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10篇 您的检索式：作者名="Paul HS"

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		题名	作者	年代	出处	被引量
	1	Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.	Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson	2005	World Journal of Gastroenterology2005，11，42：	4
	2	Randomized controlled trial of an internet- based intervention using ran dora digit dial recruitment: the disaster recovery web pro ject 显示文摘	Ruggiero KJ Resnick HS Paul LA	2012	Contemporary Clinical Trials2012，33，1：	1
	3	Anti-biofilm efficacy of ni-tric oxide-releasing silica nanoparticles 显示文摘	Hetriek EM Shin JH Paul HS e( al	2009	Biomatefials2009，30，：	1
	4	Hepatocyte transplantation improves phenotype and extends survival in a murine model of inter- mediate maple syrup urine disease 显示文摘	Skvorak KJ Paul HS Dorko K	2009	Mol Ther2009，17，7：	1
	5	Managing disruption risks in supply chains 显示文摘	Paul RK Germaine HS	2005	Production and Operations Management2005，14，1：	1
	6	Impact of diabetes mellitus ( DM ) on the health-care utilization and clinical outcomes of patients with stroke in singapore显示文摘	Sun Y Paul M Toh HS	2009	Int Soc Phaml Outcomes Res(ISPOR)2009，，：	1
	7	Dual mechanism of brain injury and novel treat-ment strategy in maple syrup urine disease显示文摘	Zinnanti WJ Lazovic J Griffin K Skvorak KJ Paul HS Ho-manics GE	2009	Brain2009，132，4：	1
	8	Treatment of closed tibial fractures显示文摘	Andrew HS Christopher GF Paul T	2003	Jour Bone Join Surg (Am)2003，85，2：	1
	9	Biofilm formation and dispersal and the transmission of human pathogens显示文摘	Luanne HS Paul S	2005	Trends in Microbiology2005，13，1：	1
	10	Managing disruption risks in supply chains 显示文摘	Paul RK Germaine HS	2005	Production and Operations Management2005，14，1：	1

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