation in a primary care setting.Raman spectroscopy and surface enhanced Raman spectroscopy(SERS) are forms of vibrational spectroscopy that offer a nondestructive method to gain molecular information about biological samples.The techniques offer a wide range of applications from in vivo or in vitro diagnostics using endoscopic probes,to the use of micro-spectrometers for analysis of biofluids.The techniques have the potential to detect molecular changes prior to any morphological changes occurring in the tissue and therefore could offer many possibilities to aid the detection of CRC.The purpose of this review is to look at the current state of diagnostic technology in the United Kingdom.The development of Raman spectroscopy and SERS in clinical applications relation for CRC will then be discussed.Finally,future areas of research of Raman/SERS as a clinical tool for the diagnosis of CRC are also discussed. | Cerys A Jenkins Paul D Lewis Peter R Dunstan Dean A Harris | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 1 |
| 9 | A survey of Canadian intensivists' resuscitation practices in early septic shock显示文摘 | Lauralyn A McIntyre Paul C Hebert Dean Fergusson | 2007 | Crit Care Med2007，11，4： | 1 |
| 10 | A phase I study of oxaliplatin in combination with gemcitabine: correlation of clinical outcome with gene expression显示文摘 | Stephen Shibata Warren Chow Paul Frankel Agnes Juhasz Lucille Leong Dean Lim Kim Margolin Robert Morgan Edward Newman George Somlo Yun Yen Timothy Synold David Gandara Heinz-Josef Lenz James Doroshow | 2007 | Cancer Chemotherapy and Pharmacology2007，，4： | 1 |
| 11 | Kryptonite Bone Cement Prevents Pathologic Sternal Displacement显示文摘 | Paul W.M. Fedak Eric Kolb Garry Borsato Dean E.C. Frohlich Aleksey Kasatkin Kishan Narine Naresh Akkarapaka Kathryn M. King | 2010 | The Annals of Thoracic Surgery2010，，3： | 1 |
| 12 | Construct design for efficient, effective and high‐throughput gene silencing in plants显示文摘 | S. VarshaWesley Christopher A.Helliwell Neil A.Smith MingBoWang Dean T.Rouse QingLiu Paul S.Gooding Surinder P.Singh DavidAbbott Peter A.Stoutjesdijk Simon P.Robinson Andrew P.Gleave Allan G.Green Peter M.Waterhouse | 2001 | The Plant Journal2001，，6： | 1 |
| 13 | Managing supply chain risk and disruption from IT security incidents 显示文摘 | Jason K Deane Cliff T Ragsdale Terry R Rakes Loren Paul Rees | 2009 | Journal of Oper Manag Res2009，，2： | 1 |
| 14 | Integrin avβ1 Is a Receptor for foot-and-mouth disease virus显示文摘 | Terry J Paul M Dean S | 2002 | J Virol2002，2，： | 1 |
| 15 | Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting显示文摘 | Mathias Ehrich Cosmin Deciu Tricia Zwiefelhofer John A. Tynan Lesley Cagasan Roger Tim Vivian Lu Ron McCullough Erin McCarthy Anders O.H. Nygren Jarrod Dean Lin Tang Don Hutchison Tim Lu Huiquan Wang Vach Angkachatchai Paul Oeth Charles R. Cantor Allan Bo | 2011 | American Journal of Obstetrics and Gynecology2011，，3： | 1 |
| 16 | Integration of CAPS markers into the RFLP map generated using recombinant inbred lines of Arabidopsis thaliana显示文摘 | Paul Jarvis Clare Lister Veronique Szabo Caroline Dean | 1994 | Plant Molecular Biology1994，，4： | 1 |
| 17 | Neuronal gap junctions in the mouse main olfactory bulb: morphological analyses on transgenic mice 显示文摘 | I Kosaka T Deans MR Paul DL | 2005 | Neuroscience2005，134，： | 1 |
| 18 | Distributive and Procedural Justice as Predictors of Satisfaction with Personal and Organizational Outcomes 显示文摘 | Dean B McFarlin Paul D Sweeney | 1992 | The Academy of Management Journal1992，35，3： | 1 |
| 19 | The Alzheimer’s Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans显示文摘 | Ju-Hee Kang Magdalena Korecka Michal J. Figurski Jon B. Toledo Kaj Blennow Henrik Zetterberg Teresa Waligorska Magdalena Brylska Leona Fields Nirali Shah Holly Soares Robert A. Dean Hugo Vanderstichele Ronald C. Petersen Paul S. Aisen Andrew J. Saykin Mic | 2015 | Alzheimer’s & Dementia: The Journal of the Alzhei2015，，7： | 1 |
| 20 | BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models显示文摘 | Ningshu Liu Bruce R. Rowley Cathy O. Bull Claudia Schneider Andrea Haegebarth Christoph A. Schatz Paul R. Fracasso Dean P. Wilkie Martin Hentemann Scott M. Wilhelm William J. Scott Dominik Mumberg Karl Ziegelbauer | 2013 | Molecular Cancer Therapeutics2013，，11： | 1 |
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